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Immunogenicity and protective efficacy offered by a ribosomal-based vaccine from Shigella flexneri 2a.

Abstract：

:Shigellosis is a major form of bacillary dysentery caused by Shigella infection. Shigella ribosome-based vaccines (SRV), considered among the potent vaccine candidates, are composed of O-antigen and ribosome isolated from S. flexneri 2a. To investigate the immunogenicity and protective efficacy of SRV, mice were vaccinated with SRV via the intranasal (i.n.) route. Interestingly, robust levels of Shigella-derived LPS-specific IgG and IgA Abs and antibody-forming cells were elicited in systemic and mucosal compartments following two i.n. administrations of SRV. Groups of mice receiving i.n. SRV developed milder pulmonary pneumonia upon challenge with virulent S. flexneri 2a than did those receiving parenteral SRV. We further found that the MyD88-dependent TLR2 signal partially mediates SRV-induced mucosal immunity, with the exception of TLR4- and TLR5-governed innate immunity. Most importantly, polymeric immunoglobulin receptor knockout (pIgR-/-) mice, which lack secretory IgA Ab, were afforded less protective efficacy than were wild-type mice. It can be concluded then that SRV is immunogenic and provides protective efficacy in mice. It can also be surmised that a mucosal SRV vaccine would be particularly relevant in targeting shigellosis, which provokes inflammation in the human colon.

journal_name

Vaccine

journal_title

Vaccine

authors

Shim DH,Chang SY,Park SM,Jang H,Carbis R,Czerkinsky C,Uematsu S,Akira S,Kweon MN

doi

10.1016/j.vaccine.2007.03.050

subject

Has Abstract

pub_date

2007-06-15 00:00:00

pages

4828-36

issue

25

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(07)00405-7

journal_volume

25

pub_type

杂志文章

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