Direct immunization of the abomasum or rectum of goats induces local lymph node responses against Haemonchus contortus mucosal antigens.


:We investigated several methods to immunize the abomasum (fourth and gastric stomach) of kid goats by direct (abomasal) or distal (rectal or nasal) routes utilizing mucosal antigens isolated from the abomasal parasite, Haemonchus contortus. Direct (ultrasound guided), immunization of the abomasal mucosa together with rectal immunization established lymphocyte proliferation responses in abomasal lymph nodes (ALNs), while distal methods, alone, produced equivocal results. The differential responses (cellular and antibody) induced by alternative immunization methods demonstrated an experimental system that can facilitate advances in mucosal immunization against H. contortus and other gastrointestinal pathogens of food animals.






Jasmer DP,Brown WC,Parish S




Has Abstract


2011-04-05 00:00:00
















  • Persistence of anti-HBs in children vaccinated against viral hepatitis B in the first year of life: follow-up at 5 and 10 years.

    abstract::The persistence of anti-HBs protective levels in groups of children who had been immunized against Hepatitis B 5 and 10 years earlier, in their first year of life, has been studied. The results were analyzed according to the type of vaccine (both plasma-derived and DNA recombinant) and the number of doses administered...


    pub_type: 杂志文章


    authors: Da Villa G,Peluso F,Picciotto L,Bencivenga M,Elia S,Pelliccia MG

    更新日期:1996-11-01 00:00:00

  • Pertussis after end of a mass vaccination project--end of the "vaccination honey-moon".

    abstract::After 16 years of no vaccination against pertussis in Sweden, mass vaccination of infants and catch-up vaccination of children up to 10 years with a monocomponent pertussis toxoid vaccine was performed in the Greater Gothenburg area of Sweden between 1995 and 1999. At the end of the project in February 1999, 56% of al...


    pub_type: 杂志文章


    authors: Trollfors B,Dotevall L,Sundh V,Welinder-Olsson C

    更新日期:2011-03-16 00:00:00

  • Protection against infectious bronchitis virus by spike ectodomain subunit vaccine.

    abstract::The avian coronavirus infectious bronchitis virus (IBV) S1 subunit of the spike (S) glycoprotein mediates viral attachment to host cells and the S2 subunit is responsible for membrane fusion. Using IBV Arkansas-type (Ark) S protein histochemistry, we show that extension of S1 with the S2 ectodomain improves binding to...


    pub_type: 杂志文章


    authors: Eldemery F,Joiner KS,Toro H,van Santen VL

    更新日期:2017-10-13 00:00:00

  • Proximity to safety-net clinics and HPV vaccine uptake among low-income, ethnic minority girls.

    abstract:PURPOSE:Human Papillomavirus (HPV) vaccine uptake remains low. Although publicly funded programs provide free or low cost vaccines to low-income children, barriers aside from cost may prevent disadvantaged girls from getting vaccinated. Prior studies have shown distance to health care as a potential barrier to utilizin...


    pub_type: 杂志文章


    authors: Tsui J,Singhal R,Rodriguez HP,Gee GC,Glenn BA,Bastani R

    更新日期:2013-04-12 00:00:00

  • Improved vaccination against Newcastle disease by an in ovo recombinant HVT-ND combined with an adjuvanted live vaccine at day-old.

    abstract::The continuous outbreaks of fatal Newcastle disease (ND) in commercial poultry flocks demonstrate that current vaccination strategies are not fully efficacious and should be improved by new generation of vaccines. In this context, maternally immune conventional layer chickens were vaccinated in ovo with a turkey herpe...


    pub_type: 杂志文章


    authors: Rauw F,Gardin Y,Palya V,Anbari S,Lemaire S,Boschmans M,van den Berg T,Lambrecht B

    更新日期:2010-01-08 00:00:00

  • Predictors of interest in HPV vaccination: A study of British adolescents.

    abstract::Human papillomavirus (HPV) vaccination is now offered to adolescent girls in the UK. Adolescents over 16 years old are likely to make their own decision about the vaccination. The purpose of this cross-sectional study was to assess acceptability of HPV vaccination among female adolescents (16 -- 19 years) and investig...


    pub_type: 杂志文章


    authors: Marlow LA,Waller J,Evans RE,Wardle J

    更新日期:2009-04-21 00:00:00

  • Targeting of envelope domain III protein of DENV type 2 to DEC-205 receptor elicits neutralizing antibodies in mice.

    abstract::Dengue virus (DENV) is the causal agent of severe disease and, in some cases, mortality in humans, but no licensed vaccines against dengue are available. An effective vaccine against dengue requires long-term humoral and cellular immune responses. Several viral proteins have been the subjects of intense research, espe...


    pub_type: 杂志文章


    authors: Coconi-Linares N,Ortega-Dávila E,López-González M,García-Machorro J,García-Cordero J,Steinman RM,Cedillo-Barrón L,Gómez-Lim MA

    更新日期:2013-05-01 00:00:00

  • Post-exposure rabies prophylaxis: establishing effectiveness of abbreviated treatments.

    abstract::Several publications have reported recently the apparently successful use of human diploid cell rabies vaccine (HDCV) in volumes of less than the 6 X 1.0 cm3 dosage schedule currently recommended by the World Health Organization for post-exposure rabies prophylaxis. The newer proposed treatments are advocated to econo...


    pub_type: 杂志文章


    authors: Gross EM,Bearman JE

    更新日期:1985-09-01 00:00:00

  • Chicken HSP70 DNA vaccine inhibits tumor growth in a canine cancer model.

    abstract::Immunization with xenogeneic DNA is a promising cancer treatment to overcome tolerance to self-antigens. Heat shock protein 70 (HSP70) is over-expressed in various kinds of tumors and is believed to be involved in tumor progression. This study tested a xenogeneic chicken HSP70 (chHSP70) DNA vaccine in an experimental ...


    pub_type: 杂志文章


    authors: Yu WY,Chuang TF,Guichard C,El-Garch H,Tierny D,Laio AT,Lin CS,Chiou KH,Tsai CL,Liu CH,Li WC,Fischer L,Chu RM

    更新日期:2011-04-18 00:00:00

  • An assessment of parents' childhood immunization beliefs, intentions, and behaviors using a smartphone panel.

    abstract:INTRODUCTION:It is important to quickly identify parent beliefs, intentions, and behaviors toward childhood vaccination, especially parents of children 19 to 35 months. This paper describes parental immunization beliefs, intentions, and behaviors; assesses the relationships between beliefs and intentions regarding chil...


    pub_type: 杂志文章


    authors: Boyle J,Berman L,Nowak GJ,Iachan R,Middleton D,Deng Y

    更新日期:2020-02-28 00:00:00

  • Vaccines against Ebola virus.

    abstract::We have just witnessed the largest and most devastating outbreak of Ebola virus disease, which highlighted the urgent need for development of an efficacious vaccine that could be used to curtail future outbreaks. Prior to 2014, there had been limited impetus worldwide to develop a vaccine since the virus was first dis...


    pub_type: 杂志文章


    authors: Venkatraman N,Silman D,Folegatti PM,Hill AVS

    更新日期:2018-08-28 00:00:00

  • The benefits of redesigning Benin's vaccine supply chain.

    abstract:INTRODUCTION:New vaccine introductions have put strains on vaccine supply chains around the world. While increasing storage and transportation may be the most straightforward options, it is also important to consider what financial and operational benefits can be incurred. In 2012, suboptimal vaccine coverage and impen...


    pub_type: 杂志文章


    authors: Brown ST,Schreiber B,Cakouros BE,Wateska AR,Dicko HM,Connor DL,Jaillard P,Mvundura M,Norman BA,Levin C,Rajgopal J,Avella M,Lebrun C,Claypool E,Paul P,Lee BY

    更新日期:2014-07-07 00:00:00

  • Vaccination of sheep with Quil-A® adjuvant expands the antibody repertoire to the Fasciola MF6p/FhHDM-1 antigen and administered together impair the growth and antigen release of flukes.

    abstract::Fasciolosis continues to be a major cause of economic losses in the livestock industry and a growing threat to humans. The limited spectrum of effective anthelmintics and the appearance of resistances urge the need for developing an effective vaccine. Most studies have been focused on the use of TH1-polarizing adjuvan...


    pub_type: 杂志文章


    authors: Orbegozo-Medina RA,Martínez-Sernández V,González-Warleta M,Castro-Hermida JA,Mezo M,Ubeira FM

    更新日期:2018-04-05 00:00:00

  • Immunogenicity and protective efficacy of an inactivated cell culture-derived Seneca Valley virus vaccine in pigs.

    abstract::Seneca Valley virus (SVV) infection in pigs is associated with porcine idiopathic vesicular disease (PIVD). Outbreaks of SVV infection in pig herds have been reported in several Asia and Americas countries. Recently, a series of outbreaks of SVV infection occurred in China, Canada, Thailand and the United States. Howe...


    pub_type: 杂志文章


    authors: Yang F,Zhu Z,Cao W,Liu H,Zhang K,Tian H,Liu X,Zheng H

    更新日期:2018-02-01 00:00:00

  • The FAI protein of group C streptococci targets B-cells and exhibits adjuvant activity.

    abstract::We have demonstrated that the fibrinogen-albumin-IgG receptor of group C streptococci (FAI) targets B-cells in vivo. We exploited the targeting properties of FAI to improve the immune responses stimulated by soluble antigens administered by the mucosal route. Enhanced systemic and mucosal immune responses were observe...


    pub_type: 杂志文章


    authors: Schulze K,Goldmann O,Toppel A,Medina E,Guzmán CA

    更新日期:2005-02-03 00:00:00

  • Clinical experience with inactivated, virosomal influenza vaccine.

    abstract::Current available influenza vaccines are safe and effective in preventing influenza. Nevertheless, there is a need for influenza vaccines with improved efficacy in the elderly. This need is underscored by both the observation that influenza has a major clinical and economic impact in the elderly and the fact that curr...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: de Bruijn IA,Nauta J,Cramer WC,Gerez L,Palache AM

    更新日期:2005-07-08 00:00:00

  • SHIV virus-like particles bind and activate human dendritic cells.

    abstract::We previously demonstrated that mucosal immunization with SHIV virus-like particles (VLPs) was able to induce strong humoral and cellular immune responses against HIV envelope protein (Env). To understand the mechanism for such enhanced immune responses, we studied the interaction between VLPs and dendritic cells (DCs...


    pub_type: 杂志文章


    authors: Zhang R,Li M,Chen C,Yao Q

    更新日期:2004-11-25 00:00:00

  • Selectively willing and conditionally able: HIV vaccine trial participation among women at "high risk" of HIV infection.

    abstract::Efficacy studies of investigational HIV vaccines require enrollment of individuals at 'high risk' for HIV. This paper examines participation in HIV vaccine trials among women at 'high risk' for HIV acquisition. In-depth interviews were conducted with 17 African-American women who use crack cocaine and/or exchange sex ...


    pub_type: 杂志文章


    authors: Voytek CD,Jones KT,Metzger DS

    更新日期:2011-08-18 00:00:00

  • Induction of autoantibody production but not autoimmune disease in HEL transgenic mice vaccinated with HEL in combination with CpG or control oligodeoxynucleotides.

    abstract::CpG oligodeoxynucleotides (ODN) are synthetic DNA sequences that mimic bacterial DNA, and bind to the TLR9 receptor. The cells that express TLR9, B cells and dendritic cells, are stimulated by CpG ODN and induce innate and acquired immune responses. Because CpG ODN induce antigen-independent immune activation there ha...


    pub_type: 杂志文章


    authors: Wang Y,Krieg AM

    更新日期:2004-06-30 00:00:00

  • Protective efficacy of group A streptococcal vaccines containing type-specific and conserved M protein epitopes.

    abstract::The amino terminal region of group A streptococcal M proteins evokes type-specific immunity while the conserved C-repeat epitopes evoke cross-protective immunity against multiple serotypes. The present studies were undertaken to compare the protective efficacy of vaccines containing either type-specific (hexavalent va...


    pub_type: 杂志文章


    authors: Penfound TA,Chiang EY,Ahmed EA,Dale JB

    更新日期:2010-07-12 00:00:00

  • Assessment of preparation time with fully-liquid versus non-fully liquid paediatric hexavalent vaccines. A time and motion study.

    abstract:BACKGROUND AND AIMS:Simplified vaccine preparation steps would save time and reduce potential immunisation errors. The aim of the study was to assess vaccine preparation time with fully-liquid hexavalent vaccine (DTaP-IPV-HB-PRP-T, Sanofi Pasteur MSD) versus non-fully liquid hexavalent vaccine that needs reconstitution...


    pub_type: 杂志文章


    authors: De Coster I,Fournie X,Faure C,Ziani E,Nicolas L,Soubeyrand B,Van Damme P

    更新日期:2015-07-31 00:00:00

  • Response to conjugate pneumococcal and Haemophilus influenzae type b vaccines in asplenic patients.

    abstract::We determined the immunogenicity of conjugated Haemophilus influenzae type b and pneumococcal vaccines by quantitative analysis of the antibody response in asplenic patients. To that end, we vaccinated 92 patients with a conjugated Hib vaccine and 54 received two doses of conjugated pneumococcal vaccine (PCV7), follow...


    pub_type: 杂志文章


    authors: Meerveld-Eggink A,de Weerdt O,van Velzen-Blad H,Biesma DH,Rijkers GT

    更新日期:2011-01-17 00:00:00

  • UV-inactivated vaccinia virus (VV) in a multi-envelope DNA-VV-protein (DVP) HIV-1 vaccine protects macaques from lethal challenge with heterologous SHIV.

    abstract::The pandemic of HIV-1 has continued for decades, yet there remains no licensed vaccine. Previous research has demonstrated the effectiveness of a multi-envelope, multi-vectored HIV-1 vaccine in a macaque-SHIV model, illustrating a potential means of combating HIV-1. Specifically, recombinant DNA, vaccinia virus (VV) a...


    pub_type: 杂志文章


    authors: Jones BG,Sealy RE,Zhan X,Freiden PJ,Surman SL,Blanchard JL,Hurwitz JL

    更新日期:2012-05-02 00:00:00

  • Immunization education for internal medicine residents: A cluster-randomized controlled trial.

    abstract:PURPOSE:The aims of this study are to evaluate the impact of a novel immunization curriculum based on the Preferred Cognitive Styles and Decision Making Model (PCSDM) on internal medicine (IM) resident continuity clinic patient panel immunization rates, as well as resident immunization knowledge, attitudes, and practic...


    pub_type: 杂志文章,随机对照试验


    authors: Whitaker JA,Poland CM,Beckman TJ,Bundrick JB,Chaudhry R,Grill DE,Halvorsen AJ,Huber JM,Kasten MJ,Mauck KF,Mehta RA,Olson T,Thomas KG,Thomas MR,Virk A,Wingo MT,Poland GA

    更新日期:2018-03-27 00:00:00

  • Financing children's vaccines.

    abstract::A 2006 Commonwealth Association of Paediatric Gastroenterology and Nutrition workshop on financing children's vaccines highlighted the potential for vaccines to control diarrhoea and other diseases as well as spur economic development through better health. Clear communication of vaccination value to decision-makers i...


    pub_type: 杂志文章


    authors: Nelson EA,Sack D,Wolfson L,Walker DG,Seng LF,Steele D

    更新日期:2009-11-20 00:00:00

  • Genetic diversity and population dynamics of Bordetella pertussis in China between 1950-2007.

    abstract::Pertussis is an acute respiratory infectious disease caused by the bacterium Bordetella pertussis. Although pertussis vaccination was introduced in the 1960s, pertussis is still an endemic disease in China. To better understand the genetic diversity of the Chinese B. pertussis population, we characterized 115 clinical...


    pub_type: 杂志文章


    authors: Xu Y,Zhang L,Tan Y,Wang L,Zhang S,Wang J

    更新日期:2015-11-17 00:00:00

  • Induction of humoral immune response against Pseudomonas aeruginosa flagellin(1-161) using gold nanoparticles as an adjuvant.

    abstract::Flagellin of Pseudomonas aeruginosa is an important vaccine candidate. N-terminal domains are highly conserved in both type a and type b flagellins. The efficacy of gold nanoparticles (AuNPs) conjugated to N-terminal domains of P. aeruginosa flagellin (flagellin(1-161)), as an immunogen in mice, has been assessed. The...


    pub_type: 杂志文章


    authors: Dakterzada F,Mohabati Mobarez A,Habibi Roudkenar M,Mohsenifar A

    更新日期:2016-03-14 00:00:00

  • Single and booster dose responses to an inactivated hepatitis A virus vaccine: comparison with immune serum globulin prophylaxis.

    abstract::Pre- and postexposure prophylaxis against hepatitis A virus (HAV) infection with immune serum globulin (Ig) is only effective for 4-6 months. We compared the safety, tolerability and immunogenicity of a single i.m. injection of Ig with a single and booster dose of an inactivated hepatitis A virus vaccine (iHAV) in adu...


    pub_type: 临床试验,杂志文章


    authors: Shouval D,Ashur Y,Adler R,Lewis JA,Armstrong ME,Davide JP,McGuire B,Kuter B,Brown L,Miller W

    更新日期:1993-01-01 00:00:00

  • Comparative evaluation of ELPylated virus-like particle vaccine with two commercial PCV2 vaccines by experimental challenge.

    abstract::Porcine circovirus type 2 (PCV2) is an economically important swine pathogen and vaccination is the primary tool for the disease control. Previously, we developed a more cost-effective PCV2 virus-like particle (VLP) vaccine by using ELPylation technology. In the present study, we compared the ELPylated VLP (ELP-VLP) P...


    pub_type: 杂志文章


    authors: Li Y,Lin Y,Xin G,Zhou X,Lu H,Zhang X,Xia X,Sun H

    更新日期:2020-05-13 00:00:00

  • Comparison of the CD8+ T cell responses and antitumor effects generated by DNA vaccine administered through gene gun, biojector, and syringe.

    abstract::DNA vaccines have emerged as an attractive approach for antigen-specific cancer immunotherapy. We have previously linked Mycobacterium tuberculosis heat shock protein 70 (HSP70) to human papillomavirus type 16 (HPV-16) E7 in the context of a DNA vaccine. Vaccination with DNA encoding E7/HSP70 has generated a dramatic ...


    pub_type: 杂志文章


    authors: Trimble C,Lin CT,Hung CF,Pai S,Juang J,He L,Gillison M,Pardoll D,Wu L,Wu TC

    更新日期:2003-09-08 00:00:00