Abstract:
OBJECTIVE:The aim of the present study was to analyse inflammatory cells in lumbar disc tissue under cyclooxygenase-2 (COX-2) inhibitor therapy, to detect their prevalence in different subtypes of lumbar disc herniations and to assess the influence of inflammatory reactions in herniated disc tissue on postoperative outcome. METHODS:In this prospective study, intervertebral disc specimens were obtained from 50 patients. All the patients were given COX-2 inhibitor therapy (Rofecoxib) 25 mg/day for 10 days before surgery. The herniated disc specimens were routinely fixed in a 10% buffered formaline solution and paraffin-embedded; 5 microm thin sections were stained with monoclonal antibodies CD-68 for macrophages, CD-45 RO for T cells and CD-20 for B cells. The specimens were microscopically examined and classified by two independent examiners in a blinded manner. RESULTS:CD-68 macrophages were evident in herniated lumbar disc tissue in 40% of the cases, but abundant inflammation was observed in only 18% of the cases. Macrophages were significantly common in sequesters with a prevalence of 80%, and no macrophages were observed in the protrusions. We obtained the best outcome scores in the patients with a sequestrated lumbar disc herniation. CONCLUSION:Although most of the specimens from all the patients showed no significant inflammatory reaction, maybe due to COX-2 inhibitor therapy, they all needed surgery with no relief of the symptoms despite conservative therapy. Nerve root compression still seems to be the leading pathomechanism.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Aydin MV,Sen O,Kayaselcuk F,Bolat F,Tufan K,Caner H,Altinors Ndoi
10.1179/016164105X49210subject
Has Abstractpub_date
2005-09-01 00:00:00pages
609-12issue
6eissn
0161-6412issn
1743-1328journal_volume
27pub_type
临床试验,杂志文章,随机对照试验abstract::We describe the technique of percutaneous carotid artery stent placement with distal protection in a patient in whom marked innominate artery ectasia prevented transfemoral access to the right common carotid artery. After induction of general anesthesia, ultrasound was used to guide direct puncture of the common carot...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164104225013978
更新日期:2004-04-01 00:00:00
abstract::Twenty-four patients presenting an acute stroke with watershed cerebral infarct on CT scan or MRI were included in this retrospective study. Age was 63 +/- 14 years (mean +/- SD), and sex ratio was 2 men for 1 woman. Main clinical features were: in anterior location, lower limb weakness and frontal syndrome with trans...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1992.11740022
更新日期:1992-01-01 00:00:00
abstract::There have been reports that superior cervical ganglionectomy (SCG) is effective as a treatment for cerebral vasospasm following subarachnoid haemorrhage (SAH). On the other hand, denervation supersensitivity is supposed to play an important role in vasospasm. The two accounts contradict each other. To investigate thi...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1988.11739836
更新日期:1988-09-01 00:00:00
abstract:OBJECTIVES:In multiple sclerosis (MS) demyelination occurs in both white and gray matter. Here we introduce an electrophysiological approach for studying functional demyelination and myelin repair in rat hippocampus, a gray matter structure, which is frequently affected in patients suffering from MS. METHODS:Using a s...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000221
更新日期:2013-10-01 00:00:00
abstract::1-Aminocyclopropanecarboxylic acid is a high affinity ligand with partial agonist properties at strychnine-insensitive glycine sites associated with the N-methyl-D-aspartate subtype of glutamate receptors. Since occupation of these sites appears required for operation of N-methyl-D-aspartate, receptor coupled cation c...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1995.11740324
更新日期:1995-08-01 00:00:00
abstract:OBJECTIVE:After a spinal cord injury (SCI), most men experience fertility related problems including poor semen quality in which decreased sperm viability and motility, have been proposed to be related to the accessory sex glands dysfunction. In this study, we investigated the probable effects of SCI on the seminal ves...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164108X268287
更新日期:2008-06-01 00:00:00
abstract::The objective of this study was to investigate the effects of transplanted bone marrow mesenchymal stem cells (BMSCs) administered via internal jugular vein injection, carotid artery injection, or intraventricular transplantation for the treatment of cerebral infarction, which was modeled in rats. The neurological sco...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132812Y.0000000152
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:Surgical management of sphenoorbital meningiomas ranges among the most complex of intracranial tumors. We report on our experience of surgical technique, outcome, and tumor recurrence in sphenoorbital meningiomas. METHODS:Between 2003 and 2013, surgical resections for sphenoorbital meningioma were performed ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132814Y.0000000329
更新日期:2014-08-01 00:00:00
abstract::The frequency of skull metastasis from hepatocellular carcinoma (HCC) is increasing together with the recent progress in the management of the primary lesion. Cases are often complicated with poor general conditions or metastasis to the other organs, and not readily indicated for surgery. A direct injection of ethanol...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740593
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVE:The actual relationship between neural stem cells and SDF-1alpha/CXCR4 after brain injury has not yet been elucidated, although recent studies have speculated that stromal cell-derived factor-1alpha (SDF-1alpha) and its receptor, CXCR4, could contribute to neural stem cells migration after brain injury. In th...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X332995
更新日期:2009-02-01 00:00:00
abstract::The therapeutic effect of insulin alone or insulin combined with 30 min delayed thrombolytic therapy was investigated in rats embolized in the right hemisphere with a fibrin clot made from autologous blood. Animals were killed seven days after embolization and the infarct volumes were measured in % of the affected hem...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164102101200096
更新日期:2002-06-01 00:00:00
abstract::The aim of this study was to examine the pre-operative clinical and neuromonitoring courses in patients with a decompressive craniectomy to assess and to compare clinical and neuromonitoring signs indicating extensive cerebral edema. We conducted a retrospective analysis of the clinical signs and courses of simultaneo...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164103101201742
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:This study investigated the role of matrix metalloproteinase-9 (MMP-9) in early brain injury after subarachnoid hemorrhage (SAH). METHOD:Sprague-Dawley male rats (n=36) weighing between 250 and 300 g were used. SAH was produced by injecting autologous arterial blood into the pre-chiasmatic cistern. MMP-9 pro...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164109X12478302362491
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Hemorrhagic transformation (HT) is a common complication of ischemic stroke. We performed this study to determine whether aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio (AAR) was related to HT, as well as compare the predictive values of AAR, ALT and AST for HT in patients with isch...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1796403
更新日期:2020-11-01 00:00:00
abstract::Localization of the pathological structures in relation to the surrounding anatomy and understanding of the surgical anatomy are probably the most important keys to successful neurosurgery. Image-guided surgery is an important tool for understanding an individual's anatomy and for precisely locating the lesion. Head r...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740481
更新日期:1998-01-01 00:00:00
abstract::Intra-arterial thrombolysis and percutaneous angioplasty is feasible in patients with acute middle cerebral artery (MCA) occlusion limited to 6 hours post-ictus, but there are some limitations such as reocclusion or hemorrhagic complications. In this report, we describe a stent placement in the treatment of a refracto...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164105X49355
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVES:The presence of beta-amyloid (betaA) deposition, induction of reactive gliosis and dystrophic neurites, is a characteristic feature of neuritic plaques in Alzheimer's disease. In vitro, betaA-exposed astrocytes become reactive, similar to astrocytes in contact with betaA plaques in vivo. How betaA-exposed re...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164105X40020
更新日期:2005-07-01 00:00:00
abstract::A computer software program (Seapit) was developed for precise determination of intracranial targets identified by stereotactic computed tomography (CT). This program was added to the software of a GE 8800 CT scanner to perform the following operations: millimetre precise calculation and display of the rectilinear coo...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1987.11739781
更新日期:1987-06-01 00:00:00
abstract::We describe the use of optical spectroscopy in the near infra-red light range to non-invasively measure regional cerebral haemoglobin oxygen saturation (rSHbO2) in cats during progressive cerebral hypoxia. This technique differs from spectroscopic techniques previously described in that the concentration ratio--percen...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1991.11739967
更新日期:1991-03-01 00:00:00
abstract:INTRODUCTION:Cerebrospinal fluid (CSF) oligoclonal bands (OB) imply intrathecal immunoglobulin synthesis and B-cell immune process. There is scarce evidence of OB having a role in disease prognosis. The objective of the present study was to determine OB's prognostic value regarding disease progression. METHODS:Betwee...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132812Y.0000000088
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVES:The present study investigated the effects of tetrahydrobiopterin (BH4) on cerebral infarction after transient focal ischemia in rats. METHODS:Focal ischemia (1·5 hours) was created in male Sprague-Dawley rats (250-280 g) by middle cerebral artery occlusion. Some rats were treated with 20 mg/kg tetrahydrob...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164110X12700393823651
更新日期:2011-12-01 00:00:00
abstract::The authors have done a revision of 450 patients admitted during the last 3 years to the emergency service of the Hospital de S. José with the diagnosis of CVA. In this retrospective study were included the patients of greater than or equal to 3 degree of the RLS/85 coma scale, the diagnostic being confirmed by CAT, a...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1992.11740023
更新日期:1992-01-01 00:00:00
abstract::Intra- and extracranial atherosclerotic stenosis has been shown to be associated with an increased risk of secondary stroke mortality. Advances in invasive and non-invasive imaging modalities have improved analysis of hemodynamic changes and allowed better delineation of the integrity of intracranial collateralization...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1080/01616412.2016.1196871
更新日期:2016-10-01 00:00:00
abstract::This study was designed to evaluate the effects of two consecutive ischaemias on extracellular monoaminergic neurotransmitter concentrations. The data on the neuroamine changes induced by the second ischaemia could be used to assess the delay in aminergic neurotransmission subsequent to the primary injury. Dopamine (D...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1993.11740134
更新日期:1993-06-01 00:00:00
abstract::We describe the advantages and clarify the technical key points of a microendoscopic, minimally invasive technique to the posterior surgical approach for cervical degenerative disease. The authors studied the microendoscopic posterior approach using the METRx system in both cadaver models and in clinical cases. This n...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164103101201058
更新日期:2003-01-01 00:00:00
abstract::We examined antioxidant activity of cabergoline, a dopamine agonist, during the aerobic oxidation of phosphatidylcholine liposomes at 37 degrees C. Cabergoline retarded the oxidation initiated with a lipid-soluble initiator significantly better than that with a water-soluble initiator, suggesting that cabergoline loca...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164104225016029
更新日期:2004-06-01 00:00:00
abstract::Decreased metabolic rate may precede cognitive impairment in Alzheimer's disease (AD) and is thus an early occurring hallmark. Several observations in post-mortem brain indicate that activated neurons are better able to withstand aging and AD, a phenomenon paraphrased by us as 'use it or lose it'. Moreover, a number o...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164103101201959
更新日期:2003-09-01 00:00:00
abstract::Recent work has suggested that one factor in the etiology of the neuromuscular disease, amyotrophic lateral sclerosis (ALS), may be an autoimmune mechanism in which presynaptic voltage-sensitive calcium channels are an antigenic target. We have developed a fluorescence technique to measure rapid Ca2+ influx through pr...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1997.11740785
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVE:Current chemotherapy treatments available for treating high-grade brain tumors, Temozolomide (TMZ) or Bevacizumab (BEV), not only have specific anti-tumor mechanisms, but also have an effect on mitochondria. However, effects of both drugs on mitochondria isolated from human brain tumors have not been thorough...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2015.1114233
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:To explore whether intracranial pulse pressure amplitudes relate to arterial pulse pressure amplitudes and whether correlations between time-related changes in intracranial and arterial pulse pressure amplitudes associate with indices of cerebral autoregulation. METHODS:A total of 257 continuous and simultan...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X172167
更新日期:2007-09-01 00:00:00