Minimum apparent diffusion coefficient for the differential diagnosis of ganglioglioma.

Abstract:

OBJECTIVES:The utility of apparent diffusion coefficient (ADC) values was evaluated for the differential diagnosis of ganglioglioma. METHODS:Ten consecutive patients, five men and five women, aged from 14 to 67 years, with histologically proven supratentorial gangliogliomas, underwent diffusion-weighted magnetic resonance imaging with echo planar imaging technique. The minimum ADC (minADC) of each tumor was pre-operatively determined from several regions of interest. The minADC of ganglioglioma was compared with that of low- or high-grade astrocytomas (astrocytoma, anaplastic astrocytoma and glioblastoma). Tumor cellularity of gangliogliomas was compared with the minADC. RESULTS:The mean minADC of the gangliogliomas (1.45 +/- 0.20 x 10(-3) mm(2)/s) was significantly higher than that of the low- or high-grade astrocytomas. Tumor cellularity of ganglioglioma was inversely correlated with the minADC value. DISCUSSION:The minADC value reflects in the low tumor cellularity of gangliogliomas and may provide a method for the differential diagnosis of ganglioglioma.

journal_name

Neurol Res

journal_title

Neurological research

authors

Kikuchi T,Kumabe T,Higano S,Watanabe M,Tominaga T

doi

10.1179/174313209X382539

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

1102-7

issue

10

eissn

0161-6412

issn

1743-1328

pii

ner1709

journal_volume

31

pub_type

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