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Bacille Calmette-Guérin vaccination at birth and differential white blood cell count in infancy. A randomised clinical trial.

Abstract：

BACKGROUND:The Bacille Calmette-Guérin (BCG) vaccine against tuberculosis (TB) may have beneficial non-specific effects (NSEs) beyond the protection against TB. This may be related to modifications of the innate immune system. We investigated the effect of BCG at birth on differential white blood cell (WBC) count in healthy, Danish infants. METHOD:The Danish Calmette Study randomised newborns to BCG at birth (Danish strain 1331, Statens Serum Institut) or no intervention. A sub-group of infants had blood samples collected 4 days after randomisation (n = 161), and at age 3 months (n = 152) and 13 months (n = 300). We evaluated the effect of BCG on WBC differential count (total leucocytes, lymphocytes, monocytes, eosinophil, neutrophil and basophil granulocytes (109 cells/L)) measured in peripheral blood. RESULTS:Overall, we found no effect of BCG on differential WBC counts at any time point. CONCLUSION:BCG at birth did not affect WBC count in our cohort of healthy, Danish infants.

journal_name

Vaccine

journal_title

Vaccine

authors

Jensen SK,Jensen TM,Birk NM,Stensballe LG,Benn CS,Jensen KJ,Pryds O,Jeppesen DL,Nissen TN

doi

10.1016/j.vaccine.2020.02.006

subject

Has Abstract

pub_date

2020-03-04 00:00:00

pages

2449-2455

issue

11

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(20)30171-7

journal_volume

38

pub_type

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