当前位置： SCI文献检索 > NEUROLOGICAL RESEARCH期刊下所有文献 > Effects of cerebrovascular autoregulation and CO2 reactivity in experimental localized brainstem infarction.

Effects of cerebrovascular autoregulation and CO2 reactivity in experimental localized brainstem infarction.

Abstract：

:Using the previously reported method of experimental localized brainstem infarct in dogs, we designed this study to elucidate sequential changes of regional cerebral blood flow (rCBF) in three separate regions of the central nervous system: the cerebral cortex, thalamus, and midbrain. The data obtained were referred to in subsequent investigations of cerebrovascular autoregulation and vasomotor reactivity to CO2. Localized brainstem infarct was produced by permanently occluding the perforators of the posterior cerebral arteries between the bilateral origins of the posterior communicating arteries. The hydrogen clearance method was applied to measure rCBF. Cerebrovascular autoregulation and CO2 reactivity were assessed in three regions 1, 3, and 5 h after vascular occlusion, respectively. Vascular occlusion resulted in a decrease of rCBF that was 65% in the midbrain and close to 30%-40% in the thalamus. However, no significant change was seen in the cerebral cortex even 5 h after vascular occlusion. Induced hypertension impaired autoregulation in the thalamus, while it was preserved in the cerebral cortex. Induced hypotension did not alter autoregulation in any of the three regions. A marked loss of CO2 reactivity was observed in the ischemic brainstem, although it was well preserved in the cerebral cortex. The results suggest that noradrenergic fibers originating from the cervical sympathetic ganglia play a main role in the cerebrovascular autoregulation in the cerebral cortex, while noradrenergic fibers possibly originating from the autonomic centers in the brainstem are responsible in the thalamus; that the noradrenergic neuron probably is not involved in the maintenance of cerebral blood flow during hypotension; and that the effect of CO2 is mediated by its direct effect on the arteriolar wall in the central nervous system.

journal_name

Neurol Res

journal_title

Neurological research

authors

Matsumoto S,Kuwabara S,Moritake K

doi

10.1080/01616412.2000.11741061

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

197-203

issue

2

eissn

0161-6412

issn

1743-1328

journal_volume

22

pub_type

杂志文章

相关文献

NEUROLOGICAL RESEARCH文献大全
  • On the rupture of an aneurysm.

    abstract：:The intracranial aneurysm, with an estimated occurrence of up to 4% in the general population, belongs among the most dangerous of cerebrovascular diseases. Although less than one-fifth of these cases results in a subarachnoid haemorrhage, the resulting disability and mortality rate is too high. More understanding is ...

    journal_title：Neurological research

    pub_type： 杂志文章

    doi：10.1080/01616412.1991.11739995

    authors： Duros J,Clark ME,Kufahl RH,Nadvornik P

    更新日期：1991-12-01 00:00:00

  • Role of the endothelium on extraluminal and intraluminal vasoactive mechanisms in the perfused rabbit basilar artery.

    abstract：:In order to investigate the role of the endothelium in the regulation of cerebrovascular tone, we studied selective intraluminal and extraluminal vasoactive mechanisms of acetylcholine, potassium and serotonin. We also examined the effects of removal of the endothelium on these vasoactive responses. With 0.75 g of ten...

    journal_title：Neurological research

    pub_type： 杂志文章

    doi：10.1080/01616412.1993.11740128

    authors： Ogawa R,Ohta T,Tsuji M,Mori M

    更新日期：1993-06-01 00:00:00

  • Is the ischemic blood-brain barrier insufficiency responsible for full-blown Alzheimer's disease?

    abstract：:The goal of this paper is to provide scientists with a comprehensive review of the state-of-the-art influence the ischemic blood-brain barrier (BBB) has on the final development of Alzheimer's disease and to provide detailed food-for-thought which will hopefully stimulate more researchers in this area of neuroscience....

    journal_title：Neurological research

    pub_type： 杂志文章,评审

    doi：10.1179/016164106X130399

    authors： Pluta R

    更新日期：2006-09-01 00:00:00

  • Coma of vascular aetiology: evaluation and prognosis.

    abstract：:The authors have done a revision of 450 patients admitted during the last 3 years to the emergency service of the Hospital de S. José with the diagnosis of CVA. In this retrospective study were included the patients of greater than or equal to 3 degree of the RLS/85 coma scale, the diagnostic being confirmed by CAT, a...

    journal_title：Neurological research

    pub_type： 杂志文章

    doi：10.1080/01616412.1992.11740023

    authors： Costa B,Candido J,Girbal A,Afonso L,Ribeiro J,Gonçalves V,Luis V,Antunes J

    更新日期：1992-01-01 00:00:00

  • Cortical spreading depression and the pathogenesis of brain disorders: a computational and neural network-based investigation.

    abstract：:This paper reviews our recent studies of the role of cortical spreading depression (CSD) in the pathogenesis of brain disorders. Our investigation is a computational one, involving the development and utilization of a complex neuro-metabolic model of the interactions assumed to occur in the cortex during the passage o...

    journal_title：Neurological research

    pub_type： 杂志文章

    doi：10.1179/016164101101198839

    authors： Ruppin E,Reggia JA

    更新日期：2001-07-01 00:00:00

  • The role of high-sensitivity C-reactive protein levels in functional outcomes in patients with large-artery atherosclerosis and small-artery occlusion.

    abstract：BACKGROUND:High-sensitivity C-reactive protein (hs-CRP) is an inflammatory marker that is associated with the outcomes of ischemic stroke. However, the role of hs-CRP levels in the functional outcomes after large-artery atherosclerosis (LAA) and small-artery occlusion (SAO) is poorly understood. METHODS:We recruited 1...

    journal_title：Neurological research

    pub_type： 杂志文章

    doi：10.1080/01616412.2017.1358937

    authors： Hou D,Liu J,Feng R,Gao Y,Wang Y,Wu J

    更新日期：2017-11-01 00:00:00

  • Mathematical model of synaptic plasticity: III. Heterosynaptic changes.

    abstract：:A mathematical model, using differential equations, of heterosynaptic plasticity is proposed. The model is based on physiological studies of invertebrates in which nonspecific conditioning, such as sensitization and heterosynaptic inhibition, starts to be elucidated and behavioral studies of classical and instrumental...

    journal_title：Neurological research

    pub_type： 杂志文章

    doi：10.1080/01616412.1980.11739576

    authors： Lara R,Tapia R,Cervantes F,Moreno A,Trujillo H

    更新日期：1980-01-01 00:00:00

  • Management of neurocysticercosis.

    abstract：BACKGROUND:Neurocysticercosis is a parasitic infection of the central nervous system caused by the larval stage of the tapeworm Taenia solium and is the most common parasitic infection involving the human nervous system. Neurocysticercosis represents one of the most common causes of symptomatic epilepsy in developing c...

    journal_title：Neurological research

    pub_type： 杂志文章,评审

    doi：10.1179/016164110X12644252260592

    authors： Ramírez-Zamora A,Alarcón T

    更新日期：2010-04-01 00:00:00

  • A new method of noninvasive brain-edema monitoring in stroke: cerebral electrical impedance measurement.

    abstract：OBJECTIVE:To explore the primary regularity of cerebral electrical impedance (CEI) change in healthy people, patients with intracerebral hemorrhage (ICH) and patients with cerebral infarction (CI). METHODS:CEI of 200 healthy volunteers, 78 patients with ICH and 51 patients with CI were measured by noninvasive brain-ed...

    journal_title：Neurological research

    pub_type： 杂志文章

    doi：10.1179/016164106X91843

    authors： Liu L,Dong W,Ji X,Chen L,Chen L,He W,Jia J

    更新日期：2006-01-01 00:00:00

  • Head registration techniques for image-guided surgery.

    abstract：:Localization of the pathological structures in relation to the surrounding anatomy and understanding of the surgical anatomy are probably the most important keys to successful neurosurgery. Image-guided surgery is an important tool for understanding an individual's anatomy and for precisely locating the lesion. Head r...

    journal_title：Neurological research

    pub_type： 杂志文章

    doi：10.1080/01616412.1998.11740481

    authors： Alp MS,Dujovny M,Misra M,Charbel FT,Ausman JI

    更新日期：1998-01-01 00:00:00

  • Watershed cerebral infarcts: retrospective study of 24 cases.

    abstract：:Twenty-four patients presenting an acute stroke with watershed cerebral infarct on CT scan or MRI were included in this retrospective study. Age was 63 +/- 14 years (mean +/- SD), and sex ratio was 2 men for 1 woman. Main clinical features were: in anterior location, lower limb weakness and frontal syndrome with trans...

    journal_title：Neurological research

    pub_type： 杂志文章

    doi：10.1080/01616412.1992.11740022

    authors： Evrard S,Woimant F,Le Coz P,Polivka M,Cousin C,Haguenau M

    更新日期：1992-01-01 00:00:00

  • Simultaneous recording of tissue PCO2, interstitial pH and potassium activity in the rat cerebral cortex during anoxia and the subsequent recovery period.

    abstract：:Tissue PCO2 (carbon dioxide tension) (PtCO2), interstitial H+ (H+e) and potassium activities (K+e) were monitored in the cerebral cortex of rats during and after 2-3 min of anoxia. Anoxia was associated with systemic hypotension and caused H+e (extracellular hydrogen ion activity) to increase from pH approximately equ...

    journal_title：Neurological research

    pub_type： 杂志文章

    doi：10.1080/01616412.1989.11739882

    authors： Ohno M,Obrenovitch TP,Hartell N,Barratt S,Bachelard HS,Symon L

    更新日期：1989-09-01 00:00:00

  • EEG abnormalities during treatment with tadalafil, a phosphodiesterase type 5 inhibitor.

    abstract：OBJECTIVE:Tadalafil is a selective phosphodiesterase type 5 (PDE-5) inhibitor approved for the treatment of erectile dysfunction. Less is known about the electroencephalography (EEG) effects of PDE-5 inhibitors, and the present study, therefore, examined the risk of EEG abnormalities associated with tadalafil. METHOD:...

    journal_title：Neurological research

    pub_type： 杂志文章

    doi：10.1179/174313209X382548

    authors： Okuyucu EE,Guven O,Duman T,Gorur S,Melek IM,Akcin S,Yilmazer S

    更新日期：2009-04-01 00:00:00

  • Homocysteine and ischemic stroke subtype: a relationship study in Chinese patients.

    abstract：OBJECTIVE:Elevated homocysteine level is a risk factor for ischemic stroke and associated with small vessel disease such as confluent leukoaraiosis in white and black population. We investigated the relationship between the total serum homocysteine level and ischemic stroke subtypes in Chinese population. METHODS:Thre...

    journal_title：Neurological research

    pub_type： 杂志文章

    doi：10.1179/016164109X12445616596445

    authors： Ma Y,Zhao X,Zhang W,Liu L,Wang Y,Fang R,Wang Y

    更新日期：2010-07-01 00:00:00

  • Effects of cerebral small vessel disease on the outcome of patients with ischemic stroke caused by large artery atherosclerosis.

    abstract：OBJECTIVE:Cerebral small vessel disease (CSVD) describes a syndrome of neuroimaging, pathological, and associated clinical features caused by small intracranial vascular lesions, which commonly coexists with large artery atherosclerosis (LAA) and has been identified as a major cause of motor impairment over time. In th...

    journal_title：Neurological research

    pub_type： 杂志文章,评审

    doi：10.1080/01616412.2018.1446283

    authors： Zhu H,Li Z,Lv J,Zhao R

    更新日期：2018-05-01 00:00:00

  • Nanoparticles and stem cells - has targeted therapy for aneurysms finally arrived?

    abstract：:Until recently, endovascular management of intracranial aneurysms has focused on mechanical and hemodynamic aspects: characterizing aneurysm morphology by angiogram, mechanical obstruction by detachable coils, and flow diversion with endovascular stents. Although now common practice, these interventions only ward off ...

    journal_title：Neurological research

    pub_type： 杂志文章,评审

    doi：10.1179/1743132814Y.0000000435

    authors： Esfahani DR,Viswanathan V,Alaraj A

    更新日期：2015-03-01 00:00:00

  • The lack of influence of IVS5-91 G>A polymorphism of the SCN1A gene on efficacy of lamotrigine in patients with focal epilepsy.

    abstract：:Background: IVS5-91G>A (rs3812718) polymorphism of the sodium voltage-gated channel alpha subunit 1 (SCN1A) gene has been associated with inadequate responsiveness to common antiepileptic drugs which act as sodium channel blockers. This study was performed to investigate the effect of IVS5-91G>A (rs3812718) polymorphi...

    journal_title：Neurological research

    pub_type： 临床试验,杂志文章

    doi：10.1080/01616412.2019.1635321

    authors： Markovic I,Pejanovic-Skobic N,Bozina N,Susak Sporis I,Sporis D,Basic S

    更新日期：2019-10-01 00:00:00

  • Immunomodulatory effectiveness of azithromycin in prevention of postlaminectomy epidural fibrosis.

    abstract：OBJECTIVE:One of the important causes of failed back surgery is the extensive peridural fibrosis collecting in the surgical field after spinal surgeries. Today we know that inflammatory mechanisms mediated by the immune system of the body plays an important role in generation of fibrosis. Azithromycin, a macrolide anti...

    journal_title：Neurological research

    pub_type： 杂志文章

    doi：10.1179/016164110X12767786356471

    authors： Emmez H,Börcek AÖ,Durdağ E,Uyar PG,Kaymaz M,Aykol S

    更新日期：2011-05-01 00:00:00

  • [15O]-water PET and intraoperative brain mapping: a comparison in the localization of eloquent cortex.

    abstract：:[15O]-water PET was performed on 12 patients with structural lesions for localization of the motor (n = 5), language (receptive and expressive; n = 6), and visual cortex (n = 1). All these patients underwent interactive image-guided surgery using an infrared digitizer and intraoperative electrical stimulation mapping ...

    journal_title：Neurological research

    pub_type： 杂志文章

    doi：10.1080/01616412.1997.11740867

    authors： Viñas FC,Zamorano L,Mueller RA,Jiang Z,Chugani H,Fuerst D,Muzik O,Mangner TJ,Diaz FG

    更新日期：1997-12-01 00:00:00

  • The protective effect of mannitol, vitamin E and glucocorticoid on ischaemic brain injury: evaluation by chemiluminescence, energy metabolism and water content.

    abstract：:We currently have used three drugs in combination [mannitol, vitamin E and glucocorticoid (beta-methasone)] for the treatment of cerebral infarction in the acute stage. For the purpose of evaluating the efficacy of this therapy, we have conducted experiments evaluated by chemiluminescence (CL), energy metabolism and w...

    journal_title：Neurological research

    pub_type： 杂志文章

    doi：10.1080/01616412.1988.11739819

    authors： Uenohara H,Imaizumi S,Suzuki J,Yoshimoto T

    更新日期：1988-06-01 00:00:00

  • Atrial fibrillation as an important clinical condition of cognitive decline; diagnosis, comorbidities and severity of symptoms in patients with dementia.

    abstract：:Objective: To determine the time of dementia diagnosis, symptom intensity and to assess the comorbidities.Methods: 110 patients with dementia or mild cognitive impairment were enrolled in this retrospective study. The study group was divided into subgroups: patients with a maximum of three (S ≤ 3 n = 62) and four or m...

    journal_title：Neurological research

    pub_type： 杂志文章

    doi：10.1080/01616412.2020.1738648

    authors： Niedziela N,Nowak MM,Lis M,Blaszkowska M,Kośmider R,Adamczyk-Sowa M

    更新日期：2020-05-01 00:00:00

  • Superior protective effects of phenytoin against hypoxia in a pharmacological screening test.

    abstract：:The selection of drugs to prevent the development of pathology in cerebral infarction remains an important problem. For the selection of effective drugs from among a large number of possible candidates, widely-used test screening techniques are sufficient for obtaining a good understanding of candidate drug effects. T...

    journal_title：Neurological research

    pub_type： 杂志文章

    doi：10.1080/01616412.1988.11739810

    authors： Imaizumi S,Suzuki J,Kinouchi H,Yoshimoto T

    更新日期：1988-03-01 00:00:00

  • Endovascular treatment of giant and large intracranial aneurysms using the neuroform stent-assisted coil placement.

    abstract：BACKGROUND:Giant and large intracranial aneurysms represent enormous therapeutic challenges for neurosurgeons as well as for endovascular therapists. Since they may involve entire vessels or be irregular in shape, the rate of complete obliteration with GDCs is low and the incidence of recanalization is very high. So th...

    journal_title：Neurological research

    pub_type： 临床试验,杂志文章

    doi：10.1179/174313208X319017

    authors： Yang X,Wu Z,Mu S,Li Y,Lv M

    更新日期：2008-07-01 00:00:00

  • Cerebrovascular risk factors in Alzheimer's disease: brain hemodynamics and pharmacogenomic implications.

    abstract：:Recent evidence indicates that different vascular risk factors are present in Alzheimer's disease (AD) and other prevalent dementia types probably contributing to deterioration of cerebrovascular function, thus enhancing neurodegeneration and premature neuronal death due to a reduction in brain perfusion. Brain blood ...

    journal_title：Neurological research

    pub_type： 杂志文章,评审

    doi：10.1179/016164103101202002

    authors： Cacabelos R,Fernández-Novoa L,Lombardi V,Corzo L,Pichel V,Kubota Y

    更新日期：2003-09-01 00:00:00

  • Change in cortical vein appearance on susceptibility-weighted MR imaging before and after carotid artery stenting.

    abstract：OBJECTIVES:Susceptibility-weighted (SW) magnetic resonance (MR) imaging is a sensitive test to detect intravenous deoxygenated blood. On SW images, dilated appearing draining veins in tissue with perfusion impairment occur due to an increase in intravenous deoxyhemoglobin levels, and could indicate poor perfusion areas...

    journal_title：Neurological research

    pub_type： 杂志文章

    doi：10.1179/016164110X12644252260510

    authors： Sorimachi T,Morita K,Sasaki O,Koike T,Fujii Y

    更新日期：2011-04-01 00:00:00

  • Combination therapy with U74006F (tirilazad mesylate), MK-801, insulin and diazepam in transient forebrain ischaemia.

    abstract：:The mechanism of cerebral ischaemic injury is complex and likely involves more than a single pathophysiologic event. Drugs are available which interfere with numerous harmful biochemical and pharmacologic processes begun by ischaemia. Hence, combination chemotherapy might be useful in cerebral ischaemia. The purpose o...

    journal_title：Neurological research

    pub_type： 杂志文章

    doi：10.1080/01616412.1995.11740301

    authors： Auer RN

    更新日期：1995-04-01 00:00:00

  • Influence of mTOR signaling pathway on ketamine-induced injuries in the hippocampal neurons of rats.

    abstract：OBJECTIVE:To explore the influences of mammalian target of rapamycin (mTOR) signaling pathway on ketamine-induced apoptosis, oxidative stress and Ca2+ concentration in the hippocampal neurons of rats. METHODS:The primary hippocampal neurons isolated from fetal Sprague Dawley rats were treated with ketamine (0, 50, 100...

    journal_title：Neurological research

    pub_type： 杂志文章

    doi：10.1080/01616412.2018.1531203

    authors： Liu FF,Zhao S,Liu P,Huo SP

    更新日期：2019-01-01 00:00:00

  • Unusual presentation of carcinomatous meningitis: case report and review of typical CSF findings.

    abstract：:This paper describes a previously unreported clinical onset of carcinomatous meningitis with bilateral deafness. Typical changes in the cerebrospinal fluid aside from positive cytology findings are reviewed. In cases of suspected carcinomatous meningitis the clustering of increased CSF protein, lactate, decreased gluc...

    journal_title：Neurological research

    pub_type： 杂志文章

    doi：10.1179/016164102101200708

    authors： Zeller JA,Zunker P,Witt K,Schlueter E,Deuschl G

    更新日期：2002-10-01 00:00:00

  • Characterisation of DWI-MRI confirmed cerebral infarcts in patients with subarachnoid haemorrhage and their association with MMP-9 levels.

    abstract：OBJECTIVES:It has been suggested that metalloproteinase-9 (MMP-9) could predict the onset of cerebral vasospasm after subarachnoidal haemorrhage (SAH). The aim of this study was to analyse, in patients with SAH, the difference between patients with MRI ischaemic infarcts and patients without, and to investigate the rol...

    journal_title：Neurological research

    pub_type： 杂志文章

    doi：10.1179/1743132815Y.0000000045

    authors： Lago A,Tembl JI,López-Cuevas R,Vallés J,Santos MT,Moscardó A,Parkhutik V

    更新日期：2015-08-01 00:00:00

  • Needle-free acupuncture benefits both patients and clinicians.

    abstract：OBJECTIVE:This study examined whether a needle-free acupuncture can be an alternative to conventional needle injection acupuncture. METHODS:Patients (n=101) suffering myofascial shoulder pain were randomly assigned to either needle-free or conventional needle injection acupuncture group. Bee venom was administered int...

    journal_title：Neurological research

    pub_type： 杂志文章,随机对照试验

    doi：10.1179/016164109X12537002793760

    authors： An K,Kim YS,Kim HY,Lee H,Hahm DH,Lee KS,Kang SK

    更新日期：2010-02-01 00:00:00