Prevention of cerebral vasospasm by nicardipine prolonged-release implants in dogs.

abstract：:Although neuronal death has been studied in experimental models of ischemia, the precise mechanisms regulating cell death remain unclear. Furthermore, the timing and pattern of neuronal death in human stroke has not been extensively studied. To further our understanding of ischemia-induced neuronal death, we examined ...

journal_title：Neurological research

authors： Guglielmo MA,Chan PT,Cortez S,Stopa EG,McMillan P,Johanson CE,Epstein M,Doberstein CE

更新日期：1998-06-01 00:00:00

abstract：:HEADTOME III, a high resolution PET, has been employed using 15O and 18F labelled pharmaceuticals to evaluate histological malignancy of gliomas preoperatively. PET study was applied on eighteen preoperative gliomas including two recurrent cases. Haemocirculatory and metabolic indices of regional cerebral blood flow (...

journal_title：Neurological research

authors： Mineura K,Yasuda T,Kowada M,Shishido F,Ogawa T,Uemura K

更新日期：1986-09-01 00:00:00

abstract：OBJECTIVES:The present study characterized glial cell injury provoked in adult rat chiasm within 24 hours after a single, high-dose irradiation of 20 Gy. METHODS:All chiasmal glial cells in a section were counted, and the percentage of TUNEL-positive glial cells exhibiting apoptotic morphology was defined as the apopt...

journal_title：Neurological research

authors： Nagayama K,Kurita H,Nakamura M,Kusuda J,Tonari A,Takayama M,Fujioka Y,Shiokawa Y

更新日期：2005-06-01 00:00:00

abstract：:Recent studies suggest that high plasma levels of tissue-type plasminogen activator (tPA) and its inhibitor (plasminogen activator inhibitor-1, PAI-1) are markers of an increased risk of atherothrombotic ischemic events such as stroke and myocardial infarction. In this prospective study, we measured tPA antigen, PAI-1...

journal_title：Neurological research

authors： Zunker P,Schick A,Padró T,Kienast J,Phillips A,Ringelstein EB

更新日期：1999-12-01 00:00:00

abstract：:1-Aminocyclopropanecarboxylic acid is a high affinity ligand with partial agonist properties at strychnine-insensitive glycine sites associated with the N-methyl-D-aspartate subtype of glutamate receptors. Since occupation of these sites appears required for operation of N-methyl-D-aspartate, receptor coupled cation c...

journal_title：Neurological research

authors： Fossom LH,Von Lubitz DK,Lin RC,Skolnick P

更新日期：1995-08-01 00:00:00

abstract：OBJECTIVES:In conditions with reduced glucose levels/inability of glucose utilization, ketone bodies, especially beta-hydroxybutyrate (BHB), become a major energy source in the brain. In animal models, BHB infusion shows acute beneficial effects on the hypoxic brain. The present prospective observational study is the f...

journal_title：Neurological research

authors： Pikija S,Trkulja V,Simundic AM,Vrcek E,Boskovic K,Bacani S

更新日期：2013-11-01 00:00:00

abstract：:Analysis of the blood flow velocities in the middle cerebral artery by transcranial Doppler ultrasonography was performed in 158 healthy volunteers (aged 14-70 years; 82 men and 76 women). In a subgroup of 38 men and 21 women the end-tidal [CO2] was also measured. The influence of biological factors such as age, sex, ...

journal_title：Neurological research

authors： Ackerstaff RG,Keunen RW,van Pelt W,Montauban van Swijndregt AD,Stijnen T

更新日期：1990-09-01 00:00:00

abstract：:Based on the successful use of fetal striatal brain grafting in the restoration of striatal function in rat and nonhuman primate models of Huntington's disease, as well as on the evidence for the clinical potential of fetal brain grafting in the treatment of Parkinson's disease, homotopic fetal striatal homotransplant...

journal_title：Neurological research

authors： Madrazo I,Franco-Bourland RE,Castrejon H,Cuevas C,Ostrosky-Solis F

更新日期：1995-08-01 00:00:00

abstract：:Our goal was to clarify the optimum management of the inaccessible unruptured giant and large aneurysms of the internal carotid artery (ICA). Since 1981, we have treated 18 patients with unclippable unruptured giant or large aneurysms of the ICA. Aneurysms were classified as either intracavernous or intradural. We per...

journal_title：Neurological research

authors： Kaminogo M,Kitagawa N,Takahata H,Matsuo Y,Hayashi K,Yoshioka T,Shibata S

更新日期：2001-06-01 00:00:00

abstract：:The objective of this study was to determine, whether 0.5-2/min oscillations in intracranial pressure ('B-waves') are a physiological phenomenon. In a group of 5 patients 0.5-2/min oscillations of ventricular pressure simultaneous with oscillations in the middle cerebral artery (MCA) flow velocity, as assessed by tran...

journal_title：Neurological research

authors： Mautner-Huppert D,Haberl RL,Dirnagl U,Villringer A,Schmiedek P,Einhäupl K

更新日期：1989-12-01 00:00:00

abstract：:Until recently, endovascular management of intracranial aneurysms has focused on mechanical and hemodynamic aspects: characterizing aneurysm morphology by angiogram, mechanical obstruction by detachable coils, and flow diversion with endovascular stents. Although now common practice, these interventions only ward off ...

journal_title：Neurological research

authors： Esfahani DR,Viswanathan V,Alaraj A

更新日期：2015-03-01 00:00:00

abstract：:Brain tumours were induced by intracerebral inoculation of beagle puppies with Avian sarcoma virus (ASV) suspension. The inoculation produced solitary or multiple sarcomas in three dogs and intraventricular anaplastic gliomas in four dogs. At the time of the first tumour positive CT-control Iodine-125 seeds (activity ...

journal_title：Neurological research

authors： Ostertag CB,Warnke P,Kleihues P,Bigner DD

更新日期：1984-12-01 00:00:00

abstract：:Induction of stress proteins is thought to be important in the protection of cells from a variety of environmental insults including heat, hypoxia and ischemia. The aim of this study was to compare the mechanism of induction of heat shock protein 72 (HSP72) in primary cultures of murine cortical astrocytes by heat and...

journal_title：Neurological research

authors： Bergeron M,Mivechi NF,Giaccia AJ,Giffard RG

更新日期：1996-02-01 00:00:00

abstract：:Synthesized Mn-TPPS, a paramagnetic metalloporphyrin, is expected to be a tumour specific contrast media for magnetic resonance (MR) imaging. We investigated the enhancing characteristics of Mn-TPPS using a transplanted rat C6 glioma model with peripheral type benzodiazepine (PBD) receptors since porphyrins are though...

journal_title：Neurological research

authors： Ikezaki K,Nomura T,Takahashi M,Fritz-Zieroth B,Inamura T,Fukui M

更新日期：1994-10-01 00:00:00

abstract：:Magnetic resonance (MR) is a powerful new imaging modality which has recently become competitive with X-ray computed tomography (CT) for imaging of the central nervous system (CNS). The advantages of MR include lack of ionizing radiation and the necessity to use iodinated contrast. MR is able to image directly in the ...

journal_title：Neurological research

authors： Bradley WG Jr

更新日期：1984-09-01 00:00:00

abstract：:We assessed the effect of a novel calmodulin antagonist, DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate) in a spontaneously hypertensive rat (SHR) permanent focal cerebral ischemia. In experiment I, the left middle cerebral ...

journal_title：Neurological research

authors： Takagi K,Sato T,Shirasaki Y,Narita K,Tamura A,Sano K

更新日期：2001-09-01 00:00:00

abstract：:To investigate the migration of neural stem cells as well as neural plastic changes in epileptic brain, spaciotemporal expression of immunoreactive highly polysialylated neural cell adhesion molecule (PSA-NCAM) was examined in amygdala kindling development of rat. The neural migration and synaptic remodeling detected ...

journal_title：Neurological research

authors： Sato K,Iwai M,Nagano I,Shoji M,Abe K

更新日期：2003-01-01 00:00:00

abstract：:Using the previously reported method of experimental localized brainstem infarct in dogs, we designed this study to elucidate sequential changes of regional cerebral blood flow (rCBF) in three separate regions of the central nervous system: the cerebral cortex, thalamus, and midbrain. The data obtained were referred t...

journal_title：Neurological research

authors： Matsumoto S,Kuwabara S,Moritake K

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVES:The stroke-prone spontaneously hypertensive rat is a genetic model of severe hypertension with secondary vascular alterations. The aim of this study was to determine the influence of chronic hypertension and ramipril treatment on the extracellular matrix in the cerebral microvasculature. METHODS:The study c...

journal_title：Neurological research

authors： Liebetrau M,Burggraf D,Büscher C,Linz W,Hamann GF

更新日期：2005-07-01 00:00:00

abstract：:With recent advancement in medical imaging, techniques, and endovascular tools more patients are diagnosed with unruptured intracranial aneurysms. The main aim of offering aneurysm treatment is to ameliorate the risk of future aneurysm bleeding, while not posing additional risks on the patient from the treatment itsel...

journal_title：Neurological research

authors： Alaraj A,Ti J,Dashti R,Aletich V

更新日期：2014-04-01 00:00:00

abstract：:The present study was performed to compare brain infarct size assessment by routine histology (haematoxylin and eosin) and by 2,3,5-triphenyltetrazolium chloride staining techniques. New Zealand white rabbits were subjected to autologous clot embolization to the anterior circulation of the brain. After a study period ...

journal_title：Neurological research

authors： Bednar MM,Fanburg JC,Anderson ML,Raymond SJ,Dooley RH,Gross CE

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:High blood pressure (BP) is a major risk factor for stroke and all of its pathological subtypes including subarachnoid hemorrhage (SAH). However, there is little evidence demonstrating whether failure to have regular BP measured could result in underestimation of people at risk for SAH. Therefore, we aimed ...

journal_title：Neurological research

authors： Shiue I,Hankey GJ,Arima H,Anderson CS

更新日期：2011-12-01 00:00:00

abstract：:Acute blood-brain barrier (BBB) opening in cerebral ischemia is an often observed but seldom studied phenomenon. Increased permeability has been implicated with several consequences including exacerbating ischemic injury, leading to hemorrhagic transformation (HT) and also predictive of chronic damage and a way of del...

journal_title：Neurological research

authors： Nagaraja TN,Keenan KA,Brown SL,Fenstermacher JD,Knight RA

更新日期：2007-01-01 00:00:00

abstract：:Objective The aim of the study was to evaluate the parameters for localizing the seizure onset zone in refractory epilepsy patients using cortico-cortical evoked potentials (CCEP). Methods Fifteen patients (nine females) with medically refractory partial epilepsy underwent stereo electro encephalography (SEEG) in Tsin...

journal_title：Neurological research

authors： Zhang N,Zhang B,Rajah GB,Geng X,Singh R,Yang Y,Yan X,Li Z,Zhou W,Ding Y,Sun W

更新日期：2018-06-01 00:00:00

abstract：:The intracranial aneurysm, with an estimated occurrence of up to 4% in the general population, belongs among the most dangerous of cerebrovascular diseases. Although less than one-fifth of these cases results in a subarachnoid haemorrhage, the resulting disability and mortality rate is too high. More understanding is ...

journal_title：Neurological research

authors： Duros J,Clark ME,Kufahl RH,Nadvornik P

更新日期：1991-12-01 00:00:00

abstract：:This paper presents the results of transsphenoidal surgery in 41 consecutive patients with visual loss from pituitary adenomas. The most common pattern of loss was bitemporal hemianopia. Transsphenoidal decompression resulted in visual improvement in 78% of patients. If patients with optic atrophy and pre-operative co...

journal_title：Neurological research

authors： el-Azouzi M,Black PM,Candia G,Zervas NT,Panagopoulos KP

更新日期：1990-03-01 00:00:00

abstract：:Objective: Nowadays, retinal microvascular structures can be investigated using optical coherence tomography angiography (OCTA). We aimed to evaluate the probable vascular changes in the foveal and peripapillary regions of patients with multiple sclerosis (MS).Methods: A total of 20 patients with relapsing remitting m...

journal_title：Neurological research

authors： Ulusoy MO,Horasanlı B,Işık-Ulusoy S

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVES:Amyloid-beta (Aβ) peptide deposition into insoluble plaques is a pathological hallmark of Alzheimer's disease (AD), but soluble oligomeric Aβ is considered to be more potent and has been hypothesized to directly impair learning and memory. Also, evidences from some clinical studies indicated that Aβ oligomer...

journal_title：Neurological research

authors： Sharma S,Verma S,Kapoor M,Saini A,Nehru B

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:Many studies have analyzed the association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and Parkinson's disease (PD), which yield inconsistent results. This meta-analysis was designed to determine the possible association between the COMT Val158Met polymorphism and the risk of PD in ...

journal_title：Neurological research

authors： Wang YC,Zou YB,Xiao J,Pan CD,Jiang SD,Zheng ZJ,Yan ZR,Tang KY,Tan LM,Tang MS

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVES:To assess whether a weaning protocol reduces the mechanical ventilation (MV) duration compared to physician's judgement-based weaning in neurological patients and to determine whether patient consciousness influences this reduction. METHODS:A randomised controlled trial was conducted in a neurological inten...

journal_title：Neurological research

authors： Fan L,Su Y,Elmadhoun OA,Zhang Y,Zhang Y,Gao D,Ye H,Chen W

更新日期：2015-11-01 00:00:00