Abstract:
OBJECTIVES:Intracranial aneurysms (IAs) of the posterior circulation (PC) rupture more frequently and their morbidity and mortality rates are higher compared to anterior circulation. Morphological parameters such as size ratio (SR), inflow angle and parent artery geometry are believed to contribute significantly in determining IA risk rupture. The aim of this study is to establish angiography-based morphometric predictors of PC IA risk rupture. METHODS:A retrospective analysis of 58 patients with PC aneurysms was incorporated into the study. The following independent variables were measured: aneurysm dome size, neck size, parent artery size, SR, neck to parent artery ratio, and inflow angle. All aneurysms were divided into ruptured and unruptured groups. The stepwise logistic regression analysis was applied to establish the predictors of PC aneurysm risk rupture. RESULTS:58 patients with 27 unruptured and 31 ruptured PC cerebral aneurysms were analyzed. The mean aneurysm dome, neck and parent vessel diameters were 8·49±3·5 mm, 2·46±1·4 mm, and 3·92±1·6 mm, respectively. Size ratio was 2·26±0·6; dome/neck 3·45±0·8 and inflow angle 115·2±22°. The relevant difference between unruptured and ruptured groups was: SR (1·91 vs 2·48), aneurysm dome (7·96 vs 8·95 mm), dome/neck (3·77 vs 3·18), and inflow angle (103·7 vs 125·2°). The significant predictive value was reached for inflow angle (OR 1·05; Cl 95% 1·01 to 1·1) and SR (OR 3·53; Cl 95% 1·09 to 11·5). Cut-off value on receiver operating characteristic curve for inflow angle (113·1°; sensitivity 67·7% and specificity 81·5%) and SR (1·99; sensitivity 77·4% and specificity 63%). DISCUSSION:The SR and inflow angle proved to be relevant predictors in estimating the aneurysm risk rupture of the posterior cerebral circulation.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Tykocki T,Nauman P,Dow Enko Adoi
10.1179/1743132813Y.0000000306subject
Has Abstractpub_date
2014-08-01 00:00:00pages
733-8issue
8eissn
0161-6412issn
1743-1328journal_volume
36pub_type
杂志文章abstract::Recent studies suggest that high plasma levels of tissue-type plasminogen activator (tPA) and its inhibitor (plasminogen activator inhibitor-1, PAI-1) are markers of an increased risk of atherothrombotic ischemic events such as stroke and myocardial infarction. In this prospective study, we measured tPA antigen, PAI-1...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1999.11741005
更新日期:1999-12-01 00:00:00
abstract::[15O]-water PET was performed on 12 patients with structural lesions for localization of the motor (n = 5), language (receptive and expressive; n = 6), and visual cortex (n = 1). All these patients underwent interactive image-guided surgery using an infrared digitizer and intraoperative electrical stimulation mapping ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1997.11740867
更新日期:1997-12-01 00:00:00
abstract:OBJECTIVE:One of the important causes of failed back surgery is the extensive peridural fibrosis collecting in the surgical field after spinal surgeries. Today we know that inflammatory mechanisms mediated by the immune system of the body plays an important role in generation of fibrosis. Azithromycin, a macrolide anti...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164110X12767786356471
更新日期:2011-05-01 00:00:00
abstract::We describe the technique of percutaneous carotid artery stent placement with distal protection in a patient in whom marked innominate artery ectasia prevented transfemoral access to the right common carotid artery. After induction of general anesthesia, ultrasound was used to guide direct puncture of the common carot...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164104225013978
更新日期:2004-04-01 00:00:00
abstract::The survival of a group of patients with malignant gliomas of the brain submitted to radical surgery and radiotherapy was studied. The average survival was nearly 4 times longer with X-ray treatment than with cobalt 60 irradiation when a comparison was made between 24 patients with glioblasto-astroblastoma (grade 3-4)...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1987.11739796
更新日期:1987-09-01 00:00:00
abstract:OBJECTIVES:Recent preclinical studies suggest that treating glioblastoma (GBM) with a combination of targeted chemotherapy and radiotherapy may enhance the anti-tumor effects of both therapies. However, the effects of these treatments on glioma growth and progression are poorly understood. METHODS:In this study, we h...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132812Y.0000000005
更新日期:2012-04-01 00:00:00
abstract::We examined the effect of local anaesthesia of the skin on somatosensory evoked potentials (SEPs) and psychophysical magnitude estimates for a constant intensity air-puff stimulation (7 kg.cm-2) in 23 normal subjects. Before and after intradermal injection (0.1 ml of 1% xylocain) to the tip of the right index finger, ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1995.11740283
更新日期:1995-02-01 00:00:00
abstract::We performed proton magnetic resonance spectroscopy (1H-MRS) in three patients with amyotrophic lateral sclerosis (ALS) to evaluate the distribution and extent of cortical neuronal damage as demonstrated by decreased N-acetyl-aspartate (NAA) levels. We examined primary motor (precentral gyrus) and parietal neocortical...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1996.11740412
更新日期:1996-06-01 00:00:00
abstract::We investigated the neuroprotective effects of a novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor (pitavastatin) on ischemic neuronal damage in gerbils using immunohistochemistry. The animals were allowed to survive for 14 days after 5 min of ischemia induced by bilateral occlusion of the comm...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164104225014102
更新日期:2004-09-01 00:00:00
abstract::Complete thrombosis followed by recanalization of giant aneurysms is an infrequent process that has been exceptionally mentioned in relation to nongiant saccular aneurysms. A 25-year-old male presented with a right temporal hematoma and associated subarachnoid hemorrhage. Cerebral angiography revealed a small blister-...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164103771953961
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the effects of oral administration of a novel benzodiazepine derivative, JM-20, on the neurological behavior of different rodent models, focusing on the GABAergic effect. We have also investigated the acute toxicity of oral administration of JM-20 in mice. METHODS:Mi...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000216
更新日期:2013-10-01 00:00:00
abstract::The effects of long-term administration of fructose-added glycerol solution (Glyceol): 10% glycerol, 5% fructose, 0.9% sodium chloride; 600-2000 ml/d intravenously for 7-63 d) were evaluated in a multi-institutional trial involving 1346 cases. Improvement of the neurological signs and symptoms of elevated intracranial...
journal_title:Neurological research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1080/01616412.1989.11739901
更新日期:1989-12-01 00:00:00
abstract::Congenital dural arteriovenous fistulas have been infrequently described in pediatric population and they generally affect the transverse, sigmoid, straight or sagittal sinuses. Congenital carotid-cavernous fistulas in infancy are considered very rare and to our knowledge, only four cases have been reported in literat...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X291612
更新日期:2008-07-01 00:00:00
abstract:INTRODUCTION:The novel coronavirus disease (COVID-19) pandemic poses a substantial threat to the health of healthcare personnel on the front line of caring for COVID-19 patients. The Centers for Medicare and Medicaid Services previously announced that all non-essential planned surgeries and procedures should be postpon...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1781455
更新日期:2020-10-01 00:00:00
abstract::The effects of etomidate on focal cerebral ischaemia following transorbital occlusion of the cat middle cerebral artery were investigated. Etomidate had no effect on CBF before or after onset of ischaemia by comparison with controls, but caused a greater fall in CBF in cats with high preocclusion or initial ischaemic ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1986.11739756
更新日期:1986-12-01 00:00:00
abstract::Although rat models implanted with C6 glioma cells have been widely utilized for the assessment of new therapeutic modalities, a convenient in vivo model is still required. We implanted C6 glioma cells into the brains and the abdominal subcutaneous regions of Wistar rats, and evaluated the volumes of the growing tumor...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101200221
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:Ischemic stroke is one of the most common causes of death worldwide. Early and accurate prediction of outcome in acute ischemic stroke (AIS) is important and influences risk-optimized therapeutic strategies. We investigated the changes in high-sensitivity C-reactive protein (Hs-CRP) and homocysteine (HCY) le...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000228
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:It is necessary to understand the mechanism of trigeminal neuralgia (TN) and hemifacial spasm (HFS) in order to seek for an effective noninvasive remedy. As previous studies implied that inflammatory cytokines induced by demyelination following the nerve injury may be the initiated factor causing neuropathic...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1564188
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Mapping of brain perfusion using bolus tracking methods is increasingly used to assess the amount and severity of cerebral ischemia in acute stroke. Using relative perfusion maps, however, it is difficult to identify the tissue at risk-maximum (TARM) of infarction with sufficient reliability and reproducibil...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X158956
更新日期:2007-04-01 00:00:00
abstract::Excessive calcium influx has been implicated in the pathophysiology of ischemic cerebral damage. The effects of nimodipine, a calcium antagonist, on the Na(+)-K+/MG+2 ATPase activity, Ca+2/Mg+2 ATPase, lipid peroxidation, and early ultrastructural findings were examined at the acute stage of ischemia in the rat brain....
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164101101198208
更新日期:2001-01-01 00:00:00
abstract::Cerebral vasospasm and/or delayed ischaemic state following subarachnoid haemorrhage still remain unsolved serious problems. With the development and introduction of calcium antagonists as well as the advances in perioperative management, however, the clinical outcome has much improved in recent years. Among such drug...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1080/01616412.1993.11740140
更新日期:1993-08-01 00:00:00
abstract::Objectives: Neurovascular compression syndromes (NVCS) could be cured with an intravascular device that releases compression of the root entry zone of cranial nerves by changing the course of offending vessels. The purpose of this study was to report our results of in vitro and in vivo experiments with a novel intra-a...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2019.1611009
更新日期:2019-07-01 00:00:00
abstract::Cerebral aneurysms are composed principally of collagen, a birefringent protein which is responsible for withstanding the forces of blood pressure. The known correlation between collagen birefringence and its mechanics provides the basis for using polarizing microscopy to evaluate the strength of collagen, layer by la...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1999.11740986
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVE:The role of inflammation in cognitive alterations in a post-operative setting is still not fully understood. Surgical interventions can cause systemic inflammations which eventually can induce neuroinflammation. However, the main causes of functional changes after surgery are still elusive. In this study, we ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2016.1242452
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Diffusion-weighted imaging (DWI) abnormalities can frequently be detected after carotid endarterectomy (CEA) and carotid angioplasty with stent placement (CAS) of the carotid arteries. We looked for possible predictors for the development of DWI lesions during the intervention. METHODS:We investigated 41 pa...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164105X49391
更新日期:2006-07-01 00:00:00
abstract::This paper summarizes the work of developing and analyzing a mathematical model of schizophrenia. First the psychological and physiological studies of patients with periodic catatonia made by R. R. Gjessing are briefly described. Then a mathematical model, which is based on Gjessing's work and consists of a set of non...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1979.11739544
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the characteristics of atherosclerotic middle cerebral artery (MCA) stenosis by high-resolution magnetic resonance imaging (HR-MRI) and determine the relationship between wall characteristics and infarction patterns. METHODS:Thirty-six patients with acute ischaemic stroke due to MCA stenosis unde...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132815Y.0000000088
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:Rats treated with progesterone (P4) after ischemia show an adequate functional performance despite a significant loss of hippocampal pyramidal neurons, suggesting that P4 could favour a permissive microenvironment for cerebral plasticity mechanisms. The possibility of P4 treatment promoting the survival of ne...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2019.1576356
更新日期:2019-05-01 00:00:00
abstract::In this study the pulsation-pressure relationship in an experimental model of aneurysms was analyzed. In addition, we have examined pulsatility of the aneurysmal wall reinforced by Guglielmi Detachable Coils (GDC). Bifurcation (BAn), aneurysms (LAn) and bilobar (BiA) aneurysms were produced in 15 mongrel dogs. The ane...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1996.11740440
更新日期:1996-08-01 00:00:00
abstract::The object of the study was to evaluate brain tissue oxygenation (p(ti)O2) for intra-operative monitoring of critical ischemic events during early cerebral aneurysm surgery of the anterior circulation supplementary to somatosensory evoked potentials (SEPs). P(ti)O2 was continuously evaluated during surgery for an intr...
journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1179/016164102101200528
更新日期:2002-09-01 00:00:00