Abstract:
:Phosphorus magnetic resonance spectroscopy (31P-MRS) was made to measure changes in brain high energy phosphate compounds, adenosine triphosphate (ATP) and phosphocreatine (PCr), inorganic phosphorus (Pi) and intracellular pH (pHi) during a prolonged period of incomplete brain ischaemia produced, in anaesthetized dogs, by bilateral carotid occlusion together with haemorrhagic hypotension for intervals of up to 300 min. Mean arterial blood pressure (MABP) was lowered in a stepwise fashion, until signs of metabolic decompensation (as estimated by MRS) occurred. At that point MABP was varied against further evidence of metabolic decompensation in an attempt to maintain a more constant degree of insult. At the end of the ischaemic period MABP was restored and the animals observed during a 3 h recovery period. At the end of the recovery period the brains were perfusion-fixed for histological examination. A semi-quantitative method of histological evaluation was used to determine the degree of histological damage. This permitted assignment of an 'ischaemic score' to the tissue sampled from each animal. Comparisons were then made between the magnitude of this 'ischaemic score' and the changes in metabolic and physiological variables (ATP, PCr, pHi and MABP) as well as an estimator of phosphorylation potential (PCr/Pi), which were all measured during the ischaemic insult. Histological examination showed a wide variety of neuronal alterations, including dark and pale type injury, which correlated directly with the metabolic derangements brought about by ischaemia. The degree of damage determined from this histological assessment correlated best with the duration and degree of change in PCr/Pi, supporting the use of this ratio as a critical index of cellular energy state. In particular there was a strong linear relationship between the degree of leucocyte recruitment and changes in PCr/Pi. To summarize, metabolic changes, determined by MRS, correlate with the degree of histological damage, and in turn, the classical descriptions of acute ischaemic neuronal injury appear to be validated by MRS determinations of metabolic changes during ischaemia.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Anderson ML,Smith DS,Nioka S,Subramanian H,Garcia JH,Halsey JH,Chance Bdoi
10.1080/01616412.1990.11739943subject
Has Abstractpub_date
1990-12-01 00:00:00pages
195-204issue
4eissn
0161-6412issn
1743-1328journal_volume
12pub_type
杂志文章abstract::The therapeutic effect of insulin alone or insulin combined with 30 min delayed thrombolytic therapy was investigated in rats embolized in the right hemisphere with a fibrin clot made from autologous blood. Animals were killed seven days after embolization and the infarct volumes were measured in % of the affected hem...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101200096
更新日期:2002-06-01 00:00:00
abstract::The possibility of the evaluation of ischemia solely by the momentary values of regional cerebral blood flow (rCBF) was investigated. Ischaemic damage was evaluated histopathologically and by observing albumin extravasation. Unilateral carotid clippings were performed for 1 h and the gerbils evaluated with regard to t...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1988.11739846
更新日期:1988-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Misery perfusion increases the risk of stroke recurrence in patients with symptomatic major cerebral artery occlusion. The ratio of brain perfusion contralateral-to-affected asymmetry in the cerebellar hemisphere to brain perfusion affected-to-contralateral asymmetry in the cerebral hemisphere ...
journal_title:Neurological research
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更新日期:2014-03-01 00:00:00
abstract::Rats were exposed in utero plus 60 days post-partum to either complex music (Mozart Sonata (k. 448)), minimalist music (a Philip Glass composition), white noise or silence, and were then tested for five days, three trials per day, in a multiple T-maze. By Day 3, the rats exposed to the Mozart work completed the maze m...
journal_title:Neurological research
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doi:10.1080/01616412.1998.11740543
更新日期:1998-07-01 00:00:00
abstract::Analysis of the blood flow velocities in the middle cerebral artery by transcranial Doppler ultrasonography was performed in 158 healthy volunteers (aged 14-70 years; 82 men and 76 women). In a subgroup of 38 men and 21 women the end-tidal [CO2] was also measured. The influence of biological factors such as age, sex, ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1990.11739941
更新日期:1990-09-01 00:00:00
abstract:OBJECTIVES:The stroke-prone spontaneously hypertensive rat is a genetic model of severe hypertension with secondary vascular alterations. The aim of this study was to determine the influence of chronic hypertension and ramipril treatment on the extracellular matrix in the cerebral microvasculature. METHODS:The study c...
journal_title:Neurological research
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doi:10.1179/016164105X49256
更新日期:2005-07-01 00:00:00
abstract::The influence of acidic fibroblast growth factor (aFGF) on sleep was studied in conscious rabbits. An intravenous (i.v.) bolus injection of aFGF induced a significant increase in sleep duration in comparison with animals that received vehicle solution. Somnogenic effects were obtained 30 min following i.v. aFGF admini...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1996.11740472
更新日期:1996-12-01 00:00:00
abstract::To estimate the regional perfusion pressure and possibly the stump pressure during carotid endarterectomy, cerebral blood flow (CBF) measurements including a vasodilatory test were performed preoperatively. CBF was measured by 133Xe inhalation and emission tomography. An intravenous dose of 1g acetazolamide (Diamox) w...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1987.11739765
更新日期:1987-03-01 00:00:00
abstract::This paper describes a previously unreported clinical onset of carcinomatous meningitis with bilateral deafness. Typical changes in the cerebrospinal fluid aside from positive cytology findings are reviewed. In cases of suspected carcinomatous meningitis the clustering of increased CSF protein, lactate, decreased gluc...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101200708
更新日期:2002-10-01 00:00:00
abstract::Cerebral hemorrhages are subject to a heavy short- and long-term case fatality. A study of prognostic factors and of relative survival based on the data of a population registry is of great value to study patients having a hematoma of all ages, irrespective of the method of care. We have listed 183 patients having a c...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2000.11740754
更新日期:2000-12-01 00:00:00
abstract::The endothelial lining of blood vessels plays an important role in the control of arterial tone by releasing a number of vasoactive factors. Among these, nitric oxide (NO) or a NO containing moiety, some cyclooxygenase products such as prostacyclin (PGl2) and a still hypothetical hyperpolarizing factor may induce dila...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1997.11740851
更新日期:1997-10-01 00:00:00
abstract::The present study aimed to examine the effects of N omega-nitro-L-arginine (LNA) on the early ischemic neuronal damage (EIND). All the experiments were carried out under general anesthesia, maintaining the blood gases and the body temperature within the physiological ranges. The local CBF, the topographically correspo...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1997.11740795
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVE:Surgical management of sphenoorbital meningiomas ranges among the most complex of intracranial tumors. We report on our experience of surgical technique, outcome, and tumor recurrence in sphenoorbital meningiomas. METHODS:Between 2003 and 2013, surgical resections for sphenoorbital meningioma were performed ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132814Y.0000000329
更新日期:2014-08-01 00:00:00
abstract::One case of dural arteriovenous malformation in the base of the anterior cranial fossa is reported. It was discovered by means of a PW-Doppler examination of angular branch of the ophthalmic artery in a patient under observation for hypertrophy of a superficial temporal artery. The nidus was located in the region of t...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1995.11740317
更新日期:1995-06-01 00:00:00
abstract::Parkinson's disease (PD) the second most common age-associated progressive neurodegenerative disorder is characterized by loss of dopaminergic neurons, cytoplasmic inclusions of aggregated proteins (Lewy bodies), and neuroinflammation. The inflammation of neurons causes release of various inflammatory mediators (IFNs,...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2016.1249997
更新日期:2016-12-01 00:00:00
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journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1544399
更新日期:2019-02-01 00:00:00
abstract::Our aim was to evaluate the relationship between the neurological outcome of tuberous sclerosis complex (TSC) and the findings obtained from both cranial magnetic resonance imaging (MRI) and single voxel proton spectroscopy (SVPS). MRIs of 13 children who met the diagnostic criteria for TSC were taken. Eleven of these...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X163996
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVES:The goals of the present study are to obtain, expand and characterize a stem cell population from human omentum and to evaluate its in vivo angiogenic capacities. METHODS:Human omental CD34+ cells were obtained from samples of human omentum by density gradient centrifugation in Ficoll. Proliferative pattern...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164105X63674
更新日期:2005-12-01 00:00:00
abstract::Cyclic GMP (cGMP) mediates smooth muscle relaxation in the central nervous system. In subarachnoid hemorrhage (SAH), decreases in intrinsic nitric oxide (NO) cause cerebral vasospasms due to the regulation of cGMP formation by NO-mediated pathways. As phosphodiesterase type V (PDE V) selectively hydrolyzes cGMP, we hy...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101200447
更新日期:2002-09-01 00:00:00
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journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164106X152043
更新日期:2006-10-01 00:00:00
abstract::From 118 transsphenoidally operated patients, 100 had a pituitary adenoma; 33 prolactinomas, 20 HGH-producing, 2 ACTH-producing and 45 inactive adenomas. The first transsphenoidal operation did not cause any mortality; after reoperation for suspected recurrence on follow-up, 2 patients died; thus, the global managemen...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1985.11739714
更新日期:1985-09-01 00:00:00
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journal_title:Neurological research
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doi:10.1179/1743132814Y.0000000365
更新日期:2014-06-01 00:00:00
abstract::The ocular microtremor (OMT) is mediated by the oculomotor area of the brainstem and is altered in several pathologic states, including traumatic brain injury, general anesthesia, brain death, coma, Parkinsonism and multiple sclerosis. The EYETECT tremor monitor is a non-invasive means of measuring the frequency and a...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164107X240198
更新日期:2007-10-01 00:00:00
abstract::This study was performed to test whether GYKI 52466, a nonNMDA receptor antagonist, would improve microregional oxygen supply and consumption balance in the focal cerebral ischemic area. Rats were anesthetized with 1.4% isoflurane. For the GYKI Group (n = 8), 10 min before middle cerebral artery (MCA) occlusion, a bol...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1999.11740935
更新日期:1999-04-01 00:00:00
abstract::A simple and reproducible method of polymerase chain reaction (PCR) assay was established to detect trinucleotide repeat expansion for Huntington's disease (HD) using a new DNA polymerase and buffer system. The system consists of an extremely heat stable DNA polymerase (Pfu), and a buffer supplemented with ammonium su...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1996.11740370
更新日期:1996-02-01 00:00:00
abstract:OBJECTIVES:Patients presenting to the emergency room with an acute or subacute onset of focal neurological deficits are evaluated initially by non-contrast computed tomogram (CT) of the brain. This is primarily carried out to differentiate an ischemic from hemorrhagic stroke. However, other neurological conditions may ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164109X12445505689607
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVES:We tested whether repetitive magnetic stimulation (rMS) induces an afferent input to the spinocerebral tract in patients with complex regional pain syndrome (CRPS). METHODS:Cortical and spinal motor evoked potentials (cMEP and sMEP), as well as the contra- and ipsilateral silent period (cCSP and iCSP), were...
journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1179/016164105X17224
更新日期:2005-06-01 00:00:00
abstract::A 52-year-old male underwent lumboperitoneal shunting after external decompressive craniectomy. His postoperative course was accompanied by remarkable displacement of the intracranial structures to the opposite side of craniectomy. This phenomenon, probably caused by the siphon effect of cerebrospinal fluid shunting, ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1991.11739979
更新日期:1991-06-01 00:00:00
abstract:OBJECTIVE:In this clinical case-control study, we investigated statin treatment in stroke patients on a range of inflammatory effectors in peripheral blood. We focus on RhoA GTPase and its downstream effectors as a future inflammatory target in stroke treatment. METHODS:Data from 10 patients already on statins at stro...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1558000
更新日期:2019-04-01 00:00:00
abstract:OBJECT:The pathologies resulting from traumatic brain injury (TBI) have been thoroughly studied, but rarely have the effects of bleeding and coagulation in the early stage of TBI been considered. In this study, we investigated the effects of topical Surgiflo® application on brain injury in experimental TBI mice using S...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2017.1330815
更新日期:2017-09-01 00:00:00