Evaluation of a single dose of half strength inactivated influenza vaccine in healthy adults.

abstract：INTRODUCTION:In 2009, girls-only HPV16/18 vaccination was introduced in the Netherlands which has achieved 46-61% uptake. Heterosexual men have benefitted from herd protection, but it is unknown whether men who have sex with men (MSM) also benefit from herd effects of the girls-only HPV16/18 vaccination program. Becaus...

journal_title：Vaccine

authors： Woestenberg PJ,van Benthem BHB,Bogaards JA,King AJ,van der Klis FRM,Pasmans H,Leussink S,van der Sande MAB,Hoebe CJPA,Medical Microbiological Laboratories, the Public Health Services.

更新日期：2020-04-09 00:00:00

abstract：:Pharmacological manipulation of the balance between pro- and anti-inflammatory mediators emerges as a key aspect of a successful treatment of sepsis. A murine model of septic shock was developed and chosen conjugates (1a, 1b, 8a, 8c) and analogs (T2) of muramyl dipeptide and tuftsin were tested in this model as prospe...

journal_title：Vaccine

authors： Wardowska A,Dzierzbicka K,Szaryńska M,Dabrowska-Szponar M,Wiśniewska K,Myśliwski A,Trzonkowski P

更新日期：2009-01-14 00:00:00

abstract：:As the clinical experience with cancer vaccines and cancer immunotherapy increases, there are important lessons that can be learned from the successes and failures of past trials. Many lessons affect the design and conduct of clinical trials themselves. Appropriate patient selection, clinical trial design, immunologic...

journal_title：Vaccine

authors： Clifton GT,Kohrt HE,Peoples GE

更新日期：2015-12-16 00:00:00

abstract：BACKGROUND AND PURPOSE:Varicella disease is a risk factor for pediatric Arterial Ischemic Stroke (AIS). Isolated case reports have emerged suggesting that varicella vaccination may also pose a risk for AIS. METHODS:This retrospective population-based cohort study assessed the risk of AIS in children who received a var...

journal_title：Vaccine

authors： MacDonald SE,Dover DC,Hill MD,Kirton A,Simmonds KA,Svenson LW

更新日期：2018-05-11 00:00:00

abstract：BACKGROUND:Little is known about inactivated influenza vaccine effectiveness (IVE) in preventing very severe disease, including influenza-associated intensive care unit (ICU) admissions. METHODS:The Southern Hemisphere Influenza and Vaccine Effectiveness Research and Surveillance (SHIVERS) project enrolled adults (age...

journal_title：Vaccine

authors： Thompson MG,Pierse N,Sue Huang Q,Prasad N,Duque J,Claire Newbern E,Baker MG,Turner N,McArthur C,SHIVERS investigation team.

更新日期：2018-09-18 00:00:00

abstract：:The great clinical and economical impact of Toxoplasma gondii infections makes the development of an effective vaccine for controlling toxoplasmosis an extremely important aim. In the presented study, we evaluate the protective and immunogenic properties of three recombinant subunit vaccines composed of rROP2+rGRA4+rS...

journal_title：Vaccine

authors： Dziadek B,Gatkowska J,Brzostek A,Dziadek J,Dzitko K,Grzybowski M,Dlugonska H

更新日期：2011-01-17 00:00:00

abstract：INTRODUCTION:Determining vaccine responsiveness is challenging in immune compromised individuals. The microbead array (MBA) assay is a rapid, inexpensive test for evaluating influenza vaccine immunogenicity. MBA performance was compared to hemagglutination inhibition assay (HAI) utilizing HIV seropositive vaccine recip...

journal_title：Vaccine

authors： Thorne A,Chowdhury F,Singer J,Keynan Y,Fowke KR,Cooper C,CIHR Canadian HIV Trials Network (CTN) Influenza Vaccine Research Group.

更新日期：2016-06-30 00:00:00

abstract：:Recombinant canarypox (CP) and fowlpox (FP) viruses that contained two forms of the HIV-1 (SF2 strain) env gene were engineered and their expression analysed in chick, simian and human cells. These vectors can efficiently replicate in avian but not in mammalian cells, in which infection is abortive. The two forms, con...

journal_title：Vaccine

authors： Radaelli A,De Giuli Morghen C

更新日期：1994-09-01 00:00:00

abstract：INTRODUCTION:Two types of Japanese encephalitis (JE) vaccines, inactivated JE vaccine (JE-I) and live-attenuated JE vaccine (JE-L), are available and used in China. In particular, one JE-L, produced by a domestic manufacturer in China, was prequalified by WHO in 2013. We assessed the safety of JE vaccines in China duri...

journal_title：Vaccine

authors： Wu W,Liu D,Li K,Nuorti JP,Nohynek HM,Xu D,Ye J,Zheng J,Wang H

更新日期：2017-06-22 00:00:00

abstract：INTRODUCTION:Self-reported measles vaccination coverage is frequently used to inform vaccination strategies in resource-poor settings. However, little is known to what extent this is a reliable indicator of underlying seroprotection, information that could provide guidance ensuring the success of measles control and el...

journal_title：Vaccine

authors： Polonsky JA,Juan-Giner A,Hurtado N,Masiku C,Kagoli M,Grais RF

更新日期：2015-08-26 00:00:00

abstract：INTRODUCTION:Endemic measles persists in China, despite >95% reported coverage of two measles-containing vaccine doses and nationwide campaign that vaccinated more than 100 million children in 2010. In 2011, almost half of the 9943 measles cases in China occurred in children eligible for measles vaccination. We conduct...

journal_title：Vaccine

authors： Hao L,Ma C,Wannemuehler KA,Su Q,An Z,Cairns L,Quick L,Rodewald L,Liu Y,He H,Xu Q,Ma Y,Yu W,Zhang N,Li L,Wang N,Luo H,Wang H,Gregory CJ

更新日期：2016-12-12 00:00:00

abstract：:The influenza immunization program in North America has been primarily designed to provide direct benefit to vaccinated individuals at highest risk of serious influenza outcomes. Some evidence suggests that immunization of certain age groups may also extend indirect protective benefit to vulnerable populations. Our go...

journal_title：Vaccine

authors： Sebastian R,Skowronski DM,Chong M,Dhaliwal J,Brownstein JS

更新日期：2008-03-04 00:00:00

abstract：BACKGROUND:The Institute of Medicine, in a 2013 report, recommended that the Vaccine Safety Datalink (VSD) expand collaborations to include more diversity in the study population. Kaiser Permanente Colorado (KPCO), an established VSD site, partnered with Denver Health (DH), an integrated safety net healthcare system, t...

journal_title：Vaccine

authors： Narwaney KJ,Breslin K,Ross CA,Shoup JA,Wain KF,Weintraub ES,McNeil MM,Hambidge SJ

更新日期：2017-03-01 00:00:00

abstract：:To investigate the 1918/19 influenza pandemic daily number of new hospitalizations in the only hospital in Florence (Central Italy) were analyzed. In order to describe the transmission dynamics of the 1918/1919 pandemic influenza a compartmental epidemic model was used. Model simulations show a high level of agreement...

journal_title：Vaccine

authors： Rizzo C,Ajelli M,Merler S,Pugliese A,Barbetta I,Salmaso S,Manfredi P

更新日期：2011-07-22 00:00:00

abstract：BACKGROUND:Expression of recombinant hemagglutinin (rHA) in insect cells represents a technology with proven efficacy in seasonal influenza and with the potential for a rapid response to the emergence of new, pandemic strains. We evaluated the safety and immunogenicity of rHA vaccine (H5/Indonesia/5/05) produced in SF+...

journal_title：Vaccine

authors： Treanor JJ,Essink B,Hull S,Reed S,Izikson R,Patriarca P,Goldenthal KL,Kohberger R,Dunkle LM

更新日期：2013-11-19 00:00:00

abstract：:The identification of new vaccine candidates for leptospirosis is of great interest. This paper describes the identification of two homologous immunogenic proteins, LigA-m and LigB-m, of Leptospira interrogans serovar manilae strain UP-MMC-NIID, which show strong similarity with LigA found recently in L. interrogans s...

journal_title：Vaccine

authors： Koizumi N,Watanabe H

更新日期：2004-03-29 00:00:00

abstract：BACKGROUND:To support vaccine decision-making we estimated from the societal perspective the potential health impact and costs averted through immunization with three vaccines - Haemophilus influenzae type b (Hib), pneumococcal conjugate vaccine (PCV) and rotavirus vaccine (RVV). METHODS:Based on variability in diseas...

journal_title：Vaccine

authors： Constenla D,Liu T

更新日期：2019-12-10 00:00:00

abstract：:Herpes B virus (Cercopithecine herpesvirus 1) is endemic in captive macaque populations and poses a serious threat to humans who work with macaques or their tissues. A vaccine that could prevent or limit B virus infection in macaques would lessen occupational risk. To that end, a DNA vaccine plasmid expressing the B v...

journal_title：Vaccine

authors： Loomis-Huff JE,Eberle R,Lockridge KM,Rhodes G,Barry PA

更新日期：2001-09-14 00:00:00

abstract：:Ricin is a plant toxin that is a CDC level B biothreat. Our recombinant ricin A chain vaccine (RiVax), which contains mutations in both known toxic sites, has no residual toxicity at doses at least 800 times the immunogenic dose. RiVax without adjuvant given intramuscularly (i.m.) protected mice against intraperitonea...

journal_title：Vaccine

authors： Smallshaw JE,Richardson JA,Vitetta ES

更新日期：2007-10-16 00:00:00

abstract：:The use of viral vectors in heterologous prime-boost regimens to induce potent T cell responses in addition to humoral immunity is a promising vaccination strategy in the fight against malaria. We conducted an open-label, first-in-human, controlled Phase I study evaluating the safety and immunogenicity of Matrix-M adj...

journal_title：Vaccine

authors： Venkatraman N,Anagnostou N,Bliss C,Bowyer G,Wright D,Lövgren-Bengtsson K,Roberts R,Poulton I,Lawrie A,Ewer K,V S Hill A

更新日期：2017-10-27 00:00:00

abstract：:Since smallpox eradication by the WHO during the 1980s, potency of new vaccines is compared to vaccines that were used during the eradication campaign. In this work we characterize the tail scarification technique in mice as a model for scarification in humans. Similar to humans, mice develop "clinical take" which is ...

journal_title：Vaccine

authors： Melamed S,Paran N,Katz L,Ben-Nathan D,Israely T,Schneider P,Levin R,Lustig S

更新日期：2007-11-07 00:00:00

abstract：:The Vaccine Adverse Event Reporting System (VAERS) is the US passive surveillance system monitoring vaccine safety. A major limitation of VAERS is the lack of denominator data (number of doses of administered vaccine), an element necessary for calculating reporting rates. Empirical Bayesian data mining, a data analysi...

journal_title：Vaccine

authors： Niu MT,Erwin DE,Braun MM

更新日期：2001-09-14 00:00:00

abstract：:Rhodococcus equi causes severe pneumonia in foals and has recently gained attention as a significant opportunistic pathogen in immunocompromised humans. However, no effective vaccine to prevent rhodococcosis is currently available. In this study, we have engineered the food-grade bacterium Lactococcus lactis to secret...

journal_title：Vaccine

authors： Cauchard S,Bermúdez-Humarán LG,Blugeon S,Laugier C,Langella P,Cauchard J

更新日期：2011-12-09 00:00:00

abstract：:Measles incidence has decreased dramatically in China due to the implement of measles-containing vaccine (MCV). However, a measles epidemic caused resurgence recently, even among vaccinated individuals. To evaluate the effectiveness of current immunization programs and discuss initiatives for the next step in measles ...

journal_title：Vaccine

authors： Cui A,Zhang Y,Zhu Z,Wang H,Mao N,Song J,Xu W

更新日期：2020-05-08 00:00:00

abstract：BACKGROUND:The Global Vaccine Action Plan highlights the need for immunisation programmes to have sustainable access to predictable funding. A good understanding of current and future funding needs, commitments, and gaps is required to enhance planning, improve resource allocation and mobilisation, and to avoid funding...

journal_title：Vaccine

authors： Guthrie T,Zikusooka C,Kwesiga B,Abewe C,Lagony S,Schutte C,Marinda E,Humphreys K,Motlogelwa K,Nombewu ZC,Brenzel L,Kinghorn A

更新日期：2015-05-07 00:00:00

abstract：BACKGROUND:Concern arose in 2010 that reactogenicity, particularly febrile seizures, to influenza A/H1N1-containing 2010-2011 trivalent seasonal inactivated influenza vaccine (TIV) could occur in young children who had been previously immunized and/or infected with the pandemic strain. We conducted a pre-season study o...

journal_title：Vaccine

authors： Langley JM,Scheifele DW,Quach C,Vanderkooi OG,Ward B,McNeil S,Dobson S,Kellner JD,Kuhn S,Kollman T,MacKinnon-Cameron D,Smith B,Li Y,Halperin SA

更新日期：2012-05-14 00:00:00

abstract：:In China, no data are available to evaluate the interchangeability between Chinese domestic inactivated hepatitis A vaccines (Healive) and imported inactivated hepatitis A vaccines (Havrix). A double-blind, randomized controlled study was to compare interchangeability and safety of Healive and Havrix among Chinese chi...

journal_title：Vaccine

authors： Zhang ZL,Zhu XJ,Wang X,Liang M,Sun J,Liu Y,Gao ZG,Wu JY,Dong XJ,Liu RK,Chen JT,Zhang YQ,Wang W,Zhang LP,Yin W

更新日期：2012-06-08 00:00:00

abstract：:The carbohydrate moieties on HIV-1 envelope glycoprotein (Env) act as shields to mask conserved neutralizing epitopes, while the hyperimmunogenic variable regions are immunodominant in inducing non-neutralizing antibodies, representing the major challenge for using Env as a vaccine candidate to induce broadly neutrali...

journal_title：Vaccine

authors： Fu M,Hu K,Hu H,Ni F,Du T,Shattock RJ,Hu Q

更新日期：2019-12-03 00:00:00

abstract：INTRODUCTION:The World Health Organization recommends that as part of the polio end-game strategy a dose of inactivated poliovirus vaccine (IPV) be introduced by the end of 2015 in all countries currently using only oral poliovirus vaccine (OPV). Administration of fractional dose (1/5 of full dose) IPV (fIPV) by intrad...

journal_title：Vaccine

authors： Resik S,Tejeda A,Mach O,Sein C,Molodecky N,Jarrahian C,Saganic L,Zehrung D,Fonseca M,Diaz M,Alemany N,Garcia G,Hung LH,Martinez Y,Sutter RW

更新日期：2015-10-26 00:00:00

abstract：:Foot and Mouth Disease (FMD) is an acute disease caused by Foot and Mouth Disease Virus (FMDV) which causes important economy losses, this is why it is necessary to obtain a vaccine that stimulates a rapid and long-lasting protective immune response. Cliptox is a mineral microparticle that in earlier studies has shown...

journal_title：Vaccine

authors： Batista A,Quattrocchi V,Olivera V,Langellotti C,Pappalardo JS,Di Giacomo S,Mongini C,Portuondo D,Zamorano P

更新日期：2010-08-31 00:00:00