Circulating cellular immune response to oral immunization of humans with cholera toxin B-subunit.

abstract：BACKGROUND:Therapeutic vaccination is a novel treatment approach for chronic hepatitis B, but only had limited success so far. We hypothesized that optimized vaccination schemes have increased immunogenicity, and aimed at increasing therapeutic hepatitis B vaccine efficacy. METHODS:Modified Vaccinia virus Ankara (MVA)...

journal_title：Vaccine

authors： Backes S,Jäger C,Dembek CJ,Kosinska AD,Bauer T,Stephan AS,Dišlers A,Mutwiri G,Busch DH,Babiuk LA,Gasteiger G,Protzer U

更新日期：2016-02-10 00:00:00

abstract：:Age-specific force of varicella infection, hospitalisation and death rates in non-immune persons were calculated using an age-based mathematical model and national data for France. A cost-effectiveness model was then applied to hypothetical cohorts of persons aged 15-45 years with a negative or uncertain history of va...

journal_title：Vaccine

authors： Hanslik T,Boëlle PY,Schwarzinger M,Carrat F,Freedberg KA,Valleron AJ,Flahault A

更新日期：2003-09-08 00:00:00

abstract：:Influenza becomes epidemic worldwide every year, and many individuals receive vaccination annually. Quality control relating to safety and potency of influenza vaccines is important to maintain public confidence. The safety of influenza vaccines has been assessed by clinical trials, and animal safety tests are perform...

journal_title：Vaccine

authors： Momose H,Sasaki E,Kuramitsu M,Hamaguchi I,Mizukami T

更新日期：2018-10-15 00:00:00

abstract：BACKGROUND:Patients with Crohn's disease (CD) have a higher risk of infectious diseases including pneumococcal infections, and the risk increases with immunotherapy. The primary endpoint of this study was to investigate the specific antibody response to two pneumococcal vaccines in CD patients with and without immunosu...

journal_title：Vaccine

authors： Kantsø B,Halkjær SI,Thomsen OØ,Belard E,Gottschalck IB,Jørgensen CS,Krogfelt KA,Slotved HC,Ingels H,Petersen AM

更新日期：2015-10-05 00:00:00

abstract：BACKGROUND:Racial differences have been observed in the rate of bacterial infection and disease progression in HIV. Here, we evaluate racial differences in seasonal influenza vaccine responses. METHODS:16 healthy controls (9 Caucasians (CC) and 7 African Americans (AA)) and 26 antiretroviral therapy (ART)-treated avir...

journal_title：Vaccine

authors： Ma P,Luo Z,Qian J,Yan Z,Zhang L,Martin L,Wang Z,Xia H,Yu F,Jiang W

更新日期：2020-02-18 00:00:00

abstract：:In a phase I clinical trial, one hundred healthy young adults were randomized to receive two doses 28 days apart of an inactivated, subvirion vaccine containing 15 or 45microg of influenza A/H5N1 hemagglutinin (HA) by the intramuscular (IM) route, or 3 or 9microg of H5 HA by the intradermal(ID) route. Seventy-seven su...

journal_title：Vaccine

authors： Patel SM,Atmar RL,El Sahly HM,Cate TR,Keitel WA

更新日期：2010-04-09 00:00:00

abstract：:Leishmania donovani promastigote soluble antigens (sLAg) were encapsulated in non-phosphatidylcholine (non-PC) liposomes (escheriosomes) prepared from E. coli lipids. The escheriosome-based vaccine was investigated for its potential to elicit a protective immune response against experimental visceral leishmaniasis. Th...

journal_title：Vaccine

authors： Sharma SK,Dube A,Nadeem A,Khan S,Saleem I,Garg R,Mohammad O

更新日期：2006-03-10 00:00:00

abstract：:The immunogenicity of four synthetic peptides was investigated in sheep. The sequences of the peptides (6, 12/13, 21/22 and 24) were derived from linear, antibody-binding epitopes of the EG95 recombinant protein, a host-protective antigen of the parasite Echinococcus granulosus. Sheep were immunised with either free p...

journal_title：Vaccine

authors： Woollard DJ,Gauci CG,Lightowlers MW

更新日期：1999-12-10 00:00:00

abstract：:Parent-to-infant transmission of pertussis remains an issue in France. Although adult booster vaccination was introduced in 2004 as part of a cocooning strategy targeted primarily to parents of young infants, vaccination coverage in this population has remained low. The aim of this study was to evaluate the impact on ...

journal_title：Vaccine

authors： Leboucher B,Sentilhes L,Abbou F,Henry E,Grimprel E,Descamps P

更新日期：2012-08-10 00:00:00

abstract：OBJECTIVES:Public health authorities have the resources to conduct efficient immunization reminder interventions to improve vaccine uptake. The objective of this initiative was to design and implement a cost-effective centralized HPV vaccine reminder using New York State Immunization Information System data as one of f...

journal_title：Vaccine

authors： Coley S,Hoefer D,Rausch-Phung E

更新日期：2018-08-06 00:00:00

abstract：INTRODUCTION:The Global Vaccine Action Plan identifies workforce capacity building as a key strategy to achieve strong immunization programs. The Strengthening Technical Assistance for Routine Immunization Training (START) approach aimed to utilize practical training methods to build capacity of district and health cen...

journal_title：Vaccine

authors： Ward K,Stewart S,Wardle M,Sodha SV,Tanifum P,Ayebazibwe N,Mayanja R,Luzze H,Ehlman DC,Conklin L,Abbruzzese M,Sandhu HS

更新日期：2019-05-09 00:00:00

abstract：:Financial sustainability plans (FSPs) were developed by over 50 of the world's poorest countries receiving funding support from the Global Alliance for Vaccines and Immunization (GAVI) to introduce new and underused vaccines, injection safety and immunization service support between 2000 and 2006. These plans were ana...

journal_title：Vaccine

authors： Kamara L,Milstien JB,Patyna M,Lydon P,Levin A,Brenzel L

更新日期：2008-12-02 00:00:00

abstract：:It is generally recognized that DNA vaccines are often less effective in large animals than in mice. One possible reason for this reduced effectiveness may be transfection efficiency and the low level of expression elicited by plasmid vectors in large animals. A possible way to improve plasmid gene expression in vivo ...

journal_title：Vaccine

authors： Babiuk S,Baca-Estrada ME,Foldvari M,Storms M,Rabussay D,Widera G,Babiuk LA

更新日期：2002-09-10 00:00:00

abstract：:The military population has a high disease burden of acute viral respiratory infections in China. To assess the efficacy and safety of a low-dose recombinant human interferon alpha-2b (rIFNalpha-2b) nasal spray in preventing acute viral respiratory infections in military population, we performed this randomized contro...

journal_title：Vaccine

authors： Gao L,Yu S,Chen Q,Duan Z,Zhou J,Mao C,Yu D,Zhu W,Nie J,Hou Y

更新日期：2010-06-17 00:00:00

abstract：:The main objective of this study was to assess the efficacy of a monovalent inactivated vaccine containing phase I Coxiella burnetii to prevent Coxiella shedding in susceptible dairy cows within infected herds in comparison to a placebo. A total of 336 dairy cows and heifers, from six spontaneously infected herds, wer...

journal_title：Vaccine

authors： Guatteo R,Seegers H,Joly A,Beaudeau F

更新日期：2008-08-12 00:00:00

abstract：:Measles is one of the most important diseases of mankind, which is so highly contagious and evokes such persistent immunity that the virus cannot be sustained in a population of less than about 500,000 persons. The first of the licensed live virus vaccines against measles was developed empirically and was approved in ...

journal_title：Vaccine

authors： Hilleman MR

更新日期：2001-12-12 00:00:00

abstract：:We determined the immunogenicity of conjugated Haemophilus influenzae type b and pneumococcal vaccines by quantitative analysis of the antibody response in asplenic patients. To that end, we vaccinated 92 patients with a conjugated Hib vaccine and 54 received two doses of conjugated pneumococcal vaccine (PCV7), follow...

journal_title：Vaccine

authors： Meerveld-Eggink A,de Weerdt O,van Velzen-Blad H,Biesma DH,Rijkers GT

更新日期：2011-01-17 00:00:00

abstract：:Little is known of men's knowledge of cervical cancer and its links with human papillomavirus (HPV), or of their attitudes and beliefs about HPV vaccination. This is despite men's sexual behaviour contributing to HPV transmission and their potential role in deciding whether their children are vaccinated against HPV. T...

journal_title：Vaccine

authors： Pitts M,Smith A,Croy S,Lyons A,Ryall R,Garland S,Wong ML,Hseon TE

更新日期：2009-05-14 00:00:00

abstract：:The use of vaccinia virus in recombinant systems may result in the occurrence of complications observed following smallpox vaccination. The results are presented of a large survey carried out in the USSR between 1968 and 1979. High complication rates are reported, particularly in older primary vaccinees; for example, ...

journal_title：Vaccine

authors： Gurvich EB

更新日期：1992-01-01 00:00:00

abstract：:ISCOMATRIX adjuvant is capable of inducing broad and potent humoral and cellular immune responses. The components are well defined and the manufacturing process is simple and robust. Many vaccines containing the ISCOMATRIX adjuvant have been tested in a range of animal models, including human and non-human primates. S...

journal_title：Vaccine

authors： Pearse MJ,Drane D

更新日期：2004-06-23 00:00:00

abstract：:Protein based therapeutics have enjoyed great success over the past decade. Unfortunately, with this clinical success comes a heavy price tag, owing to the inherently high costs of capitalization and production using mammalian cell fermentation. To address this problem, we have begun developing a system for the expres...

journal_title：Vaccine

authors： Mayfield SP,Franklin SE

更新日期：2005-03-07 00:00:00

abstract：:The tetanus and diphtheria vaccination programme in Finland has been running for 50 years. After primary doses, tetanus boosters have been offered to men in military service and decennial boosters recommended for all through the adult life. For 30 years a diphtheria booster was only offered to men in the military serv...

journal_title：Vaccine

authors： Olander RM,Auranen K,Härkänen T,Leino T

更新日期：2009-08-27 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) produces Stx1 and Stx2 causing severe diseases. Their B-subunits (StxBs) exhibit low immunogenicity and the anti-StxB antibodies neutralizing both Stxs has not been prepared yet. By intranasal vaccination with His-tagged-StxB (Stx1B-His or Stx2B-His) plus a mutant heat-labile ...

journal_title：Vaccine

authors： Tsuji T,Shimizu T,Sasaki K,Tsukamoto K,Arimitsu H,Ochi S,Shimizu T,Taniguchi K,Noda M,Neri P,Mori H

更新日期：2008-04-16 00:00:00

abstract：:A qualitative study design was adapted to explore the challenges faced by health workers (HWs) during the polio health campaign. In addition, HWs' opinions about the factors causing parents to refuse oral polio vaccination (OPV) were also explored. Four focus group discussions (FGDs) were held (from 1st January 2015-3...

journal_title：Vaccine

authors： Khan TM,Sahibzada MU

更新日期：2016-04-19 00:00:00

abstract：:Live, attenuated hepatitis A vaccines are used widely in China but there is uncertainty regarding the persistence of vaccine-induced anti-HAV antibodies after single dose and booster dose administrated at month 12. A large scale clinical trial to evaluate the live, attenuated hepatitis A vaccine was conducted in Hebei...

journal_title：Vaccine

authors： Wang XY,Xu ZY,Ma JC,von Seidlein L,Zhang Y,Hao ZY,Han OP,Zhang YL,Tian MY,Ouyang PY,Zhang ZY,Han CQ,Xing ZC,Chen JC

更新日期：2007-01-05 00:00:00

abstract：:Lyme borreliosis (LB) is the most common vector-borne disease in the northern hemisphere and there is no vaccine available for disease prevention. The majority of LB cases in Europe are caused by four different Borrelia species expressing six different OspA serotypes, whereas in the US only one of these serotypes is p...

journal_title：Vaccine

authors： Comstedt P,Hanner M,Schüler W,Meinke A,Schlegl R,Lundberg U

更新日期：2015-11-04 00:00:00

abstract：:The Global Meningococcal Initiative (GMI) is composed of an international group of scientists, clinicians and public health officials with expertise in meningococcal immunology, epidemiology and prevention. The primary goal of the GMI is the promotion of the global prevention of invasive meningococcal disease through ...

journal_title：Vaccine

authors： Harrison LH,Pelton SI,Wilder-Smith A,Holst J,Safadi MA,Vazquez JA,Taha MK,LaForce FM,von Gottberg A,Borrow R,Plotkin SA

更新日期：2011-04-18 00:00:00

abstract：:Insoluble, pure protein particles could be advantageous as single-entity vaccines or as carriers for small peptide epitopes. Dense gas anti-solvent precipitation was employed to produce pure protein particles which were found to be insoluble in water. As particulate and multimerized antigens are more immunogenic and h...

journal_title：Vaccine

authors： White PJ,Anastasopoulos F,Church JE,Kuo CY,Boyd BJ,Hickey PL,Tu LS,Burns P,Lew AM,Heath WR,Davey GM,Pouton CW

更新日期：2008-12-09 00:00:00

abstract：BACKGROUND:Measles-containing vaccine (MCV) was introduced in 1965 in Beijing and given to the children aged 8m-14y. In population-based surveillance system, real-time polymerase chain reaction (RT-PCR) and immunoglobulin M(IgM) serology tests have been conducted for each suspected case since 2013. We used the surveill...

journal_title：Vaccine

authors： Ma R,Lu L,Suo L,Zhangzhu J,Chen M,Pang X

更新日期：2019-06-27 00:00:00

abstract：:Current vaccine candidates against Rift Valley fever virus (RVFV) incorporate the viral structural glycoproteins as antigens, since triggering antibody responses against them usually correlates with protection. Here, we have focused solely on the nucleoprotein of RVFV as a potential target for vaccine development. Pre...

journal_title：Vaccine

authors： Boshra H,Lorenzo G,Rodriguez F,Brun A

更新日期：2011-06-15 00:00:00