Study of the prevalence of Parkinson's disease using dopamine transporter imaging.

Abstract:

INTRODUCTION:To investigate the prevalence of Parkinson's disease (PD), a three-phase study was conducted. METHODS:In phase 1, standardized interviews were performed in a random sample of elderly aged 65 years or older using a questionnaire. In phase 2, neurological examinations were performed to clinically diagnose PD. In phase 3, dopamine transporter (DAT) imaging was performed to support the clinical diagnosis. After the three-phase study, longitudinal clinical observation was performed. RESULTS:A total of 714 subjects participated in the phase-1. Two hundred and twenty-two subjects, scored more than two points, were referred to the movement disorder specialist. Eighteen of these subjects showed overt or equivocal parkinsonian features. Three subjects were clinically diagnosed with possible PD: five with essential tremor with equivocal extrapyramidal signs, eight with frontal-subcortical gait disorder and two with drug-induced parkinsonism. The three subjects with possible PD showed a typical PD pattern of reduced DAT density. DAT density was normal in the other 15 subjects. Results of long-term follow-up supported the diagnoses. The crude prevalence of PD was 0·42 per 100 persons. CONCLUSION:During the clinical evaluation, we encountered a very large proportion of subjects with equivocal parkinsonian features, who posed a diagnostic challenge and a substantial risk of misestimating the prevalence of PD. The combination of DAT imaging and longitudinal clinical observation of equivocal cases enabled us to differentiate PD from other conditions. We suspect that the variation in estimates of the prevalence of PD may be attributable to a considerable proportion of subjects with equivocal parkinsonian features and how they are evaluated.

journal_name

Neurol Res

journal_title

Neurological research

authors

Kim JM,Kim JS,Kim KW,Lee SB,Park JH,Lee JJ,Kim YK,Kim SE,Jeon BS

doi

10.1179/016164109X12581096796396

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

845-51

issue

8

eissn

0161-6412

issn

1743-1328

pii

ner2117

journal_volume

32

pub_type

杂志文章,随机对照试验
  • Tissue plasminogen activator and plasminogen activator inhibitor in patients with acute ischemic stroke: relation to stroke etiology.

    abstract::Recent studies suggest that high plasma levels of tissue-type plasminogen activator (tPA) and its inhibitor (plasminogen activator inhibitor-1, PAI-1) are markers of an increased risk of atherothrombotic ischemic events such as stroke and myocardial infarction. In this prospective study, we measured tPA antigen, PAI-1...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1999.11741005

    authors: Zunker P,Schick A,Padró T,Kienast J,Phillips A,Ringelstein EB

    更新日期:1999-12-01 00:00:00

  • Microsurgical anatomy of the ophthalmic artery and the distal dural ring for the juxta-dural ring aneurysms via the pterional approach.

    abstract::Microsurgical anatomy for the pterional approach was studied regarding the origin and the course of the ophthalmic artery and the distal dural ring using human cadaveric specimens, with special reference to the surrounding bony structures. In 50 human adult formalin-fixed cadaveric cerebral hemispheres and 10 block sp...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164101101198703

    authors: Hokama M,Hongo K,Gibo H,Kyoshima K,Kobayashi S

    更新日期:2001-06-01 00:00:00

  • Effects of tetrahydrobiopterin on cerebral infarction after transient focal ischemia in rats.

    abstract:OBJECTIVES:The present study investigated the effects of tetrahydrobiopterin (BH4) on cerebral infarction after transient focal ischemia in rats. METHODS:Focal ischemia (1·5 hours) was created in male Sprague-Dawley rats (250-280 g) by middle cerebral artery occlusion. Some rats were treated with 20 mg/kg tetrahydrob...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164110X12700393823651

    authors: Tang LL,Zheng JS

    更新日期:2011-12-01 00:00:00

  • One year of home-based daily FES in complete lower motor neuron paraplegia: recovery of tetanic contractility drives the structural improvements of denervated muscle.

    abstract:OBJECTIVE:Spinal cord injury (SCI) causes muscle atrophy, which is particularly severe, due to inability to perform tetanic contractions, when lower motor neurons (LMN) are involved. We performed a longitudinal study in 25 Europeans suffering from complete conus cauda syndrome from 0.7 to 8.7 years comparing functional...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/174313209X385644

    authors: Kern H,Carraro U,Adami N,Hofer C,Loefler S,Vogelauer M,Mayr W,Rupp R,Zampieri S

    更新日期:2010-02-01 00:00:00

  • AST to ALT ratio and risk of hemorrhagic transformation in patients with acute ischemic stroke.

    abstract:BACKGROUND:Hemorrhagic transformation (HT) is a common complication of ischemic stroke. We performed this study to determine whether aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio (AAR) was related to HT, as well as compare the predictive values of AAR, ALT and AST for HT in patients with isch...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2020.1796403

    authors: Wang Y,Qiu K,Song Q,Cheng Y,Liu J,Liu M

    更新日期:2020-11-01 00:00:00

  • Spermine attenuates the preconditioning of diazoxide against transient focal cerebral ischemia in rats.

    abstract::It is known that mitochondrial ATP-sensitive potassium channels (mitoKATP) play a significant role in protecting cerebral function from ischemia-reperfusion injury, which is related with a decrease in the mitochondrial matrix calcium. However, the effect of mitochondrial calcium uniporter (MCU) on diazoxide-induced ce...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132813Y.0000000299

    authors: Zhang L,Wang S,Dong H,Li Y,Wang P,Li S,Guo Y,Yao R

    更新日期:2014-07-01 00:00:00

  • New horizons for primary intracerebral hemorrhage treatment: experience from preclinical studies.

    abstract::Intracerebral hemorrhage (ICH) remains a major medical problem, for which there is no effective treatment. However, extensive experimental and clinical research carried out in recent years has brought to light new exciting ideas for novel potential treatments. First, it was well documented that the management of hyper...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/016164105X25225

    authors: Aronowski J,Hall CE

    更新日期:2005-04-01 00:00:00

  • Progesterone treatment in rats after severe global cerebral ischemia promotes hippocampal dentate gyrus neurogenesis and functional recovery.

    abstract:OBJECTIVE:Rats treated with progesterone (P4) after ischemia show an adequate functional performance despite a significant loss of hippocampal pyramidal neurons, suggesting that P4 could favour a permissive microenvironment for cerebral plasticity mechanisms. The possibility of P4 treatment promoting the survival of ne...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2019.1576356

    authors: Montes P,Vigueras-Villaseñor RM,Rojas-Castañeda JC,Monfil T,Cervantes M,Moralí G

    更新日期:2019-05-01 00:00:00

  • Stent, balloon-assisted coiling and double microcatheter for treating wide-neck aneurysms in anterior cerebral circulation.

    abstract:OBJECTIVE:To investigate the clinical application of adjuvant coiling techniques in treating anterior-circulation wide-necked aneurysms. METHODS:Over 4·5 years, 93 anterior-circulation wide-neck aneurysms in 81 patients were treated with different endovascular techniques: balloon-assisted, stent-assisted, and double-m...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132813Y.0000000234

    authors: Pan J,Xiao F,Szeder V,Yan M,Fan W,Gu J,He L,Zhan R

    更新日期:2013-12-01 00:00:00

  • The effects of early insulin treatment combined with thrombolysis in rat embolic stroke.

    abstract::The therapeutic effect of insulin alone or insulin combined with 30 min delayed thrombolytic therapy was investigated in rats embolized in the right hemisphere with a fibrin clot made from autologous blood. Animals were killed seven days after embolization and the infarct volumes were measured in % of the affected hem...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164102101200096

    authors: Meden P,Andersen M,Overgaard K,Rasmussen RS,Boysen G

    更新日期:2002-06-01 00:00:00

  • The management of arteriovenous malformations of the corpus callosum.

    abstract::A series of 15 arteriovenous malformations (AVMs) of the corpus callosum--9% of 170 intracranial AVMs admitted to the School of Medicine of the University of Rome during a 30-yr period--was studied. In all cases the lesion concerned mainly the corpus callosum, although in some it also involved the surrounding structur...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1982.11739626

    authors: Guidetti B,Spallone A

    更新日期:1982-01-01 00:00:00

  • Brain volume and perfusion asymmetry in temporal lobe epilepsy with and without hippocampal sclerosis.

    abstract:: Objectives : To detect and compare the features of interictal perfusion and volume asymmetry between temporal lobe epilepsy (TLE) patients with and without hippocampal sclerosis (HS). Methods : Sixty-one TLE patients (mean age ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2020.1853988

    authors: Zhang Y,Dou W,Zuo Z,You H,Lv Y,Hou B,Shi L,Feng F

    更新日期:2020-12-15 00:00:00

  • Serum complement factor H and Tyr402 His gene polymorphism among Egyptians with multiple sclerosis.

    abstract:BACKGROUND AND OBJECTIVES:Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system. A contribution from complement has long been suspected. We investigated the association of complement factor H (CFH) Tyr402 His gene polymorphism and serum level in Egyptian patients with MS to examine whet...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132815Y.0000000075

    authors: Abdel Rasol HA,Helmy H,Aziz MA

    更新日期:2015-10-01 00:00:00

  • Radiation-induced apoptosis of oligodendrocytes in the adult rat optic chiasm.

    abstract:OBJECTIVES:The present study characterized glial cell injury provoked in adult rat chiasm within 24 hours after a single, high-dose irradiation of 20 Gy. METHODS:All chiasmal glial cells in a section were counted, and the percentage of TUNEL-positive glial cells exhibiting apoptotic morphology was defined as the apopt...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164105X48833

    authors: Nagayama K,Kurita H,Nakamura M,Kusuda J,Tonari A,Takayama M,Fujioka Y,Shiokawa Y

    更新日期:2005-06-01 00:00:00

  • The lack of influence of IVS5-91 G>A polymorphism of the SCN1A gene on efficacy of lamotrigine in patients with focal epilepsy.

    abstract::Background: IVS5-91G>A (rs3812718) polymorphism of the sodium voltage-gated channel alpha subunit 1 (SCN1A) gene has been associated with inadequate responsiveness to common antiepileptic drugs which act as sodium channel blockers. This study was performed to investigate the effect of IVS5-91G>A (rs3812718) polymorphi...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章

    doi:10.1080/01616412.2019.1635321

    authors: Markovic I,Pejanovic-Skobic N,Bozina N,Susak Sporis I,Sporis D,Basic S

    更新日期:2019-10-01 00:00:00

  • Clinical features and prognostic analysis of moyamoya disease associated with intracranial aneurysms.

    abstract:OBJECTIVES:To explore clinical features and compare of the difference between conservative treatment and surgical treatmentin prognosis of intracranial aneurysms associated with moyamoya disease (MMD). METHODS:104 patients with MMD a ssociated with intracranial aneurysms diagnosed by digital subtraction angiography (D...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2020.1773663

    authors: Yan J,Lv M,Zeng E,Tang B,Xie S,Hong T

    更新日期:2020-09-01 00:00:00

  • CART modulates beta-amyloid metabolism-associated enzymes and attenuates memory deficits in APP/PS1 mice.

    abstract:INTRODUCTION:Cocaine- and amphetamine-regulated transcript (CART) peptide has been demonstrated to exert neuroprotective effects in stroke and some neurodegeneration diseases. In current study, we investigated the protective effects and underlying mechanisms of CART in APP/PS1 mice. METHODS:The protein levels of CART,...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2017.1348689

    authors: Yin K,Jin J,Zhu X,Yu L,Wang S,Qian L,Han L,Xu Y

    更新日期:2017-10-01 00:00:00

  • Is fusion the most suitable treatment option for recurrent lumbar disc herniation? A systematic review.

    abstract:OBJECTIVE:Recurrent lumbar disc herniation (rLDH) is a common issue after primary discectomy and can cause severe pain, morbidity, and reoperation. The purpose of this systematic review was to evaluate the surgical management of recurrent lumbar disc herniation. METHODS:A systematic literature search was conducted usi...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2020.1787661

    authors: Arif S,Brady Z,Enchev Y,Peev N

    更新日期:2020-12-01 00:00:00

  • Cerebral hemodynamics during induced tachycardia in routine electrophysiologic studies: a transcranial Doppler study.

    abstract::Supraventricular and ventricular tachyarrhythmia are established causes of syncope. We investigated the mean blood flow velocities (Vmean) of the middle cerebral arteries (MCA) during routine cardiac electrophysiologic studies in patients with supraventricular and ventricular tachyarrhythmias in order to evaluate the ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1998.11740555

    authors: Zunker P,Haase C,Borggrefe M,Georgiadis D,Georgiadis A,Ringelstein EB

    更新日期:1998-09-01 00:00:00

  • New device to treat chronic subdural hematoma--hollow screw.

    abstract::Different surgical approaches exist for the treatment of chronic subdural hematoma. None of these approaches is superior to the other, so a minimal-invasive device (a hollow screw) was developed. The system consists of a stable hollow screw of surgical steel with a perforated tip, a hand-drill, screwdriver with guide,...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1999.11740897

    authors: Emonds N,Hassler WE

    更新日期:1999-01-01 00:00:00

  • Neuroprotection with NBQX and thrombolysis with rt-PA in rat embolic stroke.

    abstract::The efficacy of delayed thrombolysis with recombinant tissue plasminogen activator was tested in combination with the ischaemic protecting drug NBQX in an embolic stroke model. In 113 rats the carotid territory was embolized with a fibrin-rich clot formed in polyethylene tube. Hemispheric cerebral blood flow (CBF) was...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1993.11740159

    authors: Overgaard K,Sereghy T,Pedersen H,Boysen G

    更新日期:1993-10-01 00:00:00

  • Synergistic inhibition of lipid peroxidation by vitamin E and a dopamine agonist, cabergoline.

    abstract::We examined antioxidant activity of cabergoline, a dopamine agonist, during the aerobic oxidation of phosphatidylcholine liposomes at 37 degrees C. Cabergoline retarded the oxidation initiated with a lipid-soluble initiator significantly better than that with a water-soluble initiator, suggesting that cabergoline loca...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164104225016029

    authors: Sohmiya M,Tanaka M,Okamoto K,Fujisawa A,Yamamoto Y

    更新日期:2004-06-01 00:00:00

  • Variation in nerve autograft length increases fibre misdirection and decreases pruning effectiveness: an experimental study in the rat median nerve.

    abstract:OBJECTIVES:In the clinical set, autologus nerve grafts are the current option for reconstruction of nerve tissue losses. The length of the nerve graft has been suggested to affect outcomes. Experiments were performed in the rat in order to test this assumption and to detect a possible mechanism to explain differences i...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164105X18494

    authors: Bertelli JA,Taleb M,Mira JC,Ghizoni MF

    更新日期:2005-09-01 00:00:00

  • Interleukin-21 expression in hippocampal astrocytes is enhanced following kainic acid-induced seizures.

    abstract:OBJECTIVE:Interleukin-21 (IL-21) is a cytokine that is an important modulator of immune responses. However, its roles in epilepsy are not completely clear. Here, we investigated the expression and distribution of IL-21 in a kainic acid (KA)-induced acute seizure mouse model. MATERIALS AND METHODS:Mice (n = 146) were r...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2015.1135557

    authors: Xiong XY,Wang TG,Yang MH,Meng ZY,Yang QW,Wang FX

    更新日期:2016-02-01 00:00:00

  • Microsurgical anatomy of the supratentorial arachnoidal trabecular membranes and cisterns.

    abstract::We examined the microsurgical anatomy of the supratentorial subarachnoid cisterns with a surgical microscope in 20 brains prepared using the immersion technique. The adult brains were immersed in Ringer's solution and air was injected into the subarachnoid cisterns while the brains remained submerged in solution. We i...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1994.11740266

    authors: Vinas FC,Fandino R,Dujovny M,Chavez V

    更新日期:1994-12-01 00:00:00

  • Dielectric measurement of cerebral water content using a Network Analyzer.

    abstract::At present, no practical method exists for monitoring the progression and severity of cerebral oedema in a clinical setting on a continuous basis. In search for such a method, we investigated the electrical characteristics of cerebral tissue at microwave frequencies to quantify cerebral oedema. The dielectric constant...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1992.11740065

    authors: Kramer GG,Cardoso ER,Shwedyk E

    更新日期:1992-06-01 00:00:00

  • Uncorrected traumatic coagulopathy is associated with severe brain swelling during decompressive surgery to evacuate a supratentorial intradural mass lesion in patients with traumatic brain injury.

    abstract:OBJECTIVE:This study investigated the relationship between traumatic coagulopathy and severe brain swelling (SBS) during decompressive surgery to evacuate a supratentorial intradural mass lesion in patients with traumatic brain injury (TBI). METHODS:A retrospective study was conducted in 96 patients who consecutively ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132813Y.0000000187

    authors: Wang K,Xue Y,Chen X,Zhou B,Lou M

    更新日期:2013-07-01 00:00:00

  • fMRI review on brain responses to acupuncture: the limitations and possibilities in traditional Korean acupuncture.

    abstract:BACKGROUND:Since the late 1990s, imaging studies have allowed the visualization of brain response to acupuncture stimulation with alteration in blood flow. In 1998, the first functional magnetic resonance imaging (fMRI) study for the Korean acupuncture was published and thereafter, many subsequent neuroimaging studies ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164107X172284

    authors: Chae Y,Park HJ,Hahm DH,Hong M,Ha E,Park HK,Lee H

    更新日期:2007-01-01 00:00:00

  • Exercise pre-conditioning reduces brain inflammation in stroke via tumor necrosis factor-alpha, extracellular signal-regulated kinase 1/2 and matrix metalloproteinase-9 activity.

    abstract:OBJECTIVE:We sought to determine whether cerebral inflammation in ischemic rats was reduced by a neuroprotective action of pre-ischemic tumor necrosis factor-alpha up-regulation, which down-regulated matrix metalloproteinase-9 activity via extracellular signal-regulated kinase 1/2 phosphorylation. MATERIAL AND METHODS...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/174313209X459101

    authors: Curry A,Guo M,Patel R,Liebelt B,Sprague S,Lai Q,Zwagerman N,Cao FX,Jimenez D,Ding Y

    更新日期:2010-09-01 00:00:00

  • Anesthetic propofol normalized the increased release of glutamate and γ-amino butyric acid in hippocampus after paradoxical sleep deprivation in rats.

    abstract:OBJECTIVE:Multiple lines of evidence suggest that general anesthesia helps the recovery from sleep deprivation. However, little is known about the underlying neurochemical mechanisms. In the current study, we investigated the effect of anesthetic propofol on the release of glutamate (Glu) and γ-amino butyric acid (GABA...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2015.1114231

    authors: Xie F,Li X,Bao M,Shi R,Yue Y,Guan Y,Wang Y

    更新日期:2015-01-01 00:00:00