Abstract:
OBJECTIVES:The purpose of this study is to use diffusion tensor imaging (DTI) parameters to evaluate cerebral ischemia/reperfusion injury in the infarct core (IC) and ischemic penumbra (IP) in a rhesus transient middle cerebral artery occlusion (MCAO) model. METHODS:Seven rhesus monkeys were used to construct the MCAO model. The temporal evolution of the relative apparent diffusion coefficient (rADC) and the relative fractional anisotropy (rFA) in the IC area, infarct growth area (IG), and reversible penumbra area (RP) were investigated. RESULTS:The rADC increased in the three areas in the early stage of reperfusion (1 hour after the reperfusion). However, the rate of rADC improvement was significantly slower in IG than in IC and RP. Different temporal evolutions of rFA were observed in the three areas in the following stage of reperfusion (3-24 hours after the reperfusion), which continued to decline in IG but slightly elevated in IC and RP. DISCUSSION:These findings suggest that the evolution of DTI parameters can help in the assessment of cerebral ischemia/reperfusion injury in the penumbra and predict the growth of the infarction area after stroke.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Guo J,Zheng HB,Duan JC,He L,Chen N,Gong QY,Tang HH,Li HX,Wang L,Cheng JQdoi
10.1179/016164110X12761752770177subject
Has Abstractpub_date
2011-01-01 00:00:00pages
108-12issue
1eissn
0161-6412issn
1743-1328pii
ner2201journal_volume
33pub_type
杂志文章abstract::Severe head injuries tend to be associated with hypermetabolism and hypercatabolism resulting in negative nitrogen balances which may exceed 30 grams day-1. Enteral feeding should begin as soon as the patient is hemodynamically stable, attempting to reach a non-protein caloric intake of at least 30-35 kcal kg-1 day-1 ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164101101198451
更新日期:2001-03-01 00:00:00
abstract::Spinal cord neuron and dorsal column fiber responses to electrical stimulation of the sciatic nerve in anesthetized cats were recorded before, during, and after periods of repetitive electrical stimulation of the sciatic nerve through an implantable nerve cuff stimulator device of the type and method used in human pat...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1981.11739598
更新日期:1981-01-01 00:00:00
abstract:OBJECTIVE:Recurrent lumbar disc herniation (rLDH) is a common issue after primary discectomy and can cause severe pain, morbidity, and reoperation. The purpose of this systematic review was to evaluate the surgical management of recurrent lumbar disc herniation. METHODS:A systematic literature search was conducted usi...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1787661
更新日期:2020-12-01 00:00:00
abstract:INTRODUCTION:Alteration of sensorium or an encephalopathy is a common diagnostic dilemma in critically ill patients and can be caused by a number of conditions. Sepsis associated encephalopathy (SAE) is now the most common encephalopathy encountered among intensive care unit (ICU) patients. DEFINITIONS:SAE is an encep...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164107X240233
更新日期:2007-10-01 00:00:00
abstract::Because clinicians require objectively demonstrable neurological deficits to confirm a diagnosis, the recognition of embolic events in the nervous system is generally restricted to the effects of ischemic necrosis produced by arterial occlusion. However, magnetic resonance imaging (MRI) has shown that lesser degrees o...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164107X181789
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVES:4-N-trimethylammonium-3-hydroxybutyric acid (L-carnitine) is an endogenous mitochondrial membrane compound and some studies have reported that L-carnitine could effectively protect various cells against oxidative injury both in vitro and in vivo. In the present study, we used the human neuroblastoma SH-SY5Y ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132810Y.0000000028
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:After a spinal cord injury (SCI), most men experience fertility related problems including poor semen quality in which decreased sperm viability and motility, have been proposed to be related to the accessory sex glands dysfunction. In this study, we investigated the probable effects of SCI on the seminal ves...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164108X268287
更新日期:2008-06-01 00:00:00
abstract::We describe a case of rebleeding from an intracranial vertebral dissecting aneurysm following proximal clipping. This case suggests that proximal clipping alone may not be an adequate surgical procedure to prevent rebleeding. Surgical treatment of intracranial dissecting aneurysms in the vertebral artery presenting as...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1080/01616412.1994.11740213
更新日期:1994-04-01 00:00:00
abstract:OBJECTIVE:Repetitive magnetic stimulation (rMS) is mainly used in transcranial applications. Only a few works have described its potential peripheral use. The aim of this investigation was to determine if conditioning peripheral (paravertebral) rMS of the cervical nerve roots in a group of healthy subjects induces chan...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X297959
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:Tissue plasminogen activator (tPA) may aggravate ischemic neuronal damage after focal cerebral ischemia and increase blood-brain barrier permeability. Human serum albumin has neuroprotective effects on ischemic stroke. However, whether albumin can attenuate the deleterious effects of tPA is yet unknown. METH...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313209X393898
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVES:The stroke-prone spontaneously hypertensive rat is a genetic model of severe hypertension with secondary vascular alterations. The aim of this study was to determine the influence of chronic hypertension and ramipril treatment on the extracellular matrix in the cerebral microvasculature. METHODS:The study c...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164105X49256
更新日期:2005-07-01 00:00:00
abstract::Excessive calcium influx has been implicated in the pathophysiology of ischemic cerebral damage. The effects of nimodipine, a calcium antagonist, on the Na(+)-K+/MG+2 ATPase activity, Ca+2/Mg+2 ATPase, lipid peroxidation, and early ultrastructural findings were examined at the acute stage of ischemia in the rat brain....
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164101101198208
更新日期:2001-01-01 00:00:00
abstract::One case of dural arteriovenous malformation in the base of the anterior cranial fossa is reported. It was discovered by means of a PW-Doppler examination of angular branch of the ophthalmic artery in a patient under observation for hypertrophy of a superficial temporal artery. The nidus was located in the region of t...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1995.11740317
更新日期:1995-06-01 00:00:00
abstract::This paper describes a previously unreported clinical onset of carcinomatous meningitis with bilateral deafness. Typical changes in the cerebrospinal fluid aside from positive cytology findings are reviewed. In cases of suspected carcinomatous meningitis the clustering of increased CSF protein, lactate, decreased gluc...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101200708
更新日期:2002-10-01 00:00:00
abstract::In models of middle cerebral artery occlusion using intraluminal suture, the size and the distribution of ischemic injury vary considerably among laboratories. In transcranial models of cerebral ischemia, a more consistent cerebral ischemic lesion is seen in Spontaneously Hypertensive rats (SHR). In the present study,...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740517
更新日期:1998-04-01 00:00:00
abstract::Refractory status epilepticus (RSE), defined as status epilepticus that fails to respond to the acute administration of two antiepileptic medications, occurs in approximately a third of patients with status epilepticus, and is associated with increased hospital length of stay, mortality, and functional disability. Com...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/1743132812Y.0000000128
更新日期:2013-03-01 00:00:00
abstract::Corticotrophin releasing factor has been shown in several models of tissue injury to be an effective treatment for edema. In a previous study we demonstrated this ability in two models of traumatic brain injury (TBI). The aim of this study was to assess whether human corticotrophin releasing factor (hCRF) could additi...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2000.11740737
更新日期:2000-10-01 00:00:00
abstract::This investigation was designed to clarify the chronic effects of cardiogenic emboli on cerebral perfusion and tissue densities within remaining noninfarcted brain. Local cerebral perfusion and tissue densities were measured by xenon-contrasted CT scanning and compared by cross-sectional designs among normal volunteer...
journal_title:Neurological research
pub_type: 杂志文章
doi:
更新日期:1995-10-01 00:00:00
abstract::Recent evidence indicates that different vascular risk factors are present in Alzheimer's disease (AD) and other prevalent dementia types probably contributing to deterioration of cerebrovascular function, thus enhancing neurodegeneration and premature neuronal death due to a reduction in brain perfusion. Brain blood ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164103101202002
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:This study investigated the relationship between traumatic coagulopathy and severe brain swelling (SBS) during decompressive surgery to evacuate a supratentorial intradural mass lesion in patients with traumatic brain injury (TBI). METHODS:A retrospective study was conducted in 96 patients who consecutively ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000187
更新日期:2013-07-01 00:00:00
abstract::Experiments were carried out to clarify the effect of serotonin [5-hydroxytryptamine (5-HT)] upon the somatosensory evoked potential (SEP) elicited by superficial radial nerve stimulation in cat, and the following results were obtained: (i) in untreated (control) animals, a significant reduction occurred in amplitude ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1989.11739871
更新日期:1989-06-01 00:00:00
abstract::Background: Surgery of parasagittal meningiomas (PSMs) is still technically challenging, for the balance between radical resection and preservation of venous circulation. In this article, we'd systemically introduce the technical nuances of a simplified strategy for radical resection of all types of PSMs. All the case...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1847530
更新日期:2020-11-11 00:00:00
abstract::Various surgical approaches have been described for treating lesions which arise in the sellar region. The popular transnasal-transsphenoidal and transethmoidal-transsphenoidal approaches avoid the morbidity associated with transcranial operations while allowing enough exposure to successfully remove most lesions that...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164101101198280
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:Meningiomas are benign intracranial tumors growing from the arachnoid cap cells. Although their behavior is usually benign, they tend to recur even after total removal, and their recurrence is dependent on different aspects. METHODS:Between 1991 and 2002, 463 patients with an intracranial meningioma were ope...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X338043
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:Neuropsychological outcomes after carotid endarterectomy (CEA) have been investigated extensively. However, cognitive impacts of carotid angioplasty and stenting (CAS), an emerging alternative to CEA, have not been studied. This study is aimed at investigating pattern and degree of cognitive changes after CAS...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X159216
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to establish a robust set of motor tasks that could be used to functionally delineate the motor cortex with blood oxygenation level dependent functional magnetic resonance imaging (BOLD fMRI) at 3 T and produce precise functional maps for pre-operative planning and functional neurona...
journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1179/016164108X323753
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVES:In this study, we aimed to investigate the effect of bone mesenchymal stem cells (BMSCs) conditioned medium on BMP4-induced activation of the Smad signaling pathway during the process of neural stem cells differentiation. METHODS:We designed four experimental groups: (A) control group, (B) BMP-4 treatment g...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2016.1232549
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVES:In the clinical set, autologus nerve grafts are the current option for reconstruction of nerve tissue losses. The length of the nerve graft has been suggested to affect outcomes. Experiments were performed in the rat in order to test this assumption and to detect a possible mechanism to explain differences i...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164105X18494
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVE:Spinal cord injury (SCI) causes muscle atrophy, which is particularly severe, due to inability to perform tetanic contractions, when lower motor neurons (LMN) are involved. We performed a longitudinal study in 25 Europeans suffering from complete conus cauda syndrome from 0.7 to 8.7 years comparing functional...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313209X385644
更新日期:2010-02-01 00:00:00
abstract::Phosphorus magnetic resonance spectroscopy (31P-MRS) was made to measure changes in brain high energy phosphate compounds, adenosine triphosphate (ATP) and phosphocreatine (PCr), inorganic phosphorus (Pi) and intracellular pH (pHi) during a prolonged period of incomplete brain ischaemia produced, in anaesthetized dogs...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1990.11739943
更新日期:1990-12-01 00:00:00