Abstract:
:Before extending the application of motor cortex stimulation it is important to investigate the intimate mechanisms by which it alleviates intractable pain and to consider possible side effects. Self-mutilation in animals following extensive neurectomy or posterior rhizotomy of a limb is thought to reveal severe dysesthesias in the deafferented zone suggesting its usefulness as an animal model of chronic pain in humans. We here show in deafferented nonhuman primates that the autotomy behavior immediately follows the surgery and disappears after 28 days. In keeping with the experience of Y. Lamarre, the simple but careful care of all wounds is sufficient to abolish this behavior. Our results do not exclude the possibility that the deafferentiation is still painful for the monkeys, but they definitely rule out that autotomy is a consistent response to deafferentation.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Pioli EY,Gross CE,Meissner W,Bioulac BH,Bezard Edoi
10.1179/016164103101201274subject
Has Abstractpub_date
2003-03-01 00:00:00pages
127-9issue
2eissn
0161-6412issn
1743-1328journal_volume
25pub_type
杂志文章abstract:OBJECTIVE:This study assesses the clinical outcome after early combined cranioplasty (own frozen bone) and shunt implantation (Codman-Medos programmable VP shunt) in patients with skull bone defects and cerebrospinal fluid (CSF) circulation disorders. METHOD:Medical records were reviewed retrospectively for the last 1...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164106X98008
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Mapping of brain perfusion using bolus tracking methods is increasingly used to assess the amount and severity of cerebral ischemia in acute stroke. Using relative perfusion maps, however, it is difficult to identify the tissue at risk-maximum (TARM) of infarction with sufficient reliability and reproducibil...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X158956
更新日期:2007-04-01 00:00:00
abstract::This paper describes a test prototype for precision robot-assisted surgery using a hexapod operating robot and a movable operating cockpit for tactile feedback. The objective of the work described is twofold: 1, to evaluate the use of hexapod robots for precisely manipulating endoscopes and surgical instruments in sub...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1999.11740887
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:Neurovascular ultrasound (nUS) is widely used as a screening and monitoring tool in patients with spontaneous cervical artery dissection (sCAD). The aim of the study was to describe the sonographical course of the affected arteries in patients with a MRI-proven sCAD by repetitive nUS. METHODS:Thirty-seven co...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X319080
更新日期:2008-09-01 00:00:00
abstract::Severe head injuries tend to be associated with hypermetabolism and hypercatabolism resulting in negative nitrogen balances which may exceed 30 grams day-1. Enteral feeding should begin as soon as the patient is hemodynamically stable, attempting to reach a non-protein caloric intake of at least 30-35 kcal kg-1 day-1 ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164101101198451
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVES:To describe the role of neurosurgical techniques in treatment of symptoms of multiple sclerosis (MS). METHODS:A review of the existing world literature searching (using PubMed, August 22, 2005) for key words 'multiple sclerosis' and multiple symptoms associated with MS including trigeminal neuralgia, pain (...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164106X98224
更新日期:2006-04-01 00:00:00
abstract::The intracranial aneurysm, with an estimated occurrence of up to 4% in the general population, belongs among the most dangerous of cerebrovascular diseases. Although less than one-fifth of these cases results in a subarachnoid haemorrhage, the resulting disability and mortality rate is too high. More understanding is ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1991.11739995
更新日期:1991-12-01 00:00:00
abstract:OBJECTIVES:Patients presenting to the emergency room with an acute or subacute onset of focal neurological deficits are evaluated initially by non-contrast computed tomogram (CT) of the brain. This is primarily carried out to differentiate an ischemic from hemorrhagic stroke. However, other neurological conditions may ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164109X12445505689607
更新日期:2009-10-01 00:00:00
abstract::We have reliable data on the degree of stenosis above which endarterectomy for symptomatic carotid stenosis is beneficial, but benefit is also influenced by other factors, particularly age, sex, the timing of surgery, plaque surface morphology and the nature of the presenting symptomatic event(s). This review will con...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164105X25298
更新日期:2005-01-01 00:00:00
abstract::Microsurgical anatomy for the pterional approach was studied regarding the origin and the course of the ophthalmic artery and the distal dural ring using human cadaveric specimens, with special reference to the surrounding bony structures. In 50 human adult formalin-fixed cadaveric cerebral hemispheres and 10 block sp...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164101101198703
更新日期:2001-06-01 00:00:00
abstract::Promyelocytic leukemia (PML) protein is involved in apoptotic death of cultured neuronal cells, but its role in ischemic brain damage remains uncertain. In this study, we investigated change of immunoreactivity for PML protein in rat brain after transient middle cerebral artery occlusion, and compared the results with...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164101101199162
更新日期:2001-10-01 00:00:00
abstract::The elements of peripheral nerve regeneration comprise a complex combination of nerve growth, muscle satellite cells proliferation and differentiation and vessel growth. There is also increasing evidence that growth factors may act at multiple levels in the regenerative response. One such factor affecting multiple cel...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164104225013851
更新日期:2004-03-01 00:00:00
abstract::The treatment of arteriovenous malformations depends on the efforts of a multidisciplinary team whose ultimate goal is to achieve better results when compared to the natural history of the pathology. The role of adjuvant treatment modalities such as radiosurgery and endovascular embolization is discussed. Treatment st...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1080/01616412.1998.11740583
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVES:Bone marrow stromal cells (BMSCs) have been reported to improve movement deficit in adult rats with spinal cord injury (SCI). The purpose of this study is to determine the distribution of BMSCs in the spinal cord lesion of the contusion model of SCI. METHODS:Laminectomy was carried out at L1 vertebra level ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X165642
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:Intracranial aneurysms (IAs) of the posterior circulation (PC) rupture more frequently and their morbidity and mortality rates are higher compared to anterior circulation. Morphological parameters such as size ratio (SR), inflow angle and parent artery geometry are believed to contribute significantly in det...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000306
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:To explore the influences of mammalian target of rapamycin (mTOR) signaling pathway on ketamine-induced apoptosis, oxidative stress and Ca2+ concentration in the hippocampal neurons of rats. METHODS:The primary hippocampal neurons isolated from fetal Sprague Dawley rats were treated with ketamine (0, 50, 100...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1531203
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:Cell-free DNA (cf-DNA) is a marker of inflammation and cell death. The purpose of the present study was to analyze the role of cf-DNA as a putative biomarker in refractory epilepsy. METHODS:Baseline concentration of cf-DNA was measured in the serum of 51 carefully evaluated refractory epilepsy patients under...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2015.1127004
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:The present study characterized glial cell injury provoked in adult rat chiasm within 24 hours after a single, high-dose irradiation of 20 Gy. METHODS:All chiasmal glial cells in a section were counted, and the percentage of TUNEL-positive glial cells exhibiting apoptotic morphology was defined as the apopt...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164105X48833
更新日期:2005-06-01 00:00:00
abstract::The survival of a group of patients with malignant gliomas of the brain submitted to radical surgery and radiotherapy was studied. The average survival was nearly 4 times longer with X-ray treatment than with cobalt 60 irradiation when a comparison was made between 24 patients with glioblasto-astroblastoma (grade 3-4)...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1987.11739796
更新日期:1987-09-01 00:00:00
abstract::The successful treatment of an intracranial arteriovenous malformation poses both technical and conceptual problems to the neurosurgeon. Treatment decisions are made in light of current understanding of the natural history of these lesions. It is important to understand the pros, cons and current indication of open cr...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164102101200122
更新日期:2002-06-01 00:00:00
abstract::Treatment modalities for metastatic spine disease have significantly expanded over the last two decades. This expansion occurred in many different fields. Improvement in surgical techniques and instrumentation now allow the oncologic spine surgeons to effectively circumferentially decompress the neural elements withou...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132814Y.0000000365
更新日期:2014-06-01 00:00:00
abstract::The possible role of nitric oxide (NO) on vibrissa-stimulated increase of regional cerebral cerebral blood flow (rCBF) and cerebral metabolic rate of glucose (rCMRglu) was investigated in conscious Wistar rats by using an inhibitor of NO synthase, NG-nitro-L-arginine (NOLAG) at a concentration of 30 mg/kg. In vivo aut...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1993.11740103
更新日期:1993-02-01 00:00:00
abstract:OBJECTIVE:To assess the clinical significance of hepatitis B virus (HBV) infection in patients with cerebral venous sinus thrombosis (CVST). METHODS:Twenty-two patients with CVST confirmed by magnetic resonance venography (MRV) or digital subtraction angiography (DSA) and 743 controls with ischemic stroke confirmed by...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132815Y.0000000003
更新日期:2015-06-01 00:00:00
abstract:INTRODUCTION:The novel coronavirus disease (COVID-19) pandemic poses a substantial threat to the health of healthcare personnel on the front line of caring for COVID-19 patients. The Centers for Medicare and Medicaid Services previously announced that all non-essential planned surgeries and procedures should be postpon...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1781455
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:Previous reports showed the reduction of dopamine transporter immunoreactivity in peripheral blood lymphocytes in Parkinson's disease. In this work, we sought to investigate the possible correlation between central and peripheral dopamine transporter immunoreactivity values in a group of 11 drug-naive patient...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313209X383259
更新日期:2009-09-01 00:00:00
abstract::This paper summarizes the work of developing and analyzing a mathematical model of schizophrenia. First the psychological and physiological studies of patients with periodic catatonia made by R. R. Gjessing are briefly described. Then a mathematical model, which is based on Gjessing's work and consists of a set of non...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1979.11739544
更新日期:1979-01-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is the most serious form of degenerative motor neuron disease in adults, whose relentless course leads to death within 2-5 years, generally due to respiratory failure. Apart from the age and site of onset, no other factors have consistently demonstrated to be related to the ALS outc...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132812Y.0000000049
更新日期:2012-07-01 00:00:00
abstract::The efficacy of delayed thrombolysis with recombinant tissue plasminogen activator was tested in combination with the ischaemic protecting drug NBQX in an embolic stroke model. In 113 rats the carotid territory was embolized with a fibrin-rich clot formed in polyethylene tube. Hemispheric cerebral blood flow (CBF) was...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1993.11740159
更新日期:1993-10-01 00:00:00
abstract::This investigation was designed to clarify the chronic effects of cardiogenic emboli on cerebral perfusion and tissue densities within remaining noninfarcted brain. Local cerebral perfusion and tissue densities were measured by xenon-contrasted CT scanning and compared by cross-sectional designs among normal volunteer...
journal_title:Neurological research
pub_type: 杂志文章
doi:
更新日期:1995-10-01 00:00:00
abstract:OBJECTIVES:One of the main obstacles of electrode implantation in epilepsy surgery is the electrode shift between implantation and the day of explantation. We evaluated this possible electrode displacement using intraoperative MRI (iopMRI) data and CT/MRI reconstruction. METHODS:Thirteen patients (nine female, four ma...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1484588
更新日期:2018-10-01 00:00:00