Relationship of hypotension and cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.

Abstract:

OBJECTIVES:Changes in systemic arterial blood pressure and the degree of cerebral vasospasm were investigated in 125 patients with aneurysmal subarachnoid hemorrhage. METHODS:Systemic arterial blood pressure was measured every 2 hours in each patient for a period of more than 2 weeks, and a fall in systemic blood pressure (FBP) was defined as a decrease of >40 mmHg of systolic blood pressure between two consecutive measurements. RESULTS:A total of 91 FBPs occurred in 52 (41.6%) of 125 patients despite specific post-operative management to prevent hypovolemia. Five (5.5%) of the 91 FBPs occurred just before the onset of symptomatic vasospasm. Symptomatic vasospasm was observed in 36 (69.2%) of 52 patients with FBP and in 32 (43.8%) of 73 patients without FBP (p<0.01, chi-squared test). A hypodense area on computed tomographic scans in association with cerebral vasospasm was observed in 25 (48.1%) of 52 patients with FBP and in 21 (28.8%) of 73 patients without FBP (p<0.05). DISCUSSION:We conclude that FBP might result from delayed cerebral vasospasm and/or brain dysfunction owing to subarachnoid hemorrhage itself.

journal_name

Neurol Res

journal_title

Neurological research

authors

Tabuchi S,Hirano N,Tanabe M,Kurosaki M,Okamoto H,Kamitani H,Yokota M,Watanabe T

doi

10.1179/016164105X48761

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

196-9

issue

2

eissn

0161-6412

issn

1743-1328

journal_volume

28

pub_type

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