Abstract:
:The effect of passively transferred RSV immune serum on the antibody response to a single dose of purified RSV fusion (F) and large (G) glycoproteins was studied in cotton rats. Passively transferred antibody that achieved serum antibody levels similar to those seen in newborn human infants resulted in a seven- to eightfold suppression of the neutralizing antibody response of cotton rats to low doses of purified F and G glycoproteins (0.2-1.7 micrograms) and a twofold suppression to higher doses of these antigens (5-15 micrograms). This suppression of the antibody response was accompanied by a reduction in the protective efficacy of the F and G purified glycoprotein vaccine. These results suggest that parenteral immunization with RSV antigens could be less immunogenic in seropositive human infants, but that this suppressive effect might be partially overcome with increased antigen dose.
journal_name
Vaccinejournal_title
Vaccineauthors
Murphy BR,Prince GA,Collins PL,Hildreth SW,Paradiso PRdoi
10.1016/0264-410x(91)90151-usubject
Has Abstractpub_date
1991-03-01 00:00:00pages
185-9issue
3eissn
0264-410Xissn
1873-2518pii
0264-410X(91)90151-Ujournal_volume
9pub_type
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