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Direct immunization of the abomasum or rectum of goats induces local lymph node responses against Haemonchus contortus mucosal antigens.

Abstract：

:We investigated several methods to immunize the abomasum (fourth and gastric stomach) of kid goats by direct (abomasal) or distal (rectal or nasal) routes utilizing mucosal antigens isolated from the abomasal parasite, Haemonchus contortus. Direct (ultrasound guided), immunization of the abomasal mucosa together with rectal immunization established lymphocyte proliferation responses in abomasal lymph nodes (ALNs), while distal methods, alone, produced equivocal results. The differential responses (cellular and antibody) induced by alternative immunization methods demonstrated an experimental system that can facilitate advances in mucosal immunization against H. contortus and other gastrointestinal pathogens of food animals.

journal_name

Vaccine

journal_title

Vaccine

authors

Jasmer DP,Brown WC,Parish S

doi

10.1016/j.vaccine.2011.02.003

subject

Has Abstract

pub_date

2011-04-05 00:00:00

pages

2938-46

issue

16

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(11)00204-0

journal_volume

29

pub_type

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