Abstract：
:We investigated several methods to immunize the abomasum (fourth and gastric stomach) of kid goats by direct (abomasal) or distal (rectal or nasal) routes utilizing mucosal antigens isolated from the abomasal parasite, Haemonchus contortus. Direct (ultrasound guided), immunization of the abomasal mucosa together with rectal immunization established lymphocyte proliferation responses in abomasal lymph nodes (ALNs), while distal methods, alone, produced equivocal results. The differential responses (cellular and antibody) induced by alternative immunization methods demonstrated an experimental system that can facilitate advances in mucosal immunization against H. contortus and other gastrointestinal pathogens of food animals.
journal_name
Vaccinejournal_title
Vaccineauthors
Jasmer DP,Brown WC,Parish Sdoi
10.1016/j.vaccine.2011.02.003subject
Has Abstractpub_date
2011-04-05 00:00:00pages
2938-46issue
16eissn
0264-410Xissn
1873-2518pii
S0264-410X(11)00204-0journal_volume
29pub_type
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