Direct immunization of the abomasum or rectum of goats induces local lymph node responses against Haemonchus contortus mucosal antigens.


:We investigated several methods to immunize the abomasum (fourth and gastric stomach) of kid goats by direct (abomasal) or distal (rectal or nasal) routes utilizing mucosal antigens isolated from the abomasal parasite, Haemonchus contortus. Direct (ultrasound guided), immunization of the abomasal mucosa together with rectal immunization established lymphocyte proliferation responses in abomasal lymph nodes (ALNs), while distal methods, alone, produced equivocal results. The differential responses (cellular and antibody) induced by alternative immunization methods demonstrated an experimental system that can facilitate advances in mucosal immunization against H. contortus and other gastrointestinal pathogens of food animals.






Jasmer DP,Brown WC,Parish S




Has Abstract


2011-04-05 00:00:00
















  • Improved vaccination against Newcastle disease by an in ovo recombinant HVT-ND combined with an adjuvanted live vaccine at day-old.

    abstract::The continuous outbreaks of fatal Newcastle disease (ND) in commercial poultry flocks demonstrate that current vaccination strategies are not fully efficacious and should be improved by new generation of vaccines. In this context, maternally immune conventional layer chickens were vaccinated in ovo with a turkey herpe...


    pub_type: 杂志文章


    authors: Rauw F,Gardin Y,Palya V,Anbari S,Lemaire S,Boschmans M,van den Berg T,Lambrecht B

    更新日期:2010-01-08 00:00:00

  • Antibody persistence and booster response in adolescents and young adults 4 and 7.5 years after immunization with 4CMenB vaccine.

    abstract:BACKGROUND:Data on duration of protection against invasive meningococcal disease post-vaccination with the recombinant, 4-component, meningococcal serogroup B vaccine (4CMenB) are limited. We evaluated bactericidal activity persistence in adolescents/young adults up to 7.5 years post-primary vaccination with 4CMenB, an...


    pub_type: 杂志文章,多中心研究


    authors: Nolan T,Santolaya ME,de Looze F,Marshall H,Richmond P,Henein S,Rheault P,Heaton K,Perrett KP,Garfield H,Gupta A,Ferguson M,D'Agostino D,Toneatto D,O'Ryan M

    更新日期:2019-02-21 00:00:00

  • Measles vaccine adverse events reported in the mass vaccination campaign of Sichuan province, China from 2007 to 2008.

    abstract::The aim of this study was to characterize the adverse events of attenuated measles vaccine in mainland China. We carried out prospective follow-up of adverse events after mass measles immunization practices, categorizing them into two groups: allergic reactions and serious adverse events. The incidence of anaphylaxis ...


    pub_type: 杂志文章


    authors: Shu M,Liu Q,Wang J,Ao R,Yang C,Fang G,Wan C,Guo W

    更新日期:2011-04-18 00:00:00

  • WHO meeting on the standardization of HPV assays and the role of the WHO HPV Laboratory Network in supporting vaccine introduction held on 24-25 January 2008, Geneva, Switzerland.

    abstract::In anticipation of the implementation of new prophylactic HPV vaccines, the WHO is supporting the establishment of a global WHO HPV Laboratory Network whose mission is to "contribute to improving the quality of laboratory services for effective surveillance and monitoring of HPV vaccination impact through enhanced, st...




    authors: Ferguson M,Wilkinson DE,Zhou T

    更新日期:2009-01-14 00:00:00

  • Characterization of virulence of Leptospira isolates in a hamster model.

    abstract::Effort has been made to identify protective antigens in order to develop a recombinant vaccine against leptospirosis. Several attempts failed to conclusively demonstrate efficacy of vaccine candidates due to the lack of an appropriate model of lethal leptospirosis. The purposes of our study were: (i) to test the virul...


    pub_type: 杂志文章


    authors: Silva EF,Santos CS,Athanazio DA,Seyffert N,Seixas FK,Cerqueira GM,Fagundes MQ,Brod CS,Reis MG,Dellagostin OA,Ko AI

    更新日期:2008-07-23 00:00:00

  • Mutant influenza A virus nucleoprotein is preferentially localized in the cytoplasm and its immunization in mice shows higher immunogenicity and cross-reactivity.

    abstract::Many influenza vaccines targeted to hemagglutinin (HA) show efficient immunogenicity for protecting subjects against influenza virus infection. Major antigenic changes to HA molecules can help influenza virus to develop resistance against HA-targeted vaccines. DNA vaccines encoding conserved antigens protect animals a...


    pub_type: 杂志文章


    authors: Ohba K,Yoshida S,Zahidunnabi Dewan M,Shimura H,Sakamaki N,Takeshita F,Yamamoto N,Okuda K

    更新日期:2007-05-22 00:00:00

  • Case-control vaccine effectiveness studies: Data collection, analysis and reporting results.

    abstract::The case-control methodology is frequently used to evaluate vaccine effectiveness post-licensure. The results of such studies provide important insight into the level of protection afforded by vaccines in a 'real world' context, and are commonly used to guide vaccine policy decisions. However, the potential for bias a...


    pub_type: 杂志文章,评审


    authors: Verani JR,Baqui AH,Broome CV,Cherian T,Cohen C,Farrar JL,Feikin DR,Groome MJ,Hajjeh RA,Johnson HL,Madhi SA,Mulholland K,O'Brien KL,Parashar UD,Patel MM,Rodrigues LC,Santosham M,Scott JA,Smith PG,Sommerfelt H,Tate

    更新日期:2017-06-05 00:00:00

  • Use of GFP-expressing influenza viruses for the detection of influenza virus A/H5N1 neutralizing antibodies.

    abstract::The hemagglutination inhibition (HI) assay is used most commonly for the detection of antibodies to influenza viruses. However, for the detection of antibodies to avian influenza viruses of the H5N1 subtype either induced by infection or by vaccination, the HI assay is insensitive. Therefore, the virus neutralization ...


    pub_type: 杂志文章


    authors: Rimmelzwaan GF,Verburgh RJ,Nieuwkoop NJ,Bestebroer TM,Fouchier RA,Osterhaus AD

    更新日期:2011-04-18 00:00:00

  • Fluorescence spectroscopy monitoring of the conformational restraint of formaldehyde- and glutaraldehyde-treated infectious bursal disease virus proteins.

    abstract::Interaction of native proteinaceous antigens during the recognition and the effector phases of an immune response leads to antigenic conformational modifications which may elicit additional specific immune response. Protein cross-linking and conformation restraining formaldehyde and glutaraldehyde have been extensivel...


    pub_type: 杂志文章


    authors: Cepica A,Beauregard M,Qian B

    更新日期:1998-12-01 00:00:00

  • Isolation and characterization of influenza C virus inhibitors in rat serum.

    abstract::Two inhibitors against haemagglutination by influenza C virus were isolated from pooled sera of normal rats by sequential chromatography on Blue Sepharose CL 6B, Ultrogel AcA 2, and DEAE-cellulose. The two inhibitors were identified as alpha 1-macroglobulin and murinoglobulin by comparison with the authentic samples. ...


    pub_type: 杂志文章


    authors: Kitame F,Nakamura K,Saito A,Sinohara H,Homma M

    更新日期:1985-09-01 00:00:00

  • A randomized double-blind trial comparing a two-component acellular to a whole-cell pertussis vaccine in Senegal.

    abstract::A randomized, double-blind trial comparing a diphtheria-tetanus-acellular pertussis vaccine (DTaP) (pertussis toxoid and filamentous hemagglutinin) with a whole-cell vaccine (DTwP) was conducted. A case-contact study was nested in the trial to estimate absolute efficacy. From 1990 through 1994, 4181 children were rand...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Simondon F,Preziosi MP,Yam A,Kane CT,Chabirand L,Iteman I,Sanden G,Mboup S,Hoffenbach A,Knudsen K,Guiso N,Wassilak S,Cadoz M

    更新日期:1997-10-01 00:00:00

  • Use of mobile phones for improving vaccination coverage among children living in rural hard-to-reach areas and urban streets of Bangladesh.

    abstract::In Bangladesh, full vaccination rates among children living in rural hard-to-reach areas and urban streets are low. We conducted a quasi-experimental pre-post study of a 12-month mobile phone intervention to improve vaccination among 0-11 months old children in rural hard-to-reach and urban street dweller areas. Softw...


    pub_type: 杂志文章


    authors: Uddin MJ,Shamsuzzaman M,Horng L,Labrique A,Vasudevan L,Zeller K,Chowdhury M,Larson CP,Bishai D,Alam N

    更新日期:2016-01-04 00:00:00

  • Hepatitis B specific T cell immunity induced by primary vaccination persists independently of the protective serum antibody level.

    abstract::In 2005, in accordance with recommendations made by the European Medicines Agency, the Italian Drug Agency ordered withdrawal of the hexavalent Hexavac(®) vaccine (Sanofi Pasteur MSD) from the market. Concerns had been raised about the low immunogenicity of the hepatitis B virus component of the vaccine, assessed by m...


    pub_type: 杂志文章


    authors: Carollo M,Palazzo R,Bianco M,Pandolfi E,Chionne P,Fedele G,Tozzi AE,Carsetti R,Romanò L,Ausiello CM

    更新日期:2013-01-07 00:00:00

  • Prospects for preventing infant invasive GBS disease through maternal vaccination.

    abstract::Group B streptococcus (GBS) is a leading cause of neonatal sepsis, with the highest incidence (1.3 per 1000 live births) reported from Africa. Although the incidence of invasive GBS disease is reportedly low in South Asia, there is disconnect between prevalence of maternal recto-vaginal colonization and the incidence ...


    pub_type: 杂志文章


    authors: Madhi SA,Dangor Z

    更新日期:2017-08-16 00:00:00

  • A West Nile virus NS4B-P38G mutant strain induces adaptive immunity via TLR7-MyD88-dependent and independent signaling pathways.

    abstract::Prior work shows that an attenuated West Nile virus (WNV), the nonstructural (NS)4B-P38G mutant infection in mice induced strong immune responses and protected host from subsequent lethal wild-type WNV infection. Here, we investigated NS4B-P38G mutant infection in myeloid differentiation factor 88-deficient (MyD88(-/-...


    pub_type: 杂志文章


    authors: Xie G,Welte T,Wang J,Whiteman MC,Wicker JA,Saxena V,Cong Y,Barrett AD,Wang T

    更新日期:2013-08-28 00:00:00

  • Developing whole mycobacteria cell vaccines for tuberculosis: Workshop proceedings, Max Planck Institute for Infection Biology, Berlin, Germany, July 9, 2014.

    abstract::On July 9, 2014, Aeras and the Max Planck Institute for Infection Biology convened a workshop entitled "Whole Mycobacteria Cell Vaccines for Tuberculosis" at the Max Planck Institute for Infection Biology on the grounds of the Charité Hospital in Berlin, Germany, close to the laboratory where, in 1882, Robert Koch fir...




    authors: Whole Mycobacteria Cell Vaccines for Tuberculosis Summary Group.

    更新日期:2015-06-12 00:00:00

  • Infants with low vaccine antibody responses have altered innate cytokine response.

    abstract::We recently identified a population of 10% of infants who respond with sub-protective antibody levels to most routine primary pediatric vaccinations due to altered innate and adaptive immune responses. We term these infants as low vaccine responders (LVRs). Here we report new data showing that TLR7/8 agonist - R848 st...


    pub_type: 杂志文章


    authors: Surendran N,Nicolosi T,Pichichero M

    更新日期:2016-11-11 00:00:00

  • Intussusception risk after RotaTeq vaccination: evaluation from worldwide spontaneous reporting data using a self-controlled case series approach.

    abstract::The increased risk of intussusception after vaccination with the rhesus-human reassortant rotavirus vaccine Rotashield led to its withdrawal in 2005. We assess the risk of intussusception following the pentavalent rotavirus vaccine (RV5) on the basis of worldwide reports to the manufacturer up to May 2014, using a sel...


    pub_type: 杂志文章


    authors: Escolano S,Hill C,Tubert-Bitter P

    更新日期:2015-02-18 00:00:00

  • An E2 sub-unit marker vaccine does not prevent horizontal or vertical transmission of classical swine fever virus.

    abstract::An experimental infection with classical swine fever (CSF) virus in E2 sub-unit marker vaccine vaccinated gilts was conducted in order to evaluate the effect of vaccination on virus transmission and course of the disease. Therefore, clinical signs as well as horizontal and vertical virus transmission were monitored in...


    pub_type: 杂志文章


    authors: Dewulf J,Laevens H,Koenen F,Mintiens K,de Kruif A

    更新日期:2001-10-12 00:00:00

  • Effectiveness of oral cholera vaccine in preventing cholera among fishermen in Lake Chilwa, Malawi: A case-control study.

    abstract:BACKGROUND:In response to a cholera outbreak among mobile, difficult-to-reach fishermen on Lake Chilwa, Malawi in 2016, a novel vaccine distribution strategy exploited the proven vaccine thermostability. Fishermen, while taking the first vaccine dose under supervision, received the second dose in a sealed bag, and were...


    pub_type: 杂志文章


    authors: Grandesso F,Kasambara W,Page AL,Debes AK,M'bang'ombe M,Palomares A,Lechevalier P,Pezzoli L,Alley I,Salumu L,Msyamboza K,Sack D,Cohuet S,Luquero FJ

    更新日期:2019-06-19 00:00:00

  • Peptide-binding assays and HLA II transgenic Abeta degrees mice are consistent and complementary tools for identifying HLA II-restricted peptides.

    abstract::The identification of MHC class II-restricted peptides has become a priority for the development of peptide-based prophylactic and therapeutic vaccines. The aim of this study was to assess the correlations between peptide-binding assays on purified HLA II molecules and immunization of human HLA II transgenic mice defi...


    pub_type: 杂志文章


    authors: Depil S,Angyalosi G,Moralès O,Delacre M,Delhem N,François V,Georges B,Hammer J,Maillère B,Auriault C,Pancré V

    更新日期:2006-03-20 00:00:00

  • Global distribution of group A rotavirus strains in horses: a systematic review.

    abstract::Group A rotavirus (RVA) is a major cause of diarrhea and diarrhea-related mortality in foals in parts of the world. In addition to careful horse farm management, vaccination is the only known alternative to reduce the RVA associated disease burden on horse farms. The precise evaluation of vaccine effectiveness against...


    pub_type: 杂志文章,评审


    authors: Papp H,Matthijnssens J,Martella V,Ciarlet M,Bányai K

    更新日期:2013-11-19 00:00:00

  • Immunogenicity of dengue virus type 1 DNA vaccines expressing truncated and full length envelope protein.

    abstract::Recombinant plasmid DNA constructs expressing truncated or full-length dengue-1 envelope (E) with or without the pre-membrane (prM) were tested for immunogenicity in mice, as candidate dengue DNA vaccines. Two plasmids, one expressing the N-terminal 80% E and the other expressing prM and full length E were immunogenic...


    pub_type: 杂志文章


    authors: Raviprakash K,Kochel TJ,Ewing D,Simmons M,Phillips I,Hayes CG,Porter KR

    更新日期:2000-05-08 00:00:00

  • Tumour-dendritic hybrid cell vaccination for the treatment of patients with malignant melanoma: immunological effects and clinical results.

    abstract::Hybrid cell vaccines of autologous tumour cells fused with allogenic dendritic cells (DC) combine the tumour's antigenicity with the immune-stimulatory capacity of mature dendritic cells and allogenic MHC class II molecules to activate T cell help and induce tumour-specific cytotoxic T cells. This concept was tested i...


    pub_type: 临床试验,杂志文章


    authors: Trefzer U,Herberth G,Wohlan K,Milling A,Thiemann M,Sharav T,Sparbier K,Sterry W,Walden P

    更新日期:2005-03-18 00:00:00

  • A vaccine based on recombinant modified Vaccinia Ankara containing the nucleoprotein from Lassa virus protects against disease progression in a guinea pig model.

    abstract::Lassa fever remains the most imported viral haemorrhagic fever in Europe and is responsible for 5000 deaths per year throughout Western Africa. There is no vaccine and treatment is often ineffective. We have developed a vaccine based on modified Vaccinia Ankara expressing the nucleoprotein from Lassa virus (MVALassaNP...


    pub_type: 杂志文章


    authors: Kennedy EM,Dowall SD,Salguero FJ,Yeates P,Aram M,Hewson R

    更新日期:2019-08-23 00:00:00

  • Quantitative assay for the transforming DNA activity in cell culture products for human use.

    abstract::DNA isolates from a number of established cell lines have been tested for their transforming capacity in the NIH3T3 transformation assay. It has been found that this assay can be used to quantify the amount of transforming DNA at a submicrogram to milligram level. This assay system has been applied to validate the red...


    pub_type: 杂志文章


    authors: van Meel FC,Steenbakkers PG,Bos E

    更新日期:1985-12-01 00:00:00

  • Safety and immunogenicity of a quadrivalent inactivated influenza vaccine in adults.

    abstract:BACKGROUND AND AIMS:Although two antigenically distinct B strain lineages of influenza have co-circulated globally since the mid-1980s, trivalent influenza vaccines (TIVs) contain only one, resulting in frequent mismatches. This study examined the safety and immunogenicity of an inactivated quadrivalent influenza vacci...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Pépin S,Donazzolo Y,Jambrecina A,Salamand C,Saville M

    更新日期:2013-11-12 00:00:00

  • Attitudes toward HPV vaccination among parents of adolescent girls in Mysore, India.

    abstract::This study investigates attitudes toward human papillomavirus (HPV) vaccination among parents of adolescent girls in Mysore, India. Seven focus group discussions were held among parents of adolescent girls stratified by sex, religion and region to explore attitudes about cervical cancer and HPV vaccination. The study ...


    pub_type: 杂志文章


    authors: Madhivanan P,Krupp K,Yashodha MN,Marlow L,Klausner JD,Reingold AL

    更新日期:2009-08-20 00:00:00

  • Adjuvant activity of immunopotentiating reconstituted influenza virosomes (IRIVs).

    abstract::Using immunopotentiating, reconstituted influenza virosomes (IRIV) as a delivery vehicle, a number of vaccines have been developed. In humans, IRIV-based vaccines containing hepatitis A and influenza antigens have been found to possess enhanced immunogenicity compared to alum-adsorbed vaccine for hepatitis A or commer...


    pub_type: 杂志文章


    authors: Glück R

    更新日期:1999-03-26 00:00:00

  • Effectiveness of H1N1/09 monovalent and trivalent influenza vaccines against hospitalization with laboratory-confirmed H1N1/09 influenza in Australia: a test-negative case control study.

    abstract::We aimed to estimate the effectiveness of H1N1/09 containing influenza vaccines against hospitalization from influenza in Australia. We performed a test-negative case control study in patients hospitalized in 15 sentinel Australian hospitals between March and November 2010, comparing influenza vaccination (H1N1/09 mon...


    pub_type: 杂志文章


    authors: Cheng AC,Kotsimbos T,Kelly HA,Irving LB,Bowler SD,Brown SG,Holmes M,Jenkins CR,Thompson P,Simpson G,Wood-Baker R,Senanayake SN,Brady SJ,Paterson DL,Wark PA,Upham JW,Korman TM,Dwyer DE,Waterer GW,Kelly PM

    更新日期:2011-10-06 00:00:00