Hyperglycaemia protects against neuronal injury around experimental brain infarcts.

Abstract:

:Regional glucose utilization was measured in the rat brain after occlusion of the middle cerebral artery. Normoglycaemic rat had increased glucose use in the cerebral cortex adjacent to the infarct. A fraction of the nerve cells were irreversibly injured in this region. In hyperglycaemic rats, the glucose metabolism remained normal and no nerve cell loss was found around the infarct. The findings indicate that hyperglycaemia protects against nerve cell injury in the areas next to experimental brain infarcts.

journal_name

Neurol Res

journal_title

Neurological research

authors

Nedergaard M,Gjedde A,Diemer NH

doi

10.1080/01616412.1987.11739802

subject

Has Abstract

pub_date

1987-12-01 00:00:00

pages

241-4

issue

4

eissn

0161-6412

issn

1743-1328

journal_volume

9

pub_type

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