Abstract：
INTRODUCTION:We performed a pooled analysis of randomised clinical trials (RCT) on HPV vaccine efficacy in preventing cervical persistent infection. METHODS:We carried out a bibliographic search on electronic databases and we selected RCT to perform the meta-analyses. RESULTS:We selected five studies. The first meta-analysis, including all studies, showed an important reduction of the risk of infection from HPV 16 in vaccinated cohort [RR 0.10 (95% CI: 0.07-0.15)]. The second and third meta-analyses, including only studies on bivalent and tetravalent vaccines, showed a RR of 0.13 (95% CI: 0.09-0.20) for HPV 16 infections and a RR of 0.22 (95% CI: 0.13-0.38) for HPV 18 ones. DISCUSSION:HPV vaccine efficacy in preventing persistent infection is high but there is the need for further studies on the duration of immunization and long-term vaccine efficacy.
journal_name
Vaccinejournal_title
Vaccineauthors
La Torre G,de Waure C,Chiaradia G,Mannocci A,Ricciardi Wdoi
10.1016/j.vaccine.2007.09.027subject
Has Abstractpub_date
2007-12-05 00:00:00pages
8352-8issue
50eissn
0264-410Xissn
1873-2518pii
S0264-410X(07)01032-8journal_volume
25pub_type
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