Abstract：
:Vaccination strategies against Klebsiella pneumoniae have largely focussed on the polysaccharide capsule. However, the large number and high prevalence of individual capsular serotypes limits the widespread applicability of capsule-based vaccines. This study establishes that immunization with purified LPS can protect mice against lethal challenge with K. pneumoniae, and that subcapsular antibodies directed against purified LPS can be used to treat and/or prevent experimental K. pneumoniae infection in mice. This approach offers potential for prophylaxis and/or therapy against drug-resistant strains of K. pneumoniae.
journal_name
Vaccinejournal_title
Vaccineauthors
Clements A,Jenney AW,Farn JL,Brown LE,Deliyannis G,Hartland EL,Pearse MJ,Maloney MB,Wesselingh SL,Wijburg OL,Strugnell RAdoi
10.1016/j.vaccine.2008.07.100subject
Has Abstractpub_date
2008-10-16 00:00:00pages
5649-53issue
44eissn
0264-410Xissn
1873-2518pii
S0264-410X(08)01007-4journal_volume
26pub_type
杂志文章相关文献
VACCINE文献大全abstract：:Mycobacterium w (Mw), is a cultivable, non-pathogenic mycobacterium and has been tried extensively as an immunomodulator in leprosy. This has been found to be safe and has shown beneficial immunoprophylactic effect in population based, double blind placebo controlled trials in North India. These effects were also obse...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2007.12.025
更新日期：2008-02-26 00:00:00
abstract：BACKGROUND:Use of a polysaccharide vaccine challenge to demonstrate immunologic memory after priming with capsular group C meningococcal conjugate vaccines (MenCC) risks induction of immunologic hyporesponsiveness. For this reason, MenCC vaccines are now used as probes of immunologic memory, however, no studies have de...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2016.10.038
更新日期：2016-12-07 00:00:00
abstract：:Influenza H3N2 viruses have recently drifted from A/Wisconsin/67/05-like to A/Brisbane/10/07-like viruses. The effect of key amino acid substitutions in the hemagglutinin (HA) protein on the replication, antigenicity and immunogenicity of cold-adapted, live attenuated vaccine strains was examined. A/Brisbane/10/07 egg...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.03.078
更新日期：2010-05-28 00:00:00
abstract：:A fusion protein, comprising the B subunit of the heat-labile enterotoxin and a portion of the precursor to the heat-stable enterotoxin of Escherichia coli, has been created by recombinant genetic techniques. It is exported successfully to the bacterial periplasm and assembles into pentamers which retain the ability t...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(93)90022-p
更新日期：1993-01-01 00:00:00
abstract：:Nucleic acid vaccination has many potential advantages over traditional methods, but suffers from the fact that DNA vaccines tend to be relatively poorly immunogenic. Attempts to enhance DNA vaccine immunogenicity have included the addition of cytokine-encoding plasmids into the formulation, as well as the use of hete...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.01.160
更新日期：2005-06-10 00:00:00
abstract：:Phage lambda particles displaying four immunodominant regions of porcine Circovirus 2 (PCV2) capsid protein (LDP-D-CAP) was shown to be immunogenic in pigs. The immunodominant regions were fused to the carboxyl-terminal of lambda head protein D. Expression of D-CAP on lambda display particles was demonstrated by ELISA...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.08.019
更新日期：2009-11-05 00:00:00
abstract：:Neisseria meningitidis is a leading cause of severe bacterial infections in infants and young children. As a major virulence factor, meningococcal capsular polysaccharide (PS) is poorly immunogenic and generally does not induce immunological memory. Conjugation of PS with a carrier protein can significantly increase t...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.09.021
更新日期：2015-10-26 00:00:00
abstract：:A gene associated with lipopolysaccharide (LPS) transport was cloned from a local clinical Vibrio cholerae O1 strain of the Ogawa serotype by using the Lactococcus lactis nisin-controlled expression (NICE) system. The V. cholerae wzm gene, which codes for an integral membrane transporter protein, was expressed and tar...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.02.012
更新日期：2012-05-02 00:00:00
abstract：BACKGROUND:In the Netherlands, a relatively low varicella disease burden compared to other European countries is observed within routine surveillance. To validate this, we estimated the varicella-related consultation rate using The Integrated Primary Care Information database. METHODS:In this retrospective cohort stud...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.04.034
更新日期：2014-06-12 00:00:00
abstract：:This randomized, double-blind trial conducted in the US and Canada was conducted to compare the safety and immunogenicity of two dosages of live attenuated oral monovalent G1 human rotavirus (HRV) vaccine administered orally at a 2-month interval concomitantly with routine childhood vaccines to healthy infants 5-15 we...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2005.07.030
更新日期：2006-05-01 00:00:00
abstract：CONTEXT:The true level of influenza vaccine efficacy is controversial and many factors may influence its estimation. OBJECTIVES:To estimate the efficacy of vaccination of children and non-elderly adults for the prevention of influenza and to explore the impact of type of vaccine, age, degree of strain matching, influe...
journal_title：Vaccine
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.vaccine.2012.10.084
更新日期：2012-12-17 00:00:00
abstract：:Human adenoviruses (AdVs) have been extensively studied as vectors for gene therapy and vaccination. However, little attention has been paid to AdV vaccine development and treatment. Currently, there is a lack of information concerning the immunogenicity of AdV major capsid proteins. Here, using AdV7 as a model, we co...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.05.118
更新日期：2018-07-05 00:00:00
abstract：:This large study investigates the associations between bovine major histocompatibility complex DRB3 alleles and their binding pockets with the immune response to a 40-mer peptide derived from foot-and-mouth disease virus (FMDV) VP1. A crossbred (Charolais and Holstein) cattle population (n=197) was immunised with the ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.09.131
更新日期：2009-12-10 00:00:00
abstract：:The epidemiology of infection due to Haemophilus influenzae type b (Hib) varies in different groups of Australian and New Zealand children. In most populations the annual case attack rate is approximately 40-60 per 100,000 children under 5 years of age and epiglottitis accounts for a relatively high but variable propo...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(91)90173-4
更新日期：1991-06-01 00:00:00
abstract：:Seasonal influenza epidemics are associated with high morbidity and mortality particularly in high-risk patients. Conventionally administered influenza vaccines show reduced efficacy in populations with weakened immune systems such as solid-organ transplant patients. This study assesses the safety and immunogenicity o...
journal_title：Vaccine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.vaccine.2010.08.015
更新日期：2010-10-04 00:00:00
abstract：:Patterns of microRNA expression appear to delineate the process of spontaneous neoplastic development-transformation (SPNDT) occurring in the African green monkey kidney (AGMK) VERO cell line (Teferedegne et al., 2010). Analysis of microarray data identified 6 microRNAs whose high-level of expression peaked when the W...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.04.004
更新日期：2017-10-04 00:00:00
abstract：:Post-licensure real world evaluation of vaccine implementation is important for establishing evidence of vaccine effectiveness (VE) and programme impact, including indirect effects. Large cohort studies offer an important epidemiological approach for evaluating VE, but have inherent methodological challenges. Since Ma...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2015.07.062
更新日期：2015-09-11 00:00:00
abstract：OBJECTIVE:To examine current vaccine sentiment on social media by constructing and analyzing semantic networks of vaccine information from highly shared websites of Twitter users in the United States; and to assist public health communication of vaccines. BACKGROUND:Vaccine hesitancy continues to contribute to subopti...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.05.052
更新日期：2017-06-22 00:00:00
abstract：INTRODUCTION:This study aimed to develop and undertake a preliminary validation of a French Survey Questionnaire for the Determinants of HPV Vaccine Hesitancy (FSQD-HPVH). METHODS:We undertook an electronic-based Delphi consultation among a panel of Francophone experts in two rounds. Round 1 consisted of the assessmen...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.07.027
更新日期：2020-09-03 00:00:00
abstract：:Effective immunoprophylaxis directed against the pre-erythrocytic stages of the malaria parasite requires a vaccine that can elicit humoral and cell mediated immunity in individuals of diverse genetic background. In order for a synthetic peptide malaria vaccine to meet these requirements, problems associated with gene...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(97)00238-7
更新日期：1998-04-01 00:00:00
abstract：:Neutralizing antibody is associated with the prevention and clearance of influenza virus infection. Microneutralization (MN) and hemagglutination inhibition (HI) assays are currently used to evaluate neutralizing antibody responses against human and avian influenza viruses, including H5N1. The MN assay is somewhat lab...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.08.056
更新日期：2009-11-12 00:00:00
abstract：BACKGROUND:Patients with inflammatory rheumatic diseases are at higher risk for influenza and current guidelines recommend vaccination for this group of patients. The aim of this study was to evaluate the vaccination coverage and predictors for influenza vaccination among patients with inflammatory rheumatic diseases. ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.06.065
更新日期：2018-08-06 00:00:00
abstract：:Topological and stereo-electron characteristics are essential in major histocompability class II-peptide-T-cell receptor (MHC-p-TCR) complex formation for inducing an appropriate immune response. Modified high activity binding peptides (mHABPs) were synthesised for complete full protection antimalarial vaccine develop...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.02.003
更新日期：2014-04-11 00:00:00
abstract：:Respiratory syncytial virus is one of the major respiratory pathogens for infants and immunocompromized children. With the exception of young children, all the population has encountered RSV and is seropositive. Recent reports have demonstrated however that the virus also affects the elderly and represents a major cau...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(00)00064-5
更新日期：2000-06-01 00:00:00
abstract：:Alternative DNA vaccine constructs such as fully synthetic linear expressing cassettes (LECs) offer the advantage of accelerated manufacturing techniques as well as the lack of both antibiotic resistance genes and bacterial contaminants. The speed of manufacture makes LEC technology a possible future vaccination strat...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.02.071
更新日期：2012-11-06 00:00:00
abstract：:We tested the hypothesis that removal of viral lipids using diisopropylether can enhance antigenicity of SIVmac251. DIPE delipidation removed cholesterol from SIVmac251 without significant loss of viral protein or RNA. Mice immunized with the same SIV preparation but boosted with delipidated SIVmac251 exhibited signif...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.04.038
更新日期：2005-09-07 00:00:00
abstract：:Multiple-antigen peptides (MAPs), containing B- and T-cell epitopes of the Plasmodium falciparum circumsporozoite (CS) protein, have been designed to overcome the limitations of first-generation peptide vaccines caused by low epitope density, carrier toxicity and the lack of parasite-derived T-cell epitopes. The immun...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(94)90337-9
更新日期：1994-08-01 00:00:00
abstract：:Several approaches are being taken worldwide to develop vaccines against H5N1 viruses; most of them, however, pose both practical and immunological challenges. One potential strategy for improving the immunogenicity of vaccines involves the use of alphavirus replicons and VP22, a herpes simplex type 1 (HSV-1) protein....
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.05.014
更新日期：2009-12-09 00:00:00
abstract：:Although 80% of HIV infections occur through mucosal routes and vaccine strategies need to be designed for inducing protective immune responses at the site of the viral entry, it has proven to be very challenging to measure these responses. A 2-day workshop was convened by Division of AIDS, National Institutes of Heal...
journal_title：Vaccine
pub_type：
doi：10.1016/j.vaccine.2010.04.092
更新日期：2010-07-05 00:00:00
abstract：:DNA vaccines are promising tools to fight parasitic diseases, including amoebiasis caused by the protozoan Entamoeba histolytica. Here we studied the immunogenicity and protective efficacy of a DNA vaccine against this parasite composed by the EhCPADH surface complex encoding genes (Ehcp112 and Ehadh112). EhCPADH is f...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.04.051
更新日期：2009-06-24 00:00:00
