Abstract：
:Live-attenuated influenza vaccine (LAIV) delivered by large droplet intranasal spray is efficacious against infection. However, many of the large droplets are trapped in the external nares and do not reach the target nasal airway tissues. Smaller droplets might provide better distribution yielding similar protection with lower doses. We evaluated 20 and 30 μm aerosol delivery of influenza virus in mice. A 15s aerosol exposure optimally protected against homologous and heterologous influenza infection and induced a robust immune response. These results demonstrate the feasibility of nasal vaccination using aerosolized particles, providing a strategy to improve vaccine efficacy and delivery.
journal_name
Vaccinejournal_title
Vaccineauthors
Smith JH,Brooks P,Johnson S,Tompkins SM,Custer KM,Haas DL,Mair R,Papania M,Tripp RAdoi
10.1016/j.vaccine.2011.01.059subject
Has Abstractpub_date
2011-03-21 00:00:00pages
2568-75issue
14eissn
0264-410Xissn
1873-2518pii
S0264-410X(11)00119-8journal_volume
29pub_type
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