Abstract：
:The ability to elicit humoral and cell-mediated immune (CMI) responses from DNA immunization by combinational use of codon optimization and C3d component of complement was evaluated in this study. DNA vaccines that express either the wild type or the codon optimized gp120 gene coding for the envelope (Env) glycoprotein of human immunodeficiency virus (HIV-1) from the primary isolate JR-FL strain were compared to the same forms fused to three tandem copies of the murine C3d genes. Either codon optimization or C3d fusion alone was effective at generating early appearance, higher binding and neutralizing antibody responses. We also observed that cell-mediated immune responses against HIV Env could also be enhanced by C3d fusion. However, for both humoral and CMI responses, there were no synergistic effects when the combination of codon optimization and C3d fusion was employed.
journal_name
Vaccinejournal_title
Vaccineauthors
Liu F,Mboudjeka I,Shen S,Chou TH,Wang S,Ross TM,Lu Sdoi
10.1016/j.vaccine.2003.09.054subject
Has Abstractpub_date
2004-04-16 00:00:00pages
1764-72issue
13-14eissn
0264-410Xissn
1873-2518pii
S0264410X04001008journal_volume
22pub_type
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