Abstract:
:The aim of this study was to examine the pre-operative clinical and neuromonitoring courses in patients with a decompressive craniectomy to assess and to compare clinical and neuromonitoring signs indicating extensive cerebral edema. We conducted a retrospective analysis of the clinical signs and courses of simultaneous monitoring of intracranial pressure (ICP) and cerebral oxygenation (PtiO2) in 26 consecutive patients who were sedated and treated with a decompressive craniectomy due to extensive cerebral edema after aneurysmal subarachnoid hemorrhage (SAH) (n = 20) or severe head injury (SHI) (n = 6). Pathological monitoring trends always preceded clinical deterioration. In 18 of 26 patients extensive cerebral edema was indicated solely by increasing ICP > 20 mmHg or decreasing PtiO2 < 10 mmHg or both. Anisocoria occurred in only 8 of 26 patients. As opposed to SHI patients, 9 of 20 SAH patients showed decreasing PtiO2 as first warning sign clearly before neurological deterioration or ICP increase. This series shows the utility of combined ICP and PtiO2 monitoring in patients who develop extensive cerebral edema. Pathological monitoring trends indicate deterioration prior to clinical signs which offers a wider therapeutical window. PtiO2 monitoring appears to be particularly valuable after aneurysmal SAH as adjunct to ICP monitoring and CT imaging.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Strege RJ,Lang EW,Stark AM,Scheffner H,Fritsch MJ,Barth H,Mehdorn HMdoi
10.1179/016164103101201742subject
Has Abstractpub_date
2003-07-01 00:00:00pages
510-5issue
5eissn
0161-6412issn
1743-1328journal_volume
25pub_type
杂志文章abstract::Intracerebral hemorrhage (ICH) remains a major medical problem, for which there is no effective treatment. However, extensive experimental and clinical research carried out in recent years has brought to light new exciting ideas for novel potential treatments. First, it was well documented that the management of hyper...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164105X25225
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVE:Surgical management of sphenoorbital meningiomas ranges among the most complex of intracranial tumors. We report on our experience of surgical technique, outcome, and tumor recurrence in sphenoorbital meningiomas. METHODS:Between 2003 and 2013, surgical resections for sphenoorbital meningioma were performed ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132814Y.0000000329
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVES:Our objective was to characterize the heat shock response (HSR) in a model of traumatic brain injury (TBI) and to determine the association of HSR to cell death. METHODS:We used immunofluorescent detection of HSP-70 to characterize HSR and TUNEL labeling to determine the pattern of cell death. RESULTS:HSP-...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X204666
更新日期:2007-06-01 00:00:00
abstract::To investigate the migration of neural stem cells as well as neural plastic changes in epileptic brain, spaciotemporal expression of immunoreactive highly polysialylated neural cell adhesion molecule (PSA-NCAM) was examined in amygdala kindling development of rat. The neural migration and synaptic remodeling detected ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164103101200969
更新日期:2003-01-01 00:00:00
abstract::Ninety percent of cerebral aneurysms were diagnosed after their first rupture with consecutive subarachnoid haemorrhage. In order to detect the aneurysms before rupture investigation by transcranial Doppler sonography was used on the basis of intra-operative evaluation of the normal aneurysmal flow pattern. In 34 pati...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1989.11739860
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:Mapping of brain perfusion using bolus tracking methods is increasingly used to assess the amount and severity of cerebral ischemia in acute stroke. Using relative perfusion maps, however, it is difficult to identify the tissue at risk-maximum (TARM) of infarction with sufficient reliability and reproducibil...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X158956
更新日期:2007-04-01 00:00:00
abstract::In this study the pulsation-pressure relationship in an experimental model of aneurysms was analyzed. In addition, we have examined pulsatility of the aneurysmal wall reinforced by Guglielmi Detachable Coils (GDC). Bifurcation (BAn), aneurysms (LAn) and bilobar (BiA) aneurysms were produced in 15 mongrel dogs. The ane...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1996.11740440
更新日期:1996-08-01 00:00:00
abstract::We describe a novel approach for analysing the hemodynamic alterations that result after focal cerebral ischemia. This approach utilizes a temporal correlation analysis of first pass transit data obtained with functional imaging. First pass transits of injected contrast agents are measured with dynamic CT scanning. No...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1996.11740394
更新日期:1996-04-01 00:00:00
abstract::This paper summarizes the work of developing and analyzing a mathematical model of schizophrenia. First the psychological and physiological studies of patients with periodic catatonia made by R. R. Gjessing are briefly described. Then a mathematical model, which is based on Gjessing's work and consists of a set of non...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1979.11739544
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVES:The suppressor gene maspin (Serpin B5) is a promising candidate for future treatment. We have examined the messenger RNA (mRNA) and protein expression of maspin in normal breast tissue, breast cancer primaries, brain metastases and breast cancer cell lines. Results were compared to hormone receptor expressio...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164109X12518779082192
更新日期:2010-04-01 00:00:00
abstract::Electrical stimulation of peripheral nerves can be used to cause muscle contraction, to activate reflexes, and to modulate some functions of the central nervous system (neuromodulation). If applied to the spinal cord or nerves controlling the lower urinary tract, electrical stimulation can produce bladder or sphincter...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164102101200294
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVE:This study examined whether a needle-free acupuncture can be an alternative to conventional needle injection acupuncture. METHODS:Patients (n=101) suffering myofascial shoulder pain were randomly assigned to either needle-free or conventional needle injection acupuncture group. Bee venom was administered int...
journal_title:Neurological research
pub_type: 杂志文章,随机对照试验
doi:10.1179/016164109X12537002793760
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVES:It has been suggested that metalloproteinase-9 (MMP-9) could predict the onset of cerebral vasospasm after subarachnoidal haemorrhage (SAH). The aim of this study was to analyse, in patients with SAH, the difference between patients with MRI ischaemic infarcts and patients without, and to investigate the rol...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132815Y.0000000045
更新日期:2015-08-01 00:00:00
abstract::Recent evidence indicates that different vascular risk factors are present in Alzheimer's disease (AD) and other prevalent dementia types probably contributing to deterioration of cerebrovascular function, thus enhancing neurodegeneration and premature neuronal death due to a reduction in brain perfusion. Brain blood ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164103101202002
更新日期:2003-09-01 00:00:00
abstract::Intraoperative use of somatosensory evoked potentials (SEP's) to monitor intracranial aneurysm surgery and flash visual evoked potentials (F-VEP's) for parasellar surgery have been routinely employed in our clinic. We found that both EP modalities are sensitive to the changing concentration of our standard hypotensive...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1985.11739701
更新日期:1985-06-01 00:00:00
abstract::This investigation was designed to clarify the chronic effects of cardiogenic emboli on cerebral perfusion and tissue densities within remaining noninfarcted brain. Local cerebral perfusion and tissue densities were measured by xenon-contrasted CT scanning and compared by cross-sectional designs among normal volunteer...
journal_title:Neurological research
pub_type: 杂志文章
doi:
更新日期:1995-10-01 00:00:00
abstract::The possibility of the evaluation of ischemia solely by the momentary values of regional cerebral blood flow (rCBF) was investigated. Ischaemic damage was evaluated histopathologically and by observing albumin extravasation. Unilateral carotid clippings were performed for 1 h and the gerbils evaluated with regard to t...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1988.11739846
更新日期:1988-12-01 00:00:00
abstract::Ahead of Print article withdrawn by publisher. ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164109X12445616596283
更新日期:2009-08-21 00:00:00
abstract::Excessive calcium influx has been implicated in the pathophysiology of ischemic cerebral damage. The effects of nimodipine, a calcium antagonist, on the Na(+)-K+/MG+2 ATPase activity, Ca+2/Mg+2 ATPase, lipid peroxidation, and early ultrastructural findings were examined at the acute stage of ischemia in the rat brain....
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164101101198208
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:To investigate mechanisms behind the faster rehabilitation of limb fractures when associated with traumatic brain injury (TBI). METHODS:New Zealand rabbits were divided into TBI group and sham-operation group for four studies as follows: (1) blood and cerebrospinal fluid (CSF) were drawn on days 1, 3, and 7 ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000201
更新日期:2013-06-01 00:00:00
abstract::Objectives: Neurovascular compression syndromes (NVCS) could be cured with an intravascular device that releases compression of the root entry zone of cranial nerves by changing the course of offending vessels. The purpose of this study was to report our results of in vitro and in vivo experiments with a novel intra-a...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2019.1611009
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVES:Catalpol has been identified to have neuroprotective effect on gerbils subjected to transient global cerebral ischemia. However, the mechanism that catalpol prevents ischemia is still unclear. In the present study, PC12 cells, exposed to oxygen and glucose deprivation (OGD) followed by reperfusion, were used...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X229894
更新日期:2008-02-01 00:00:00
abstract::The endogenous clock of humans can be influenced by light application to the popliteal region. Previously, it had been assumed that light must fall directly into the eye in order to influence the inner circadian clock. This study, published in 1998, has not been reproduced. We investigated the effects of laser light i...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164101101199388
更新日期:2001-12-01 00:00:00
abstract::Recovery of motor function following stroke is believed to be supported, at least in part, by functional compensation involving residual neural tissue. The present study used a rodent model of focal ischemia and intracortical microstimulation (ICMS) to examine the behavioral and physiological effects of cortical stimu...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164103771953862
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVE:We sought to assess the current status of blood pressure control and the use of antihypertensive drugs in patients with ischemic stroke (IS) or transient ischemic attack (TIA) in China. SUBJECTS AND METHODS:A cross-sectional study (across 19 urban outpatient clinics) on secondary stroke prevention measures w...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X300323
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVES:Ischemia/hypoxia (I/H) causes severe neonatal brain injury, such as periventricular leukomaracia and hypoxic/ischemic encephalopathy. Neural stem cell research could lead to a treatment for such disorders. In order to elucidate the dynamic changes in neural stem cells in the neonatal brain after I/H, we inve...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164105X49283
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVES:Progesterone modulates dopamine (DA) release in corpus striatum. Our objective was to evaluate the effect of the i.c.v injection of the neurosteroid allopregnanolone (ALL), a progesterone metabolite on dopaminergic activity in the corpus striatum of rats under different gonadal hormonal conditions. METHODS:...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X166281
更新日期:2007-09-01 00:00:00
abstract::The intracranial aneurysm, with an estimated occurrence of up to 4% in the general population, belongs among the most dangerous of cerebrovascular diseases. Although less than one-fifth of these cases results in a subarachnoid haemorrhage, the resulting disability and mortality rate is too high. More understanding is ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1991.11739995
更新日期:1991-12-01 00:00:00
abstract::Acute presentation of Type I Chiari malformation in children is distinctly rare. An 11 year old male suffered a trauma to the right temporal-parietal region in a tobogganing accident resulting in an open depressed skull fracture. Radiographic evaluation included a Computed Tomographic scan which also demonstrated a si...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740599
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:Acquired neurological diseases such as severe traumatic brain or spinal cord injury (SCI) cause irreversible disability. Olfactory ensheathing cell (OEC) transplantation has been trialed as a promising SCI treatment. Extracellular vesicles (EVs), which regulate cell-cell interactions, have recently garnered e...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1794371
更新日期:2020-11-01 00:00:00