Abstract:
:Objectives: To investigate the thrombolysis with recombinant human prourokinase (rhPro-UK) on thromboembolic stroke in rats at different therapeutic time windows (TTW). Methods: Rats were subjected to embolic middle cerebral artery occlusion. RhPro-UK and positive control drugs rt-PA,UK were administered 3 h, 4.5 h, 6 h after inducing thromboem-bolic stroke. Neurological deficit scoring (NDS) was evaluated at 6 h and 24 h after the treatment. The lesion volume in cerebral hemispheres was measured by MRI scanning machine after 6 h of thrombolysis, and the infarct volume was measured by TTC stain, together with hemorrhagic volume quantified by a spectrophotometric assay after 24 h of thrombolysis. Results: RhPro-UK 10, 20 × 104 U/kg significantly improved the NDS after cerebral thromboembolism in rats at 3 h, 4.5 h TTW, and at the 6 h TTW, the NDS was improved by 28.0% (P = 0.0690) and 29.2% (P = 0.0927) at 6 h and 24 h after rhPro-UK 20 ×104 U/kg administration, respectively. RhPro-UK 10, 20 × 104 U/kg significantly reduced the brain lesions measured by MRI at 3 h and 4.5 h TTW. RhPro-UK 10, 20 × 104 U/kg significantly reduced the cerebral infarction measured by TTC at 3 h, 4.5 h TTW. There was no increase in cerebral hemorrhage compared with untreated group after rhPro-UK administration. Conclusions: RhPro-UK had an obvious therapeutic effect on ischemic stroke caused by thrombosis, and could be started within 4.5 h TTW with less side effects of cerebral hemorrhage than that of UK.
journal_name
Neurol Resjournal_title
Neurological researchauthors
Hao CH,Ding WX,Sun Q,Li XX,Wang WT,Zhao ZY,Tang LDdoi
10.1080/01616412.2019.1672388subject
Has Abstractpub_date
2019-11-01 00:00:00pages
1034-1042issue
11eissn
0161-6412issn
1743-1328journal_volume
41pub_type
杂志文章abstract::Sixty-five years old patient suffering from acute stroke was treated by rTPA intravenously. TCD monitoring of both middle cerebral arteries (MCA) was carried out simultaneously with administration of rTPA. Seven microemboli were found in right and four in left MCA. Duplex ultrasound, CT angiography and digital subtrac...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X289589
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:Surgical resection of complex glomus vagale tumors can be complicated by extensive blood loss and might require surgical sacrifice of an encased internal carotid artery. METHODS:A young patient presented with mass effect from glomus valage tumor. Computerized tomography angiography showed an encased interna...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/1743132812Y.0000000036
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:Meningiomas are benign intracranial tumors growing from the arachnoid cap cells. Although their behavior is usually benign, they tend to recur even after total removal, and their recurrence is dependent on different aspects. METHODS:Between 1991 and 2002, 463 patients with an intracranial meningioma were ope...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X338043
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:To explore whether intracranial pulse pressure amplitudes relate to arterial pulse pressure amplitudes and whether correlations between time-related changes in intracranial and arterial pulse pressure amplitudes associate with indices of cerebral autoregulation. METHODS:A total of 257 continuous and simultan...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164107X172167
更新日期:2007-09-01 00:00:00
abstract::The purpose of the present study was to examine the effect of nilvadipine (a dihydropyridine-type calcium entry blocker) on the cerebral circulation, experimental models of cerebral ischemia were used to measure abrupt changes in the cortical cerebral blood flow (CBF) at the 'penumbra' (the boundary region between the...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1996.11740430
更新日期:1996-08-01 00:00:00
abstract:OBJECTIVE:To investigate the clinical application of adjuvant coiling techniques in treating anterior-circulation wide-necked aneurysms. METHODS:Over 4·5 years, 93 anterior-circulation wide-neck aneurysms in 81 patients were treated with different endovascular techniques: balloon-assisted, stent-assisted, and double-m...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000234
更新日期:2013-12-01 00:00:00
abstract::Advances in neuromodulation techniques offer the promise of new therapeutic interventions for patients with neuropsychiatric maladies. Several complex social, ethical and policy issues will attend developments in this area. In this paper an ethical framework for clinical research in interventional cognitive neuroscien...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1080/01616412.2000.11740670
更新日期:2000-04-01 00:00:00
abstract::Neuronal nitric oxide synthase (nNOS) regulates neurogenesis in normal developing brain, but the role of nNOS in neurogenesis in the ischemic brain remains unclear. To investigate the temporal and spatial relationship between cell proliferation of the ependymal/subventricular zone (SVZ), a principal neuroproliferative...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164106X91942
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:This review will describe the novel contributions to the field of nerve repair from the emerging disciplines of microtechnology and nanotechnology. METHOD:This broad review will cover the advances described in the literature of the medical and biological fields and the engineering and physical sciences. The ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/174313208X362532
更新日期:2008-12-01 00:00:00
abstract::Magnetic resonance (MR) is a powerful new imaging modality which has recently become competitive with X-ray computed tomography (CT) for imaging of the central nervous system (CNS). The advantages of MR include lack of ionizing radiation and the necessity to use iodinated contrast. MR is able to image directly in the ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1080/01616412.1984.11739671
更新日期:1984-09-01 00:00:00
abstract::Cerebral blood flow (CBF), 113mIndium-DPTA, and 14C-glucose extraction were measured simultaneously in rat brain from 2 to 58 days following a thermal insult. In the early stage of a cold induced lesion (2 days), the blood-brain barrier (BBB) was disrupted with resulting leakage and diffusionary loss of both glucose a...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1980.11739556
更新日期:1980-01-01 00:00:00
abstract::Promyelocytic leukemia (PML) protein is involved in apoptotic death of cultured neuronal cells, but its role in ischemic brain damage remains uncertain. In this study, we investigated change of immunoreactivity for PML protein in rat brain after transient middle cerebral artery occlusion, and compared the results with...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164101101199162
更新日期:2001-10-01 00:00:00
abstract::The influence of acidic fibroblast growth factor (aFGF) on sleep was studied in conscious rabbits. An intravenous (i.v.) bolus injection of aFGF induced a significant increase in sleep duration in comparison with animals that received vehicle solution. Somnogenic effects were obtained 30 min following i.v. aFGF admini...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1996.11740472
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVES:Parkinson's disease (PD) afflicts approximately 1-2% of the population over 50 years of age. No cures or effective modifying treatments exist and clinical diagnosis is currently confounded by a lack of definitive biomarkers. We sought to discover potential biomarkers in the cerebrospinal fluid (CSF) of neuro...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132812Y.0000000063
更新日期:2012-09-01 00:00:00
abstract::Cerebral aneurysms are composed principally of collagen, a birefringent protein which is responsible for withstanding the forces of blood pressure. The known correlation between collagen birefringence and its mechanics provides the basis for using polarizing microscopy to evaluate the strength of collagen, layer by la...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1999.11740986
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:Crossed-uncrossed differentials (CUDs) are viewed as surrogates for interhemispheric transfer time (IHTT). Not uncommonly CUDs assume statistically significant negative values (inverted CUDs). This raises doubts of the accepted interpretation of CUDs, i.e. intra- and inter-hemispheric routings of signals in ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164106X115107
更新日期:2006-10-01 00:00:00
abstract::The possible role of nitric oxide (NO) on vibrissa-stimulated increase of regional cerebral cerebral blood flow (rCBF) and cerebral metabolic rate of glucose (rCMRglu) was investigated in conscious Wistar rats by using an inhibitor of NO synthase, NG-nitro-L-arginine (NOLAG) at a concentration of 30 mg/kg. In vivo aut...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1993.11740103
更新日期:1993-02-01 00:00:00
abstract:OBJECTIVE:Chronic subdural hematoma (cSDH) has an increasing incidence and results in high morbidity and mortality. We review here the 10-year experience of a single institution and the literature regarding the treatment and major associations of cSDH. METHODS:We retrospectively reviewed all cSDHs surgically treated f...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/1743132813Y.0000000166
更新日期:2013-04-01 00:00:00
abstract::The relationship between the states of spinal impact injuries and magnetically evoked electromyograms (EMGs) were studied in rats. Impact injuries to the spinal cord were induced at a depth of 0.25-2.0 mm by insertion of a cylinder tip measuring 2 mm in diameter into the lumbar vertebrae L1-L2. Magnetically induced el...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2000.11740747
更新日期:2000-10-01 00:00:00
abstract::1-Aminocyclopropanecarboxylic acid is a high affinity ligand with partial agonist properties at strychnine-insensitive glycine sites associated with the N-methyl-D-aspartate subtype of glutamate receptors. Since occupation of these sites appears required for operation of N-methyl-D-aspartate, receptor coupled cation c...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1995.11740324
更新日期:1995-08-01 00:00:00
abstract::A series of 15 arteriovenous malformations (AVMs) of the corpus callosum--9% of 170 intracranial AVMs admitted to the School of Medicine of the University of Rome during a 30-yr period--was studied. In all cases the lesion concerned mainly the corpus callosum, although in some it also involved the surrounding structur...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1982.11739626
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Ischemic stroke is one of the most common causes of death worldwide. Early and accurate prediction of outcome in acute ischemic stroke (AIS) is important and influences risk-optimized therapeutic strategies. We investigated the changes in high-sensitivity C-reactive protein (Hs-CRP) and homocysteine (HCY) le...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132813Y.0000000228
更新日期:2013-11-01 00:00:00
abstract:: Objectives : To detect and compare the features of interictal perfusion and volume asymmetry between temporal lobe epilepsy (TLE) patients with and without hippocampal sclerosis (HS). Methods : Sixty-one TLE patients (mean age ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1853988
更新日期:2020-12-15 00:00:00
abstract:OBJECTIVE:Venous compression might be the main cause of incomplete decompression and symptom recurrence after microvascular decompression (MVD) in patients with trigeminal neuralgia. Although it can be killed in most cases, cutting the vein sometimes has the potential risk arising from venous congestion. To maneuver th...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/174313208X289624
更新日期:2008-09-01 00:00:00
abstract::Supraventricular and ventricular tachyarrhythmia are established causes of syncope. We investigated the mean blood flow velocities (Vmean) of the middle cerebral arteries (MCA) during routine cardiac electrophysiologic studies in patients with supraventricular and ventricular tachyarrhythmias in order to evaluate the ...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.1998.11740555
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:The amyloid hypothesis stimulates the discovery of compounds, which promotes beta-amyloid peptide (Aβ) clearance, thereby altering the underlying pathophysiology of Alzheimer's disease (AD). Hence, the present study aims at the evaluation of anti-amyloidogenic potential of Gelidiella acerosa. METHODS:Prevent...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/1743132814Y.0000000422
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Acquired neurological diseases such as severe traumatic brain or spinal cord injury (SCI) cause irreversible disability. Olfactory ensheathing cell (OEC) transplantation has been trialed as a promising SCI treatment. Extracellular vesicles (EVs), which regulate cell-cell interactions, have recently garnered e...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2020.1794371
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVES:Microglial cells in spinal dorsal horn can be activated by nociceptive stimuli and the activated microglial cells release various cytokines enhancing the nociceptive transmission. However, the mechanisms underlying the activation of spinal microglia during nociceptive stimuli have not been well understood. I...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1080/01616412.2017.1281198
更新日期:2017-03-01 00:00:00
abstract::We investigated the neuroprotective effects of a novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor (pitavastatin) on ischemic neuronal damage in gerbils using immunohistochemistry. The animals were allowed to survive for 14 days after 5 min of ischemia induced by bilateral occlusion of the comm...
journal_title:Neurological research
pub_type: 杂志文章
doi:10.1179/016164104225014102
更新日期:2004-09-01 00:00:00
abstract::Recent evidence indicates that different vascular risk factors are present in Alzheimer's disease (AD) and other prevalent dementia types probably contributing to deterioration of cerebrovascular function, thus enhancing neurodegeneration and premature neuronal death due to a reduction in brain perfusion. Brain blood ...
journal_title:Neurological research
pub_type: 杂志文章,评审
doi:10.1179/016164103101202002
更新日期:2003-09-01 00:00:00