Abstract:
OBJECTIVES:Amyloid-beta (Aβ) peptide deposition into insoluble plaques is a pathological hallmark of Alzheimer's disease (AD), but soluble oligomeric Aβ is considered to be more potent and has been hypothesized to directly impair learning and memory. Also, evidences from some clinical studies indicated that Aβ oligomer formation is the major cause for early AD onset. However, the biochemical mechanism involved in the oligomer-induced toxicity is not very well addressed. So, thise present study was undertaken to study the effects of single intracerebroventricular (icv) injection of protofibrillar Aβ 1-42 on the behavioral and biochemical profile in rats. METHODS:Rats were divided into two groups (n = 8 per group): (1) sham control group and (2) Aβ 1-42 injected group. A single dose of protofibrillar Aβ 1-42 (5 ul) through icv injection was bilaterally administered into the dorsal hippocampus, while sham control animals were administered with 5 µl of vehicle. RESULTS:The results demonstrated that the protofibrillar Aβ significantly inhibited long-term memory retention and increased anxiety levels as shown by the behavioral studies. The amyloid deposits were present inside the brain even six weeks after injection as confirmed by thioflavin-T staining and the neurodegeneration induced by these deposits was confirmed by Nissl's staining in hippocampal and cortical regions. The amyloid aggregates induced reactive oxygen species (ROS) production, acetylcholinesterase activity, nitrite levels, lipid peroxidation, and inhibited antioxidant enzyme activity in hippocampus, cortex, and striatum regions of rat brain after six weeks. DISCUSSION:The present study indicated that protofibrillar Aβ 1-42 injection altered long term memory, induced anxiety-like behavior and also developed Alzheimer's disease like pathology in rats.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Sharma S,Verma S,Kapoor M,Saini A,Nehru Bdoi
10.1080/01616412.2016.1209337subject
Has Abstractpub_date
2016-09-01 00:00:00pages
838-50issue
9eissn
0161-6412issn
1743-1328journal_volume
38pub_type
杂志文章abstract:OBJECTIVE:Spinal cord injury (SCI) causes muscle atrophy, which is particularly severe, due to inability to perform tetanic contractions, when lower motor neurons (LMN) are involved. We performed a longitudinal study in 25 Europeans suffering from complete conus cauda syndrome from 0.7 to 8.7 years comparing functional...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313209X385644
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVES:This study sought to compare the atherosclerotic plaque burden between middle cerebral artery (MCA) and extracranial carotid artery (ECA) in ischemic stroke patients using high-resolution, black-blood (HR BB) MRI and to investigate the relationship between plaque burden found in both arteries and stroke seve...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2017.1281196
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVES:To study whether Clopidogrel-Aspirin combined treatment for high risk transient ischaemic attack (TIA) or minor stroke results in increased number of lesions associated with anti-thrombotic cerebral haemorrhage or cerebral micro-bleeds (CMB) than aspirin alone treatment. METHODS:The patients recruited in CH...
journal_title:Neurological research
pub_type: 杂志文章,随机对照试验
doi:10.1179/1743132815Y.0000000087
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVES:To review the use of immunoassays in the diagnosis and research of disorders affecting the nervous system. METHODS:Systematic review of the English literature. RESULTS:Immunoassays have demonstrated utility for: (1) the detection of antigen (molecules, genes, gene products, peptides, hormones and drug meta...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164105X49535
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to analyse inflammatory cells in lumbar disc tissue under cyclooxygenase-2 (COX-2) inhibitor therapy, to detect their prevalence in different subtypes of lumbar disc herniations and to assess the influence of inflammatory reactions in herniated disc tissue on postoperative out...
journal_title:Neurological research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1179/016164105X49210
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:Catalpol has been identified to have neuroprotective effect on gerbils subjected to transient global cerebral ischemia. However, the mechanism that catalpol prevents ischemia is still unclear. In the present study, PC12 cells, exposed to oxygen and glucose deprivation (OGD) followed by reperfusion, were used...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X229894
更新日期:2008-02-01 00:00:00
abstract::It has been established that following injury to the central nervous system two types of damage take place, the initial insult and the secondary response to injury. This review will focus on the secondary molecular aspects of neurotrauma. These responses may be either deleterious or have protective effects upon the in...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164101101198343
更新日期:2001-03-01 00:00:00
abstract::Brain tumours were induced by intracerebral inoculation of beagle puppies with Avian sarcoma virus (ASV) suspension. The inoculation produced solitary or multiple sarcomas in three dogs and intraventricular anaplastic gliomas in four dogs. At the time of the first tumour positive CT-control Iodine-125 seeds (activity ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1984.11739685
更新日期:1984-12-01 00:00:00
abstract:OBJECTIVE:The role of inflammation in cognitive alterations in a post-operative setting is still not fully understood. Surgical interventions can cause systemic inflammations which eventually can induce neuroinflammation. However, the main causes of functional changes after surgery are still elusive. In this study, we ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2016.1242452
更新日期:2016-11-01 00:00:00
abstract::The present study used immunohistochemistry to investigate p53 expression in rat brain following transient occlusion of the middle cerebral artery. In the control group, no p53-immunoreactive cells were found in any region of the central nervous system. P53 expression in reactive astrocytes was not obvious in the fore...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101199828
更新日期:2002-04-01 00:00:00
abstract::It was predicted, based on a mathematical model of the cortex, that early music training would enhance spatial-temporal reasoning. We have demonstrated that preschool children given six months of piano keyboard lessons improved dramatically on spatial-temporal reasoning while children in appropriate control groups did...
journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1080/01616412.1999.11740910
更新日期:1999-03-01 00:00:00
abstract:OBJECTIVES:The syntheses of endothelin receptors A and B were previously shown to be upregulated in rat dorsal hippocampus after traumatic brain injury. Here we characterize endothelin receptor A and endothelin receptor B cellular distribution in hippocampus after permanent global brain ischemia and their possible asso...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164111X12881719352291
更新日期:2011-03-01 00:00:00
abstract::Various surgical approaches have been described for treating lesions which arise in the sellar region. The popular transnasal-transsphenoidal and transethmoidal-transsphenoidal approaches avoid the morbidity associated with transcranial operations while allowing enough exposure to successfully remove most lesions that...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164101101198280
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to characterize mouse neural stem cells (NSC) transduced by a multigenic lentiviral vector (LV) and stably express recombinant human nerve growth factor (rhNGF). We obtained NSC-derived cell lines which express human NGF in relevant amount to exploit their ability for therapeuti...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164106X115161
更新日期:2006-07-01 00:00:00
abstract::The objective was to examine the effect of the nitric oxide synthase inhibitor, N omega-nitro-L-arginine methyl ester (L-NAME) on leukocyte adhesion in the cerebral microcirculation during reperfusion following partial forebrain ischemia in the rat. Intravital fluorescence video-microscopy through a closed cranial win...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1999.11740947
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVES:Papaverine has been used in treating vasospasm following subarachnoid hemorrhage (SAH). However, its action mechanism for cerebral vascular relaxation is not clear. Potassium and calcium channels are closely related to the contraction and relaxation of cerebral smooth muscle. Therefore, to identify the role ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X191021
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVES:We reviewed our most recent work on the protective effect of adenosine A(2A)antagonism in cerebral ischemia. METHODS:Focal ischemia was produced in rats by introducing a nylon monofilament pre-coated with silicone through the external carotid artery to occlude the right MCA at its origin. RESULTS:A(2A) ant...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164105X21913
更新日期:2005-03-01 00:00:00
abstract::The endothelial lining of blood vessels plays an important role in the control of arterial tone by releasing a number of vasoactive factors. Among these, nitric oxide (NO) or a NO containing moiety, some cyclooxygenase products such as prostacyclin (PGl2) and a still hypothetical hyperpolarizing factor may induce dila...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1997.11740851
更新日期:1997-10-01 00:00:00
abstract::Excessive entry of Ca2+ into injured cochlear neurons activates various Ca(2+)-activated enzymes and subsequent spiral ganglion cell death. Therefore, preventing intracellular calcium overload by using Ca2+ channel antagonists may become an important countermeasure to spiral ganglion cell death. We experimentally inve...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101200889
更新日期:2002-12-01 00:00:00
abstract::To investigate the migration of neural stem cells as well as neural plastic changes in epileptic brain, spaciotemporal expression of immunoreactive highly polysialylated neural cell adhesion molecule (PSA-NCAM) was examined in amygdala kindling development of rat. The neural migration and synaptic remodeling detected ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164103101200969
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:To determine the functional abnormalities of the Leu89Pro mutation in connexin32 (CX32), which we have previously reported is present within an X-linked dominant Charcot-Marie-Tooth disease family. In this family, male patients were moderately to severely affected. METHODS:We performed immunofluorescence to ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2016.1204494
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVES:Surgical management of tumors in the sacropelvic region is a challenging field of spine surgery because of the region's complex local anatomy and biomechanics. Recent developments in anesthesia and intensive care have allowed us to perform extended surgeries focused on the en bloc resection of sacropelvic tu...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/1743132814Y.0000000370
更新日期:2014-06-01 00:00:00
abstract::Two hundred and sixty-one neurologically asymptomatic patients were examined by computed tomography (CT) following a variable number of transient ischaemic attacks (TIAs) experienced over different time intervals. Cerebral infarcts were discovered in 101 patients. Dominant hemisphere infarcts were usually small, of re...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1985.11739720
更新日期:1985-12-01 00:00:00
abstract::An approach to aneurysms arising at the bifurcation of the basilar artery and its neighborhood is described. The temporal pole of the nondominant side is retracted posteriorly to provide a wide operative field and a better view of aneurysms. ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1980.11739588
更新日期:1980-01-01 00:00:00
abstract::It is known that mitochondrial ATP-sensitive potassium channels (mitoKATP) play a significant role in protecting cerebral function from ischemia-reperfusion injury, which is related with a decrease in the mitochondrial matrix calcium. However, the effect of mitochondrial calcium uniporter (MCU) on diazoxide-induced ce...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000299
更新日期:2014-07-01 00:00:00
abstract::Lectin-like oxidized low-density lipoprotein receptor (LOX-1) and monocyte chemoattractant protein-1 (MCP-1) are molecules involving in the initiation and progression of atherosclerosis. In order to examine a possible difference in LOX-1 and MCP-1 expressions depending on the severity of early stage of atherosclerosis...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164104225016074
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:To investigate the perfusion parameters of computed tomography (CT) in hypoxicischemic encephalopathy (HIE) after off-pump coronary artery bypass grafting (OPCABG), and its potential in predicting the occurrence and prognosis of hypoxic-ischemic encephalopathy. METHODS:We selected 830 patients. The patients ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2017.1315862
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVES:Changes in systemic arterial blood pressure and the degree of cerebral vasospasm were investigated in 125 patients with aneurysmal subarachnoid hemorrhage. METHODS:Systemic arterial blood pressure was measured every 2 hours in each patient for a period of more than 2 weeks, and a fall in systemic blood pres...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164105X48761
更新日期:2006-03-01 00:00:00
abstract::We examined the microsurgical anatomy of the supratentorial subarachnoid cisterns with a surgical microscope in 20 brains prepared using the immersion technique. The adult brains were immersed in Ringer's solution and air was injected into the subarachnoid cisterns while the brains remained submerged in solution. We i...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1994.11740266
更新日期:1994-12-01 00:00:00
abstract:OBJECTIVE:To evaluate by MR diffusion weighted image (DWI-MR) the presence of new ischemic cerebral lesions after carotid artery stenting (CAS) and distal cerebral protection, in patients with internal carotid artery (ICA) stenosis >70. METHODS:Sixty-seven CAS were performed under cerebral protection with a distal fil...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164105X35431
更新日期:2005-01-01 00:00:00