Preventing the BDNF and NGF loss involved in the effects of cornel iridoid glycoside on attenuation of experimental autoimmune encephalomyelitis in mice.

Abstract:

:The present study was designed to investigate the beneficial effects of cornel iridoid glycoside (CIG), a main component extract from Cornus officinalis, on neurotrophin expression in mouse experimental autoimmune encephalomyelitis (EAE), a classical model of multiple sclerosis (MS). After EAE initiation, CIG was intragastrically administered daily for 32 days and reduced disease severity. Histopathological staining and western blotting both showed that CIG could prevent brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) loss in the spinal cord of EAE mice. In conclusion, our findings indicated that CIG treatment suppressed disease severity of EAE partially through blocking downregulation of neurotrophic factor expression such as BDNF and NGF, suggesting that CIG may have beneficial effects for the treatment of demyelinating diseases such as MS.

journal_name

Neurol Res

journal_title

Neurological research

authors

Qu Z,Zheng N,Zhang Y,Zhang L,Liu J,Wang Q,Yin L

doi

10.1080/01616412.2016.1200766

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

831-7

issue

9

eissn

0161-6412

issn

1743-1328

journal_volume

38

pub_type

杂志文章
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