Abstract:
:Thromboxane A2 (TXA2) is a proaggregatory vasoconstrictor that is synthesized and released during reperfusion of ischaemic brain. We administered a TXA2 receptor antagonist, SQ29,548, and a thromboxane A synthase inhibitor, 1-benzylimidazole (1-BI), to rats subjected to 30 min of reversible forebrain ischaemia. Cerebral thromboxane B2 (TXB2), the stable metabolite of TXA2, measured after 60 min of reperfusion was 0.37 +/- 0.08 ng/mg brain protein in animals treated with SQ29,548/1-BI compared with 1.20 +/- 0.16 in ischaemic controls (p < 0.05). Cerebral pH determined by 31P magnetic resonance spectroscopy was higher in treated animals, 7.06 +/- 0.04, than in ischaemic controls, 6.5 +/- 0.01, after 20 min of reperfusion (p < or = 0.01). The significant elevation of cerebral pH in treated animals persisted at 30 (7.17 +/- 0.05 vs. 6.5 +/- 0.01; p < or = 0.01), 35 (7.17 +/- 0.05 vs. 6.44 +/- 0.04; p < or = 0.01), and 40 min of reperfusion (7.06 +/- 0.06 vs. 6.37 +/- 0.01; p < or = 0.05). We conclude that SQ29,548/1-BI reduces thromboxane levels and promotes resolution of tissue acidosis in ischaemic brain. The combination of a TXA2 receptor antagonist with a thromboxane A synthase inhibitor deserves further study as a potential treatment for acute cerebral infarction.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Pettigrew LC,Hazle JD,Gutierrez G,Smith CD,Ogletree MLdoi
10.1080/01616412.1992.11740080subject
Has Abstractpub_date
1992-09-01 00:00:00pages
335-9issue
4eissn
0161-6412issn
1743-1328journal_volume
14pub_type
杂志文章abstract:INTRODUCTION:Here, we investigated inflammatory signs of peripheral nerves in leptin-deficient obese ob/ob mice and the modulating effects of the exogenous iron load. METHODS:Ob/ob and ob/+ control mice were fed with high, standard, or low iron diet for four months. RESULTS:We found intraepidermal nerve fiber degener...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1564191
更新日期:2019-04-01 00:00:00
abstract::Supraventricular and ventricular tachyarrhythmia are established causes of syncope. We investigated the mean blood flow velocities (Vmean) of the middle cerebral arteries (MCA) during routine cardiac electrophysiologic studies in patients with supraventricular and ventricular tachyarrhythmias in order to evaluate the ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740555
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVES:Hourly neurologic assessments for traumatic brain injury (TBI) in the critical care setting are common practice but prolonged use may actually be harming patients through sleep deprivation. We reviewed practice patterns at our institution in order to gain insight into the role of frequent neurological assess...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000285
更新日期:2014-02-01 00:00:00
abstract::It is known that mitochondrial ATP-sensitive potassium channels (mitoKATP) play a significant role in protecting cerebral function from ischemia-reperfusion injury, which is related with a decrease in the mitochondrial matrix calcium. However, the effect of mitochondrial calcium uniporter (MCU) on diazoxide-induced ce...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000299
更新日期:2014-07-01 00:00:00
abstract::The survival of a group of patients with malignant gliomas of the brain submitted to radical surgery and radiotherapy was studied. The average survival was nearly 4 times longer with X-ray treatment than with cobalt 60 irradiation when a comparison was made between 24 patients with glioblasto-astroblastoma (grade 3-4)...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1987.11739796
更新日期:1987-09-01 00:00:00
abstract::The present study used immunohistochemistry to investigate p53 expression in rat brain following transient occlusion of the middle cerebral artery. In the control group, no p53-immunoreactive cells were found in any region of the central nervous system. P53 expression in reactive astrocytes was not obvious in the fore...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101199828
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to investigate the ability of bone marrow mesenchymal stem cells (BMSCs) to survive in the striatum and improve motor function in the quinolinic acid (QA) lesion rat model of Huntington's disease (HD). METHODS:One week following QA lesioning of the striatum, rats were transplan...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164110X12816242542571
更新日期:2011-04-01 00:00:00
abstract::Changes in membrane AChRs in skeletal muscles located near or distant from burn injury similar to denervated muscles may make electrodiagnostic features indistinguishable from true neuropathic changes. The aim of this study was to examine electrodiagnostic changes of muscles at sites local and distant from the burn af...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2015.1105583
更新日期:2016-04-01 00:00:00
abstract::More reliable prediction of outcome would be helpful for clinicians who treat severely head-injured patients. To determine if neural network modeling would improve outcome prediction compared with standard logistic regression analysis and to determine if data available 24 h after severe head injury allows better predi...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1997.11740813
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVE:To study histopathologic changes and the role of the microglia/macrophage cell in the therapeutic effect of I-125 interstitial brachytherapy on the cerebral gliomas. METHODS:Out of a series of 60 cases with cerebral astrocytomas and other brain tumors treated with I-125 interstitial brachytherapy, autopsy ma...
journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1179/016164107X158875
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:After a spinal cord injury (SCI), most men experience fertility related problems including poor semen quality in which decreased sperm viability and motility, have been proposed to be related to the accessory sex glands dysfunction. In this study, we investigated the probable effects of SCI on the seminal ves...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164108X268287
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To investigate risk factors for neurological complications after off-pump coronary artery bypass grafting (OPCABG). METHODS:We reviewed the cases of 813 patients who underwent OPCABG between August 2010 and September 2013.Data from preoperative 320 dynamic volume computed tomography (CT), CT angiography (CTA...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132815Y.0000000030
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVES:In multiple sclerosis (MS) demyelination occurs in both white and gray matter. Here we introduce an electrophysiological approach for studying functional demyelination and myelin repair in rat hippocampus, a gray matter structure, which is frequently affected in patients suffering from MS. METHODS:Using a s...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000221
更新日期:2013-10-01 00:00:00
abstract::In order to investigate the role of the endothelium in the regulation of cerebrovascular tone, we studied selective intraluminal and extraluminal vasoactive mechanisms of acetylcholine, potassium and serotonin. We also examined the effects of removal of the endothelium on these vasoactive responses. With 0.75 g of ten...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1993.11740128
更新日期:1993-06-01 00:00:00
abstract::Cerebral hemorrhages are subject to a heavy short- and long-term case fatality. A study of prognostic factors and of relative survival based on the data of a population registry is of great value to study patients having a hematoma of all ages, irrespective of the method of care. We have listed 183 patients having a c...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2000.11740754
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVE:We sought to determine whether cerebral inflammation in ischemic rats was reduced by a neuroprotective action of pre-ischemic tumor necrosis factor-alpha up-regulation, which down-regulated matrix metalloproteinase-9 activity via extracellular signal-regulated kinase 1/2 phosphorylation. MATERIAL AND METHODS...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313209X459101
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:It is necessary to understand the mechanism of trigeminal neuralgia (TN) and hemifacial spasm (HFS) in order to seek for an effective noninvasive remedy. As previous studies implied that inflammatory cytokines induced by demyelination following the nerve injury may be the initiated factor causing neuropathic...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1564188
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVES:In the clinical set, autologus nerve grafts are the current option for reconstruction of nerve tissue losses. The length of the nerve graft has been suggested to affect outcomes. Experiments were performed in the rat in order to test this assumption and to detect a possible mechanism to explain differences i...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164105X18494
更新日期:2005-09-01 00:00:00
abstract::This study was performed to test whether GYKI 52466, a nonNMDA receptor antagonist, would improve microregional oxygen supply and consumption balance in the focal cerebral ischemic area. Rats were anesthetized with 1.4% isoflurane. For the GYKI Group (n = 8), 10 min before middle cerebral artery (MCA) occlusion, a bol...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1999.11740935
更新日期:1999-04-01 00:00:00
abstract::Objective Preoperative magnetic resonance (MR) angiography sometimes shows the absence of collateral flow via the circle of Willis. This study examined whether brain temperature (BT) imaging on multi-voxel proton MR spectroscopy after this finding increases the accuracy of predicting hemispheric ischemia during intern...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1457130
更新日期:2018-08-01 00:00:00
abstract::We describe the use of optical spectroscopy in the near infra-red light range to non-invasively measure regional cerebral haemoglobin oxygen saturation (rSHbO2) in cats during progressive cerebral hypoxia. This technique differs from spectroscopic techniques previously described in that the concentration ratio--percen...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1991.11739967
更新日期:1991-03-01 00:00:00
abstract::As early as 1 to 3 hr after cord transection, proliferation of many reactive oligodendrocytes was observed. Bundles of microfilaments and microtubules were observed in those cells that sent out long, complex pseudopodlike processes near the area of injury. These reactive oligodendrocytes may be comparable to Vaughn's ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1980.11739566
更新日期:1980-01-01 00:00:00
abstract::Alzheimer disease (AD), a central nervous system degenerative disease, is characterized by abnormal deposition of amyloid-β peptide (Aβ), neurofibrillary tangles formed by hyperphosphorylated tau and synaptic loss. It is widely accepted that Aβ is the chief culprit of AD. Aβ peptide is the cleavage product of amyloid-...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1080/01616412.2015.1133485
更新日期:2016-02-01 00:00:00
abstract::Electrical stimulation of peripheral nerves can be used to cause muscle contraction, to activate reflexes, and to modulate some functions of the central nervous system (neuromodulation). If applied to the spinal cord or nerves controlling the lower urinary tract, electrical stimulation can produce bladder or sphincter...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164102101200294
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVE:To determine the functional abnormalities of the Leu89Pro mutation in connexin32 (CX32), which we have previously reported is present within an X-linked dominant Charcot-Marie-Tooth disease family. In this family, male patients were moderately to severely affected. METHODS:We performed immunofluorescence to ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2016.1204494
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:High blood pressure (BP) is a major risk factor for stroke and all of its pathological subtypes including subarachnoid hemorrhage (SAH). However, there is little evidence demonstrating whether failure to have regular BP measured could result in underestimation of people at risk for SAH. Therefore, we aimed ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132811Y.0000000020
更新日期:2011-12-01 00:00:00
abstract::Intra-arterial thrombolysis and percutaneous angioplasty is feasible in patients with acute middle cerebral artery (MCA) occlusion limited to 6 hours post-ictus, but there are some limitations such as reocclusion or hemorrhagic complications. In this report, we describe a stent placement in the treatment of a refracto...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164105X49355
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVES:Occipital petalia is an anatomic description where one of the occipital lobes protrudes towards the contralateral side. Transverse sinus (TS) asymmetry might cause diagnostic challenges with regards to thrombotic or compressive pathologies involving these sinuses. In this study, we investigated the associati...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1560643
更新日期:2019-04-01 00:00:00
abstract::Monitoring of regional cerebral oxygen saturation (r. cereb. O2 satn.) was carried out continuously in 12 healthy subjects (mean age 35.2 +/- 4.4 years; range 26-41 years; 4 women, 8 men), prior to, during and following acupuncture. Measurements were obtained with the INVOS 3100 cerebral oximeter (Somanetics Corp., Tr...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740605
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:Vascular endothelial growth factor is a potent stimulator of angiogenesis; activation of hypoxia inducible factor-1alpha and p44/42 mitogen-activated protein kinase pathways has been associated with vascular endothelial growth factor production. The present study examined if thrombin modulates vascular endoth...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313209X385699
更新日期:2009-09-01 00:00:00