Neonatal immunity and immunisation in early age: lessons from veterinary medicine.

abstract：:We aim to develop a method that confers rapid protection against foot-and-mouth disease (FMD) by passive immunization with recombinant llama single-domain antibody fragments (VHHs). Previously constructed genetic fusions of two VHHs (VHH2s) that either neutralizes FMDV or binds to porcine immunoglobulin to increase th...

journal_title：Vaccine

authors： Harmsen MM,Fijten HP,Engel B,Dekker A,Eblé PL

更新日期：2009-03-18 00:00:00

abstract：:Francisella tularensis is the intracellular bacterial pathogen causing the respiratory life-threatening disease tularemia. Development of tularemia vaccines has been hampered by an incomplete understanding of the correlates of immunity. Moreover, the importance of lung cellular immunity in vaccine-mediated protection ...

journal_title：Vaccine

authors： Bar-On L,Cohen H,Elia U,Rotem S,Bercovich-Kinori A,Bar-Haim E,Chitlaru T,Cohen O

更新日期：2017-12-15 00:00:00

abstract：:Oral polio vaccine (OPV) and diphtheria-tetanus-pertussis (DTP) vaccines are given simultaneously in routine immunisation programmes in developing countries. It is therefore difficult to determine the separate effects of these vaccines on survival. We used the shortage of DTP vaccine in Bissau to examine the impact of...

journal_title：Vaccine

authors： Aaby P,Rodrigues A,Biai S,Martins C,Veirum JE,Benn CS,Jensen H

更新日期：2004-08-13 00:00:00

abstract：:Successful emergency vaccination campaigns rely on effective deployment and vaccination plans. This applies to localised outbreaks as well as for pandemics. In the wake of the 2009 H1N1 influenza pandemic, analysis of the global Vaccine Deployment Initiative, through which the World Health Organization (WHO) donated p...

journal_title：Vaccine

authors： Ghiga I,Richardson S,Álvarez AMR,Kato M,Naidoo D,Otsu S,Nguyen PT,Nguyen PN,Nguyen T

更新日期：2021-01-08 00:00:00

abstract：:Since 1992, hepatitis B vaccine has been an integrated part of Thailand's expanded programme on immunisation (EPI). Based on the data from five representative provinces, we have evaluated its impact on the countrywide prevalence of HBV infection and carrier rate. The population studied comprised 400-488 healthy and im...

journal_title：Vaccine

authors： Poovorawan Y,Theamboonlers A,Vimolket T,Sinlaparatsamee S,Chaiear K,Siraprapasiri T,Khwanjaipanich S,Owatanapanich S,Hirsch P,Chunsuttiwat S

更新日期：2000-11-22 00:00:00

abstract：:Immunization with a combination of several virulence-associated proteins is one of the strategies of developing effective protein-based vaccines to enhance the protection against Streptococcus pneumoniae. In this study, we evaluated the protection effects against pneumococcal infection caused by S. pneumoniae TIGR4 in...

journal_title：Vaccine

authors： Cao J,Chen D,Xu W,Chen T,Xu S,Luo J,Zhao Q,Liu B,Wang D,Zhang X,Shan Y,Yin Y

更新日期：2007-06-28 00:00:00

abstract：:Live-attenuated influenza vaccine (LAIV) delivered by large droplet intranasal spray is efficacious against infection. However, many of the large droplets are trapped in the external nares and do not reach the target nasal airway tissues. Smaller droplets might provide better distribution yielding similar protection w...

journal_title：Vaccine

authors： Smith JH,Brooks P,Johnson S,Tompkins SM,Custer KM,Haas DL,Mair R,Papania M,Tripp RA

更新日期：2011-03-21 00:00:00

abstract：:Orally-administered cholera vaccine (OCV) has been increasingly examined as an additional tool to intervene against endemic and epidemic cholera. In 2013, short- and long-term field experience with OCV under nine distinctive field settings was reported from India, Bangladesh, Vietnam, Guinea, Haiti, and Thailand. Lead...

journal_title：Vaccine

authors： Hall RH,Sack DA

更新日期：2015-01-15 00:00:00

abstract：:The virulence and immunogenicity of a wild-type respiratory syncytial (RS) virus together with four temperature sensitive (ts) mutants derived from this isolate were tested by intranasal inoculation into adult volunteers. Resistance to challenge correlated with neutralizing antibody titres in nasal secretions and to a...

journal_title：Vaccine

authors： Watt PJ,Robinson BS,Pringle CR,Tyrrell DA

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:In 2003, severe acute respiratory syndrome (SARS) resulted in hundreds of infections and deaths globally. We aim to assess immunogenicity and protective efficacy of purified inactivated Vero-cell SARS vaccine in monkeys. METHODS:The cultures of SARS coronavirus (SARS-CoV) BJ-01 strain infected Vero cells we...

journal_title：Vaccine

authors： Qin E,Shi H,Tang L,Wang C,Chang G,Ding Z,Zhao K,Wang J,Chen Z,Yu M,Si B,Liu J,Wu D,Cheng X,Yang B,Peng W,Meng Q,Liu B,Han W,Yin X,Duan H,Zhan D,Tian L,Li S,Wu J,Tan G,Li Y,Li Y,Liu Y,Liu H,Lv F

更新日期：2006-02-13 00:00:00

abstract：:Barriers to human papillomavirus (HPV) vaccine acceptability in Israel include Israel's relatively low incidence of cervical cancer; the religiously-based 80% circumcision rate in Israel, which is regarded as contributing to the lower incidence of HPV infection in the country; the fact that HPV vaccine provides immuni...

journal_title：Vaccine

authors： Fisher WA,Laniado H,Shoval H,Hakim M,Bornstein J

更新日期：2013-11-22 00:00:00

abstract：:In HIV vaccine trials, the collection and analysis of participant behavior data associated with risk of acquiring HIV-infection is important for a number of reasons. Although the rationale for behavioral risk assessment in HIV vaccine clinical trials is clear, consistent collection of behavioral data over time and acr...

journal_title：Vaccine

authors： Andrasik MP,Karuna ST,Nebergall M,Koblin BA,Kublin JG,NIAID HIV Vaccine Trials Network.

更新日期：2013-09-13 00:00:00

abstract：:Tick-borne encephalitis virus isolates from widely separated geographic regions of the USSR, six isolates from Hungary and one from France were compared with the European and Far Eastern prototype viruses. Peptide mapping by limited proteolysis yielded similar patterns for five selected isolates from the USSR. All iso...

journal_title：Vaccine

authors： Holzmann H,Vorobyova MS,Ladyzhenskaya IP,Ferenczi E,Kundi M,Kunz C,Heinz FX

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:The 2015/2016 influenza season was characterized in Europe by the circulation of A(H1N1)pdm09 clade 6B.1 and B/Victoria-lineage influenza viruses. The components of the vaccines used in the current and past two seasons in the Valencia region were similar but not well matched to the 2015/2016 dominant influen...

journal_title：Vaccine

authors： Puig-Barberà J,Guglieri-López B,Tortajada-Girbés M,López-Labrador FX,Carballido-Fernández M,Mollar-Maseres J,Schwarz-Chavarri G,Baselga-Moreno V,Mira-Iglesias A,Díez-Domingo J,Valencia Hospital Network for the Study of Influenza, Res

更新日期：2017-12-19 00:00:00

abstract：:To test whether inactivated influenza vaccines distributed during the 2003-2004 influenza season in the northern hemisphere were able to confer protection against the mismatched variant A/Fujian/411/2002 virus strain, we measured haemagglutination inhibiting (HI) antibodies in elderly subjects vaccinated with three in...

journal_title：Vaccine

authors： Del Giudice G,Hilbert AK,Bugarini R,Minutello A,Popova O,Toneatto D,Schoendorf I,Borkowski A,Rappuoli R,Podda A

更新日期：2006-04-12 00:00:00

abstract：:The objective of the present study was to investigate the feasibility of a subunit vaccine and a live bacteria vaccine to protect chickens against infectious bursal disease virus (IBDV) infection. The gene for VP2 of a new wild-type very virulent IBDV (vvIBDV) strain was cloned into an Escherichia coli expression syst...

journal_title：Vaccine

authors： Rong J,Cheng T,Liu X,Jiang T,Gu H,Zou G

更新日期：2005-09-23 00:00:00

abstract：:A total of 105 hybridomas secreting anti-Japanese encephalitis (JE) virus monoclonal antibodies (mAbs) were generated from six fusions against four strains of JE virus: wild-type strains SA14 and G8924 and live attenuated vaccines SA14-5-3 and SA14-14-2 (PDK-9). Most of the mAbs (87%) elicited haemagglutination inhibi...

journal_title：Vaccine

authors： Sil BK,Wills MR,Cao JX,Sharda R,Islam MA,Stagg DJ,Jennings AD,Gibson CA,Barrett AD

更新日期：1992-01-01 00:00:00

abstract：:Safe RSV vaccine development has challenged the medical community since a formalin-killed RSV vaccine caused disease exacerbation in the 1960s. Disease was replicated using the bovine RSV system in one of two studies. The studies differed in viral protein dose and length of time between vaccination and infection. Dise...

journal_title：Vaccine

authors： Kalina WV,Woolums AR,Berghaus RD,Gershwin LJ

更新日期：2004-03-29 00:00:00

abstract：:Mucin1 (MUC1) is expressed ubiquitously on breast cancer cells and is a potential target for the generation of cytotoxic T cells for vaccination against breast cancer. Thus far studies of the immunogenicity of MUC1 have used peptides from the variable number of tandem repeat (VNTR); mice so immunised can generate stro...

journal_title：Vaccine

authors： Pietersz GA,Li W,Osinski C,Apostolopoulos V,McKenzie IF

更新日期：2000-04-03 00:00:00

abstract：:A rapid and sensitive assay using surface plasmon resonance (SPR) immunoassay has been developed for the detection of Clostridium perfringens beta-toxin. The SPR immunoassay was conducted off-line by passing fermentation broth by a sensor chip coated with a monoclonal antibody specific for C. perfringens beta-toxin. Q...

journal_title：Vaccine

authors： Hsieh HV,Stewart B,Hauer P,Haaland P,Campbell R

更新日期：1998-05-01 00:00:00

abstract：:In order to prevent hepatitis B virus (HBV) infection of infants of hepatitis B surface antigen (HBsAg)-positive mothers, a nation-wide immunization programme was initiated in Italy in January 1984. During the first 3 years (1984-86), 651,667 out of 1726,000 pregnant women (37.8%) were screened for HBsAg; the percenta...

journal_title：Vaccine

authors： Stroffolini T,Pasquini P,Mele A

更新日期：1989-04-01 00:00:00

abstract：:Little is known of men's knowledge of cervical cancer and its links with human papillomavirus (HPV), or of their attitudes and beliefs about HPV vaccination. This is despite men's sexual behaviour contributing to HPV transmission and their potential role in deciding whether their children are vaccinated against HPV. T...

journal_title：Vaccine

authors： Pitts M,Smith A,Croy S,Lyons A,Ryall R,Garland S,Wong ML,Hseon TE

更新日期：2009-05-14 00:00:00

abstract：:Hemagglutinin, the major surface protein of influenza viruses, was recombinantly expressed in eukaryotic cells as a monomer instead of its native trimer, and was only immunogenic when administered with an adjuvant [Pion et al. 2014]. In order to multimerize this antigen to increase its immunogenicity, a cysteine-rich ...

journal_title：Vaccine

authors： Peubez I,Margot S,Buffin S,Pion C,Bernard MC,Dinadayala P,Poncet D,Deloire S,Marco S,Legastelois I

更新日期：2020-11-25 00:00:00

abstract：:Obesity is a risk factor for complicated influenza A/H1N1 disease and poor vaccine immunogenicity. Leptin, an adipocyte-derived hormone/cytokine, has many immune regulatory functions and therefore could explain susceptibility to infections and poor vaccine outcomes. We recruited 159 healthy adults (50-74 years old) wh...

journal_title：Vaccine

authors： Ovsyannikova IG,White SJ,Larrabee BR,Grill DE,Jacobson RM,Poland GA

更新日期：2014-02-07 00:00:00

abstract：BACKGROUND:Little is known about inactivated influenza vaccine effectiveness (IVE) in preventing very severe disease, including influenza-associated intensive care unit (ICU) admissions. METHODS:The Southern Hemisphere Influenza and Vaccine Effectiveness Research and Surveillance (SHIVERS) project enrolled adults (age...

journal_title：Vaccine

authors： Thompson MG,Pierse N,Sue Huang Q,Prasad N,Duque J,Claire Newbern E,Baker MG,Turner N,McArthur C,SHIVERS investigation team.

更新日期：2018-09-18 00:00:00

abstract：:Immunological memory induced by nasal immunization with adjuvant-combined influenza vaccine was analyzed in different ages and strains of mice. The memory activities were assessed by secondary nasal-wash IgA and serum IgG antibody (Ab) responses and protection against challenge infection with a lethal dose of influenz...

journal_title：Vaccine

authors： Asanuma H,Fujihashi K,Miyakoshi T,Yoshikawa T,Fujita-Yamaguchi Y,Kojima N,Nakata M,Suzuki Y,Tamura S,Kurata T,Sata T

更新日期：2007-09-28 00:00:00

abstract：:Long-term effects of therapeutic vaccination of human immunodeficiency virus (HIV)-1-infected subjects with HIV-1 p17/p24:Ty virus-like particles (p24-VLP) on progression to AIDS, death, a CD4 cell count

journal_title：Vaccine

authors： Lindenburg CE,Stolte I,Langendam MW,Miedema F,Williams IG,Colebunders R,Weber JN,Fisher M,Coutinho RA

更新日期：2002-05-22 00:00:00

abstract：:Ten prospective clinical trials conducted in elderly and high-risk adults have failed to show that pneumococcal vaccine prevents pneumococcal bacteraemia and all pneumonia. Several of these trials focused on unrepresentative populations and most had serious methodological problems. Few adequately considered sample siz...

journal_title：Vaccine

authors： Fedson DS,Liss C

更新日期：2004-02-25 00:00:00

abstract：:A national two-dose vaccination program with a combined measles, mumps and rubella (MMR-II) vaccine was introduced in Finland, in 1982, immunizing children at the ages of 14-18 months and 6 years. Antibody levels were determined from serial samples from a group of originally 350 children during 15 years. The latest sa...

journal_title：Vaccine

authors： Davidkin I,Peltola H,Leinikki P,Valle M

更新日期：2000-07-15 00:00:00

abstract：:We recently reported that administration of low doses of myotoxins at vaccination sites potentiated antigen-specific T-cell immunity induced by genetic cancer vaccines in mice, an effect which was superior to TLR agonists. In the current study, we found unexpectedly that the mechanism of this potent adjuvant effect wa...

journal_title：Vaccine

authors： Qin H,Cha SC,Neelapu SS,Liu C,Wang YH,Wei J,Qin XF,Liu YJ,Kwak LW

更新日期：2010-11-23 00:00:00