Abstract：
:Domestic ducks remain a major source of zoonotic Salmonella enterica infections for man worldwide and approaches to protection should include vaccine-mediated immunity. With this in mind we developed several genetically defined mutants in a virulent duck Salmonella typhimurium isolate TT-1. From initial tests for virulence in day-old ducks, ΔrpoS, ΔhilA, and ΔslyA mutants retained some virulence so were not studied further. Amongst the mutants showing greater attenuation, ΔssrB, ΔphoPQ, ΔompR, and ΔclpP also showed high levels of protection when 1-day-old ducks, which were vaccinated orally, were challenged 1 week later demonstrating the capacity to protect ducks in the first few weeks of life when they are most susceptible and when the risk of infection is greatest. Immunized ducks triggered Omp-specific IgG, IgM, and IgA responses and raised IL-2 and IFN-γ levels in the serum coupled with IL-4 suppression.
journal_name
Vaccinejournal_title
Vaccineauthors
Tang T,Gao Q,Barrow P,Wang M,Cheng A,Jia R,Zhu D,Chen S,Liu M,Sun K,Yang Q,Chen Xdoi
10.1016/j.vaccine.2015.09.004subject
Has Abstractpub_date
2015-10-13 00:00:00pages
5564-5571issue
42eissn
0264-410Xissn
1873-2518pii
S0264-410X(15)01247-5journal_volume
33pub_type
杂志文章相关文献
VACCINE文献大全abstract：:We described here the characterization of Schistosoma mansoni egg antigens recognized by human monoclonal antibodies B10 (HmAb-B10) and D5 (HmAb-D5). SDS-PAGE and Western blot analysis revealed that these monoclonals recognized two antigens of M W 44.7/56.8 kDa, with pI of 7.0 and 7.8, respectively. The passive transf...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(96)00305-2
更新日期：1997-06-01 00:00:00
abstract：BACKGROUND:Evidence that respiratory infections trigger stroke suggests that influenza or pneumococcal vaccination might prevent stroke. We aimed to investigate whether influenza or pneumococcal vaccination or both together were associated with reduced risk of stroke or transient ischaemic attack (TIA). METHODS:We use...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.01.029
更新日期：2014-03-10 00:00:00
abstract：:Human papillomavirus (HPV) vaccination is now offered to adolescent girls in the UK. Adolescents over 16 years old are likely to make their own decision about the vaccination. The purpose of this cross-sectional study was to assess acceptability of HPV vaccination among female adolescents (16 -- 19 years) and investig...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.02.057
更新日期：2009-04-21 00:00:00
abstract：:Many influenza vaccines targeted to hemagglutinin (HA) show efficient immunogenicity for protecting subjects against influenza virus infection. Major antigenic changes to HA molecules can help influenza virus to develop resistance against HA-targeted vaccines. DNA vaccines encoding conserved antigens protect animals a...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.02.074
更新日期：2007-05-22 00:00:00
abstract：:Influenza is an important public health issue and schools play an important part in preventing influenza outbreaks. However, little is known about teachers' knowledge and attitudes toward influenza and vaccination. The purposes of this project were to assess preservice and early career teachers' knowledge and attitude...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.10.040
更新日期：2018-11-19 00:00:00
abstract：:Accidental freezing of vaccines is a growing threat and a real risk for national immunization programs when the potency of many vaccines can be compromised if these are exposed to sub-zero temperatures in the cold chain. In Tunisia, this issue is compounded by using sub-standard domestic cold chain equipment instead o...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.10.080
更新日期：2015-02-11 00:00:00
abstract：INTRODUCTION:We performed a pooled analysis of randomised clinical trials (RCT) on HPV vaccine efficacy in preventing cervical persistent infection. METHODS:We carried out a bibliographic search on electronic databases and we selected RCT to perform the meta-analyses. RESULTS:We selected five studies. The first meta-...
journal_title：Vaccine
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.vaccine.2007.09.027
更新日期：2007-12-05 00:00:00
abstract：:Actinobacillus pleuropneumoniae is the causative agent of porcine pleuropneumonia, a highly contagious and often fatal disease. We have previously reported the construction and characterization of a single gene apxIIC deletion mutant HB04C(-) based on A. pleuropneumoniae serovar 7 which produces ApxII toxin and ApxIV....
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.07.053
更新日期：2007-11-01 00:00:00
abstract：:We successfully re-vaccinated hepatitis B virus (HBV) vaccine non-responders using a double dose of the combined hepatitis A virus (HAV) and HBV vaccine. The hope was to improve priming of hepatitis B surface antigen (HBsAg)-specific cell mediated immune response (CMI) by an increased antigen dose and a theoretical ad...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2008.08.054
更新日期：2008-11-05 00:00:00
abstract：:The ability to elicit humoral and cell-mediated immune (CMI) responses from DNA immunization by combinational use of codon optimization and C3d component of complement was evaluated in this study. DNA vaccines that express either the wild type or the codon optimized gp120 gene coding for the envelope (Env) glycoprotei...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2003.09.054
更新日期：2004-04-16 00:00:00
abstract：:Thirty-two rhesus monkeys were used to evaluate the dose response of a recombinant HEV vaccine, and the efficacy of the vaccine based on the ORF2 protein of the Pakistani strain for pre- and post-exposure vaccination against intravenous challenge with homologous or heterologous virus was examined. Post-exposure vaccin...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(97)00145-x
更新日期：1997-12-01 00:00:00
abstract：:Recently, an outbreak of fatal infection caused by a pantropic variant (strain CB/05) of canine coronavirus (CCoV) has been reported. In this study, evidence is provided that immunity induced by natural exposure to enteric CCoV is not fully protective against strain CB/05. Twenty-two, 10-week-old beagles with a recent...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.10.077
更新日期：2010-01-08 00:00:00
abstract：:The purpose of the present research work is to explore the potential of dendrosomes in genetic immunization against hepatitis B. Plasmid DNA encoding pRc/CMV-HBs[S] (5.6 kb), encoding the small region of the hepatitis B surface antigen, was complexed with 5th generation poly(propyleneimine) dendrimer (PPI) in differen...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2008.04.058
更新日期：2008-06-25 00:00:00
abstract：:In this work, the propagation of the 17DD yellow fever virus in Vero cells grown on Cytodex-1 microcarriers was evaluated. After verifying that upon infection the virus adsorption step could be performed under continuous agitation, experiments were carried out in spinners and sparged lab-scale stirred-tank bioreactor ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.06.023
更新日期：2009-10-30 00:00:00
abstract：:Liposome and cholera toxin (CT) are considered to be effective antigen delivery vehicles and adjuvants for mucosal vaccines. The effect of these antigen delivery systems on adjuvant responses to mucosally administered pneumococcal polysaccharide (Pnup) was investigated in this study. Both mucosal (e.g. oral) and syste...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(95)00198-a
更新日期：1996-04-01 00:00:00
abstract：:Delivery of antigens to antigen presenting cell surface receptors represents a promising strategy to improve immune response to weak immunogenic antigens. We have analyzed the potential of porcine sialoadhesin (Sn) and CD163 as antigen targeting receptors using mouse Igs as surrogate antigens. Sn and CD163 are two end...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.04.076
更新日期：2011-06-24 00:00:00
abstract：:Streptococcus pneumoniae (pneumococcus) is responsible for significant morbidity and mortality in worldwide. After introduction of current pneumococcal vaccines, a marked decrease in the incidence of pneumococcal disease was observed. Unfortunately, serotype shifts in carriage and disease, including capsular switch an...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.11.073
更新日期：2012-03-02 00:00:00
abstract：:Every year, meningococcal meningitis causes thousands of deaths within the meningitis belt in sub-Saharan African countries. Large epidemic waves occur with a periodicity of 5-12 years. The waves do correspond to molecular changes in the expression of capsular or subcapsular antigens, which allow the bug to spread in ...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2007.04.032
更新日期：2007-09-03 00:00:00
abstract：:Attenuated strains of Salmonella have been used as vaccines to deliver heterologous antigens mainly to generate a humoral immune response. However, little is known about their ability to induce a cell-mediated immune response to the T-cell epitopes of another infectious agent or how optimally to deliver these epitopes...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(95)93308-v
更新日期：1995-02-01 00:00:00
abstract：:Although rare, invasive meningococcal disease remains an important cause of mortality and morbidity in children and young adults. Vaccines have been successfully introduced to help protect against meningococcal disease caused by serogroups A, C, W and Y, but until recently, a vaccine for serogroup B (MenB) was not ava...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2015.11.057
更新日期：2016-02-10 00:00:00
abstract：BACKGROUND:The relative importance of different attitudes in predicting vaccination among healthcare personnel (HCP) is unclear. We hypothesized that HCP who feel at risk without vaccination or say they would regret not getting vaccinated would be more likely to get vaccinated than HCP who do not expect these emotional...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.03.062
更新日期：2012-05-21 00:00:00
abstract：:Peripheral blood mononuclear cells were taken from subjects before and after oral immunization with cholera toxin B-subunit. Cells obtained from naive volunteers before immunization did not proliferate in vitro to B-subunit. Oral immunization induced a proliferative response in all volunteers with a peak stimulation i...
journal_title：Vaccine
pub_type： 临床试验,杂志文章
doi：10.1016/0264-410x(93)90005-i
更新日期：1993-01-01 00:00:00
abstract：:The amounts of pertussis toxin (PT), filamentous haemagglutinin (FHA), 69 kDa outer membrane protein (69 kDa OMP) and agglutinogens (AGG) 2 and 3 in extracts from the Danish whole-cell pertussis vaccine were studied in quantitative capture ELISA. With the exception of PT, the most effective extraction of these antigen...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(93)90193-2
更新日期：1993-01-01 00:00:00
abstract：:The anti-tumor immunologic effects of plasmid DNA vaccines encoding human carcinoembryonic antigen (CEA) fused to mouse granulocyte/macrophage colony-stimulating factor (GM-CSF) were examined. Immunization of C57BL/6 mice with the CEA-GMCSF fusion plasmids in a three injection, high-dose immunization schedule led to T...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2004.08.043
更新日期：2005-01-26 00:00:00
abstract：:The global health community is beginning to gain an understanding of the global burden of norovirus-associated disease, which appears to have significant burden in both developed- and developing-country populations. Of particular importance is the growing recognition of norovirus as a leading cause of gastroenteritis ...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2016.03.077
更新日期：2016-06-03 00:00:00
abstract：:The aim of this study was to estimate the effectiveness of 2009 seasonal trivalent inactivated vaccine in reducing hospitalizations due to the novel influenza A H1N1 virus among positive cases. Data collected from Argentina's national epidemiological surveillance system were analyzed. All patients had a clinical diagn...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.05.051
更新日期：2010-07-19 00:00:00
abstract：:Measles vaccination programmes at two vaccination centres in Ibadan, Nigeria were evaluated using the following factors as indicators: type of vaccination centre, age at vaccination, titre of vaccine, economic, health and social status of vaccinee. There was a significant association between type of vaccination centre...
journal_title：Vaccine
pub_type： 临床试验,杂志文章
doi：10.1016/0264-410x(92)90419-k
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:A randomized trial demonstrated that a high-dose inactivated influenza vaccine (IIV-HD) was 24.2% more efficacious than a standard-dose vaccine (IIV-SD) against laboratory-confirmed influenza illness in adults ≥65 years. To evaluate the consistency of IIV-HD benefits, supplemental analyses explored efficacy ...
journal_title：Vaccine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.vaccine.2015.07.003
更新日期：2015-08-26 00:00:00
abstract：INTRODUCTION:The World Health Organization recommends that as part of the polio end-game strategy a dose of inactivated poliovirus vaccine (IPV) be introduced by the end of 2015 in all countries currently using only oral poliovirus vaccine (OPV). Administration of fractional dose (1/5 of full dose) IPV (fIPV) by intrad...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2015.06.071
更新日期：2015-10-26 00:00:00
abstract：:Carbopol is a polyanionic carbomer used in man for topical application and drug delivery purposes. However parenteral administration of Carbopol in animal models results in systemic adjuvant activity including strong pro-inflammatory type-1 T-cell (Th1) polarization. Here we investigated potential pathways of immune a...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2016.03.025
更新日期：2016-04-27 00:00:00
