Association between Endothelial nitric oxide synthase G894T gene polymorphism and risk of ischemic stroke in North Indian population: a case-control study.

Abstract:

BACKGROUND AND PURPOSE:Stroke is a multi-factorial disease influenced by both genetic and environmental factors. The aim of this case-control study was to determine the association between Endothelial Nitric Oxide Synthase G894T (rs1799983) gene polymorphism and susceptibility to ischemic stroke (IS) in North Indian population. METHODS:In this present case-control study, genotyping was performed by using Polymerase chain reaction - Restriction fragment length polymorphism (PCR-RFLP) method for 250 IS patients and 250 age and sex matched controls. PCR results were confirmed by DNA sequencing. Frequency distribution of genotypes and alleles were compared between cases and controls using conditional logistic regression. RESULTS:Hypertension, Diabetes, Dyslipidemia, Low Socioeconomic Status and Family History of Stroke were found to be independent risk factors for IS. Mean age of cases and controls were 52.83 ± 12.59 and 50.97 ± 12.70 years. Multivariate logistic regression analysis showed a significant association between eNOS G894T (rs1799983) polymorphism and risk of IS [OR = 1.57; 95%CI 1.05-2.37; p = 0.028] under dominant model. Based on Trial of Org 10172 in Acute Stroke Treatment classification, an independent association of large vessel disease (LVD) was observed with the risk of IS under the dominant [OR = 2.09; 95% CI 1.17-3.75; p = 0.01] and recessive [4.09 95% CI 1.06-15.68; p = 0.04] models. All the observed genotype frequencies were in accordance with the Hardy-Weinberg equilibrium (HWE) in both cases and controls. CONCLUSION:The findings of the present study suggest that polymorphism in G894T position of eNOS gene might be a risk factor for IS mainly for LVD stroke subtype in North Indian population. Further large prospective studies are required to confirm these findings.

journal_name

Neurol Res

journal_title

Neurological research

authors

Kumar A,Misra S,Kumar P,Sagar R,Prasad K,Pandit AK,Chakravarty K,Kathuria P,Yadav AK

doi

10.1080/01616412.2016.1181376

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

575-9

issue

7

eissn

0161-6412

issn

1743-1328

journal_volume

38

pub_type

杂志文章
  • Hemodynamic alterations in focal cerebral ischemia: temporal correlation analysis for functional imaging.

    abstract::We describe a novel approach for analysing the hemodynamic alterations that result after focal cerebral ischemia. This approach utilizes a temporal correlation analysis of first pass transit data obtained with functional imaging. First pass transits of injected contrast agents are measured with dynamic CT scanning. No...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1996.11740394

    authors: Lo EH,Rogowska J,Batchelder KF,Wolf GL

    更新日期:1996-04-01 00:00:00

  • Resveratrol prevents global cerebral ischemia-induced decrease in lipid content.

    abstract:OBJECTIVE:The present study was undertaken to evaluate whether resveratrol (RSV) modulates membrane lipid composition, as well as on ganglioside profile in ischemia/reperfusion injury. METHODS:Global cerebral ischemia was induced by four-vessel occlusion for 10 minutes. RSV (30 mg/kg) or vehicle was intraperitoneally...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132812Y.0000000116

    authors: Simão F,Matté A,Breier AC,Kreutz F,Trindade VM,Netto CA,Salbego CG

    更新日期:2013-01-01 00:00:00

  • N omega-nitro-L-arginine attenuates early ischemic neuronal damage of prolonged focal cerebral ischemia and recirculation in rats.

    abstract::The present study aimed to examine the effects of N omega-nitro-L-arginine (LNA) on the early ischemic neuronal damage (EIND). All the experiments were carried out under general anesthesia, maintaining the blood gases and the body temperature within the physiological ranges. The local CBF, the topographically correspo...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1997.11740795

    authors: Matsui T,Nagafuji T,Mori T,Asano T

    更新日期:1997-04-01 00:00:00

  • Does the nutritional status of acute stroke patients affect the neurological status in the early post-stroke period?

    abstract::According to recent reports, malnutrition may be associated with a worse prognosis in stroke patients. The aim of this study was to determine the nutritional status of stroke patients and its impact on neurological and functional status of patients in the early post-stroke period. Our prospective study included a tota...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2019.1672379

    authors: Wierzbicki K,Horyniecki M,Mamak D,Szopa M,Buchała J,Stawarz G,Florek S,Adamczyk-Sowa M

    更新日期:2020-01-01 00:00:00

  • Electrical stimulation for the treatment of bladder dysfunction: current status and future possibilities.

    abstract::Electrical stimulation of peripheral nerves can be used to cause muscle contraction, to activate reflexes, and to modulate some functions of the central nervous system (neuromodulation). If applied to the spinal cord or nerves controlling the lower urinary tract, electrical stimulation can produce bladder or sphincter...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/016164102101200294

    authors: Jezernik S,Craggs M,Grill WM,Creasey G,Rijkhoff NJ

    更新日期:2002-07-01 00:00:00

  • Temporal profile of neural stem cell proliferation in the subventricular zone after ischemia/hypoxia in the neonatal rat brain.

    abstract:OBJECTIVES:Ischemia/hypoxia (I/H) causes severe neonatal brain injury, such as periventricular leukomaracia and hypoxic/ischemic encephalopathy. Neural stem cell research could lead to a treatment for such disorders. In order to elucidate the dynamic changes in neural stem cells in the neonatal brain after I/H, we inve...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164105X49283

    authors: Iwai M,Ikeda T,Hayashi T,Sato K,Nagata T,Nagano I,Shoji M,Ikenoue T,Abe K

    更新日期:2006-06-01 00:00:00

  • Non-invasive brainstem monitoring: the ocular microtremor.

    abstract::The ocular microtremor (OMT) is mediated by the oculomotor area of the brainstem and is altered in several pathologic states, including traumatic brain injury, general anesthesia, brain death, coma, Parkinsonism and multiple sclerosis. The EYETECT tremor monitor is a non-invasive means of measuring the frequency and a...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/016164107X240198

    authors: Robertson J,Timmons S

    更新日期:2007-10-01 00:00:00

  • The effects of the pre-treatment of intravenous nimodipine on Na(+)-K+/Mg+2 ATPase, Ca+2/Mg+2 ATPase, lipid peroxidation and early ultrastructural findings following middle cerebral artery occlusion in the rat.

    abstract::Excessive calcium influx has been implicated in the pathophysiology of ischemic cerebral damage. The effects of nimodipine, a calcium antagonist, on the Na(+)-K+/MG+2 ATPase activity, Ca+2/Mg+2 ATPase, lipid peroxidation, and early ultrastructural findings were examined at the acute stage of ischemia in the rat brain....

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164101101198208

    authors: Ildan F,Göçer AI,Tuna M,Polat S,Kaya M,Isbir T,Cetinalp E

    更新日期:2001-01-01 00:00:00

  • Homocysteine and ischemic stroke subtype: a relationship study in Chinese patients.

    abstract:OBJECTIVE:Elevated homocysteine level is a risk factor for ischemic stroke and associated with small vessel disease such as confluent leukoaraiosis in white and black population. We investigated the relationship between the total serum homocysteine level and ischemic stroke subtypes in Chinese population. METHODS:Thre...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164109X12445616596445

    authors: Ma Y,Zhao X,Zhang W,Liu L,Wang Y,Fang R,Wang Y

    更新日期:2010-07-01 00:00:00

  • Feasibility and limitations of the rat model by C6 gliomas implanted at the subcutaneous region.

    abstract::Although rat models implanted with C6 glioma cells have been widely utilized for the assessment of new therapeutic modalities, a convenient in vivo model is still required. We implanted C6 glioma cells into the brains and the abdominal subcutaneous regions of Wistar rats, and evaluated the volumes of the growing tumor...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164102101200221

    authors: Watanabe K,Sakamoto M,Somiya M,Amin MR,Kamitani H,Watanabe T

    更新日期:2002-07-01 00:00:00

  • Screening and treatment of unruptured cerebral aneurysms.

    abstract::Thirty outpatients with unruptured cerebral aneurysms screened by computed angiotomography have been analysed and followed up in our clinic since 1979. Seventeen were men and the age range was 41 to 74 years old (mean 57.7 years). Patients had no or only mild neurological symptoms, such as headache, sensorimotor or sp...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1986.11739736

    authors: Yamamoto Y,Asari S,Sunami N,Kunishio K,Fukui K,Sadamoto K

    更新日期:1986-06-01 00:00:00

  • Simultaneous recording of tissue PCO2, interstitial pH and potassium activity in the rat cerebral cortex during anoxia and the subsequent recovery period.

    abstract::Tissue PCO2 (carbon dioxide tension) (PtCO2), interstitial H+ (H+e) and potassium activities (K+e) were monitored in the cerebral cortex of rats during and after 2-3 min of anoxia. Anoxia was associated with systemic hypotension and caused H+e (extracellular hydrogen ion activity) to increase from pH approximately equ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1989.11739882

    authors: Ohno M,Obrenovitch TP,Hartell N,Barratt S,Bachelard HS,Symon L

    更新日期:1989-09-01 00:00:00

  • Expression of metastasis suppressor gene maspin is reduced in breast cancer brain metastases and correlates with the estrogen receptor status.

    abstract:OBJECTIVES:The suppressor gene maspin (Serpin B5) is a promising candidate for future treatment. We have examined the messenger RNA (mRNA) and protein expression of maspin in normal breast tissue, breast cancer primaries, brain metastases and breast cancer cell lines. Results were compared to hormone receptor expressio...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164109X12518779082192

    authors: Stark AM,Schem C,Maass N,Hugo HH,Jonat W,Mehdorn HM,Held-Feindt J

    更新日期:2010-04-01 00:00:00

  • Does the siphon effect of cerebrospinal fluid shunting develop in vivo? Report of a case casting doubt on the presence of this phenomenon.

    abstract::A 52-year-old male underwent lumboperitoneal shunting after external decompressive craniectomy. His postoperative course was accompanied by remarkable displacement of the intracranial structures to the opposite side of craniectomy. This phenomenon, probably caused by the siphon effect of cerebrospinal fluid shunting, ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1991.11739979

    authors: Aoki N

    更新日期:1991-06-01 00:00:00

  • Optical coherence tomography angiography findings of multiple sclerosis with or without optic neuritis.

    abstract::Objective: Nowadays, retinal microvascular structures can be investigated using optical coherence tomography angiography (OCTA). We aimed to evaluate the probable vascular changes in the foveal and peripapillary regions of patients with multiple sclerosis (MS).Methods: A total of 20 patients with relapsing remitting m...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2020.1726585

    authors: Ulusoy MO,Horasanlı B,Işık-Ulusoy S

    更新日期:2020-04-01 00:00:00

  • Is fusion the most suitable treatment option for recurrent lumbar disc herniation? A systematic review.

    abstract:OBJECTIVE:Recurrent lumbar disc herniation (rLDH) is a common issue after primary discectomy and can cause severe pain, morbidity, and reoperation. The purpose of this systematic review was to evaluate the surgical management of recurrent lumbar disc herniation. METHODS:A systematic literature search was conducted usi...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2020.1787661

    authors: Arif S,Brady Z,Enchev Y,Peev N

    更新日期:2020-12-01 00:00:00

  • Combined clopidogrel-aspirin treatment for high risk TIA or minor stroke does not increase cerebral microbleeds.

    abstract:OBJECTIVES:To study whether Clopidogrel-Aspirin combined treatment for high risk transient ischaemic attack (TIA) or minor stroke results in increased number of lesions associated with anti-thrombotic cerebral haemorrhage or cerebral micro-bleeds (CMB) than aspirin alone treatment. METHODS:The patients recruited in CH...

    journal_title:Neurological research

    pub_type: 杂志文章,随机对照试验

    doi:10.1179/1743132815Y.0000000087

    authors: Wang Z,Xu C,Wang P,Wang Y,Xin H

    更新日期:2015-11-01 00:00:00

  • Sepsis associated encephalopathy.

    abstract:INTRODUCTION:Alteration of sensorium or an encephalopathy is a common diagnostic dilemma in critically ill patients and can be caused by a number of conditions. Sepsis associated encephalopathy (SAE) is now the most common encephalopathy encountered among intensive care unit (ICU) patients. DEFINITIONS:SAE is an encep...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/016164107X240233

    authors: Maramattom BV

    更新日期:2007-10-01 00:00:00

  • Surgical resection and reconstruction after resection of tumors involving the sacropelvic region.

    abstract:OBJECTIVES:Surgical management of tumors in the sacropelvic region is a challenging field of spine surgery because of the region's complex local anatomy and biomechanics. Recent developments in anesthesia and intensive care have allowed us to perform extended surgeries focused on the en bloc resection of sacropelvic tu...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/1743132814Y.0000000370

    authors: Varga PP,Szoverfi Z,Lazary A

    更新日期:2014-06-01 00:00:00

  • Bone mesenchymal stem cell-conditioned medium induces the upregulation of Smad6, which inhibits the BMP-4/Smad1/5/8 signaling pathway.

    abstract:OBJECTIVES:In this study, we aimed to investigate the effect of bone mesenchymal stem cells (BMSCs) conditioned medium on BMP4-induced activation of the Smad signaling pathway during the process of neural stem cells differentiation. METHODS:We designed four experimental groups: (A) control group, (B) BMP-4 treatment g...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2016.1232549

    authors: Fang H,Song P,Shen C,Liu X,Li H

    更新日期:2016-11-01 00:00:00

  • Association of glutathione S-transferases M1, P1 and T1 variations and risk of late-onset Alzheimer's disease.

    abstract:OBJECTIVE:Late-onset Alzheimer's disease (AD) is a genetically heterogeneous neurodegenerative disorder. Associations of the glutathione S-transferases (GSTs) polymorphisms with the risk factors for AD have not been definitely confirmed. We investigated the association of GSTM1 and GSTT1 null deletion and GSTP1 313 A/G...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2017.1390902

    authors: Jafarian Z,Saliminejad K,Kamali K,Ohadi M,Kowsari A,Nasehi L,Khorram Khorshid HR

    更新日期:2018-01-01 00:00:00

  • Effects of nilvadipine (a dihydropyridine-type calcium entry blocker) on cerebral blood flow in acute experimental brain ischemia in rats.

    abstract::The purpose of the present study was to examine the effect of nilvadipine (a dihydropyridine-type calcium entry blocker) on the cerebral circulation, experimental models of cerebral ischemia were used to measure abrupt changes in the cortical cerebral blood flow (CBF) at the 'penumbra' (the boundary region between the...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1996.11740430

    authors: Tanaka R,Miyasaka Y,Maruyama S,Nagai S,Fujii K

    更新日期:1996-08-01 00:00:00

  • Haemodynamic study of arteriovenous malformations using a hydraulic model.

    abstract::Despite the accumulation of intraoperative data on arteriovenous malformations (AVMs), details of the haemodynamics have not yet been elucidated. A hydraulic model was constructed from silicone and glass tubes to simulate a high-flow AVM. During stepwise obliteration of the nidus, haemodynamic changes were continuousl...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1993.11740174

    authors: Nagasawa S,Kawanishi M,Tanaka H,Ohta T,Nagayasu S,Kikuchi H

    更新日期:1993-12-01 00:00:00

  • Extracellular vesicles isolated from human olfactory ensheathing cells enhance the viability of neural progenitor cells.

    abstract:OBJECTIVE:Acquired neurological diseases such as severe traumatic brain or spinal cord injury (SCI) cause irreversible disability. Olfactory ensheathing cell (OEC) transplantation has been trialed as a promising SCI treatment. Extracellular vesicles (EVs), which regulate cell-cell interactions, have recently garnered e...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2020.1794371

    authors: Tu YK,Hsueh YH

    更新日期:2020-11-01 00:00:00

  • Embryonic chick cocultures of neuronal and muscle cells.

    abstract:OBJECTIVE:The aim of this report was to set up an effective experimental model of cocultures between cells from spinal cord explants and myotubes from adductor muscle. METHODS:We obtained neuronal cells from chick spinal cord explants at embryonic day 5 (ED5) by means of an enzymatic digestion. Small spinal cord fragm...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/174313208X281064

    authors: Martinello T,Patruno M

    更新日期:2008-03-01 00:00:00

  • Angiogenic capacity of human omental stem cells.

    abstract:OBJECTIVES:The goals of the present study are to obtain, expand and characterize a stem cell population from human omentum and to evaluate its in vivo angiogenic capacities. METHODS:Human omental CD34+ cells were obtained from samples of human omentum by density gradient centrifugation in Ficoll. Proliferative pattern...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164105X63674

    authors: García-Gómez I,Goldsmith HS,Angulo J,Prados A,López-Hervás P,Cuevas B,Dujovny M,Cuevas P

    更新日期:2005-12-01 00:00:00

  • Nitric oxide does not act as a mediator coupling cerebral blood flow to neural activity following somatosensory stimuli in rats.

    abstract::The possible role of nitric oxide (NO) on vibrissa-stimulated increase of regional cerebral cerebral blood flow (rCBF) and cerebral metabolic rate of glucose (rCMRglu) was investigated in conscious Wistar rats by using an inhibitor of NO synthase, NG-nitro-L-arginine (NOLAG) at a concentration of 30 mg/kg. In vivo aut...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1993.11740103

    authors: Wang Q,Kjaer T,Jørgensen MB,Paulson OB,Lassen NA,Diemer NH,Lou HC

    更新日期:1993-02-01 00:00:00

  • Improved maze learning through early music exposure in rats.

    abstract::Rats were exposed in utero plus 60 days post-partum to either complex music (Mozart Sonata (k. 448)), minimalist music (a Philip Glass composition), white noise or silence, and were then tested for five days, three trials per day, in a multiple T-maze. By Day 3, the rats exposed to the Mozart work completed the maze m...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1998.11740543

    authors: Rauscher FH,Robinson KD,Jens JJ

    更新日期:1998-07-01 00:00:00

  • Window narrowing: a new method for standardized assessment of the tissue at risk-maximum of infarction in CT based brain perfusion maps.

    abstract:BACKGROUND:Mapping of brain perfusion using bolus tracking methods is increasingly used to assess the amount and severity of cerebral ischemia in acute stroke. Using relative perfusion maps, however, it is difficult to identify the tissue at risk-maximum (TARM) of infarction with sufficient reliability and reproducibil...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164107X158956

    authors: Nabavi DG,Dittrich R,Kloska SP,Nam EM,Klotz E,Heindel W,Ringelstein EB

    更新日期:2007-04-01 00:00:00

  • Role of neuroinflammation and latent transcription factors in pathogenesis of Parkinson's disease.

    abstract::Parkinson's disease (PD) the second most common age-associated progressive neurodegenerative disorder is characterized by loss of dopaminergic neurons, cytoplasmic inclusions of aggregated proteins (Lewy bodies), and neuroinflammation. The inflammation of neurons causes release of various inflammatory mediators (IFNs,...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2016.1249997

    authors: Pal R,Tiwari PC,Nath R,Pant KK

    更新日期:2016-12-01 00:00:00