A nonNMDA antagonist, GYKI 52466 improves microscopic O2 balance in the cortex during focal cerebral ischemia.

abstract：:Mild vascular cognitive impairment (mVCI) is a broader term that is intended to detect cognitive loss before the development of dementia. The identification of preventable risk factors as well as therapeutic strategies of intervention is still unclear. It has been suggested that carotid endarterectomy (CEA) improves c...

journal_title：Neurological research

authors： Borroni B,Tiberio G,Bonardelli S,Cottini E,Facheris M,Akkawi N,Pezzini A,Cervi E,Giulini SM,Padovani A

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVES:Amyloid-beta (Aβ) peptide deposition into insoluble plaques is a pathological hallmark of Alzheimer's disease (AD), but soluble oligomeric Aβ is considered to be more potent and has been hypothesized to directly impair learning and memory. Also, evidences from some clinical studies indicated that Aβ oligomer...

journal_title：Neurological research

authors： Sharma S,Verma S,Kapoor M,Saini A,Nehru B

更新日期：2016-09-01 00:00:00

abstract：INTRODUCTION:Cerebrospinal fluid (CSF) oligoclonal bands (OB) imply intrathecal immunoglobulin synthesis and B-cell immune process. There is scarce evidence of OB having a role in disease prognosis. The objective of the present study was to determine OB's prognostic value regarding disease progression. METHODS:Betwee...

journal_title：Neurological research

authors： Rojas JI,Tizio S,Patrucco L,Cristiano E

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:To assess prospectively the significance of sonographic measurements of the median nerve in the diagnosis of carpal tunnel syndrome (CTS), to look for proper parameters and cutoff values for the sonographic diagnosis, and to correlate with the electrophysiological findings. MATERIALS AND METHODS:This study ...

journal_title：Neurological research

authors： Guan J,Ji F,Chen W,Chu H,Lu Z

更新日期：2011-11-01 00:00:00

abstract：:We examined regional cerebral blood flow (rCBF) and oxygen metabolism (rCMRO2) in 10 patients with progressive dementia and amyotrophic lateral sclerosis (DALS), in 21 patients with classical amyotrophic lateral sclerosis without dementia (ALS), and in 17 controls. The mean rCBF and rCMRO2, especially in the anterior ...

journal_title：Neurological research

authors： Tanaka M,Ichiba T,Kondo S,Hirai S,Okamoto K

更新日期：2003-06-01 00:00:00

abstract：:HEADTOME III, a high resolution PET, has been employed using 15O and 18F labelled pharmaceuticals to evaluate histological malignancy of gliomas preoperatively. PET study was applied on eighteen preoperative gliomas including two recurrent cases. Haemocirculatory and metabolic indices of regional cerebral blood flow (...

journal_title：Neurological research

authors： Mineura K,Yasuda T,Kowada M,Shishido F,Ogawa T,Uemura K

更新日期：1986-09-01 00:00:00

abstract：:Regional glucose utilization was measured in the rat brain after occlusion of the middle cerebral artery. Normoglycaemic rat had increased glucose use in the cerebral cortex adjacent to the infarct. A fraction of the nerve cells were irreversibly injured in this region. In hyperglycaemic rats, the glucose metabolism r...

journal_title：Neurological research

authors： Nedergaard M,Gjedde A,Diemer NH

更新日期：1987-12-01 00:00:00

abstract：:In patients with head trauma and consecutive acute diffuse cerebral swelling the sudden initial rise in intracranial pressure with subsequent impairment of cerebral blood flow is explained by engorgement due to vasoparalysis. How quickly hyperaemic brain swelling can occur is shown by a case report. The review of clin...

journal_title：Neurological research

authors： Krasznai L,Grote EH

更新日期：1994-02-01 00:00:00

abstract：:Using the previously reported method of experimental localized brainstem infarct in dogs, we designed this study to elucidate sequential changes of regional cerebral blood flow (rCBF) in three separate regions of the central nervous system: the cerebral cortex, thalamus, and midbrain. The data obtained were referred t...

journal_title：Neurological research

authors： Matsumoto S,Kuwabara S,Moritake K

更新日期：2000-03-01 00:00:00

abstract：:Thromboxane A2 (TXA2) is a proaggregatory vasoconstrictor that is synthesized and released during reperfusion of ischaemic brain. We administered a TXA2 receptor antagonist, SQ29,548, and a thromboxane A synthase inhibitor, 1-benzylimidazole (1-BI), to rats subjected to 30 min of reversible forebrain ischaemia. Cerebr...

journal_title：Neurological research

authors： Pettigrew LC,Hazle JD,Gutierrez G,Smith CD,Ogletree ML

更新日期：1992-09-01 00:00:00

abstract：:Previous work has shown that unsaturated fatty acid components of model membrane phospholipids in vitro, damaged via a free radical mechanism, are protected by the presence of cholesterol in these membranes. The participation of these membrane lipids in the pathogenesis of traumatic injury to brain was studied in vivo...

journal_title：Neurological research

authors： Mitamura JA,Seligman ML,Solomon JJ,Flamm ES,Demopoulos HB,Ransohoff J

更新日期：1981-01-01 00:00:00

abstract：:The purpose of this prospective observational study was to investigate the relation between the frequency of critical neuromonitoring parameters (brain tissue pO2, (PtiO2) < or = 10 mmHg, intracranial pressure (ICP) > 20 mmHg, cerebral perfusion pressure (CPP) < or = 70 mmHg) and outcome after severe aneurysmal subara...

journal_title：Neurological research

authors： Meixensberger J,Vath A,Jaeger M,Kunze E,Dings J,Roosen K

更新日期：2003-07-01 00:00:00

abstract：:Brain tumours were induced by intracerebral inoculation of beagle puppies with Avian sarcoma virus (ASV) suspension. The inoculation produced solitary or multiple sarcomas in three dogs and intraventricular anaplastic gliomas in four dogs. At the time of the first tumour positive CT-control Iodine-125 seeds (activity ...

journal_title：Neurological research

authors： Ostertag CB,Warnke P,Kleihues P,Bigner DD

更新日期：1984-12-01 00:00:00

abstract：OBJECTIVES:In this study, we aimed to investigate the effect of bone mesenchymal stem cells (BMSCs) conditioned medium on BMP4-induced activation of the Smad signaling pathway during the process of neural stem cells differentiation. METHODS:We designed four experimental groups: (A) control group, (B) BMP-4 treatment g...

journal_title：Neurological research

authors： Fang H,Song P,Shen C,Liu X,Li H

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:Daughter aneurysms have been strongly associated with saccular aneurysm rupture. We constructed a mathematical model to help explain this association as a possible hemodynamic mechanism for intracranial saccular aneurysm rupture. METHODS:Our model is based on the assumption that when an aneurysm reaches a s...

journal_title：Neurological research

authors： Meng H,Feng Y,Woodward SH,Bendok BR,Hanel RA,Guterman LR,Hopkins LN

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:Interleukin-21 (IL-21) is a cytokine that is an important modulator of immune responses. However, its roles in epilepsy are not completely clear. Here, we investigated the expression and distribution of IL-21 in a kainic acid (KA)-induced acute seizure mouse model. MATERIALS AND METHODS:Mice (n = 146) were r...

journal_title：Neurological research

authors： Xiong XY,Wang TG,Yang MH,Meng ZY,Yang QW,Wang FX

更新日期：2016-02-01 00:00:00

abstract：:Objectives: Brain arteriovenous malformations (AVMs) represent high-flow vascular lesions made up of a complex network of feeding arteries and draining veins interposed by a nidus and without a capillary bed. The management of the AVMs represents a challenge, and the optimal treatment should be considered based on the...

journal_title：Neurological research

authors： Gorgan RM,Petrescu GED,Brehar FM

更新日期：2020-12-01 00:00:00

abstract：:The present study used immunohistochemistry to investigate p53 expression in rat brain following transient occlusion of the middle cerebral artery. In the control group, no p53-immunoreactive cells were found in any region of the central nervous system. P53 expression in reactive astrocytes was not obvious in the fore...

journal_title：Neurological research

authors： Chung YH,Shin CM,Kim MJ,Lee EY,Kim G,Cha CI

更新日期：2002-04-01 00:00:00

abstract：:The association between glucocerebrosidase (GBA) mutations and Parkinson's disease (PD) is attracting increased attention worldwide. Results from previous studies on the association of GBA mutations with PD in different ethnicities remain contradictory. In order to derive a more comprehensive understanding of the rela...

journal_title：Neurological research

authors： Mao X,Wang T,Peng R,Chang X,Li N,Gu Y,Zhao D,Liao Q,Liu M

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:To explore whether intracranial pulse pressure amplitudes relate to arterial pulse pressure amplitudes and whether correlations between time-related changes in intracranial and arterial pulse pressure amplitudes associate with indices of cerebral autoregulation. METHODS:A total of 257 continuous and simultan...

journal_title：Neurological research

authors： Eide PK,Czosnyka M,Sorteberg W,Pickard JD,Smielewski P

更新日期：2007-09-01 00:00:00

abstract：:We examined whether or not NF-kappaB, a factor that regulates expression of the genes that code for pro-inflammatory cytokines, is activated in cerebrospinal fluid (CSF) cells to investigate the production of pro-inflammatory cytokines by CSF cells in patients with meningitis. Western blotting demonstrated that NF-kap...

journal_title：Neurological research

authors： Ichiyama T,Isumi H,Yoshitomi T,Nishikawa M,Matsubara T,Furukawa S

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVES:We reviewed our most recent work on the protective effect of adenosine A(2A)antagonism in cerebral ischemia. METHODS:Focal ischemia was produced in rats by introducing a nylon monofilament pre-coated with silicone through the external carotid artery to occlude the right MCA at its origin. RESULTS:A(2A) ant...

journal_title：Neurological research

authors： Pedata F,Gianfriddo M,Turchi D,Melani A

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:A reproducible brain tumor model using experimental animals is required to study biological behavior and develop more potent antineoplastic drugs and effective therapeutic modalities. In this work, we attempted to establish diffuse leptomeningeal gliomatosis in the rat by intracarotid injection of C6 glioma c...

journal_title：Neurological research

authors： Wasita B,Kamitani H,Kinoshita Y,Mamun MH,Watanabe T

更新日期：2009-06-01 00:00:00

abstract：:Regional CBF was measured by 133Xe inhalation in unilateral cerebral infarction, carotid TIAs, and normal volunteers. Regional CBF values were bilaterally and symmetrically reduced in patients measured within 3 weeks after stroke. Later, rCBF values returned toward normal in the contralateral hemisphere of patients wi...

journal_title：Neurological research

authors： Meyer JS,Naritomi H,Sakai F,Ishihara N,Grant P

更新日期：1979-01-01 00:00:00

abstract：OBJECTIVE:Tadalafil is a selective phosphodiesterase type 5 (PDE-5) inhibitor approved for the treatment of erectile dysfunction. Less is known about the electroencephalography (EEG) effects of PDE-5 inhibitors, and the present study, therefore, examined the risk of EEG abnormalities associated with tadalafil. METHOD:...

journal_title：Neurological research

authors： Okuyucu EE,Guven O,Duman T,Gorur S,Melek IM,Akcin S,Yilmazer S

更新日期：2009-04-01 00:00:00

abstract：:This article covers the basis of tethered cord syndrome as a stretch-induced spinal cord disorder, including pathophysiology, signs and symptoms, imaging diagnosis, indication for surgical treatment, and surgical procedures. Anomalies that cause mechanical spinal cord tethering are listed, and the surgical untethering...

journal_title：Neurological research

authors： Yamada S,Won DJ,Siddiqi J,Yamada SM

更新日期：2004-10-01 00:00:00

abstract：:In models of middle cerebral artery occlusion using intraluminal suture, the size and the distribution of ischemic injury vary considerably among laboratories. In transcranial models of cerebral ischemia, a more consistent cerebral ischemic lesion is seen in Spontaneously Hypertensive rats (SHR). In the present study,...

journal_title：Neurological research

authors： Dogan A,Başkaya MK,Rao VL,Rao AM,Dempsey RJ

更新日期：1998-04-01 00:00:00

abstract：:Cerebral vasospasm and/or delayed ischaemic state following subarachnoid haemorrhage still remain unsolved serious problems. With the development and introduction of calcium antagonists as well as the advances in perioperative management, however, the clinical outcome has much improved in recent years. Among such drug...

journal_title：Neurological research

authors： Hongo K,Kobayashi S

更新日期：1993-08-01 00:00:00

abstract：OBJECTIVES:Recent preclinical studies suggest that treating glioblastoma (GBM) with a combination of targeted chemotherapy and radiotherapy may enhance the anti-tumor effects of both therapies. However, the effects of these treatments on glioma growth and progression are poorly understood. METHODS:In this study, we h...

journal_title：Neurological research

authors： D'Amico R,Lei L,Kennedy BC,Sisti J,Ebiana V,Crisman C,Christensen JG,Gil O,Rosenfeld SS,Canoll P,Bruce JN

更新日期：2012-04-01 00:00:00

abstract：:Various surgical approaches have been described for treating lesions which arise in the sellar region. The popular transnasal-transsphenoidal and transethmoidal-transsphenoidal approaches avoid the morbidity associated with transcranial operations while allowing enough exposure to successfully remove most lesions that...

journal_title：Neurological research

authors： Das K,Spencer W,Nwagwu CI,Schaeffer S,Wenk E,Weiss MH,Couldwell WT

更新日期：2001-01-01 00:00:00