Use of protamine sulphate for elimination of substrate DNA in poliovaccines produced on continuous cell lines.

abstract：BACKGROUND:The primary prevention measure for influenza infection has been the use of influenza vaccines. However, even when the vaccine and circulating strains are well-matched, some healthy children do not respond to the vaccine, likely due to a genetic basis for immune hyporesponsiveness. The primary objective of th...

journal_title：Vaccine

authors： Narwaney KJ,Glanz JM,Norris JM,Fingerlin TE,Hokanson JE,Rewers M,Hambidge SJ

更新日期：2013-02-04 00:00:00

abstract：:There is currently much interest in generating cytotoxic T lymphocyte (CTL) responses against tumor antigens as a therapy for cancer. In this study mouse fibroblasts (H-2(b)) were genetically modified to express a costimulatory B7.1 and a mature interleukin (IL)-18, and then loaded with an ovalbumin (OVA) epitope (SII...

journal_title：Vaccine

authors： Chung SW,Cohen EP,Kim TS

更新日期：2004-06-30 00:00:00

abstract：:Serological surveys in many communities show a high prevalence of antibodies to hepatitis A virus (HAV) in people over the age of 50 years. However, few of that age can recall a previous episode of hepatitis, indicating that subclinical infections are common. The outcome of infection with HAV depends on the age at whi...

journal_title：Vaccine

authors： Gust ID

更新日期：1992-01-01 00:00:00

abstract：:HIV-infected children (N=243), >or=5 to <18 years old, receiving stable antiretroviral therapy, were stratified by immunologic status and randomly assigned to receive intranasal live attenuated influenza vaccine (LAIV) or intramuscular trivalent inactivated influenza vaccine (TIV). The safety profile after LAIV or TIV...

journal_title：Vaccine

authors： Levin MJ,Song LY,Fenton T,Nachman S,Patterson J,Walker R,Kemble G,Allende M,Hultquist M,Yi T,Nowak B,Weinberg A

更新日期：2008-08-05 00:00:00

abstract：:DNA vaccines contribute to a promising new approach for the generation of cytotoxic T lymphocytes (CTL). DNA vaccines do have several disadvantages, including poor immunogenicity and oncogene expression. We used the natural killer T-cell (NKT) ligand α-galactosylceramide (α-GalCer) as an adjuvant to prime initial DNA ...

journal_title：Vaccine

authors： Kim D,Hung CF,Wu TC,Park YM

更新日期：2010-10-21 00:00:00

abstract：:After 16 years of no vaccination against pertussis in Sweden, mass vaccination of infants and catch-up vaccination of children up to 10 years with a monocomponent pertussis toxoid vaccine was performed in the Greater Gothenburg area of Sweden between 1995 and 1999. At the end of the project in February 1999, 56% of al...

journal_title：Vaccine

authors： Trollfors B,Dotevall L,Sundh V,Welinder-Olsson C

更新日期：2011-03-16 00:00:00

abstract：:To assess human papillomavirus (HPV) prevalence and genotype distribution by age and cervical cytology/histology status among women undergoing routine gynecological examinations, and to discuss the possible impact on preventive strategies. Liquid-based cytology (LBC) samples were tested for HPV DNA, mRNA, and HPV geno...

journal_title：Vaccine

authors： Monsonego J,Zerat L,Syrjänen K,Zerat JC,Smith JS,Halfon P

更新日期：2012-07-27 00:00:00

abstract：:The whole cell vaccine (WCV) of Bordetella pertussis is protective in the intracerebral (i.c.) mouse protection assay. We found a correlation between the i.c. mouse protection assay potency and the presence of the virulence-associated outer membrane proteins (OMPs) in outer membrane complexes (OMC). The virulence-asso...

journal_title：Vaccine

authors： Hamstra HJ,Kuipers B,Schijf-Evers D,Loggen HG,Poolman JT

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:We assessed 2 investigational 11- and 12-valent vaccines, containing capsular polysaccharides of 10 serotypes as in the pneumococcal non-typeable Haemophilus influenzae protein D-conjugate vaccine (PHiD-CV) and CRM197-conjugated capsular polysaccharides of serotypes 19A (11-valent) or 19A and 6A (12-valent)....

journal_title：Vaccine

authors： Carmona Martinez A,Prymula R,Miranda Valdivieso M,Otero Reigada MDC,Merino Arribas JM,Brzostek J,Szenborn L,Ruzkova R,Horn MR,Jackowska T,Centeno-Malfaz F,Traskine M,Dobbelaere K,Borys D

更新日期：2019-01-03 00:00:00

abstract：:HIV vaccines of the first generation are, in contrast to most currently licensed vaccines, unlikely to provide sterilizing immunity against infection with HIV. However, they are expected to exert a beneficial effect on the maintenance of CD4 T-cell counts by reducing viral load. There is a recognized need for clarifyi...

journal_title：Vaccine

authors： Fruth U

更新日期：2009-03-23 00:00:00

abstract：:A prospective epidemiologic surveillance of hospitalizations associated with influenza was conducted in order to calculate population-based hospitalization rates. Eligible children were 6 months to 13 years of age and were admitted to one of the two large children's hospitals in the Athens area during two influenza se...

journal_title：Vaccine

authors： Sakkou Z,Stripeli F,Papadopoulos NG,Critselis E,Georgiou V,Mavrikou M,Drossatou P,Constantopoulos A,Kafetzis D,Tsolia M

更新日期：2011-02-01 00:00:00

abstract：INTRODUCTION:It is important to quickly identify parent beliefs, intentions, and behaviors toward childhood vaccination, especially parents of children 19 to 35 months. This paper describes parental immunization beliefs, intentions, and behaviors; assesses the relationships between beliefs and intentions regarding chil...

journal_title：Vaccine

authors： Boyle J,Berman L,Nowak GJ,Iachan R,Middleton D,Deng Y

更新日期：2020-02-28 00:00:00

abstract：:This study was designed to determine the impact of maternal HIV-1 specific immunity on HIV-DNA immunization of 2-week-old pups during the breast-feeding period. Adult female mice received intranasal or intradermal HIV-DNA (gp160Env, p37Gag, Nef, Tat and Rev) prime and recombinant protein boost immunizations, which ind...

journal_title：Vaccine

authors： Bråve A,Johansen K,Palma P,Benthin R,Hinkula J

更新日期：2008-11-05 00:00:00

abstract：:Domestic ducks remain a major source of zoonotic Salmonella enterica infections for man worldwide and approaches to protection should include vaccine-mediated immunity. With this in mind we developed several genetically defined mutants in a virulent duck Salmonella typhimurium isolate TT-1. From initial tests for viru...

journal_title：Vaccine

authors： Tang T,Gao Q,Barrow P,Wang M,Cheng A,Jia R,Zhu D,Chen S,Liu M,Sun K,Yang Q,Chen X

更新日期：2015-10-13 00:00:00

abstract：BACKGROUND:A randomized, double-blind, placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a pentavalent live human-bovine reassortant rotavirus vaccine (RotaTeq™, RV5) against rotavirus gastroenteritis (RVGE). METHODS:4040 participants aged 6-12weeks were...

journal_title：Vaccine

authors： Mo Z,Mo Y,Li M,Tao J,Yang X,Kong J,Wei D,Fu B,Liao X,Chu J,Qiu Y,Hille DA,Nelson M,Kaplan SS

更新日期：2017-10-13 00:00:00

abstract：:The worldwide HIV-1 vaccine research endeavor is focused increasingly on subtype C, which is now the predominant strain of the present HIV/AIDS epidemic. Expression cassettes of HIV-1 subtype C gag, pol and versions of gagpol fusion cassettes were constructed and evaluated for their relative abilities to induce cellul...

journal_title：Vaccine

authors： Megede JZ,Otten GR,Doe B,Liu H,Srivastava R,Greer C,Legg H,Tang T,Polo JM,Donnelly JJ,Ulmer JB,Barnett SW

更新日期：2006-04-05 00:00:00

abstract：BACKGROUND:Human papillomavirus (HPV) vaccines were first licensed as a three-dose series; a two-dose series is now recommended in some age groups and there is interest in possible one-dose vaccination. METHODS:We conducted a systematic literature review of HPV vaccine effectiveness by number of doses, including asses...

journal_title：Vaccine

authors： Markowitz LE,Drolet M,Perez N,Jit M,Brisson M

更新日期：2018-08-06 00:00:00

abstract：INTRODUCTION:The strategy to Eliminate Yellow Fever Epidemics (EYE) is a global initiative that includes all countries with risk of yellow fever (YF) virus transmission. Of these, 40 countries (27 in Africa and 13 in the Americas) are considered high-risk and targeted for interventions to increase coverage of YF vaccin...

journal_title：Vaccine

authors： Adrien N,Hyde TB,Gacic-Dobo M,Hombach J,Krishnaswamy A,Lambach P

更新日期：2019-07-26 00:00:00

abstract：INTRODUCTION:Vaccination of health care workers (HCW) reduces transmission of influenza among patients, yet uptake of vaccination remains low. If vaccination education is integrated into the early medical school curriculum, will student attitudes toward the vaccine change? The objectives of the study were to: (1) Deter...

journal_title：Vaccine

authors： Afonso N,Kavanagh M,Swanberg S

更新日期：2014-01-16 00:00:00

abstract：:In the present study we assessed the capacity of recombinant E. coli- or plasmid-expressed chicken interferons (IFN) and chicken IL-1beta, to exert immunostimulatory activities for humoral immune responses, in day-old and adult chickens. We observed that both recombinant E. coli-expressed chicken IFN-alpha/beta and IF...

journal_title：Vaccine

authors： Schijns VE,Weining KC,Nuijten P,Rijke EO,Staeheli P

更新日期：2000-04-14 00:00:00

abstract：:The carboxyl-terminal region of the merozoite surface protein-1 (MSP1) is a leading candidate for a vaccine against malaria in the erythrocytic stage. In this study, we investigated the utility of interleukin-12 (IL-12) cDNA as an adjuvant for malaria DNA vaccine in a mouse challenge model. We found that co-immunizati...

journal_title：Vaccine

authors： Sakai T,Hisaeda H,Nakano Y,Zhang M,Takashima M,Ishii K,Maekawa Y,Matsumoto S,Nitta Y,Miyazaki Ji,Yamamoto S,Himeno K

更新日期：2003-03-28 00:00:00

abstract：INTRODUCTION:The recent emergence of avian influenza strains has fuelled concern about pandemic preparedness since vaccines targeting these viruses are often poorly immunogenic. Weak antibody responses to vaccines have been seen across multiple platforms including plant-made VLPs. To better understand these differences...

journal_title：Vaccine

authors： Hendin HE,Pillet S,Lara AN,Wu CY,Charland N,Landry N,Ward BJ

更新日期：2017-05-02 00:00:00

abstract：OBJECTIVE:To evaluate whether the social media strategy developed for the campaign Stop HPV - stop cervical cancer was successful at engaging target groups in communication regarding HPV vaccination. INTRODUCTION:In 2009, the Human Papillomavirus (HPV) vaccine became part of the Danish childhood vaccination program to...

journal_title：Vaccine

authors： Pedersen EA,Loft LH,Jacobsen SU,Søborg B,Bigaard J

更新日期：2020-06-26 00:00:00

abstract：:In clinical trials, the specificity of the disease endpoint is critical to an accurate estimate of vaccine efficacy. We used a logistic regression model to analyse parasite densities among children before and after treatment with antimalarials, in order to estimate the impact that clearing asymptomatic parasitaemia ha...

journal_title：Vaccine

authors： Bejon P,Mwangi T,Lowe B,Peshu N,Hill AV,Marsh K

更新日期：2007-11-23 00:00:00

abstract：:We present the burden of human papillomavirus (HPV)-related cancers (cancers of the cervix, anogenital areas, and oral cavity and pharynx) in terms of incidence and mortality, for the countries of the Asia Pacific region. The region contains more than half of the world population, and manifests a wide geographic diver...

journal_title：Vaccine

authors： Parkin DM,Louie KS,Clifford G

更新日期：2008-08-19 00:00:00

abstract：:In order to evaluate a combination of yellow fever and typhoid fever vaccine, we conducted a controlled trial comparing reactogenicity and immunogenicity of Vi polysaccharide (ViPS) vaccine and yellow fever 17D (YF) vaccine after single, simultaneous and combined administration. The combined YF/ViPS vaccine was prepar...

journal_title：Vaccine

authors： Ambrosch F,Fritzell B,Gregor J,Jonas S,Kollaritsch H,Teulieres L,Wiedermann G

更新日期：1994-05-01 00:00:00

abstract：:A robust vaginal immune response is considered essential for an effective prophylactic vaccine that prevents transmission of HIV and other sexually acquired diseases. Considerable attention has recently focused on the potential of vaginally administered vaccines as a means to induce such local immunity. However, the p...

journal_title：Vaccine

authors： Pattani A,McKay PF,Curran RM,McCaffrey J,Gupta PN,Lowry D,Kett VL,Shattock RJ,McCarthy HO,Malcolm RK

更新日期：2012-04-05 00:00:00

abstract：:Haemophilus parasuis (H. parasuis) is a swine pathogen responsible for the Glässer's disease, which has received more attention in the past decade due to the increasing economic losses in the pig industry worldwide. As traditional inactive vaccine of H. parasuis has obvious disadvantage, to identify efficient immunopr...

journal_title：Vaccine

authors： Li M,Song S,Yang D,Li C,Li G

更新日期：2015-03-30 00:00:00

abstract：BACKGROUND:Females who receive the human papillomavirus (HPV) vaccine may believe they are protected from developing cervical cancer and no longer require screening. Concern has also been expressed that vaccinated females are those that would be screened regularly. This study assesses the Pap testing behavior of vaccin...

journal_title：Vaccine

authors： Kliewer EV,Mahmud SM,Demers AA,Lambert P

更新日期：2013-12-17 00:00:00

abstract：:Fasciolosis continues to be a major cause of economic losses in the livestock industry and a growing threat to humans. The limited spectrum of effective anthelmintics and the appearance of resistances urge the need for developing an effective vaccine. Most studies have been focused on the use of TH1-polarizing adjuvan...

journal_title：Vaccine

authors： Orbegozo-Medina RA,Martínez-Sernández V,González-Warleta M,Castro-Hermida JA,Mezo M,Ubeira FM

更新日期：2018-04-05 00:00:00