Ultrastructure of rat seminal vesicle epithelium in the acute phase of spinal cord transection.


OBJECTIVE:After a spinal cord injury (SCI), most men experience fertility related problems including poor semen quality in which decreased sperm viability and motility, have been proposed to be related to the accessory sex glands dysfunction. In this study, we investigated the probable effects of SCI on the seminal vesicle epithelium in rat. METHODS:Spinal cord was injured in adult male rats by surgical transection at the level of T9. Controls received similar surgery without transection. Five days later, animals were killed and the seminal vesicles were removed, subjected to routine procedures for light and transmission electron microscopy respectively. RESULTS:Acute inflammation of the seminal vesicles including vasodilatation and migration of leukocytes to epithelium was observed through the light microscopy. Transmission electron microscopy study revealed significant changes in the experimental epithelium, such as decrease in rough endoplasmic reticulum, secretory granules and Golgi apparatus dimensions, accumulations of fat droplets and lipofuscin in the cytoplasm, euchromatinized and swelled nuclei, decrease in cell diameters, and the presence of macrophages and hollow spaces in the epithelium. The seminal vesicle of sham-operated animals showed normal morphology. DISCUSSION:Histologic evidence in this study confirms dysfunction of seminal vesicle in the acute phase of SCI. Further works are needed to follow up the reversibility of such lesions.


Neurol Res


Neurological research


Dashtdar H,Valojerdi MR




Has Abstract


2008-06-01 00:00:00












  • Sleep promoting effects of intravenously administered acidic fibroblast growth factor.

    abstract::The influence of acidic fibroblast growth factor (aFGF) on sleep was studied in conscious rabbits. An intravenous (i.v.) bolus injection of aFGF induced a significant increase in sleep duration in comparison with animals that received vehicle solution. Somnogenic effects were obtained 30 min following i.v. aFGF admini...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Galan JM,Cuevas B,Dujovny N,Giménez-Gallego G,Cuevas P

    更新日期:1996-12-01 00:00:00

  • Motor cortex stimulation enhances motor recovery and reduces peri-infarct dysfunction following ischemic insult.

    abstract::Recovery of motor function following stroke is believed to be supported, at least in part, by functional compensation involving residual neural tissue. The present study used a rodent model of focal ischemia and intracortical microstimulation (ICMS) to examine the behavioral and physiological effects of cortical stimu...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Kleim JA,Bruneau R,VandenBerg P,MacDonald E,Mulrooney R,Pocock D

    更新日期:2003-12-01 00:00:00

  • Local fibrinolysis and aspiration of intracerebral hematomas in rats. An experimental study using MR monitoring.

    abstract::Serial magnetic resonance (MR) imaging has not yet been validated in the therapy of experimental intracerebral hematomas in a rat model. It is possible to test the effect of local fibrinolysis and aspiration on the clot volume using serial magnetic resonance imaging and different MR-sequences. Experiments were carried...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Deinsberger W,Hartmann M,Vogel J,Jansen O,Kuschinsky W,Sartor K,Böker DK

    更新日期:1998-06-01 00:00:00

  • Protocol-directed weaning from mechanical ventilation in neurological patients: a randomised controlled trial and subgroup analyses based on consciousness.

    abstract:OBJECTIVES:To assess whether a weaning protocol reduces the mechanical ventilation (MV) duration compared to physician's judgement-based weaning in neurological patients and to determine whether patient consciousness influences this reduction. METHODS:A randomised controlled trial was conducted in a neurological inten...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Fan L,Su Y,Elmadhoun OA,Zhang Y,Zhang Y,Gao D,Ye H,Chen W

    更新日期:2015-11-01 00:00:00

  • Detection of the bladder volume from the neural afferent activities in dogs: experimental results.

    abstract:OBJECTIVE:We evaluate the bladder volume and pressure through recording the bladder afferent activity in the sacral nerve roots in acute experiments of paraplegic dogs. These measurements are intended to report the status of the bladder and to adjust the stimulation parameters of an implantable electric stimulator. ME...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Saleh A,Sawan M,Elzayat EA,Corcos J,Elhilali MM

    更新日期:2008-02-01 00:00:00

  • Effect of magnesium, MK-801 and combination of magnesium and MK-801 on blood-brain barrier permeability and brain edema after experimental traumatic diffuse brain injury.

    abstract:OBJECTIVE:Glutamate antagonists are very attractive drugs in laboratory works to protect neural tissue against ischemia. In this work, the effects of magnesium, MK-801 and combination of magnesium and MK-801 on blood-brain barrier (BBB) and brain edema after experimentally induced traumatic brain injury are evaluated. ...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Imer M,Omay B,Uzunkol A,Erdem T,Sabanci PA,Karasu A,Albayrak SB,Sencer A,Hepgul K,Kaya M

    更新日期:2009-11-01 00:00:00

  • Use of immunoassays in neurological diagnosis and research.

    abstract:OBJECTIVES:To review the use of immunoassays in the diagnosis and research of disorders affecting the nervous system. METHODS:Systematic review of the English literature. RESULTS:Immunoassays have demonstrated utility for: (1) the detection of antigen (molecules, genes, gene products, peptides, hormones and drug meta...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: Meriggioli MN

    更新日期:2005-10-01 00:00:00

  • Cerebral blood flow regulation under activation of the primary somatosensory cortex during electrical stimulation of the forearm.

    abstract::Coupling of neuronal activity to cerebral blood flow (CBF) is widely accepted, but the exact mechanism is still under investigation. We assessed the responses of CBF coupled with electrical activity over the primary somatosensory cortex (S-I) during electrical stimulation of the contralateral forearm in cats. CBF in S...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Ichimi K,Kuchiwaki H,Inao S,Shibayama M,Yoshida J

    更新日期:1999-09-01 00:00:00

  • A model of global forebrain ischemia/reperfusion in the awake rat.

    abstract::Anesthesia is an essential element during the induction of ischemia/reperfusion and cerebral blood flow (CBF) measurement in most animal models. Cerebral neuroprotection and intrinsic effects on CBF afforded by anesthetics are confounding variables in those models. A new model of global forebrain ischemia/reperfusion ...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Melgar MA,Park H,Rafols JA,Diaz FG

    更新日期:2002-01-01 00:00:00

  • Combined preoperative onyx embolization and protective internal carotid artery covered stent placement for treatment of glomus vagale tumor: review of literature and illustrative case.

    abstract:OBJECTIVE:Surgical resection of complex glomus vagale tumors can be complicated by extensive blood loss and might require surgical sacrifice of an encased internal carotid artery. METHODS:A young patient presented with mass effect from glomus valage tumor. Computerized tomography angiography showed an encased interna...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: Alaraj A,Pytynia K,Carlson AP,Krishna PH,Charbel FT,Amin-Hanjani S,Aletich V

    更新日期:2012-07-01 00:00:00

  • Online assessment of brain tissue oxygen autoregulation in traumatic brain injury and subarachnoid hemorrhage.

    abstract::Monitoring of brain tissue oxygenation (ptiO2) enables early diagnosis of secondary cerebral ischemia and may guide a cerebral perfusion pressure (CPP) orientated therapy. The purpose of our study was to explain the concept of ptiO2-autoregulation, defined as the ability of the brain to maintain ptiO2 despite changes ...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Soehle M,Jaeger M,Meixensberger J

    更新日期:2003-06-01 00:00:00

  • Detection of experimentally induced brain tumors in rats using high resolution computed tomography.

    abstract:OBJECTIVE:The feasibility of high resolution CT imaging for evaluating experimentally-induced brain tumors in rats was assessed. METHODS:The gliosarcoma cell line (9 L/lacZ) was inoculated in 34 male Fischer 344 rats and CT studies were performed prior to and at 4, 7, 9, 12 and 14 days post-tumor cell implantation. Br...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Psarros TG,Mickey B,Giller C

    更新日期:2005-01-01 00:00:00

  • A brief review of the effects of chronic hydrocephalus on the gonadotropin releasing hormone system: implications for amenorrhea and precocious puberty.

    abstract::Precocious puberty and amenorrhea have been associated with hydrocephalus, but the pathogenesis has not been determined. Approximately 22 cases of amenorrhea, and a few cases of precocious puberty, have been reported in hydrocephalic patients. Shunt treatment leads to initiation and maintenance of normal reproductive ...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: Abdolvahabi RM,Mitchell JA,Diaz FG,McAllister JP 2nd

    更新日期:2000-01-01 00:00:00

  • Smear technique in the intra-operative brain tumor diagnosis: its advantages and limitations.

    abstract::The role of intra-operative pathological diagnosis increases along with a development of minimally invasive neurosurgery, especially stereotactic and endoscopic techniques. The authors present their own experience with the cytological method and evaluate its usefulness in intra-operative diagnosis of brain tumors. Bra...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章


    authors: Slowiński J,Harabin-Slowińska M,Mrówka R

    更新日期:1999-01-01 00:00:00

  • Calcium antagonists for the treatment of vasospasm following subarachnoid haemorrhage.

    abstract::Cerebral vasospasm and/or delayed ischaemic state following subarachnoid haemorrhage still remain unsolved serious problems. With the development and introduction of calcium antagonists as well as the advances in perioperative management, however, the clinical outcome has much improved in recent years. Among such drug...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: Hongo K,Kobayashi S

    更新日期:1993-08-01 00:00:00

  • Magnetic resonance imaging of the central nervous system.

    abstract::Magnetic resonance (MR) is a powerful new imaging modality which has recently become competitive with X-ray computed tomography (CT) for imaging of the central nervous system (CNS). The advantages of MR include lack of ionizing radiation and the necessity to use iodinated contrast. MR is able to image directly in the ...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: Bradley WG Jr

    更新日期:1984-09-01 00:00:00

  • Cerebral density and perfusion measured among heart disease patients with and without stroke.

    abstract::This investigation was designed to clarify the chronic effects of cardiogenic emboli on cerebral perfusion and tissue densities within remaining noninfarcted brain. Local cerebral perfusion and tissue densities were measured by xenon-contrasted CT scanning and compared by cross-sectional designs among normal volunteer...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Obara K,Meyer JS,Muramatsu K,Mortel KF

    更新日期:1995-10-01 00:00:00

  • Electrical stimulation for the treatment of bladder dysfunction: current status and future possibilities.

    abstract::Electrical stimulation of peripheral nerves can be used to cause muscle contraction, to activate reflexes, and to modulate some functions of the central nervous system (neuromodulation). If applied to the spinal cord or nerves controlling the lower urinary tract, electrical stimulation can produce bladder or sphincter...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: Jezernik S,Craggs M,Grill WM,Creasey G,Rijkhoff NJ

    更新日期:2002-07-01 00:00:00

  • Temporal and spacial changes of highly polysialylated neural cell adhesion molecule immunoreactivity in amygdala kindling development.

    abstract::To investigate the migration of neural stem cells as well as neural plastic changes in epileptic brain, spaciotemporal expression of immunoreactive highly polysialylated neural cell adhesion molecule (PSA-NCAM) was examined in amygdala kindling development of rat. The neural migration and synaptic remodeling detected ...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Sato K,Iwai M,Nagano I,Shoji M,Abe K

    更新日期:2003-01-01 00:00:00

  • Cerebrospinal fluid biomarkers of neuropathologically diagnosed Parkinson's disease subjects.

    abstract:OBJECTIVES:Parkinson's disease (PD) afflicts approximately 1-2% of the population over 50 years of age. No cures or effective modifying treatments exist and clinical diagnosis is currently confounded by a lack of definitive biomarkers. We sought to discover potential biomarkers in the cerebrospinal fluid (CSF) of neuro...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Maarouf CL,Beach TG,Adler CH,Shill HA,Sabbagh MN,Wu T,Walker DG,Kokjohn TA,Roher AE,Arizona PD Consortium.

    更新日期:2012-09-01 00:00:00

  • The time course of glucose metabolism in rat cerebral ischemia with middle cerebral artery occlusion-reperfusion model and the effect of MK-801.

    abstract::Following cerebral ischemia, the extracellular concentration of excitatory amino acids increases, and the excitatory cell death may play an important role contributing to ischemic neuronal damage. Although sequential metabolic changes in permanent local cerebral ischemia have been reported, the effect of reperfusion i...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Liu Y,Mituska S,Hashizume K,Hosaka T,Nukui H

    更新日期:1996-12-01 00:00:00

  • Catalpol protects rat pheochromocytoma cells against oxygen and glucose deprivation-induced injury.

    abstract:OBJECTIVES:Catalpol has been identified to have neuroprotective effect on gerbils subjected to transient global cerebral ischemia. However, the mechanism that catalpol prevents ischemia is still unclear. In the present study, PC12 cells, exposed to oxygen and glucose deprivation (OGD) followed by reperfusion, were used...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Wang Z,An LJ,Duan YL,Li YC,Jiang B

    更新日期:2008-02-01 00:00:00

  • Suboptimal awareness and control of hypertension increases the risk of subarachnoid hemorrhage in the community: results from the ACROSS.

    abstract:BACKGROUND:High blood pressure (BP) is a major risk factor for stroke and all of its pathological subtypes including subarachnoid hemorrhage (SAH). However, there is little evidence demonstrating whether failure to have regular BP measured could result in underestimation of people at risk for SAH. Therefore, we aimed ...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Shiue I,Hankey GJ,Arima H,Anderson CS

    更新日期:2011-12-01 00:00:00

  • Head registration techniques for image-guided surgery.

    abstract::Localization of the pathological structures in relation to the surrounding anatomy and understanding of the surgical anatomy are probably the most important keys to successful neurosurgery. Image-guided surgery is an important tool for understanding an individual's anatomy and for precisely locating the lesion. Head r...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Alp MS,Dujovny M,Misra M,Charbel FT,Ausman JI

    更新日期:1998-01-01 00:00:00

  • Microsurgical anatomy of the ophthalmic artery and the distal dural ring for the juxta-dural ring aneurysms via the pterional approach.

    abstract::Microsurgical anatomy for the pterional approach was studied regarding the origin and the course of the ophthalmic artery and the distal dural ring using human cadaveric specimens, with special reference to the surrounding bony structures. In 50 human adult formalin-fixed cadaveric cerebral hemispheres and 10 block sp...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Hokama M,Hongo K,Gibo H,Kyoshima K,Kobayashi S

    更新日期:2001-06-01 00:00:00

  • Hourly neurologic assessments for traumatic brain injury in the ICU.

    abstract:OBJECTIVES:Hourly neurologic assessments for traumatic brain injury (TBI) in the critical care setting are common practice but prolonged use may actually be harming patients through sleep deprivation. We reviewed practice patterns at our institution in order to gain insight into the role of frequent neurological assess...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Stone JJ,Childs S,Smith LE,Battin M,Papadakos PJ,Huang JH

    更新日期:2014-02-01 00:00:00

  • Humoral immune response to influenza vaccine in natalizumab-treated MS patients.

    abstract:OBJECTIVES:Natalizumab is a drug with documented efficacy in relapsing-remitting multiple sclerosis (RRMS). The mechanism of action of natalizumab has immunosuppressive properties and it is not yet investigated if treatment with natalizumab affects the immunological response to vaccination. This study aims to investig...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Vågberg M,Kumlin U,Svenningsson A

    更新日期:2012-09-01 00:00:00

  • The role of CD8+ T-cells in lesion formation and axonal dysfunction in multiple sclerosis.

    abstract::The etiology of multiple sclerosis (MS) remains unknown. However, both genetic and environmental factors play important roles in its pathogenesis. While demyelination of axons is a hallmark histological feature of MS, axonal and neuronal dysfunction may correlate better with clinical disability. All major immune cell ...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: McDole J,Johnson AJ,Pirko I

    更新日期:2006-04-01 00:00:00

  • Pros, cons, and current indications of open craniotomy versus gamma knife in the treatment of arteriovenous malformations and the role of endovascular embolization.

    abstract::The successful treatment of an intracranial arteriovenous malformation poses both technical and conceptual problems to the neurosurgeon. Treatment decisions are made in light of current understanding of the natural history of these lesions. It is important to understand the pros, cons and current indication of open cr...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: Surdell DL Jr,Bhattacharjee S,Loftus CM

    更新日期:2002-06-01 00:00:00

  • Mathematical model of the rupture mechanism of intracranial saccular aneurysms through daughter aneurysm formation and growth.

    abstract:OBJECTIVES:Daughter aneurysms have been strongly associated with saccular aneurysm rupture. We constructed a mathematical model to help explain this association as a possible hemodynamic mechanism for intracranial saccular aneurysm rupture. METHODS:Our model is based on the assumption that when an aneurysm reaches a s...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Meng H,Feng Y,Woodward SH,Bendok BR,Hanel RA,Guterman LR,Hopkins LN

    更新日期:2005-07-01 00:00:00