Effects of pretreatment with etomidate, ketamine, phenytoin, and phenytoin/midazolam on acute, lethal cocaine toxicity.

Abstract:

OBJECTIVE:To evaluate the effects of etomidate, ketamine, phenytoin, and phenytoin/midazolam in a mouse model of acute cocaine toxicity. METHODS:We performed a randomized controlled study consisting of five groups (n = 25 each) of rats that received intraperitoneal injections of normal saline solution, 5 mg/kg ketamine, 7.5 mg/kg etomidate, 40 mg/kg phenytoin, and 40 mg/kg phenytoin and 2 mg/kg midazolam 10 minutes before cocaine hydrochloride (105 mg/kg). Following cocaine administration, a blinded observer watched the animals for 30 minutes to assess seizures (popcorn jumping, tonic-clonic activity, or loss of righting reflex), and lethality for 30 minutes. RESULTS:The number of animals with seizures was lower in the etomidate (60%), phenytoin (40%), and phenytoin/midazolam (40%) groups (P<0.001). The etomidate (24%) and phenytoin/midazolam (16%) treatments were most effective in preventing lethality (P<0.001). Conversely, compared to the vehicle group (72%), cocaine-induced lethality was higher in the ketamine (84%) and phenytoin (92%) groups. All treatments prolonged the time to seizure, but this effect was most pronounced in the etomidate and phenytoin/midazolam groups, which also had the longest average time to lethality. DISCUSSION:The present study provides the first experimental evidence supporting the use of etomidate to treat cocaine-induced seizures. Notably, ketamine and phenytoin were ineffective. Our findings suggest that premedication with etomidate, phenytoin, and phenytoin/midazolam reduced seizure activity in an acute cocaine toxicity mouse model.

journal_name

Neurol Res

journal_title

Neurological research

authors

Erdur B,Degirmenci E,Kortunay S,Yuksel A,Seyit M,Ergin A

doi

10.1179/1743132812Y.0000000097

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

952-6

issue

10

eissn

0161-6412

issn

1743-1328

pii

ner2897

journal_volume

34

pub_type

杂志文章
  • Intra- and extracranial atherosclerotic disease: casting a new light on emerging trends.

    abstract::Intra- and extracranial atherosclerotic stenosis has been shown to be associated with an increased risk of secondary stroke mortality. Advances in invasive and non-invasive imaging modalities have improved analysis of hemodynamic changes and allowed better delineation of the integrity of intracranial collateralization...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1080/01616412.2016.1196871

    authors: Ding J,Wang X

    更新日期:2016-10-01 00:00:00

  • Mechanism of heat shock protein 72 induction in primary cultured astrocytes after oxygen-glucose deprivation.

    abstract::Induction of stress proteins is thought to be important in the protection of cells from a variety of environmental insults including heat, hypoxia and ischemia. The aim of this study was to compare the mechanism of induction of heat shock protein 72 (HSP72) in primary cultures of murine cortical astrocytes by heat and...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1996.11740380

    authors: Bergeron M,Mivechi NF,Giaccia AJ,Giffard RG

    更新日期:1996-02-01 00:00:00

  • Nimodipine ameliorates trauma-induced cochlear neuronal death.

    abstract::Excessive entry of Ca2+ into injured cochlear neurons activates various Ca(2+)-activated enzymes and subsequent spiral ganglion cell death. Therefore, preventing intracellular calcium overload by using Ca2+ channel antagonists may become an important countermeasure to spiral ganglion cell death. We experimentally inve...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164102101200889

    authors: Sekiya T,Yagihashi A,Asano K,Suzuki S

    更新日期:2002-12-01 00:00:00

  • Endovascular treatment of congenital carotid-cavernous fistulas in infancy.

    abstract::Congenital dural arteriovenous fistulas have been infrequently described in pediatric population and they generally affect the transverse, sigmoid, straight or sagittal sinuses. Congenital carotid-cavernous fistulas in infancy are considered very rare and to our knowledge, only four cases have been reported in literat...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/174313208X291612

    authors: Cohen JE,Gomori JM,Grigoriadis S,Rajz G

    更新日期:2008-07-01 00:00:00

  • Hyperglycaemia protects against neuronal injury around experimental brain infarcts.

    abstract::Regional glucose utilization was measured in the rat brain after occlusion of the middle cerebral artery. Normoglycaemic rat had increased glucose use in the cerebral cortex adjacent to the infarct. A fraction of the nerve cells were irreversibly injured in this region. In hyperglycaemic rats, the glucose metabolism r...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1987.11739802

    authors: Nedergaard M,Gjedde A,Diemer NH

    更新日期:1987-12-01 00:00:00

  • Mutations in GBA and risk of Parkinson's disease: a meta-analysis based on 25 case-control studies.

    abstract::The association between glucocerebrosidase (GBA) mutations and Parkinson's disease (PD) is attracting increased attention worldwide. Results from previous studies on the association of GBA mutations with PD in different ethnicities remain contradictory. In order to derive a more comprehensive understanding of the rela...

    journal_title:Neurological research

    pub_type: 杂志文章,meta分析,评审

    doi:10.1179/1743132813Y.0000000224

    authors: Mao X,Wang T,Peng R,Chang X,Li N,Gu Y,Zhao D,Liao Q,Liu M

    更新日期:2013-10-01 00:00:00

  • Differentiation of HT22 neurons induces expression of NMDA receptor that mediates homocysteine cytotoxicity.

    abstract:INTRODUCTION:Neurotoxic homocysteine (Hcy) is thought to be an independent risk factor for neurodegenerative diseases, including Alzheimer's disease. This study is to determine whether HT22 cells, a murine hippocampal neuronal model, can be used as an in vitro model, besides the primary neuronal cultures, to investiga...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132811Y.0000000057

    authors: Zhao Z,Lu R,Zhang B,Shen J,Yang L,Xiao S,Liu J,Suo WZ

    更新日期:2012-01-01 00:00:00

  • Neuroprotection with NBQX and thrombolysis with rt-PA in rat embolic stroke.

    abstract::The efficacy of delayed thrombolysis with recombinant tissue plasminogen activator was tested in combination with the ischaemic protecting drug NBQX in an embolic stroke model. In 113 rats the carotid territory was embolized with a fibrin-rich clot formed in polyethylene tube. Hemispheric cerebral blood flow (CBF) was...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1993.11740159

    authors: Overgaard K,Sereghy T,Pedersen H,Boysen G

    更新日期:1993-10-01 00:00:00

  • Non-invasive brainstem monitoring: the ocular microtremor.

    abstract::The ocular microtremor (OMT) is mediated by the oculomotor area of the brainstem and is altered in several pathologic states, including traumatic brain injury, general anesthesia, brain death, coma, Parkinsonism and multiple sclerosis. The EYETECT tremor monitor is a non-invasive means of measuring the frequency and a...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/016164107X240198

    authors: Robertson J,Timmons S

    更新日期:2007-10-01 00:00:00

  • Effects of popliteal illumination on cerebral near-infrared spectroscopy.

    abstract::The endogenous clock of humans can be influenced by light application to the popliteal region. Previously, it had been assumed that light must fall directly into the eye in order to influence the inner circadian clock. This study, published in 1998, has not been reproduced. We investigated the effects of laser light i...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164101101199388

    authors: Litscher G

    更新日期:2001-12-01 00:00:00

  • Diffusion tensor MRI for the assessment of cerebral ischemia/reperfusion injury in the penumbra of non-human primate stroke model.

    abstract:OBJECTIVES:The purpose of this study is to use diffusion tensor imaging (DTI) parameters to evaluate cerebral ischemia/reperfusion injury in the infarct core (IC) and ischemic penumbra (IP) in a rhesus transient middle cerebral artery occlusion (MCAO) model. METHODS:Seven rhesus monkeys were used to construct the MCAO...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164110X12761752770177

    authors: Guo J,Zheng HB,Duan JC,He L,Chen N,Gong QY,Tang HH,Li HX,Wang L,Cheng JQ

    更新日期:2011-01-01 00:00:00

  • Association between peridural scar and activity-related pain after lumbar discectomy.

    abstract::The purpose of this study was to investigate the correlation between activity-related pain six months after first surgery for herniated lumbar disc, and the extent of lumbar epidural fibrosis present at the surgical site, assessed by magnetic resonance imaging. The 298 patients who underwent surgery for lumbar disc he...

    journal_title:Neurological research

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1080/01616412.1999.11741025

    authors: BenDebba M,Augustus van Alphen H,Long DM

    更新日期:1999-01-01 00:00:00

  • The relationship of asymptomatic intracranial artery stenosis and Framingham stroke risk profile in a Northern Chinese industrial city.

    abstract:BACKGROUND:Intracranial artery stenosis may be the most frequent cause of ischemic stroke in the world. Early detection of asymptomatic intracranial artery stenosis may allow for therapeutic intervention. Most elements of the Framingham stroke risk profile (FSRP) are also risk factors for intracranial artery stenosis....

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132812Y.0000000024

    authors: Zhang Y,Wu S,Jia Z,Zhou Y,Liu X,Wang W,Wang T,Wang L,Zhang S,Jin C,Zhao X

    更新日期:2012-05-01 00:00:00

  • Is hyperlipidemia correlated with longer survival in patients with amyotrophic lateral sclerosis?

    abstract::Amyotrophic lateral sclerosis (ALS) is the most serious form of degenerative motor neuron disease in adults, whose relentless course leads to death within 2-5 years, generally due to respiratory failure. Apart from the age and site of onset, no other factors have consistently demonstrated to be related to the ALS outc...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132812Y.0000000049

    authors: Dedic SI,Stevic Z,Dedic V,Stojanovic VR,Milicev M,Lavrnic D

    更新日期:2012-07-01 00:00:00

  • Recurrence of intracranial meningiomas: did better methods of diagnosis and surgical treatment change the outcome in the last 30 years?

    abstract:OBJECTIVE:Meningiomas are benign intracranial tumors growing from the arachnoid cap cells. Although their behavior is usually benign, they tend to recur even after total removal, and their recurrence is dependent on different aspects. METHODS:Between 1991 and 2002, 463 patients with an intracranial meningioma were ope...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/174313208X338043

    authors: Strassner C,Buhl R,Mehdorn HM

    更新日期:2009-06-01 00:00:00

  • Reduction of nerve growth factor receptor immunoreactivity in ischaemic gerbil hippocampal CA1 neurons after treatment with L-threo-3,4-dihydroxyphenylserine (DOPS).

    abstract::Nerve growth factor (NGF) synthesis in cultured mouse L-M fibroblast and astroglial cells can be increased after the treatment with L-threo-3,4-dihydroxyphenylserine (DOPS). Since the increase of NGF is not blocked by the treatment with decarboxylase inhibitor, DOPS may have direct effect to increase the NGF content. ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1994.11740227

    authors: Lee TH,Abe K,Nakamura M,Kogure K,Itoyama Y

    更新日期:1994-06-01 00:00:00

  • Haemodynamic study of arteriovenous malformations using a hydraulic model.

    abstract::Despite the accumulation of intraoperative data on arteriovenous malformations (AVMs), details of the haemodynamics have not yet been elucidated. A hydraulic model was constructed from silicone and glass tubes to simulate a high-flow AVM. During stepwise obliteration of the nidus, haemodynamic changes were continuousl...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1993.11740174

    authors: Nagasawa S,Kawanishi M,Tanaka H,Ohta T,Nagayasu S,Kikuchi H

    更新日期:1993-12-01 00:00:00

  • Yoga-plus exercise mix promotes cognitive, affective, and physical functions in elderly people.

    abstract::Objectives: Increased attention is being paid to Asian medicine in balanced total health care. We investigated the effects of mixed exercise including yoga ('Yoga-plus') among elderly individuals. Methods: A total of 385 subjects (72 males and 313 females, 75.5 ± 8.7 years old) participated in a 12-month (M) exercise ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2019.1672380

    authors: Hishikawa N,Takahashi Y,Fukui Y,Tokuchi R,Furusawa J,Takemoto M,Sato K,Yamashita T,Ohta Y,Abe K

    更新日期:2019-11-01 00:00:00

  • Diffusion tensor tractography to visualize axonal outgrowth and regeneration in a 4-cm reverse autograft sciatic nerve rabbit injury model.

    abstract:BACKGROUND:Diffusion tensor tractography (DTT) has recently been shown to accurately detect nerve injury and regeneration. This study assesses whether 7-tesla (7T) DTT imaging is a viable modality to observe axonal outgrowth in a 4 cm rabbit sciatic nerve injury model fixed by a reverse autograft (RA) surgical techniqu...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2018.1554284

    authors: Farinas AF,Pollins AC,Stephanides M,O'Neill D,Al-Kassis S,Esteve IVM,Colazo JM,Keller PR,Rankin T,Wormer BA,Kaoutzanis C,Dortch RD,Thayer WP

    更新日期:2019-03-01 00:00:00

  • Odontoid calcification and crowned dens syndrome: data from a Chinese center.

    abstract:OBJECTIVES:To assess the prevalence of calcification surrounding the odontoid process (odontoid calcification) with crowned dens syndrome (CDS) and without CDS (non-CDS) and investigate factors that may related to the onset of CDS. METHODS:Retrospective review of consecutive patients visited Sir Run Run Shaw Hospital ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2020.1792700

    authors: Lu PL,Niu ZF,Qiu CW,Hu XY

    更新日期:2020-11-01 00:00:00

  • The effects of human corticotrophin releasing factor on motor and cognitive deficits after impact acceleration injury.

    abstract::Corticotrophin releasing factor has been shown in several models of tissue injury to be an effective treatment for edema. In a previous study we demonstrated this ability in two models of traumatic brain injury (TBI). The aim of this study was to assess whether human corticotrophin releasing factor (hCRF) could additi...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2000.11740737

    authors: Beaumont A,Marmarou C,Marmarou A

    更新日期:2000-10-01 00:00:00

  • The effect of normothermic and hypothermic hypoxia-ischemia on brain hypoxanthine phosphoribosyl transferase activity.

    abstract:OBJECTIVES:Cerebral hypoxia-ischemia leads to the depletion of ATP. Hypoxanthine, a degradation product of ATP, can be salvaged by hypoxanthine phosphoribosyl transferase (HPRT) and used to reform high-energy purines. Hypothermia conserves ATP in hypoxia-ischemia, possibly by preserving HPRT activity. We hypothesized t...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164105X49229

    authors: Cherin T,Catbagan M,Treiman S,Mink R

    更新日期:2006-12-01 00:00:00

  • WITHDRAWN: Activation of TLR4/NF-kappaB signaling pathway in early brain injury after subarachnoid hemorrhage.

    abstract::Ahead of Print article withdrawn by publisher. ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164109X12445616596283

    authors: Ma CX,Yin WN,Cai BW,He M,Wu J,Wang JY,Zeng Y,Ding JL,You C

    更新日期:2009-08-21 00:00:00

  • Temporal and spacial changes of highly polysialylated neural cell adhesion molecule immunoreactivity in amygdala kindling development.

    abstract::To investigate the migration of neural stem cells as well as neural plastic changes in epileptic brain, spaciotemporal expression of immunoreactive highly polysialylated neural cell adhesion molecule (PSA-NCAM) was examined in amygdala kindling development of rat. The neural migration and synaptic remodeling detected ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/016164103101200969

    authors: Sato K,Iwai M,Nagano I,Shoji M,Abe K

    更新日期:2003-01-01 00:00:00

  • Characterization of the anxiolytic and sedative profile of JM-20: a novel benzodiazepine-dihydropyridine hybrid molecule.

    abstract:OBJECTIVES:The aim of this study was to investigate the effects of oral administration of a novel benzodiazepine derivative, JM-20, on the neurological behavior of different rodent models, focusing on the GABAergic effect. We have also investigated the acute toxicity of oral administration of JM-20 in mice. METHODS:Mi...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132813Y.0000000216

    authors: Figueredo YN,Rodríguez EO,Reyes YV,Domínguez CC,Parra AL,Sánchez JR,Hernández RD,Verdecia MP,Pardo Andreu GL

    更新日期:2013-10-01 00:00:00

  • Neurosurgical treatment of multiple sclerosis.

    abstract:OBJECTIVES:To describe the role of neurosurgical techniques in treatment of symptoms of multiple sclerosis (MS). METHODS:A review of the existing world literature searching (using PubMed, August 22, 2005) for key words 'multiple sclerosis' and multiple symptoms associated with MS including trigeminal neuralgia, pain (...

    journal_title:Neurological research

    pub_type: 杂志文章,评审

    doi:10.1179/016164106X98224

    authors: Patwardhan RV,Minagar A,Kelley RE,Nanda A

    更新日期:2006-04-01 00:00:00

  • Brain volume and perfusion asymmetry in temporal lobe epilepsy with and without hippocampal sclerosis.

    abstract:: Objectives : To detect and compare the features of interictal perfusion and volume asymmetry between temporal lobe epilepsy (TLE) patients with and without hippocampal sclerosis (HS). Methods : Sixty-one TLE patients (mean age ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2020.1853988

    authors: Zhang Y,Dou W,Zuo Z,You H,Lv Y,Hou B,Shi L,Feng F

    更新日期:2020-12-15 00:00:00

  • Augmentation of endoplasmic reticulum stress in cerebral ischemia/reperfusion injury associated with comorbid type 2 diabetes.

    abstract:OBJECTIVE:Diabetes is one of the major risk factors for ischemic stroke and is reported to aggravate the ischemic brain damage in different experimental models as well as clinical situations. However, the mechanisms underlying the exacerbated ischemia/reperfusion (I/R) brain injury associated with comorbid diabetes ar...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1179/1743132811Y.0000000015

    authors: Srinivasan K,Sharma SS

    更新日期:2011-10-01 00:00:00

  • Cognitive functions in pediatric multiple sclerosis: 2-years follow-up.

    abstract::Objective: To assess the neuropsychological status of pediatric multiple sclerosis (MS) patients and its relationship with clinical variables in a longitudinal study.Methods: Patients with MS (n = 46) and age- and gender-matched healthy control subjects (HCs, n = 53) were given tests of non-verbal reasoning, attention...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.2019.1710417

    authors: Öztürk Z,Gücüyener K,Soysal Ş,Konuşkan GD,Konuşkan B,Dikmen AU,Anlar B

    更新日期:2020-02-01 00:00:00

  • An ultrastructural study on the reactive oligodendrocytes, myeloclasts, and myelophages in transected dog spinal cord.

    abstract::As early as 1 to 3 hr after cord transection, proliferation of many reactive oligodendrocytes was observed. Bundles of microfilaments and microtubules were observed in those cells that sent out long, complex pseudopodlike processes near the area of injury. These reactive oligodendrocytes may be comparable to Vaughn's ...

    journal_title:Neurological research

    pub_type: 杂志文章

    doi:10.1080/01616412.1980.11739566

    authors: Chang LW,Kao CC

    更新日期:1980-01-01 00:00:00