Abstract:
INTRODUCTION:Cocaine- and amphetamine-regulated transcript (CART) peptide has been demonstrated to exert neuroprotective effects in stroke and some neurodegeneration diseases. In current study, we investigated the protective effects and underlying mechanisms of CART in APP/PS1 mice. METHODS:The protein levels of CART, soluble Aβ1-40 and Aβ1-42 were measured in the hippocampus of APP/PS1 mice by enzyme-linked immunosorbent assay. We determined the mRNA and protein levels of Aβ metabolism-associated enzymes including neprilysin (NEP), insulin-degrading enzyme (IDE), receptor for advanced glycation end products (RAGE), and low-density lipoprotein receptor-related protein 1 (LRP-1) in the hippocampus of APP/PS1 mice using real-time PCR and western blotting. Spatial memory was measured in APP/PS1 mice using the Morris water maze. The phosphorylation of AKT, ERK, p38, and JNK was determined using western blotting. RESULTS:The levels of soluble Aβ1-40 and Aβ1-42 were significantly decreased in the hippocampus of APP/PS1 mice after CART treatment. CART modulated the levels of NEP, IDE, RAGE, and LRP-1. In addition, CART inhibited the MAPK pathways and activated the AKT pathway, whereas inhibition of the AKT pathway decreased the levels of IDE and LRP-1. Furthermore, CART attenuated spatial memory deficits in the APP/PS1 mice. CONCLUSION:CART decreases the levels of soluble Aβ in the hippocampus of APP/PS1 mice by modulating the expression of Aβ metabolism-associated enzymes, which may be associated with the MAPK and AKT pathways.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Yin K,Jin J,Zhu X,Yu L,Wang S,Qian L,Han L,Xu Ydoi
10.1080/01616412.2017.1348689subject
Has Abstractpub_date
2017-10-01 00:00:00pages
885-894issue
10eissn
0161-6412issn
1743-1328journal_volume
39pub_type
杂志文章abstract::The mechanism of cerebral ischaemic injury is complex and likely involves more than a single pathophysiologic event. Drugs are available which interfere with numerous harmful biochemical and pharmacologic processes begun by ischaemia. Hence, combination chemotherapy might be useful in cerebral ischaemia. The purpose o...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1995.11740301
更新日期:1995-04-01 00:00:00
abstract::1-Aminocyclopropanecarboxylic acid is a high affinity ligand with partial agonist properties at strychnine-insensitive glycine sites associated with the N-methyl-D-aspartate subtype of glutamate receptors. Since occupation of these sites appears required for operation of N-methyl-D-aspartate, receptor coupled cation c...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1995.11740324
更新日期:1995-08-01 00:00:00
abstract::We assessed the effect of a novel calmodulin antagonist, DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate) in a spontaneously hypertensive rat (SHR) permanent focal cerebral ischemia. In experiment I, the left middle cerebral ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164101101198992
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVE:We evaluate the bladder volume and pressure through recording the bladder afferent activity in the sacral nerve roots in acute experiments of paraplegic dogs. These measurements are intended to report the status of the bladder and to adjust the stimulation parameters of an implantable electric stimulator. ME...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164108X268250
更新日期:2008-02-01 00:00:00
abstract::Ninety percent of cerebral aneurysms were diagnosed after their first rupture with consecutive subarachnoid haemorrhage. In order to detect the aneurysms before rupture investigation by transcranial Doppler sonography was used on the basis of intra-operative evaluation of the normal aneurysmal flow pattern. In 34 pati...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1989.11739860
更新日期:1989-03-01 00:00:00
abstract::Objective Preoperative magnetic resonance (MR) angiography sometimes shows the absence of collateral flow via the circle of Willis. This study examined whether brain temperature (BT) imaging on multi-voxel proton MR spectroscopy after this finding increases the accuracy of predicting hemispheric ischemia during intern...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2018.1457130
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:To investigate mechanisms behind the faster rehabilitation of limb fractures when associated with traumatic brain injury (TBI). METHODS:New Zealand rabbits were divided into TBI group and sham-operation group for four studies as follows: (1) blood and cerebrospinal fluid (CSF) were drawn on days 1, 3, and 7 ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000201
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVES:Patent foramen ovale (PFO) is considered as an important risk factor for cerebrovascular diseases. Nevertheless, the relationship between the distribution of high-intensity transient signals (HITS), resulting from injection of air mixed with saline and detected by transcranial Doppler (TCD), and clinical cer...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164105X18458
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:Bone marrow stromal cells (BMSCs) have been reported to improve movement deficit in adult rats with spinal cord injury (SCI). The purpose of this study is to determine the distribution of BMSCs in the spinal cord lesion of the contusion model of SCI. METHODS:Laminectomy was carried out at L1 vertebra level ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X165642
更新日期:2007-01-01 00:00:00
abstract::The haemodynamic mechanisms responsible for the appearance of paraparetic transient ischaemic attacks in ten patients with childhood moyamoya disease who subsequently underwent bifrontal omental transplantation were investigated. Cerebral perfusion (CP) was measured with 99mTc-hexamethylene-propyleneamine oxime single...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1995.11740306
更新日期:1995-06-01 00:00:00
abstract::Induction of stress proteins is thought to be important in the protection of cells from a variety of environmental insults including heat, hypoxia and ischemia. The aim of this study was to compare the mechanism of induction of heat shock protein 72 (HSP72) in primary cultures of murine cortical astrocytes by heat and...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1996.11740380
更新日期:1996-02-01 00:00:00
abstract:OBJECTIVES:Epilepsy is a common seizure disorder affecting approximately 70 million people worldwide. Mitochondrial dysfunction and antioxidant/prooxidant imbalance are emerging as factors that contribute to epileptogenesis. As medical ozone was able to reestablish cellular redox balance and to maintain the protective ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132814Y.0000000445
更新日期:2015-03-01 00:00:00
abstract::In 75 patients with completed stroke hypervolemic haemodilution was performed for 1 day with 500 ml 6% HES 200.000/0.6-0.66 (Elohäst) to test the acute influence of application time for haemorheological changes. The patients were divided into 3 groups randomly selected: group A received the infusion for 2 hours, group...
journal_title:Neurological research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/01616412.1992.11740043
更新日期:1992-01-01 00:00:00
abstract::Basic fibroblast growth factor (bFGF) possesses neuroprotective effects on a variety of neurons. Here we report that it delays progression of motor neuron disease (MND) in the wobbler mouse. After initial diagnosis of MND at post-natal age 3-4 weeks, wobbler mice receive either recombinant human bFGF (1 mg kg-1, n = 1...
journal_title:Neurological research
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract::The objective was to examine the effect of the nitric oxide synthase inhibitor, N omega-nitro-L-arginine methyl ester (L-NAME) on leukocyte adhesion in the cerebral microcirculation during reperfusion following partial forebrain ischemia in the rat. Intravital fluorescence video-microscopy through a closed cranial win...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1999.11740947
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVES:The present study investigated the effects of tetrahydrobiopterin (BH4) on cerebral infarction after transient focal ischemia in rats. METHODS:Focal ischemia (1·5 hours) was created in male Sprague-Dawley rats (250-280 g) by middle cerebral artery occlusion. Some rats were treated with 20 mg/kg tetrahydrob...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164110X12700393823651
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:This study investigated the role of matrix metalloproteinase-9 (MMP-9) in early brain injury after subarachnoid hemorrhage (SAH). METHOD:Sprague-Dawley male rats (n=36) weighing between 250 and 300 g were used. SAH was produced by injecting autologous arterial blood into the pre-chiasmatic cistern. MMP-9 pro...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164109X12478302362491
更新日期:2010-09-01 00:00:00
abstract::The possibility of the evaluation of ischemia solely by the momentary values of regional cerebral blood flow (rCBF) was investigated. Ischaemic damage was evaluated histopathologically and by observing albumin extravasation. Unilateral carotid clippings were performed for 1 h and the gerbils evaluated with regard to t...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1988.11739846
更新日期:1988-12-01 00:00:00
abstract:OBJECTIVE:Meningiomas are benign intracranial tumors growing from the arachnoid cap cells. Although their behavior is usually benign, they tend to recur even after total removal, and their recurrence is dependent on different aspects. METHODS:Between 1991 and 2002, 463 patients with an intracranial meningioma were ope...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X338043
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to establish a robust set of motor tasks that could be used to functionally delineate the motor cortex with blood oxygenation level dependent functional magnetic resonance imaging (BOLD fMRI) at 3 T and produce precise functional maps for pre-operative planning and functional neurona...
journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1179/016164108X323753
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:This study examined whether a needle-free acupuncture can be an alternative to conventional needle injection acupuncture. METHODS:Patients (n=101) suffering myofascial shoulder pain were randomly assigned to either needle-free or conventional needle injection acupuncture group. Bee venom was administered int...
journal_title:Neurological research
pub_type: 杂志文章,随机对照试验
doi:10.1179/016164109X12537002793760
更新日期:2010-02-01 00:00:00
abstract::Spinal cord neuron and dorsal column fiber responses to electrical stimulation of the sciatic nerve in anesthetized cats were recorded before, during, and after periods of repetitive electrical stimulation of the sciatic nerve through an implantable nerve cuff stimulator device of the type and method used in human pat...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1981.11739598
更新日期:1981-01-01 00:00:00
abstract:OBJECTIVE:It is not fully understood how the stimulus/response curves obtained by transcranial magnetic stimulation (TMS) reflect the function of the cortico-motoneuronal (CM) and spinal motoneuronal (SM) systems in healthy subjects. To understand these response functions, we studied patients with amyotrophic lateral s...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164108X323717
更新日期:2008-12-01 00:00:00
abstract::The intracranial aneurysm, with an estimated occurrence of up to 4% in the general population, belongs among the most dangerous of cerebrovascular diseases. Although less than one-fifth of these cases results in a subarachnoid haemorrhage, the resulting disability and mortality rate is too high. More understanding is ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1991.11739995
更新日期:1991-12-01 00:00:00
abstract::Promyelocytic leukemia (PML) protein is involved in apoptotic death of cultured neuronal cells, but its role in ischemic brain damage remains uncertain. In this study, we investigated change of immunoreactivity for PML protein in rat brain after transient middle cerebral artery occlusion, and compared the results with...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164101101199162
更新日期:2001-10-01 00:00:00
abstract::Insertion of pedicle screws in the thoracolumbar spine can be challenging. Incorrect placement can lead to a failure of fusion or to significant neurologic morbidity. Recently, techniques utilizing intraoperative monitoring and stereotaxis have been developed to achieve proper screw placement. While these techniques m...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1997.11740877
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The predictive effect of blood cell ratio on ischemic event has been widely confirmed. Whether PWR and PNR can assess the risk of endovascular treatment (EVT) is largely unclear. This study aimed to investigate the prognostic value of PNR and PWR in acute ischemic stroke patients treated with EVT...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1790868
更新日期:2020-10-01 00:00:00
abstract::Choroid plexus carcinoma in an adult case is a very rare tumor and difficult to differentiate from metastatic tumors. The authors report a case of a 49-year-old female with choroid plexus carcinoma who previously had multiple carcinomas. In this case, synaptophysin immunohistochemistry proved to be extremely helpful f...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2000.11740704
更新日期:2000-07-01 00:00:00
abstract::In this work, we evaluated the differences between epileptic electroencephalogram (EEG) and interictal EEG by computing some non-linear features. Correlation dimension (CD) and Hurst exponent (H) were calculated for 100 segments of epileptic EEG and 100 segments of interictal EEG. A comparison was made between epilept...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132811Y.0000000041
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To review past, present and future applications of near-infrared spectroscopy (NIRS) in clinical neuroscience. METHODS:The literature and personal experience of the authors were critically reviewed in order to provide a balanced overview of the basic principles, clinical validation, previous experience and c...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/174313209X383286
更新日期:2009-07-01 00:00:00