Abstract：
:Our goal was to clarify the optimum management of the inaccessible unruptured giant and large aneurysms of the internal carotid artery (ICA). Since 1981, we have treated 18 patients with unclippable unruptured giant or large aneurysms of the ICA. Aneurysms were classified as either intracavernous or intradural. We performed proximal carotid occlusion in 12 patients and conservatively treated six patients. We retrospectively analyzed long-term outcomes in these patients. Four of seven patients with intradural aneurysm underwent proximal carotid occlusion, with good long-term outcomes. The three patients with intradural aneurysm, who were treated conservatively, died of subarachnoid hemorrhage. Eight of 11 patients with intracavernous aneurysm underwent proximal carotid occlusion, one dying of massive nasal bleeding 25 months after the procedure. In this case, the aneurysm was partially thrombosed, and residual lumen growth was revealed 22 months after proximal carotid occlusion. Cranial nerve paresis improved in five of the eight patients (63%), and two patients had a minor ischemic attack. Neurological problems failed to occur in the three patients with intracavernous aneurysm who were treated conservatively. The risk of rupture is relatively high in intradural giant and large aneurysms. Proximal carotid occlusion can effectively prevent bleeding from intradural aneurysms. Aggressive management is justified for intradural aneurysms with poor collateral circulation. Operative procedures in the management of an intracavernous aneurysm require careful consideration.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Kaminogo M,Kitagawa N,Takahata H,Matsuo Y,Hayashi K,Yoshioka T,Shibata Sdoi
10.1179/016164101101198604subject
Has Abstractpub_date
2001-06-01 00:00:00pages
388-96issue
4eissn
0161-6412issn
1743-1328journal_volume
23pub_type
杂志文章abstract：:The ocular microtremor (OMT) is mediated by the oculomotor area of the brainstem and is altered in several pathologic states, including traumatic brain injury, general anesthesia, brain death, coma, Parkinsonism and multiple sclerosis. The EYETECT tremor monitor is a non-invasive means of measuring the frequency and a...
journal_title：Neurological research
pub_type： 杂志文章,评审
doi：10.1179/016164107X240198
更新日期：2007-10-01 00:00:00
abstract：:The purpose of this study was to investigate the correlation between activity-related pain six months after first surgery for herniated lumbar disc, and the extent of lumbar epidural fibrosis present at the surgical site, assessed by magnetic resonance imaging. The 298 patients who underwent surgery for lumbar disc he...
journal_title：Neurological research
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1080/01616412.1999.11741025
更新日期：1999-01-01 00:00:00
abstract：:Background: IVS5-91G>A (rs3812718) polymorphism of the sodium voltage-gated channel alpha subunit 1 (SCN1A) gene has been associated with inadequate responsiveness to common antiepileptic drugs which act as sodium channel blockers. This study was performed to investigate the effect of IVS5-91G>A (rs3812718) polymorphi...
journal_title：Neurological research
pub_type： 临床试验,杂志文章
doi：10.1080/01616412.2019.1635321
更新日期：2019-10-01 00:00:00
abstract：:The mechanism of cerebral ischaemic injury is complex and likely involves more than a single pathophysiologic event. Drugs are available which interfere with numerous harmful biochemical and pharmacologic processes begun by ischaemia. Hence, combination chemotherapy might be useful in cerebral ischaemia. The purpose o...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1995.11740301
更新日期：1995-04-01 00:00:00
abstract：:Recent publications have suggested that intra-ocular pressure (IOP) may be an indirect assessment of intra-cranial pressure (ICP). Both IOP and ICP have similar physiologic pressure ranges and similar responses to changes in intra-abdominal, intra-thoracic and aortic pressure. Previous studies have demonstrated the re...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1999.11740925
更新日期：1999-04-01 00:00:00
abstract：OBJECTIVES:The suppressor gene maspin (Serpin B5) is a promising candidate for future treatment. We have examined the messenger RNA (mRNA) and protein expression of maspin in normal breast tissue, breast cancer primaries, brain metastases and breast cancer cell lines. Results were compared to hormone receptor expressio...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/016164109X12518779082192
更新日期：2010-04-01 00:00:00
abstract：:Cerebral vasospasm and/or delayed ischaemic state following subarachnoid haemorrhage still remain unsolved serious problems. With the development and introduction of calcium antagonists as well as the advances in perioperative management, however, the clinical outcome has much improved in recent years. Among such drug...
journal_title：Neurological research
pub_type： 杂志文章,评审
doi：10.1080/01616412.1993.11740140
更新日期：1993-08-01 00:00:00
abstract：:The decrease in intracellular creatine concentration in Duchenne muscular dystrophy may contribute to the deterioration of intracellular energy homeostasis and may thus be one of the factors aggravating muscle weakness and degeneration. Oral creatine supplementation should have potential in alleviating the clinical sy...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.2000.11741051
更新日期：2000-03-01 00:00:00
abstract：:Induction of stress proteins is thought to be important in the protection of cells from a variety of environmental insults including heat, hypoxia and ischemia. The aim of this study was to compare the mechanism of induction of heat shock protein 72 (HSP72) in primary cultures of murine cortical astrocytes by heat and...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1996.11740380
更新日期：1996-02-01 00:00:00
abstract：:The object of the study was to evaluate brain tissue oxygenation (p(ti)O2) for intra-operative monitoring of critical ischemic events during early cerebral aneurysm surgery of the anterior circulation supplementary to somatosensory evoked potentials (SEPs). P(ti)O2 was continuously evaluated during surgery for an intr...
journal_title：Neurological research
pub_type： 临床试验,杂志文章
doi：10.1179/016164102101200528
更新日期：2002-09-01 00:00:00
abstract：:The objective of this study was to investigate the effects of transplanted bone marrow mesenchymal stem cells (BMSCs) administered via internal jugular vein injection, carotid artery injection, or intraventricular transplantation for the treatment of cerebral infarction, which was modeled in rats. The neurological sco...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/1743132812Y.0000000152
更新日期：2013-03-01 00:00:00
abstract：:Coupling of neuronal activity to cerebral blood flow (CBF) is widely accepted, but the exact mechanism is still under investigation. We assessed the responses of CBF coupled with electrical activity over the primary somatosensory cortex (S-I) during electrical stimulation of the contralateral forearm in cats. CBF in S...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1999.11740980
更新日期：1999-09-01 00:00:00
abstract：:This study was performed to test whether GYKI 52466, a nonNMDA receptor antagonist, would improve microregional oxygen supply and consumption balance in the focal cerebral ischemic area. Rats were anesthetized with 1.4% isoflurane. For the GYKI Group (n = 8), 10 min before middle cerebral artery (MCA) occlusion, a bol...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1999.11740935
更新日期：1999-04-01 00:00:00
abstract：OBJECTIVES:In the present study, we investigated the effects of treadmill exercise on microglial activation and the subsequent release of tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 and IL-1-beta in the hippocampus in a rat model of type 2 diabetes. METHODS:At 30 weeks of age, diabetic (Zucker diabeti...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/1743132815Y.0000000015
更新日期：2015-08-01 00:00:00
abstract：:Intravenous infusion of glycerol has been used in patients with a cerebral infarction, expecting improvement in brain edema and cerebral blood flow (CBF). However, the mechanism of the improvement of CBF has not been clearly demonstrated. The aim of this study in the rat pial microvasculature after transient middle ce...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1999.11741015
更新日期：1999-12-01 00:00:00
abstract：INTRODUCTION:To investigate the prevalence of Parkinson's disease (PD), a three-phase study was conducted. METHODS:In phase 1, standardized interviews were performed in a random sample of elderly aged 65 years or older using a questionnaire. In phase 2, neurological examinations were performed to clinically diagnose P...
journal_title：Neurological research
pub_type： 杂志文章,随机对照试验
doi：10.1179/016164109X12581096796396
更新日期：2010-10-01 00:00:00
abstract：:Endolymphatic sac tumors are rare, low-grade adenocarcinomas of the petrous bone. These tumors are highly vascularized and surgical removal is often challenging. We present a staged endovascular-neurosurgical approach consisting of stent-assisted angioplasty of the petrous carotid, selective endovascular embolization ...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/016164103101201436
更新日期：2003-04-01 00:00:00
abstract：:In this work, we evaluated the differences between epileptic electroencephalogram (EEG) and interictal EEG by computing some non-linear features. Correlation dimension (CD) and Hurst exponent (H) were calculated for 100 segments of epileptic EEG and 100 segments of interictal EEG. A comparison was made between epilept...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/1743132811Y.0000000041
更新日期：2011-11-01 00:00:00
abstract：OBJECTIVES:Brain death is a clinical diagnosis often confirmed with supplementary tests. In this study, we examined the relationship between brain death and the partial pressure of brain tissue oxygen (PbtO(2)). We hypothesized that a sustained PbtO(2) of 0 is associated with brain death. METHODS:One hundred and twent...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/016164107X208121
更新日期：2007-10-01 00:00:00
abstract：:In 75 patients with completed stroke hypervolemic haemodilution was performed for 1 day with 500 ml 6% HES 200.000/0.6-0.66 (Elohäst) to test the acute influence of application time for haemorheological changes. The patients were divided into 3 groups randomly selected: group A received the infusion for 2 hours, group...
journal_title：Neurological research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1080/01616412.1992.11740043
更新日期：1992-01-01 00:00:00
abstract：:It is being increasingly suggested that the microcirculation, which is known to be in a large part responsible for maintaining an adequate and constant microenvironment for function of the central nervous system, functions as part of a neurovascular unit. The neurovascular unit includes neurons, astrocytes and element...
journal_title：Neurological research
pub_type： 杂志文章,评审
doi：10.1179/016164104X3815
更新日期：2004-12-01 00:00:00
abstract：OBJECTIVE:Cell-free DNA (cf-DNA) is a marker of inflammation and cell death. The purpose of the present study was to analyze the role of cf-DNA as a putative biomarker in refractory epilepsy. METHODS:Baseline concentration of cf-DNA was measured in the serum of 51 carefully evaluated refractory epilepsy patients under...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.2015.1127004
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Crossed-uncrossed differentials (CUDs) are viewed as surrogates for interhemispheric transfer time (IHTT). Not uncommonly CUDs assume statistically significant negative values (inverted CUDs). This raises doubts of the accepted interpretation of CUDs, i.e. intra- and inter-hemispheric routings of signals in ...
journal_title：Neurological research
pub_type： 杂志文章,评审
doi：10.1179/016164106X115107
更新日期：2006-10-01 00:00:00
abstract：:The possible role of nitric oxide (NO) on vibrissa-stimulated increase of regional cerebral cerebral blood flow (rCBF) and cerebral metabolic rate of glucose (rCMRglu) was investigated in conscious Wistar rats by using an inhibitor of NO synthase, NG-nitro-L-arginine (NOLAG) at a concentration of 30 mg/kg. In vivo aut...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1993.11740103
更新日期：1993-02-01 00:00:00
abstract：:This study was designed to evaluate the effects of two consecutive ischaemias on extracellular monoaminergic neurotransmitter concentrations. The data on the neuroamine changes induced by the second ischaemia could be used to assess the delay in aminergic neurotransmission subsequent to the primary injury. Dopamine (D...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1993.11740134
更新日期：1993-06-01 00:00:00
abstract：:Six cases of very large anterior circulation intracranial aneurysms are presented. Aneurysms of 53-84 mm in three female and two male adults and a 40 mm lesion in a seven week infant were successfully excised. Three patients tolerated trial intraluminal balloon occlusion preoperatively and underwent subsequent parent ...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1992.11740053
更新日期：1992-01-01 00:00:00
abstract：OBJECTIVE:The feasibility of high resolution CT imaging for evaluating experimentally-induced brain tumors in rats was assessed. METHODS:The gliosarcoma cell line (9 L/lacZ) was inoculated in 34 male Fischer 344 rats and CT studies were performed prior to and at 4, 7, 9, 12 and 14 days post-tumor cell implantation. Br...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/016164105X18250
更新日期：2005-01-01 00:00:00
abstract：:Analysis of the blood flow velocities in the middle cerebral artery by transcranial Doppler ultrasonography was performed in 158 healthy volunteers (aged 14-70 years; 82 men and 76 women). In a subgroup of 38 men and 21 women the end-tidal [CO2] was also measured. The influence of biological factors such as age, sex, ...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1080/01616412.1990.11739941
更新日期：1990-09-01 00:00:00
abstract：OBJECTIVES:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder, characterized by a selective progressive degeneration of the motor system. Electromyography is essential for the diagnosis of ALS. The measurement of motor conduction of peripheral nerves is of major importance to recognize other poss...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/016164107X159261
更新日期：2007-07-01 00:00:00
abstract：:Lectin-like oxidized low-density lipoprotein receptor (LOX-1) and monocyte chemoattractant protein-1 (MCP-1) are molecules involving in the initiation and progression of atherosclerosis. In order to examine a possible difference in LOX-1 and MCP-1 expressions depending on the severity of early stage of atherosclerosis...
journal_title：Neurological research
pub_type： 杂志文章
doi：10.1179/016164104225016074
更新日期：2004-10-01 00:00:00
