Abstract：
:We previously demonstrated that recombinant raccoonpox (RCN) virus could serve as a vector for an influenza vaccine. RCN constructs expressing the hemagglutinin (HA) from H5N1 viruses were immunogenic in chickens. In the current study, we generated several recombinant RCN constructs expressing influenza (H5N1) antigens and a molecular adjuvant (Heat-Labile enterotoxin B from E. coli: RCN-LTB), demonstrated their expression in vitro, and evaluated their ability to protect mice against H5N1 virus challenge. RCN-HA provided strong protection when administered intradermally (ID), but not intranasally (IN). Conversely, the RCN-neuraminidase (NA) construct was highly efficacious by the IN route and elicited high titers of neutralizing antibodies in mice. Vaccination by combined ID (RCN-HA) and IN (RCN-NA) routes offered mice the best protection against an IN challenge with heterologous H5N1 virus. However, protection was reduced when the different RCN constructs were pre-mixed, perhaps due to reduced expression of antigen.
journal_name
Vaccinejournal_title
Vaccineauthors
Kingstad-Bakke B,Brewoo JN,Mai le Q,Kawaoka Y,Osorio JEdoi
10.1016/j.vaccine.2012.08.018subject
Has Abstractpub_date
2012-10-05 00:00:00pages
6402-8issue
45eissn
0264-410Xissn
1873-2518pii
S0264-410X(12)01197-8journal_volume
30pub_type
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