Abstract:
BACKGROUND:Crossed-uncrossed differentials (CUDs) are viewed as surrogates for interhemispheric transfer time (IHTT). Not uncommonly CUDs assume statistically significant negative values (inverted CUDs). This raises doubts of the accepted interpretation of CUDs, i.e. intra- and inter-hemispheric routings of signals in uncrossed and crossed responses, respectively. METHOD:Based on the evidence supporting directionality in callosal traffic, data are provided indicating that callosal transfers exclusively involve non-dominant responses and such transfers are modality non-specific. The evidence also indicates that neural handedness corresponds to behavioral only in a statistical manner and the former remains unchanged regardless of the subject's life experience. RESULTS:The neurally dominant side is the side that is directly connected to the major hemisphere (command center). The connection of the non-dominant side to the command center is via the corpus callosum; therefore, a delay occurs in the reaction time of all non-dominant effectors, corresponding to IHTT. Accordingly, negative CUDs indicate a mismatch of neural and behavioral (avowed) handedness of the subject. This group comprises a minority of 15-20% of the population. CONCLUSION:Comparing the response time of symmetrically located effector is a robust way of lateralizing a person's major hemisphere. The latter is also the site of initiation of seizures, as the minor hemisphere is bereft of independent motor activity. Sensory signals arising from the nondominant side of the body traverse the callosum before reaching the major hemisphere. Searching for ipsilateral somatosensory evoked potentials provides another approach in lateralizing the non-dominant side of the body (ipsilateral to the major hemisphere). Practical uses of a conceptually revamped Poffenberger paradigm in neurosurgery are briefly reviewed.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Derakhshan Idoi
10.1179/016164106X115107subject
Has Abstractpub_date
2006-10-01 00:00:00pages
777-84issue
7eissn
0161-6412issn
1743-1328journal_volume
28pub_type
杂志文章,评审abstract::The therapeutic effect of insulin alone or insulin combined with 30 min delayed thrombolytic therapy was investigated in rats embolized in the right hemisphere with a fibrin clot made from autologous blood. Animals were killed seven days after embolization and the infarct volumes were measured in % of the affected hem...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101200096
更新日期:2002-06-01 00:00:00
abstract::A new suction device for microneurosurgery is presented. A surgical cottonoid is covered with a polyethylene film so that vacuum power is maintained throughout the length of the cottonoid. One end is connected to a vacuum pump via a plastic tube. Five to 10 mm of the surgical cottonoid are exposed for suctioning at th...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740565
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVES:Susceptibility-weighted (SW) magnetic resonance (MR) imaging is a sensitive test to detect intravenous deoxygenated blood. On SW images, dilated appearing draining veins in tissue with perfusion impairment occur due to an increase in intravenous deoxyhemoglobin levels, and could indicate poor perfusion areas...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164110X12644252260510
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Giant and large intracranial aneurysms represent enormous therapeutic challenges for neurosurgeons as well as for endovascular therapists. Since they may involve entire vessels or be irregular in shape, the rate of complete obliteration with GDCs is low and the incidence of recanalization is very high. So th...
journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1179/174313208X319017
更新日期:2008-07-01 00:00:00
abstract::Objectives: Natalizumab (NTZ), a treatment indicated for patients with highly active Relapsing - Remitting Multiple Sclerosis (RRMS), is known to induce increased relative frequency of lymphocytes. Progressive Multifocal Leukoencephalitis (PML) is a rare but serious adverse event related to NTZ. Moreover, reduced L-se...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1722913
更新日期:2020-03-01 00:00:00
abstract::Thirty outpatients with unruptured cerebral aneurysms screened by computed angiotomography have been analysed and followed up in our clinic since 1979. Seventeen were men and the age range was 41 to 74 years old (mean 57.7 years). Patients had no or only mild neurological symptoms, such as headache, sensorimotor or sp...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1986.11739736
更新日期:1986-06-01 00:00:00
abstract::Sixty-five years old patient suffering from acute stroke was treated by rTPA intravenously. TCD monitoring of both middle cerebral arteries (MCA) was carried out simultaneously with administration of rTPA. Seven microemboli were found in right and four in left MCA. Duplex ultrasound, CT angiography and digital subtrac...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X289589
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:To review past, present and future applications of near-infrared spectroscopy (NIRS) in clinical neuroscience. METHODS:The literature and personal experience of the authors were critically reviewed in order to provide a balanced overview of the basic principles, clinical validation, previous experience and c...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/174313209X383286
更新日期:2009-07-01 00:00:00
abstract::Rats were exposed in utero plus 60 days post-partum to either complex music (Mozart Sonata (k. 448)), minimalist music (a Philip Glass composition), white noise or silence, and were then tested for five days, three trials per day, in a multiple T-maze. By Day 3, the rats exposed to the Mozart work completed the maze m...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740543
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVE:After a spinal cord injury (SCI), most men experience fertility related problems including poor semen quality in which decreased sperm viability and motility, have been proposed to be related to the accessory sex glands dysfunction. In this study, we investigated the probable effects of SCI on the seminal ves...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164108X268287
更新日期:2008-06-01 00:00:00
abstract::Congenital dural arteriovenous fistulas have been infrequently described in pediatric population and they generally affect the transverse, sigmoid, straight or sagittal sinuses. Congenital carotid-cavernous fistulas in infancy are considered very rare and to our knowledge, only four cases have been reported in literat...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X291612
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVES:Patients presenting to the emergency room with an acute or subacute onset of focal neurological deficits are evaluated initially by non-contrast computed tomogram (CT) of the brain. This is primarily carried out to differentiate an ischemic from hemorrhagic stroke. However, other neurological conditions may ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164109X12445505689607
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Diffusion-weighted imaging (DWI) abnormalities can frequently be detected after carotid endarterectomy (CEA) and carotid angioplasty with stent placement (CAS) of the carotid arteries. We looked for possible predictors for the development of DWI lesions during the intervention. METHODS:We investigated 41 pa...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164105X49391
更新日期:2006-07-01 00:00:00
abstract::[15O]-water PET was performed on 12 patients with structural lesions for localization of the motor (n = 5), language (receptive and expressive; n = 6), and visual cortex (n = 1). All these patients underwent interactive image-guided surgery using an infrared digitizer and intraoperative electrical stimulation mapping ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1997.11740867
更新日期:1997-12-01 00:00:00
abstract:OBJECTIVE:To assess the effect of sensory nerve stimulation in older people with peripheral neuropathy associated with diabetes (DPN). MATERIALS AND METHODS:A randomized, placebo controlled, double blind trial was used to assess the effect of 12 weeks of low frequency sensory nerve stimulation (LF-SNS) in the lower li...
journal_title:Neurological research
pub_type: 杂志文章,随机对照试验
doi:10.1179/016164107X208095
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:Computed tomographic angiography (CTA) was invented more than 20 years ago, but only gained acceptance recently, thanks to advancements in the computer technology. It can demonstrate areas of arterial stenosis or occlusion with accuracy nearly that of digital subtraction angiography (DSA). It is also able to ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X340969
更新日期:2008-10-01 00:00:00
abstract::Acute blood-brain barrier (BBB) opening in cerebral ischemia is an often observed but seldom studied phenomenon. Increased permeability has been implicated with several consequences including exacerbating ischemic injury, leading to hemorrhagic transformation (HT) and also predictive of chronic damage and a way of del...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313206X153815
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Since the late 1990s, imaging studies have allowed the visualization of brain response to acupuncture stimulation with alteration in blood flow. In 1998, the first functional magnetic resonance imaging (fMRI) study for the Korean acupuncture was published and thereafter, many subsequent neuroimaging studies ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X172284
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:To assess whether a weaning protocol reduces the mechanical ventilation (MV) duration compared to physician's judgement-based weaning in neurological patients and to determine whether patient consciousness influences this reduction. METHODS:A randomised controlled trial was conducted in a neurological inten...
journal_title:Neurological research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1179/1743132815Y.0000000092
更新日期:2015-11-01 00:00:00
abstract::We examined regional cerebral blood flow (rCBF) and oxygen metabolism (rCMRO2) in 10 patients with progressive dementia and amyotrophic lateral sclerosis (DALS), in 21 patients with classical amyotrophic lateral sclerosis without dementia (ALS), and in 17 controls. The mean rCBF and rCMRO2, especially in the anterior ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164103101201670
更新日期:2003-06-01 00:00:00
abstract::Child patients with Moyamoya disease initially present with ischemic symptoms. However, the long-term risk of intracranial hemorrhage for childhood Moyamoya disease is unknown. Hemodynamic overload to the fragile collateral vessels has been considered to cause hemorrhage. We reviewed angiograms to evaluate the effect ...
journal_title:Neurological research
pub_type: 临床试验,杂志文章
doi:10.1080/01616412.2000.11740680
更新日期:2000-06-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is the most serious form of degenerative motor neuron disease in adults, whose relentless course leads to death within 2-5 years, generally due to respiratory failure. Apart from the age and site of onset, no other factors have consistently demonstrated to be related to the ALS outc...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132812Y.0000000049
更新日期:2012-07-01 00:00:00
abstract::The purpose of this study was to investigate the correlation between activity-related pain six months after first surgery for herniated lumbar disc, and the extent of lumbar epidural fibrosis present at the surgical site, assessed by magnetic resonance imaging. The 298 patients who underwent surgery for lumbar disc he...
journal_title:Neurological research
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1080/01616412.1999.11741025
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:Cerebral small vessel disease (CSVD) describes a syndrome of neuroimaging, pathological, and associated clinical features caused by small intracranial vascular lesions, which commonly coexists with large artery atherosclerosis (LAA) and has been identified as a major cause of motor impairment over time. In th...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1080/01616412.2018.1446283
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:Music-supported therapy (MST) is a new approach for motor rehabilitation of stroke patients. Recently, many studies have demonstrated that MST improved the motor functions of post-stroke patients. However, the underlying mechanism for this effect is still unclear. It may result from repeated practice or repea...
journal_title:Neurological research
pub_type: 杂志文章,随机对照试验
doi:10.1179/1743132815Y.0000000034
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:Rats treated with progesterone (P4) after ischemia show an adequate functional performance despite a significant loss of hippocampal pyramidal neurons, suggesting that P4 could favour a permissive microenvironment for cerebral plasticity mechanisms. The possibility of P4 treatment promoting the survival of ne...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2019.1576356
更新日期:2019-05-01 00:00:00
abstract::Cerebral vasospasm and/or delayed ischaemic state following subarachnoid haemorrhage still remain unsolved serious problems. With the development and introduction of calcium antagonists as well as the advances in perioperative management, however, the clinical outcome has much improved in recent years. Among such drug...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1080/01616412.1993.11740140
更新日期:1993-08-01 00:00:00
abstract::Despite the accumulation of intraoperative data on arteriovenous malformations (AVMs), details of the haemodynamics have not yet been elucidated. A hydraulic model was constructed from silicone and glass tubes to simulate a high-flow AVM. During stepwise obliteration of the nidus, haemodynamic changes were continuousl...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1993.11740174
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVE:This review will describe the novel contributions to the field of nerve repair from the emerging disciplines of microtechnology and nanotechnology. METHOD:This broad review will cover the advances described in the literature of the medical and biological fields and the engineering and physical sciences. The ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/174313208X362532
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:Acquired neurological diseases such as severe traumatic brain or spinal cord injury (SCI) cause irreversible disability. Olfactory ensheathing cell (OEC) transplantation has been trialed as a promising SCI treatment. Extracellular vesicles (EVs), which regulate cell-cell interactions, have recently garnered e...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1794371
更新日期:2020-11-01 00:00:00