Abstract：
INTRODUCTION:Institutionalized mentally retarded subjects are well-known to be at-risk for HBV infection. We studied the persistence of vaccine-induced anti-HBs antibodies and the robustness of the HBsAg-specific immune memory in this population, 18-20 years after the first vaccine dose. MATERIALS AND METHODS:Non-immune residents of 4 institutions were immunized in 1984-1986. In 2004, 207 subjects were bled to determine humoral and cellular immune memory. Immune response to a booster dose was evaluated in subjects with anti-HBs level <100 IU/L. RESULTS:Four subjects showed anti-HBc seroconversion, without clinical implications. Pre-booster anti-HBs levels <100 IU/L were found in 45 subjects (22%); 34/39 (87%) responded with a rapid and high anti-HBs titer to the booster dose. Robust T and B cell memory was present pre- and post-booster. DISCUSSION AND CONCLUSION:Overall results confirm that hepatitis B vaccines are highly effective and immunogenic, and confer long-term persistence of antibodies and immune memory in an at-risk population.
journal_name
Vaccinejournal_title
Vaccineauthors
Braeckman T,Van Herck K,Jilg W,Bauer T,Van Damme Pdoi
10.1016/j.vaccine.2012.05.044subject
Has Abstractpub_date
2012-07-06 00:00:00pages
4757-61issue
32eissn
0264-410Xissn
1873-2518pii
S0264-410X(12)00762-1journal_volume
30pub_type
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