Fructose-added glycerol (Glyceol) for therapy of elevated intracranial pressure: analysis of the side effects of long-term administration in a multi-institutional trial.


:The effects of long-term administration of fructose-added glycerol solution (Glyceol): 10% glycerol, 5% fructose, 0.9% sodium chloride; 600-2000 ml/d intravenously for 7-63 d) were evaluated in a multi-institutional trial involving 1346 cases. Improvement of the neurological signs and symptoms of elevated intracranial pressure was recognized by responsible physicians in close association with the administration of Glyceol (75.1%). The intracranial pressure measured directly also decreased in most cases following the administration of Glyceol (81.2%). No significant changes were observed in serum electrolytes and osmolarity at the end of the long-term administration. Unfavourable changes in clinical conditions which were considered very likely or suspected to be due to the long-term administration of Glyceol were recorded in 2 cases (0.1%) or 13 cases (1.0%), respectively. Most of these changes were abnormalities of serum electrolytes. It appeared, however, that the abnormalities of serum electrolytes may be readily correctable, and rarely induced if standard care of the serum water-electrolyte balance is carried out and unless too large doses are employed. Other changes appeared to be related more to preexistent complications and/or the administration of other drugs, rather than to the administration of Glyceol alone. Thus, administration of Glyceol appeared feasible for the therapy of elevated intracranial pressure over the long term.


Neurol Res


Neurological research


Tsubokawa T,Katayama Y,Ishii S




Has Abstract


1989-12-01 00:00:00












  • Mapping the primary motor cortex in healthy subjects and patients with peri-rolandic brain lesions before neurosurgery.

    abstract:OBJECTIVE:The aim of this study was to establish a robust set of motor tasks that could be used to functionally delineate the motor cortex with blood oxygenation level dependent functional magnetic resonance imaging (BOLD fMRI) at 3 T and produce precise functional maps for pre-operative planning and functional neurona...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章


    authors: Berntsen EM,Samuelsen P,Lagopoulos J,Rasmussen IA Jr,Håberg AK,Haraldseth O

    更新日期:2008-11-01 00:00:00

  • Neuroprotective effect of basic fibroblast growth factor on wobbler mouse motor neuron disease.

    abstract::Basic fibroblast growth factor (bFGF) possesses neuroprotective effects on a variety of neurons. Here we report that it delays progression of motor neuron disease (MND) in the wobbler mouse. After initial diagnosis of MND at post-natal age 3-4 weeks, wobbler mice receive either recombinant human bFGF (1 mg kg-1, n = 1...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Ikeda K,Iwasaki Y,Tagaya N,Shiojima T,Kobayashi T,Kinoshita M

    更新日期:1995-12-01 00:00:00

  • Association between intracranial, arterial pulse pressure amplitudes and cerebral autoregulation in head injury patients.

    abstract:OBJECTIVE:To explore whether intracranial pulse pressure amplitudes relate to arterial pulse pressure amplitudes and whether correlations between time-related changes in intracranial and arterial pulse pressure amplitudes associate with indices of cerebral autoregulation. METHODS:A total of 257 continuous and simultan...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Eide PK,Czosnyka M,Sorteberg W,Pickard JD,Smielewski P

    更新日期:2007-09-01 00:00:00

  • Preventing the BDNF and NGF loss involved in the effects of cornel iridoid glycoside on attenuation of experimental autoimmune encephalomyelitis in mice.

    abstract::The present study was designed to investigate the beneficial effects of cornel iridoid glycoside (CIG), a main component extract from Cornus officinalis, on neurotrophin expression in mouse experimental autoimmune encephalomyelitis (EAE), a classical model of multiple sclerosis (MS). After EAE initiation, CIG was intr...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Qu Z,Zheng N,Zhang Y,Zhang L,Liu J,Wang Q,Yin L

    更新日期:2016-09-01 00:00:00

  • Neurointerventional treatment of vasospasm.

    abstract:OBJECTIVES:To review the historical development and current status of endovascular techniques used in the treatment of symptomatic vasospasm following aneurysmal subarachnoid hemorrhage. METHODS:This article summarizes the relevant literature on neurointerventional therapy for vasospasm, namely instillation of intraar...

    journal_title:Neurological research

    pub_type: 杂志文章,评审


    authors: Brisman JL,Eskridge JM,Newell DW

    更新日期:2006-10-01 00:00:00

  • Odontoid calcification and crowned dens syndrome: data from a Chinese center.

    abstract:OBJECTIVES:To assess the prevalence of calcification surrounding the odontoid process (odontoid calcification) with crowned dens syndrome (CDS) and without CDS (non-CDS) and investigate factors that may related to the onset of CDS. METHODS:Retrospective review of consecutive patients visited Sir Run Run Shaw Hospital ...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Lu PL,Niu ZF,Qiu CW,Hu XY

    更新日期:2020-11-01 00:00:00

  • Intracerebral hemorrhage survival: French register data.

    abstract::Cerebral hemorrhages are subject to a heavy short- and long-term case fatality. A study of prognostic factors and of relative survival based on the data of a population registry is of great value to study patients having a hematoma of all ages, irrespective of the method of care. We have listed 183 patients having a c...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: el Chami B,Milan C,Giroud M,Sautreaux JL,Faivre J

    更新日期:2000-12-01 00:00:00

  • Investigation of subdural electrode displacement in invasive epilepsy surgery workup using neuronavigation and intraoperative MRI.

    abstract:OBJECTIVES:One of the main obstacles of electrode implantation in epilepsy surgery is the electrode shift between implantation and the day of explantation. We evaluated this possible electrode displacement using intraoperative MRI (iopMRI) data and CT/MRI reconstruction. METHODS:Thirteen patients (nine female, four ma...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Sommer B,Rampp S,Doerfler A,Stefan H,Hamer HM,Buchfelder M,Roessler K

    更新日期:2018-10-01 00:00:00

  • Anesthetic propofol normalized the increased release of glutamate and γ-amino butyric acid in hippocampus after paradoxical sleep deprivation in rats.

    abstract:OBJECTIVE:Multiple lines of evidence suggest that general anesthesia helps the recovery from sleep deprivation. However, little is known about the underlying neurochemical mechanisms. In the current study, we investigated the effect of anesthetic propofol on the release of glutamate (Glu) and γ-amino butyric acid (GABA...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Xie F,Li X,Bao M,Shi R,Yue Y,Guan Y,Wang Y

    更新日期:2015-01-01 00:00:00

  • The role of dietary non-heme iron load and peripheral nerve inflammation in the development of peripheral neuropathy (PN) in obese non-diabetic leptin-deficient ob/ob mice.

    abstract:INTRODUCTION:Here, we investigated inflammatory signs of peripheral nerves in leptin-deficient obese ob/ob mice and the modulating effects of the exogenous iron load. METHODS:Ob/ob and ob/+ control mice were fed with high, standard, or low iron diet for four months. RESULTS:We found intraepidermal nerve fiber degener...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Kosacka J,Woidt K,Toyka KV,Paeschke S,Klöting N,Bechmann I,Blüher M,Thiery J,Ossmann S,Baum P,Nowicki M

    更新日期:2019-04-01 00:00:00

  • Induction of PML immunoreactivity in rat brain neurons after transient middle cerebral artery occlusion.

    abstract::Promyelocytic leukemia (PML) protein is involved in apoptotic death of cultured neuronal cells, but its role in ischemic brain damage remains uncertain. In this study, we investigated change of immunoreactivity for PML protein in rat brain after transient middle cerebral artery occlusion, and compared the results with...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Hayashi T,Sasaki C,Iwai M,Sato K,Zhang WR,Warita H,Abe K

    更新日期:2001-10-01 00:00:00

  • Microemboli in MCA ipsilateral to occluded common carotid artery: an observation and short review of the literature.

    abstract::Sixty-five years old patient suffering from acute stroke was treated by rTPA intravenously. TCD monitoring of both middle cerebral arteries (MCA) was carried out simultaneously with administration of rTPA. Seven microemboli were found in right and four in left MCA. Duplex ultrasound, CT angiography and digital subtrac...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Telman G,Kouperberg E,Eran A,Goldsher D,Yarnitsky D

    更新日期:2008-09-01 00:00:00

  • Hemodynamic alterations in focal cerebral ischemia: temporal correlation analysis for functional imaging.

    abstract::We describe a novel approach for analysing the hemodynamic alterations that result after focal cerebral ischemia. This approach utilizes a temporal correlation analysis of first pass transit data obtained with functional imaging. First pass transits of injected contrast agents are measured with dynamic CT scanning. No...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Lo EH,Rogowska J,Batchelder KF,Wolf GL

    更新日期:1996-04-01 00:00:00

  • The role of high-sensitivity C-reactive protein levels in functional outcomes in patients with large-artery atherosclerosis and small-artery occlusion.

    abstract:BACKGROUND:High-sensitivity C-reactive protein (hs-CRP) is an inflammatory marker that is associated with the outcomes of ischemic stroke. However, the role of hs-CRP levels in the functional outcomes after large-artery atherosclerosis (LAA) and small-artery occlusion (SAO) is poorly understood. METHODS:We recruited 1...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Hou D,Liu J,Feng R,Gao Y,Wang Y,Wu J

    更新日期:2017-11-01 00:00:00

  • Allopregnanolone modulates striatal dopamingergic activity of rats under different gonadal hormones conditions.

    abstract:OBJECTIVES:Progesterone modulates dopamine (DA) release in corpus striatum. Our objective was to evaluate the effect of the i.c.v injection of the neurosteroid allopregnanolone (ALL), a progesterone metabolite on dopaminergic activity in the corpus striatum of rats under different gonadal hormonal conditions. METHODS:...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Laconi MR,Reggiani PC,Penissi A,Yunes R,Cabrera RJ

    更新日期:2007-09-01 00:00:00

  • Detection of experimentally induced brain tumors in rats using high resolution computed tomography.

    abstract:OBJECTIVE:The feasibility of high resolution CT imaging for evaluating experimentally-induced brain tumors in rats was assessed. METHODS:The gliosarcoma cell line (9 L/lacZ) was inoculated in 34 male Fischer 344 rats and CT studies were performed prior to and at 4, 7, 9, 12 and 14 days post-tumor cell implantation. Br...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Psarros TG,Mickey B,Giller C

    更新日期:2005-01-01 00:00:00

  • Tissue plasminogen activator and plasminogen activator inhibitor in patients with acute ischemic stroke: relation to stroke etiology.

    abstract::Recent studies suggest that high plasma levels of tissue-type plasminogen activator (tPA) and its inhibitor (plasminogen activator inhibitor-1, PAI-1) are markers of an increased risk of atherothrombotic ischemic events such as stroke and myocardial infarction. In this prospective study, we measured tPA antigen, PAI-1...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Zunker P,Schick A,Padró T,Kienast J,Phillips A,Ringelstein EB

    更新日期:1999-12-01 00:00:00

  • Temporal and spacial changes of highly polysialylated neural cell adhesion molecule immunoreactivity in amygdala kindling development.

    abstract::To investigate the migration of neural stem cells as well as neural plastic changes in epileptic brain, spaciotemporal expression of immunoreactive highly polysialylated neural cell adhesion molecule (PSA-NCAM) was examined in amygdala kindling development of rat. The neural migration and synaptic remodeling detected ...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Sato K,Iwai M,Nagano I,Shoji M,Abe K

    更新日期:2003-01-01 00:00:00

  • Correction of ischaemic brain acidosis with SQ29,548/1-benzylimidazole.

    abstract::Thromboxane A2 (TXA2) is a proaggregatory vasoconstrictor that is synthesized and released during reperfusion of ischaemic brain. We administered a TXA2 receptor antagonist, SQ29,548, and a thromboxane A synthase inhibitor, 1-benzylimidazole (1-BI), to rats subjected to 30 min of reversible forebrain ischaemia. Cerebr...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Pettigrew LC,Hazle JD,Gutierrez G,Smith CD,Ogletree ML

    更新日期:1992-09-01 00:00:00

  • Combination of blood flow asymmetry in the cerebral and cerebellar hemispheres on brain perfusion SPECT predicts 5-year outcome in patients with symptomatic unilateral major cerebral artery occlusion.

    abstract:BACKGROUND AND OBJECTIVE:Misery perfusion increases the risk of stroke recurrence in patients with symptomatic major cerebral artery occlusion. The ratio of brain perfusion contralateral-to-affected asymmetry in the cerebellar hemisphere to brain perfusion affected-to-contralateral asymmetry in the cerebral hemisphere ...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Nomura J,Ogasawara K,Saito H,Terasaki K,Matsumoto Y,Takahashi Y,Ogasawara Y,Saura H,Yoshida K,Sato Y,Kubo Y,Ogawa A

    更新日期:2014-03-01 00:00:00

  • A correlative analysis between inflammatory cytokines and trigeminal neuralgia or hemifacial spasm.

    abstract:BACKGROUND:It is necessary to understand the mechanism of trigeminal neuralgia (TN) and hemifacial spasm (HFS) in order to seek for an effective noninvasive remedy. As previous studies implied that inflammatory cytokines induced by demyelination following the nerve injury may be the initiated factor causing neuropathic...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Liu MX,Zhong J,Xia L,Dou NN,Li ST

    更新日期:2019-04-01 00:00:00

  • Neuroprotection with NBQX and thrombolysis with rt-PA in rat embolic stroke.

    abstract::The efficacy of delayed thrombolysis with recombinant tissue plasminogen activator was tested in combination with the ischaemic protecting drug NBQX in an embolic stroke model. In 113 rats the carotid territory was embolized with a fibrin-rich clot formed in polyethylene tube. Hemispheric cerebral blood flow (CBF) was...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Overgaard K,Sereghy T,Pedersen H,Boysen G

    更新日期:1993-10-01 00:00:00

  • Is on-admission capillary blood beta-hydroxybutyrate concentration associated with the acute stroke severity and short-term functional outcome?

    abstract:OBJECTIVES:In conditions with reduced glucose levels/inability of glucose utilization, ketone bodies, especially beta-hydroxybutyrate (BHB), become a major energy source in the brain. In animal models, BHB infusion shows acute beneficial effects on the hypoxic brain. The present prospective observational study is the f...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Pikija S,Trkulja V,Simundic AM,Vrcek E,Boskovic K,Bacani S

    更新日期:2013-11-01 00:00:00

  • Oral creatine supplementation in Duchenne muscular dystrophy: a clinical and 31P magnetic resonance spectroscopy study.

    abstract::The decrease in intracellular creatine concentration in Duchenne muscular dystrophy may contribute to the deterioration of intracellular energy homeostasis and may thus be one of the factors aggravating muscle weakness and degeneration. Oral creatine supplementation should have potential in alleviating the clinical sy...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Felber S,Skladal D,Wyss M,Kremser C,Koller A,Sperl W

    更新日期:2000-03-01 00:00:00

  • The combination of a programmable valve and a subclavicular anti-gravity device in hydrocephalus patients at high risk for hygromas.

    abstract:OBJECTIVES:In order to avoid occurrence of post-operative hygromas in specific hydrocephalus patients being at high risk of overdrainage, a combination of programmable valve and anti-gravity device is widely recommended. We analyzed our series of hydrocephalus patients implanted with such a shunt configuration focusin...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Zachenhofer I,Donat M,Roessler K

    更新日期:2012-04-01 00:00:00

  • New device to treat chronic subdural hematoma--hollow screw.

    abstract::Different surgical approaches exist for the treatment of chronic subdural hematoma. None of these approaches is superior to the other, so a minimal-invasive device (a hollow screw) was developed. The system consists of a stable hollow screw of surgical steel with a perforated tip, a hand-drill, screwdriver with guide,...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Emonds N,Hassler WE

    更新日期:1999-01-01 00:00:00

  • Effect of Fluosol-DA and hetastarch on local cerebral blood flow, cortical O2 availability and computerized EEG data during cerebral ischaemia.

    abstract::This study was designed to assess the effects of volume expansion with Fluosol-DA and hetastarch on local cerebral blood flow (CBF), cortical O2 availability (O2a) and computerized EEG power data during cerebral ischaemia in a primate stroke model. Focal cerebral ischaemia was produced in 20 anaesthetized Macaca monke...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Tranmer BI,Iacobacci R,Feiler S

    更新日期:1990-03-01 00:00:00

  • Mutations in GBA and risk of Parkinson's disease: a meta-analysis based on 25 case-control studies.

    abstract::The association between glucocerebrosidase (GBA) mutations and Parkinson's disease (PD) is attracting increased attention worldwide. Results from previous studies on the association of GBA mutations with PD in different ethnicities remain contradictory. In order to derive a more comprehensive understanding of the rela...

    journal_title:Neurological research

    pub_type: 杂志文章,meta分析,评审


    authors: Mao X,Wang T,Peng R,Chang X,Li N,Gu Y,Zhao D,Liao Q,Liu M

    更新日期:2013-10-01 00:00:00

  • The dynamic triple peak impact factor in traumatic brain injury influences native protein structures in gray and white matter as measured with computational simulation.

    abstract:BACKGROUND:Traumatic brain injuries (TBIs) cause a substantial burden to the patient, relatives, and the society as a whole. Much experience and knowledge during the last two decades have improved the neurosurgical treatment as well as the outcome. However, there is still much debate on what actually happens when exter...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Holst Hv,Li X

    更新日期:2013-10-01 00:00:00

  • Basilar artery to bilateral posterior cerebral artery 'Y stenting' for endovascular reconstruction of wide-necked basilar apex aneurysms: report of three cases.

    abstract::Endovascular reconstruction of basilar artery (BA) apex aneurysms has been augmented by adjunctive techniques such as balloon and stent assistance. We present three cases of a wide-necked BA apex aneurysm involving the bilateral P1 segments of both posterior cerebral arteries (PCAs) treated by placement of BA to PCA s...

    journal_title:Neurological research

    pub_type: 杂志文章


    authors: Perez-Arjona E,Fessler RD

    更新日期:2004-04-01 00:00:00