Abstract：
:Mucin1 (MUC1) is expressed ubiquitously on breast cancer cells and is a potential target for the generation of cytotoxic T cells for vaccination against breast cancer. Thus far studies of the immunogenicity of MUC1 have used peptides from the variable number of tandem repeat (VNTR); mice so immunised can generate strong cellular and antibody responses to the VNTR of human MUC1. We now demonstrate that significant CTL and CTLp can be induced to other regions of MUC1. Using the whole native MUC1 molecule, the human milk fat globule membrane antigen (HMFG) linked to mannan, cytotoxic T cell precursors (CTLp) can be generated in BALB/c, C57BL/6, transgenic HLA-A*0201/K(b) and double transgenic HLA-A*0201/K(b)xhuman MUC1 (A2 K(b)MUC1) mice. By immunising with HMFG and testing selectively on (a) extracellular (non-VNTR); (b) VNTR and (c) intracellular peptides, it was shown that all three regions generated effective CTL. Further, the CTL responses to non-VNTR peptides were as strong as those generated to the VNTR. Epitope prediction algorithms were not particularly helpful to describe CTL epitopes: overlapping peptides had to be synthesised and tested to find the epitopes. Thus, for CTL generation, the whole HMFG molecule is a powerful immunogen when linked to mannan, especially as multiple peptide epitopes for presentation by many Class I molecules are contained within the one molecule. Furthermore, Class I restricted MUC1 CTL were generated in double transgenic A2 K(b)MUC1 mice by immunising with mannan-native mucin (HMFG), suggesting that tolerance to MUC1 can be overcome with mannan-HMFG.
journal_name
Vaccinejournal_title
Vaccineauthors
Pietersz GA,Li W,Osinski C,Apostolopoulos V,McKenzie IFdoi
10.1016/s0264-410x(99)00515-0subject
Has Abstractpub_date
2000-04-03 00:00:00pages
2059-71issue
19eissn
0264-410Xissn
1873-2518pii
S0264-410X(99)00515-0journal_volume
18pub_type
杂志文章相关文献
VACCINE文献大全abstract：:Current available influenza vaccines are safe and effective in preventing influenza. Nevertheless, there is a need for influenza vaccines with improved efficacy in the elderly. This need is underscored by both the observation that influenza has a major clinical and economic impact in the elderly and the fact that curr...
journal_title：Vaccine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.vaccine.2005.04.020
更新日期：2005-07-08 00:00:00
abstract：:We examined the long-term clinical and economic benefits of quadrivalent human papillomavirus (qHPV) vaccine as a secondary/adjunct prevention strategy in the prevention of recurrent high-grade intraepithelial neoplasia (HGAIN) in HIV-negative men who have sex with men (MSM) and are 27 years or older. We constructed a...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.10.052
更新日期：2014-12-05 00:00:00
abstract：:Amebiasis remains one of the leading parasitic causes of death worldwide. A vaccine that prevented amebic liver abscess would significantly reduce mortality from this disease. To test the feasibility of a DNA vaccine to prevent amebic liver abscess, we immunized both mice and gerbils with plasmid DNA encoding the seri...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(99)00343-6
更新日期：1999-12-10 00:00:00
abstract：:Understanding the requirements for protection against pneumococcal carriage and pneumonia will greatly benefit efforts in controlling these diseases. Several antigens, in addition to the polysaccharide capsule, have been implicated in both the virulence and protective immunity against Streptococcus pneumoniae; one of ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.12.020
更新日期：2012-02-01 00:00:00
abstract：:Funded immunization programs are best able to achieve high participation rates, optimal protection of the target population, and indirect protection of others. However, in many countries public funding of approved vaccines can be substantially delayed, limited to a portion of the at-risk population or denied altogethe...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2013.12.027
更新日期：2014-02-07 00:00:00
abstract：:Vaccine exposure to temperatures below recommended ranges in the cold chain may decrease vaccine potency of freeze-sensitive vaccines leading to a loss of vaccine investments and potentially places children at risk of contracting vaccine preventable illnesses. This literature review is an update to one previously publ...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2016.09.070
更新日期：2017-04-19 00:00:00
abstract：:Current recommendations have not resulted in routine vaccination of correctional facility inmates for hepatitis B. We investigated two hepatitis B outbreaks. Outbreak 1 involved 4 cases epidemiologically linked to persons who had been in jail. Outbreak 2 involved 48 community cases; 69% had a history of incarceration....
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.09.023
更新日期：2006-02-27 00:00:00
abstract：:The immunological enhancement characteristics of the immunopotentiator CVC1302 were evaluated for foot-and-mouth disease virus (FMDV) inactivated vaccine in pigs. Eight-week-old piglets were vaccinated with the foot-and-mouth disease (FMD) vaccine alone (FMD-vaccine group) or with the addition of CVC1302 (FMD-CVC1302 ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.11.012
更新日期：2018-12-18 00:00:00
abstract：:Measles is one of the most important diseases of mankind, which is so highly contagious and evokes such persistent immunity that the virus cannot be sustained in a population of less than about 500,000 persons. The first of the licensed live virus vaccines against measles was developed empirically and was approved in ...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/s0264-410x(01)00384-x
更新日期：2001-12-12 00:00:00
abstract：:Surface modified poly-ɛ-caprolactone microspheres as an antigen carrier was explored in a fish model. Outer membrane vesicles of Edwardsiella tarda adsorbed on to surface modified poly-ɛ-caprolactone microspheres with chitosan and alginate induces both innate and adaptive immune responses which persist up to 63 days o...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.05.028
更新日期：2012-07-27 00:00:00
abstract：:After decades of inconsequential infections, and sporadic outbreaks in the Asia-Pacific region between 2007 and 2013, Zika virus caused a widespread epidemic in South America in 2015 that was complicated by severe congenital infections. After the WHO declared a Public Health Emergency of International Concern in Febru...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2019.04.013
更新日期：2019-05-06 00:00:00
abstract：:In China, no data are available to evaluate the interchangeability between Chinese domestic inactivated hepatitis A vaccines (Healive) and imported inactivated hepatitis A vaccines (Havrix). A double-blind, randomized controlled study was to compare interchangeability and safety of Healive and Havrix among Chinese chi...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2012.04.038
更新日期：2012-06-08 00:00:00
abstract：:We previously observed that a detoxified Escherichia coli O111, Rc chemotype J5 lipopolysaccharide (J5dLPS)/group B meningococcal outer membrane protein (OMP) vaccine protected animals from experimental lethal sepsis when immune antibodies were given passively as treatment at the onset of fever or when vaccine was giv...
journal_title：Vaccine
pub_type： 临床试验,杂志文章
doi：10.1016/s0264-410x(03)00483-3
更新日期：2003-11-07 00:00:00
abstract：:Fish has a soluble form of TLR5 ortholog (TLR5S), which does not exist in mammals. We identified TLR5S from rainbow trout and named rtTLR5S, which was about 38% homologous to the extracellular domains of human (hu) and mouse TLR5. Adjuvancy of rtTLR5S to flagellin response by human TLR5 (huTLR5) was tested in this stu...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.11.003
更新日期：2006-03-15 00:00:00
abstract：:Salmonellae are commonly isolated from dogs. The number of dogs infected with Salmonella spp. is surprisingly high and greater than the incidence of clinical disease would suggest. Salmonellosis is common in greyhound kennels. Morbidity can approach 100% in puppies and the mortality ranges to nearly 40%. To date, ther...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(01)00516-3
更新日期：2002-02-22 00:00:00
abstract：:Measles transmission has been well documented in healthcare facilities. Healthcare personnel who are unvaccinated and who lack other evidence of measles immunity put themselves and their patients at risk for measles. We conducted a systematic literature review of measles vaccination policies and their implementation i...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2013.11.005
更新日期：2014-08-27 00:00:00
abstract：BACKGROUND:Pregnant women are at risk of severe influenza disease and are a priority group for influenza vaccination programs. Nicaragua expanded recommendations to include influenza vaccination to all pregnant women in the municipality of Managua in 2013. METHODS:We carried out a survey among 1,807 pregnant women who...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.12.065
更新日期：2016-02-17 00:00:00
abstract：:The bioavailability of oseltamivir phosphate and oseltamivir carboxylate were assessed in healthy volunteers when delivered as a solution of the active pharmaceutical ingredient (API) compared with the commercial capsule formulation. The 90% confidence intervals (CIs) for the ratios of the two treatments (capsule vers...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2006.05.080
更新日期：2006-11-10 00:00:00
abstract：:Addressing inequities in immunisation must be the main priority for the Decade of Vaccines. Children who remain unreached are those who need vaccination - and other health services - most. Reaching these children and other underserved target groups will require a reorientation of current approaches and resource alloca...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2012.11.088
更新日期：2013-04-18 00:00:00
abstract：:A qualitative study design was adapted to explore the challenges faced by health workers (HWs) during the polio health campaign. In addition, HWs' opinions about the factors causing parents to refuse oral polio vaccination (OPV) were also explored. Four focus group discussions (FGDs) were held (from 1st January 2015-3...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2016.03.008
更新日期：2016-04-19 00:00:00
abstract：:In order to meet the global demand for rapid production of pandemic influenza vaccines, we have developed a recombinant fusion vaccine platform in which the globular head of hemagglutinin (HA) antigen is genetically fused to bacterial flagellin (a TLR5 ligand). These flagellin-HA fusion vaccine candidates elicit highl...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.09.013
更新日期：2012-11-06 00:00:00
abstract：:This article presents the World Health Organization's (WHO) recommendations on the use of polio vaccine excerpted from the WHO position paper on polio vaccines - March 2016, published in the Weekly Epidemiological Record [1]. This position paper on polio vaccines replaces the 2014 WHO position paper [2]. The position ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2016.11.017
更新日期：2017-03-01 00:00:00
abstract：:Peripheral blood mononuclear cells (PBMCs) from unvaccinated and vaccinated bovine calves were employed to study the alteration of different T-cell subpopulations, functional competence and detection of foot-and-mouth disease virus (FMDV) at different hours post in vitro infection (hpi) with FMDV serotype either O or ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.08.107
更新日期：2009-11-12 00:00:00
abstract：BACKGROUND:Haemophilus influenzae type b (Hib) conjugate vaccines have significantly limited Hib's disease impact in every country where it was introduced. We previously estimated invasive Hib disease incidence in Singapore at ∼4.4 per 100,000 children <5 years (from 1994 to 2003, period 1), but the vaccine was not inc...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.08.046
更新日期：2014-10-07 00:00:00
abstract：:WHO is now celebrating more than 30 years of freedom from smallpox. What was originally seen as a victory over an ancient scourge can now be viewed as an epidemiologically driven programme to overcome governmental inertia and under-achievement in delivering an off-patent vaccine. Though efforts are accelerating global...
journal_title：Vaccine
pub_type： 社论
doi：10.1016/j.vaccine.2009.08.006
更新日期：2010-01-22 00:00:00
abstract：BACKGROUND:Expression of recombinant hemagglutinin (rHA) in insect cells represents a technology with proven efficacy in seasonal influenza and with the potential for a rapid response to the emergence of new, pandemic strains. We evaluated the safety and immunogenicity of rHA vaccine (H5/Indonesia/5/05) produced in SF+...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2013.08.064
更新日期：2013-11-19 00:00:00
abstract：:We show here that the immunogenicity of the Modified Vaccinia Ankara MVA vaccine strain can be improved by deletion of the A35 gene, without diminishing the ability of the virus to replicate. Deletion of the A35 gene resulted in increased virus-specific immunoglobulin production, class switching to IgG isotypes, and v...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.02.023
更新日期：2011-04-12 00:00:00
abstract：:Vaccination remains the most cost-effective biomedical approach for controlling influenza disease. In times of pandemics, however, these vaccines cannot be produced in sufficient quantities for worldwide use by the current manufacturing capacities and practices. What is needed is the development of adjuvanted vaccines...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.05.029
更新日期：2018-06-14 00:00:00
abstract：:Plague is a zoonotic disease caused by Yersinia pestis, an etiological agent of pneumonic and bubonic plague. There is a need for an improved plague vaccine that may overcome the limitation of presently available whole cell vaccine. An alternative approach described here, is the use of protective epitopes from immunod...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2006.01.031
更新日期：2006-04-12 00:00:00
abstract：BACKGROUND:Influenza vaccination among health-care workers is poor, and the effectiveness of hospital vaccination programs remains unclear. Little is known about the effectiveness of intensive evidence-based vaccination programs in nursing staff. We determined whether the recommended vaccination rate could be achieved ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2008.03.033
更新日期：2008-06-02 00:00:00
