Second-year surveillance of recipients of a respiratory syncytial virus (RSV) F protein subunit vaccine, PFP-1: evaluation of antibody persistence and possible disease enhancement.


:In a previous study, children 18 to 36 months of age and seropositive for respiratory syncytial virus (RSV) were vaccinated with an RSV subunit vaccine (PFP-1) consisting of the viral fusion protein. Vaccines developed substantial increases in anti-fusion and neutralizing antibody and exhibited protection against RSV infection through one RSV epidemic, in comparison to controls. This present study of the same cohort was undertaken to determine the persistence of antibody responses and immunity to reinfection, as well as to monitor for enhanced disease upon subsequent RSV infection during the second RSV season after vaccination. Vaccinees continued to have greater ELISA specific anti-fusion (F) antibody responses than controls up to 18 months after vaccination. Neutralizing antibody titres were not as durable, and the attack rates for RSV in the second winter season after vaccination (25% in vaccines versus 42% in controls) were not significantly different (p = 0.23). Nevertheless, 'high-responder' subgroups may have had residual protection into the second postvaccination year. Enhanced illness did not occur. PFP-1 is immunogenic and appears safe, but yearly reimmunization may be necessary to maintain immunity to RSV infection.






Tristram DA,Welliver RC,Hogerman DA,Hildreth SW,Paradiso P




Has Abstract


1994-05-01 00:00:00
















  • Biocompatible cationic solid lipid nanoparticles as adjuvants effectively improve humoral and T cell immune response of foot and mouth disease vaccines.

    abstract::In this work, we explored the potential of cationic solid lipid nanoparticles (cSLN) as efficient adjuvants for inactivated foot and mouth disease virus (iFMDV) vaccine. The cSLN were prepared by O/W emulsion method with Compritol 888 ATO as lipid matrix, and were modified by cationic lipid Didodecyldimethylammonium b...


    pub_type: 杂志文章


    authors: Li S,Yang Y,Lin X,Li Z,Ma G,Su Z,Zhang S

    更新日期:2020-03-04 00:00:00

  • Immunosuppressive drugs impairs antibody response of the polysaccharide and conjugated pneumococcal vaccines in patients with Crohn's disease.

    abstract:BACKGROUND:Patients with Crohn's disease (CD) have a higher risk of infectious diseases including pneumococcal infections, and the risk increases with immunotherapy. The primary endpoint of this study was to investigate the specific antibody response to two pneumococcal vaccines in CD patients with and without immunosu...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Kantsø B,Halkjær SI,Thomsen OØ,Belard E,Gottschalck IB,Jørgensen CS,Krogfelt KA,Slotved HC,Ingels H,Petersen AM

    更新日期:2015-10-05 00:00:00

  • BBG2Na an RSV subunit vaccine candidate intramuscularly injected to human confers protection against viral challenge after nasal immunization in mice.

    abstract::Respiratory syncytial virus (RSV) is a major respiratory pathogen responsible for severe pulmonary disease. We have developed a parenterally administered vaccine, BBG2Na, which is currently in a phase III clinical trial. BBG2Na comprises residues 130--230 of RSV-A G protein (G2Na) fused to the BB carrier protein. In t...


    pub_type: 杂志文章


    authors: Goetsch L,Plotnicky-Gilquin H,Aubry JP,De-Lys P,Haeuw JF,Bonnefoy JY,Nguyen NT,Corvaïa N,Velin D

    更新日期:2001-07-16 00:00:00

  • Contrasting substitution patterns between HA proteins of avian and human influenza viruses: Implication for monitoring human influenza epidemics.

    abstract::The HA1 domain of influenza A viruses is critical for immune escape and host receptor recognition. However, the association between HA1 evolution and host species-specific adaptations remains unclear. We have identified the amino acid sites that are related to the host species-specific adaptations by systematically co...


    pub_type: 杂志文章


    authors: Liao YC,Chen FC,Hsiung CA

    更新日期:2010-11-23 00:00:00

  • A local reaction at or near injection site: case definition and guidelines for collection, analysis, and presentation of immunization safety data.

    abstract::The need for developing a case definition and guidelines for a local reaction at or near the injection site, methods for the development of the case definition and guidelines as an adverse event following immunization as well as the rationale for selected decisions about the case definition for a local reaction at or ...


    pub_type: 指南,杂志文章


    authors: Gidudu J,Kohl KS,Halperin S,Hammer SJ,Heath PT,Hennig R,Hoet B,Rothstein E,Schuind A,Varricchio F,Walop W,Brighton Collaboration Local Reactions Working Group for a Local Reaction at or near Injection Site.

    更新日期:2008-12-09 00:00:00

  • Impact of influenza infection on children's hospital admissions during two seasons in Athens, Greece.

    abstract::A prospective epidemiologic surveillance of hospitalizations associated with influenza was conducted in order to calculate population-based hospitalization rates. Eligible children were 6 months to 13 years of age and were admitted to one of the two large children's hospitals in the Athens area during two influenza se...


    pub_type: 杂志文章


    authors: Sakkou Z,Stripeli F,Papadopoulos NG,Critselis E,Georgiou V,Mavrikou M,Drossatou P,Constantopoulos A,Kafetzis D,Tsolia M

    更新日期:2011-02-01 00:00:00

  • Efficacy, safety and immunogenicity of a pneumococcal protein-based vaccine co-administered with 13-valent pneumococcal conjugate vaccine against acute otitis media in young children: A phase IIb randomized study.

    abstract:BACKGROUND:Native American populations experience a substantial burden of pneumococcal disease despite use of highly effective pneumococcal conjugate vaccines (PCVs). Protein-based pneumococcal vaccines may extend protection beyond the serotype-specific protection elicited by PCVs. METHODS:In this phase IIb, double-bl...


    pub_type: 杂志文章,随机对照试验


    authors: Hammitt LL,Campbell JC,Borys D,Weatherholtz RC,Reid R,Goklish N,Moulton LH,Traskine M,Song Y,Swinnen K,Santosham M,O'Brien KL

    更新日期:2019-12-03 00:00:00

  • Knowledge, attitudes and beliefs related to seasonal influenza vaccine among pregnant women in Thailand.

    abstract:BACKGROUND:In 2009, Thailand recommended pregnant women be prioritized for influenza vaccination. Vaccine uptake among Thai pregnant women is lower than other high-risk groups. METHODS:During December 2012-April 2013, we conducted a cross-sectional survey of a convenience sample of Thai pregnant women aged ≥ 15 years ...


    pub_type: 杂志文章


    authors: Ditsungnoen D,Greenbaum A,Praphasiri P,Dawood FS,Thompson MG,Yoocharoen P,Lindblade KA,Olsen SJ,Muangchana C

    更新日期:2016-04-19 00:00:00

  • Genome-wide association study of antibody response to smallpox vaccine.

    abstract::We performed a genome-wide association study (GWAS) of antibody levels in a multi-ethnic group of 1071 healthy smallpox vaccine recipients. In Caucasians, the most prominent association was found with promoter SNP rs10489759 in the LOC647132 pseudogene on chromosome 1 (p=7.77×10(-8)). In African-Americans, we identifi...


    pub_type: 杂志文章


    authors: Ovsyannikova IG,Kennedy RB,O'Byrne M,Jacobson RM,Pankratz VS,Poland GA

    更新日期:2012-06-13 00:00:00

  • A unique algorithm for the determination of peptide-carrier protein conjugation ratio by amino acid analysis using intrinsic internal standard.

    abstract::An N-terminal peptide of the HIV-1 fusion peptide (FP) with eight amino acid residues (FP8) was conjugated to a recombinant Tetanus Toxoid Heavy Chain Fragment C (rTTHc) as a carrier protein to help boosting immunogenicity against HIV-1. In this rapid communication, a unique algorithm to determine FP-rTTHc conjugation...


    pub_type: 杂志文章


    authors: Yang GJ,Yang Y,Shaddeau A,Cai CX,Li Y,Gulla K,Zhang Y,Ou L,Cooper JW,Lei QP

    更新日期:2020-06-15 00:00:00

  • Understanding differences in predictions of HPV vaccine effectiveness: A comparative model-based analysis.

    abstract::Mathematical models of HPV vaccine effectiveness and cost-effectiveness have produced conflicting results. The aim of this study was to use mathematical models to compare and isolate the impact of the assumptions most commonly made when modeling the effectiveness of HPV vaccines. Our results clearly show that differen...


    pub_type: 杂志文章


    authors: Van de Velde N,Brisson M,Boily MC

    更新日期:2010-07-26 00:00:00

  • Development of an in process control filtration-assisted chemiluminometric immunoassay to quantify foot and mouth disease virus (FMDV) non-capsid proteins in vaccine-antigen batches.

    abstract::In many countries, foot and mouth disease (FMD) is controlled by vaccination and surveillance against non-capsid proteins (NCP); therefore vaccines are required not to induce antibodies against NCP. Vaccine purity is evaluated by repeated inoculation of naïve cattle, an expensive and time consuming protocol that raise...


    pub_type: 杂志文章


    authors: Capozzo AV,Martínez MR,Schielen WJ

    更新日期:2010-09-14 00:00:00

  • Cloning and characterization of Rhipicephalus appendiculatus voraxinalpha and its effect as anti-tick vaccine.

    abstract::Male tick-derived voraxinalpha and voraxinbeta, a pair of testicular proteins, are transferred to female via copulation to stimulate female blood feeding in the tick Amblyomma hebraeum (A. hebraeum). Immunized animals with recombinant (r-)voraxinalpha and voraxinbeta have been shown as highly resistant to the tick inf...


    pub_type: 杂志文章


    authors: Yamada S,Konnai S,Imamura S,Ito T,Onuma M,Ohashi K

    更新日期:2009-10-09 00:00:00

  • Methodological challenges in measuring vaccine effectiveness using population cohorts in low resource settings.

    abstract::Post-licensure real world evaluation of vaccine implementation is important for establishing evidence of vaccine effectiveness (VE) and programme impact, including indirect effects. Large cohort studies offer an important epidemiological approach for evaluating VE, but have inherent methodological challenges. Since Ma...


    pub_type: 杂志文章,评审


    authors: King C,Beard J,Crampin AC,Costello A,Mwansambo C,Cunliffe NA,Heyderman RS,French N,Bar-Zeev N,VacSurv Consortium.

    更新日期:2015-09-11 00:00:00

  • Preparation-free method can enable rapid surfactant screening during industrial processing of influenza vaccines.

    abstract::Triton X-100 (TX-100) is the most common surfactant used to split viruses during the production of influenza split-virus vaccines. It is a mild surfactant not known to denature the viral proteins; this property makes TX-100 useful for maintaining antigen conformational structure, and, as an added benefit, for partiall...


    pub_type: 杂志文章


    authors: Sahin Z,Neeleman R,Haines J,Kayser V

    更新日期:2019-02-14 00:00:00

  • RNA-based adjuvant CV8102 enhances the immunogenicity of a licensed rabies vaccine in a first-in-human trial.

    abstract:BACKGROUND:We report the first-in-concept human trial of the safety, tolerability and immunogenicity when a novel TLR 7/8/RIG I agonist RNA-based adjuvant, CV8102, was administered alone or mixed with fractional doses of a licensed rabies vaccine (Rabipur®) as model antigen. METHODS:The primary objective was to assess...


    pub_type: 杂志文章


    authors: Doener F,Hong HS,Meyer I,Tadjalli-Mehr K,Daehling A,Heidenreich R,Koch SD,Fotin-Mleczek M,Gnad-Vogt U

    更新日期:2019-03-22 00:00:00

  • GM-CSF-surface-modified B16.F10 melanoma cell vaccine.

    abstract::Through the specific and tight interaction between streptavidin and biotin, a novel platform was developed to allow for rapid (less than 2h), efficient and durable display of streptavidin-tagged bioactive GM-CSF on the surface of biotinylated B16.F10 tumor cells. This technology involved biotinylation of the cell memb...


    pub_type: 杂志文章


    authors: Gao J,Huang S,Li M,Luo R,Wang X,Takashima A

    更新日期:2006-06-19 00:00:00

  • Are vaccinated measles cases protected against severe disease?

    abstract:OBJECTIVES:We aimed to estimate vaccine effectiveness against severe measles based on the number of vaccine doses administered and the time since last vaccination. PATIENTS AND METHODS:We included measles cases aged at least 2 years and born since 1980 who were notified in France between 2006 and mid-2019. We consider...


    pub_type: 杂志文章


    authors: Bonneton M,Antona D,Danis K,Aït-Belghiti F,Levy-Bruhl D

    更新日期:2020-06-15 00:00:00

  • Fluorescence spectroscopy monitoring of the conformational restraint of formaldehyde- and glutaraldehyde-treated infectious bursal disease virus proteins.

    abstract::Interaction of native proteinaceous antigens during the recognition and the effector phases of an immune response leads to antigenic conformational modifications which may elicit additional specific immune response. Protein cross-linking and conformation restraining formaldehyde and glutaraldehyde have been extensivel...


    pub_type: 杂志文章


    authors: Cepica A,Beauregard M,Qian B

    更新日期:1998-12-01 00:00:00

  • The member of the cyclic di-nucleotide family bis-(3', 5')-cyclic dimeric inosine monophosphate exerts potent activity as mucosal adjuvant.

    abstract::Here we demonstrated that bis-(3',5')-cyclic dimeric inosine monophosphate (c-di-IMP) exhibits potent adjuvant properties. BALB/c or C57BL/6 mice were immunized with the model antigens beta-galactosidase (beta-Gal) or Ovalbumin (OVA) alone or co-administered with c-di-IMP by the intranasal route. Animals receiving c-d...


    pub_type: 杂志文章


    authors: Libanova R,Ebensen T,Schulze K,Bruhn D,Nörder M,Yevsa T,Morr M,Guzmán CA

    更新日期:2010-03-02 00:00:00

  • Epitope polarity and adjuvants influence the fine specificity of the humoral response against Semliki Forest virus specific peptide vaccines.

    abstract::The humoral response to synthetic peptide vaccines against Semliki Forest virus (SFV) in H-2d BALB/c mice was investigated with the enzyme linked immunosorbent assay and the pepscan technique. The peptide vaccines consisted of amino acid sequences 240-255 (B) and 137-151 (T) of the E2 membrane protein of SFV colinearl...


    pub_type: 杂志文章


    authors: Fernández IM,Harmsen M,Benaissa-Trouw BJ,Stuij I,Puyk W,Meloen RH,Snippe H,Kraaijeveld CA

    更新日期:1998-10-01 00:00:00

  • South Asia symposium on pneumococcal disease and the promise of vaccines - Meeting report.

    abstract::Despite the licensure of the pneumococcal conjugate vaccine (PCV) in the US and other Western countries for over 14 years, as of September 2014 only 4 South Asian countries were using PCV in their universal immunization program. To generate momentum toward addressing this issue a "South Asia symposium on pneumococcal ...


    pub_type: 杂志文章


    authors: Kumar R,Arora N,Santosham M

    更新日期:2016-05-17 00:00:00

  • Towards improved process efficiency in vaccine innovation: The Vaccine Innovation Cycle as a validated, conceptual stage-gate model.

    abstract::Continuing investments in vaccine innovation are insufficiently translated into market entries of novel vaccines. This innovation paradox is in part caused by stakeholders lacking complete understanding of the complex array of steps necessary for vaccine development and collaboration difficulties between the wide vari...


    pub_type: 杂志文章


    authors: Van de Burgwal LHM,Ribeiro CDS,Van der Waal MB,Claassen E

    更新日期:2018-11-26 00:00:00

  • Novel polysaccharide adjuvant from the roots of Actinidia eriantha with dual Th1 and Th2 potentiating activity.

    abstract::The plant polysaccharides are recognized as an effective biological response modifier with low toxicity. In this study, the water-soluble polysaccharide from the roots of Actinidia eriantha (AEPS) was evaluated for its toxicity and adjuvant potential on the specific cellular and humoral immune responses to ovalbumin (...


    pub_type: 杂志文章


    authors: Sun HX,Wang H,Xu HS,Ni Y

    更新日期:2009-06-19 00:00:00

  • Avian paramyxovirus serotypes 2-9 (APMV-2-9) vary in the ability to induce protective immunity in chickens against challenge with virulent Newcastle disease virus (APMV-1).

    abstract::The avian paramyxoviruses (APMVs) belong to the genus Avulavirus of family Paramyxoviridae. The APMVs are classified into nine serotypes on the basis of hemagglutination inhibition (HI) and neuraminidase inhibition (NI) assays, although some serologic cross-reaction exists. Newcastle disease virus (NDV), which constit...


    pub_type: 杂志文章


    authors: Nayak B,Dias FM,Kumar S,Paldurai A,Collins PL,Samal SK

    更新日期:2012-03-09 00:00:00

  • The impact of administration of conjugate vaccines containing cross reacting material on Haemophilus influenzae type b antibody responses in infants: A systematic review and meta-analysis of randomised controlled trials.

    abstract:BACKGROUND:Protein-polysaccharide conjugate vaccines such as Haemophilus influenzae type b (Hib), meningococcal, and pneumococcal vaccine, induce immunological memory and longer lasting protection than plain polysaccharide vaccines. The most common proteins used as carriers are tetanus toxoid (TT) and cross reacting ma...


    pub_type: 杂志文章,meta分析,评审


    authors: Voysey M,Sadarangani M,Clutterbuck E,Bolgiano B,Pollard AJ

    更新日期:2016-07-25 00:00:00

  • Investigating adverse events following immunisation with pneumococcal polysaccharide vaccine using electronic General Practice data.

    abstract:BACKGROUND:In early 2011, following an increased number of reports of severe vaccine-related injection site reactions, Australian authorities recommended against administering repeat doses of the 23-valent pneumococcal polysaccharide vaccine (23vPPV) in otherwise healthy adults. The aim of this study was to assess a so...


    pub_type: 杂志文章


    authors: Trinh L,Macartney K,McIntyre P,Chiu C,Dey A,Menzies R

    更新日期:2017-03-13 00:00:00

  • A malaria vaccine for travelers and military personnel: Requirements and top candidates.

    abstract::Malaria remains an important health threat to non-immune travelers with the explosive growth of global travel. Populations at high risk of acquiring malaria infections include once semi-immune travelers who visit friends and relatives, military forces, business travelers and international tourists with destinations to...


    pub_type: 杂志文章


    authors: Teneza-Mora N,Lumsden J,Villasante E

    更新日期:2015-12-22 00:00:00

  • Amount of maternal rotavirus-specific antibodies influence the outcome of rotavirus vaccination of newborn mice with virus-like particles.

    abstract::In presence of low or high levels of rotavirus-specific maternal antibodies, the ability of newborn mice to respond to immunization with rotavirus RF 8*-2/6/7 VLPs, was evaluated. After parenteral vaccination, 100% of offspring born to low-antibody-titer dams developed rotavirus-specific IgG antibodies (n=7). In contr...


    pub_type: 杂志文章


    authors: Johansson E,Istrate C,Charpilienne A,Cohen J,Hinkula J,Poncet D,Svensson L,Johansen K

    更新日期:2008-02-06 00:00:00

  • Lasting immune memory against hepatitis B following challenge 10-11 years after primary vaccination with either three doses of hexavalent DTPa-HBV-IPV/Hib or monovalent hepatitis B vaccine at 3, 5 and 11-12 months of age.

    abstract:BACKGROUND:The combined hexavalent diphtheria-tetanus-pertussis-hepatitis B-inactivated poliomyelitis - Haemophilus influenzae type b conjugate vaccine (Infanrix hexa™; DTPa-HBV-IPV/Hib: GlaxoSmithKline Vaccines) induces robust responses to the HBV component when administered at 3, 5 and 11-12 months of age. We assesse...


    pub_type: 杂志文章


    authors: Avdicova M,Crasta PD,Hardt K,Kovac M

    更新日期:2015-05-28 00:00:00