Abstract：
:A devastating disease spread by mosquitoes with high-efficiency, malaria imposes an enormous burden for which no licensed vaccine currently exists. Although the genome complexity of the parasite has made vaccine development tenuous, an effective malaria vaccine would be a valuable tool for control, elimination and eventual eradication. The Plasmodium serine repeat antigen 5 (SERA5) is an abundant asexual blood stage antigen that does not show any antigenic variation and exhibits limited polymorphism, making it a suitable vaccine candidate. Identified by comparing the IgG status of people in endemic areas with protective immunity and those with malaria symptoms, the vaccine potential of the N-terminal domain of Plasmodium falciparum SERA5 is also strongly supported by experimental data and immune responses both measured in vitro and in animal challenge models. The current understanding of SERA5 will be presented, particularly in relation to its path towards clinical development. The review highlights lessons learned and sorts out issues upon which further research efforts are needed.
journal_name
Vaccinejournal_title
Vaccineauthors
Palacpac NM,Arisue N,Tougan T,Ishii KJ,Horii Tdoi
10.1016/j.vaccine.2011.06.052subject
Has Abstractpub_date
2011-08-11 00:00:00pages
5837-45issue
35eissn
0264-410Xissn
1873-2518pii
S0264-410X(11)00916-9journal_volume
29pub_type
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