当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Inducing systemic and mucosal immune responses to B-T construct of F1 antigen of Yersinia pestis in microsphere delivery.

Inducing systemic and mucosal immune responses to B-T construct of F1 antigen of Yersinia pestis in microsphere delivery.

Abstract：

:Plague is a zoonotic disease caused by Yersinia pestis, an etiological agent of pneumonic and bubonic plague. There is a need for an improved plague vaccine that may overcome the limitation of presently available whole cell vaccine. An alternative approach described here, is the use of protective epitopes from immunodominant antigen of Y. pestis. One such antigen is the F1 antigen, a major envelope and virulent protein that possess antiphagocytic and anti-microbial properties. The present study was aimed to develop a peptide-based vaccine, based upon the constructs made between B and T cell epitopes of F1 antigen of Y. pestis. The immunogenicity, IgG subclass pattern, affinity, avidity and in vivo protective efficacy of the antibodies generated for different B-T constructs were studied in murine model using microsphere as the delivery vehicle. The mode of immunization was both intranasal and intramuscular, with single and multiple doses of immunization, respectively. Intranasal immunization generated consistent high titre and long lasting immune response both for IgG and IgA in sera and sIgA in washes while intramuscular route generated peak IgG levels in sera only. The IgG isotypic levels pattern showed higher IgG2a/IgG2b levels in intranasal route while mixed isotypic levels of IgG1, IgG2a/IgG2b were observed in intramuscular route. The affinity and relative avidity of antibodies showed best results with intranasal route as compared to the intramuscular route. The specific activity measurement (IgG/IgA content) in sera and washes were well correlated with the antibody levels. Finally, in vivo protective studies showed that B1T1 and B2T1 conjugates protected the mice till day 15 while rest of the conjugates showed poor protection.

journal_name

Vaccine

journal_title

Vaccine

authors

Tripathi V,Chitralekha KT,Bakshi AR,Tomar D,Deshmukh RA,Baig MA,Rao DN

doi

10.1016/j.vaccine.2006.01.031

subject

Has Abstract

pub_date

2006-04-12 00:00:00

pages

3279-89

issue

16

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(06)00032-6

journal_volume

24

pub_type

杂志文章

相关文献

VACCINE文献大全
  • Comparable humoral response after two doses of adjuvanted influenza A/H1N1pdm2009 vaccine or natural infection in allogeneic stem cell transplant recipients.

    abstract：BACKGROUND:The present study evaluated immunogenicity and tolerance of two-dose influenza A/H1N1pdm09 vaccination in allogeneic hematopoietic stem cell transplantation (HSCT) recipients, and compared the vaccine-induced humoral response to that triggered by natural infection in another group of HSCT patients. METHODS:...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2013.11.073

    authors： Dhédin N,Krivine A,Le Corre N,Mallet A,Lioure B,Bay JO,Rubio MT,Agape P,Thiébaut A,Le Goff J,Autran B,Ribaud P

    更新日期：2014-01-23 00:00:00

  • Feasibility of using regional sentinel surveillance to monitor the rotavirus vaccine impact, effectiveness and intussusception incidence in the African Region.

    abstract：:The 9th African rotavirus symposium was held in Maputo, Mozambique from the 8th to 10th of December 2015, including a total of 101 delegates from 17 countries, 15 of which were African countries. This forum brought together participants with various expertise including scientists, clinicians, immunization program mana...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.01.072

    authors： Mandomando I,Weldegebriel G,de Deus N,Mwenda JM

    更新日期：2017-03-23 00:00:00

  • Protection against diverse highly pathogenic H5 avian influenza viruses in chickens immunized with a recombinant fowlpox vaccine containing an H5 avian influenza hemagglutinin gene insert.

    abstract：:A recombinant fowlpox vaccine with an H5 hemagglutinin gene insert protected chickens against clinical signs and death following challenge by nine different highly pathogenic H5 avian influenza viruses. The challenge viruses had 87.3 to 100% deduced hemagglutinin amino acid sequence similarity with the recombinant vac...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(99)00369-2

    authors： Swayne DE,Garcia M,Beck JR,Kinney N,Suarez DL

    更新日期：2000-01-06 00:00:00

  • Inflammatory responses in influenza A virus infection.

    abstract：:Influenza A virus causes respiratory tract infections, which are occasionally complicated by secondary bacterial infections. Influenza A virus replicates in epithelial cells and leukocytes resulting in the production of chemokines and cytokines, which favor the extravasation of blood mononuclear cells and the developm...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/s0264-410x(00)00275-9

    authors： Julkunen I,Melén K,Nyqvist M,Pirhonen J,Sareneva T,Matikainen S

    更新日期：2000-12-08 00:00:00

  • Rhesus macaques with high levels of vaccine induced IFN-gamma producing cells better control viral set-point following challenge with SIV239.

    abstract：:HIV-1 specific cellular immune responses play a significant part in controlling HIV-1 viral replication and are an important component of an HIV-1 vaccine induced immune response. We reported earlier that recombinant DNA vaccine delivered intramuscularly, and recombinant Listeria monocytogenes, delivered orally induce...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2005.08.016

    authors： Boyer JD,Maciag PC,Parkinson R,Wu L,Lewis MG,Weiner DB,Paterson Y

    更新日期：2006-05-22 00:00:00

  • Development of a bivalent conjugate vaccine candidate against malaria transmission and typhoid fever.

    abstract：:Immune responses to poorly immunogenic antigens, such as polysaccharides, can be enhanced by conjugation to carriers. Our previous studies indicate that conjugation to Vi polysaccharide of Salmonella Typhi may also enhance immunogenicity of some protein carriers. We therefore explored the possibility of generating a b...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.04.035

    authors： An SJ,Scaria PV,Chen B,Barnafo E,Muratova O,Anderson C,Lambert L,Chae MH,Yang JS,Duffy PE

    更新日期：2018-05-17 00:00:00

  • Recombinant vesicular stomatitis virus-based west Nile vaccine elicits strong humoral and cellular immune responses and protects mice against lethal challenge with the virulent west Nile virus strain LSU-AR01.

    abstract：:Vesicular stomatitis virus (VSV) has been extensively utilized as a viral vector system for the induction of protective immune responses against a variety of pathogens. We constructed recombinant VSVs specifying either the Indiana or Chandipura virus G glycoprotein and expressing the West Nile virus (WNV) envelope (E)...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.11.087

    authors： Iyer AV,Pahar B,Boudreaux MJ,Wakamatsu N,Roy AF,Chouljenko VN,Baghian A,Apetrei C,Marx PA,Kousoulas KG

    更新日期：2009-02-05 00:00:00

  • Economic assessment of a high-dose versus a standard-dose influenza vaccine in the US Veteran population: Estimating the impact on hospitalization cost for cardio-respiratory disease.

    abstract：OBJECTIVE:To compare the economic impact of high-dose trivalent (HD) versus standard-dose trivalent (SD) influenza vaccination on direct medical costs for cardio-respiratory hospitalizations in adults aged 65 years or older enrolled in the United States (US) Veteran's Health Administration (VHA). METHODS:Leveraging a ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.06.066

    authors： van Aalst R,Russo EM,Neupane N,Mahmud SM,Mor V,Wilschut J,Chit A,Postma M,Young-Xu Y

    更新日期：2019-07-26 00:00:00

  • Immunization of eyed channel catfish, Ictalurus punctatus, eggs with monovalent Flavobacterium columnare vaccine and bivalent F. columnare and Edwardsiella ictaluri vaccine.

    abstract：:The efficacy of a modified live monovalent Flavobacterium columnare vaccine and bivalent F. columnare and Edwardsiella ictaluri vaccines were evaluated following immersion vaccination of eyed channel catfish (Ictalurus punctatus) eggs. The modified live F. columnare vaccine was grown in modified Shieh broth and admini...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.09.055

    authors： Shoemaker CA,Klesius PH,Evans JJ

    更新日期：2007-01-22 00:00:00

  • The fight against rabies in Africa: From recognition to action.

    abstract：:As a follow-up to the first AfroREB meeting, held in Grand Bassam (Côte d'Ivoire) in March 2008, African rabies experts of the AfroREB network met a second time to complete the evaluation of the rabies situation in Africa and define specific action plans. About 40 French speaking rabies specialists from northern, west...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.06.030

    authors： Dodet B,Africa Rabies Bureau (AfroREB).

    更新日期：2009-08-13 00:00:00

  • Observational study of vaccine effectiveness 20 years after the introduction of universal hepatitis B vaccination in Tunisia.

    abstract：OBJECTIVES:The objectives of this study were to estimate the national prevalence of hepatitis B infection in Tunisia using data from a nationwide survey, to compare results with those obtained in 1996 survey and to evaluate the impact of vaccination twenty years after its introduction. METHODS:A National household-bas...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.08.038

    authors： Ben Hadj M,Bouguerra H,Saffar F,Chelly S,Hechaichi A,Talmoudi K,Bahrini A,Chouki T,Hazgui O,Hannachi N,Letaief H,Bellali H,Bahri O,Ben-Alaya-Bouafif N

    更新日期：2018-09-18 00:00:00

  • What maintains parental support for vaccination when challenged by anti-vaccination messages? A qualitative study.

    abstract：:This study sought to explore how parents respond to competing media messages about vaccine safety. Six focus groups with mothers of infants were shown television vignettes of typical pro- and anti-vaccination claims. Thematic analysis of transcripts was undertaken. Mothers expressed surprise and concern about alleged ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.05.010

    authors： Leask J,Chapman S,Hawe P,Burgess M

    更新日期：2006-11-30 00:00:00

  • B cell immunopathology during HIV-1 infection: lessons to learn for HIV-1 vaccine design.

    abstract：:Induction of broad HIV-1 neutralizing antibodies should be a major goal of an effective HIV-1 vaccine. However, B cells are severely damaged during HIV-1 infection with loss of memory B cells and decline of serological memory. The molecular events leading to B cell damage must be further characterized with the aim of ...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2007.11.063

    authors： Cagigi A,Nilsson A,De Milito A,Chiodi F

    更新日期：2008-06-06 00:00:00

  • In vivo evidence of immunological masking of the Vibrio cholerae O antigen of a hybrid Salmonella typhi Ty21a-Vibrio cholerae oral vaccine in humans.

    abstract：:The immunogenicity of the live oral hybrid vaccine organism Salmonella typhi Ty21a/V. cholerae Inaba (EX210) following its growth in media containing variable concentrations of supplemental galactose was examined in human volunteer subjects. The local intestinal IgA-specific antibody responses to both typhoid and chol...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0264-410x(91)90039-9

    authors： Forrest BD,LaBrooy JT

    更新日期：1991-07-01 00:00:00

  • Nasopharyngeal carriage of Streptococcus pneumoniae and other bacteria in the 7th year after implementation of the pneumococcal conjugate vaccine in the Netherlands.

    abstract：:After introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in the infant national immunization program (NIP) in the Netherlands in 2006, Streptococcus pneumoniae strains of the non-vaccine serotype 19A emerged and became the dominant serotype in carriage in children and their parents. Similar patterns we...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.11.060

    authors： Bosch AATM,van Houten MA,Bruin JP,Wijmenga-Monsuur AJ,Trzciński K,Bogaert D,Rots NY,Sanders EAM

    更新日期：2016-01-20 00:00:00

  • Defining hard-to-reach populations for vaccination.

    abstract：:Extending the benefits of vaccination to everyone who is eligible requires an understanding of which populations current vaccination efforts have struggled to reach. A clear definition of "hard-to-reach" populations - also known as high-risk or marginalized populations, or reaching the last mile - is essential for est...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2019.06.081

    authors： Ozawa S,Yemeke TT,Evans DR,Pallas SE,Wallace AS,Lee BY

    更新日期：2019-09-03 00:00:00

  • Leptospiral immunoglobulin-like proteins elicit protective immunity.

    abstract：:The identification of new vaccine candidates for leptospirosis is of great interest. This paper describes the identification of two homologous immunogenic proteins, LigA-m and LigB-m, of Leptospira interrogans serovar manilae strain UP-MMC-NIID, which show strong similarity with LigA found recently in L. interrogans s...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2003.10.007

    authors： Koizumi N,Watanabe H

    更新日期：2004-03-29 00:00:00

  • Developing an HPV vaccine to prevent cervical cancer and genital warts.

    abstract：:The challenges of the journey from target identification through development of a prophylactic quadrivalent human papillomavirus (HPV) vaccine have been met in Gardasil. Cervical cancer is the second leading cause of cancer-related death in women worldwide. Approximately 70% of cervical cancer is caused by infection w...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2007.01.013

    authors： Bryan JT

    更新日期：2007-04-20 00:00:00

  • Carrier priming with CRM 197 or diphtheria toxoid has a different impact on the immunogenicity of the respective glycoconjugates: biophysical and immunochemical interpretation.

    abstract：:Glycoconjugate vaccines play an enormous role in preventing infectious diseases. The main carrier proteins used in commercial conjugate vaccines are the non-toxic mutant of diphtheria toxin (CRM197), diphtheria toxoid (DT) and tetanus toxoid (TT). Modern childhood routine vaccination schedules include the administrati...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2014.11.026

    authors： Pecetta S,Lo Surdo P,Tontini M,Proietti D,Zambonelli C,Bottomley MJ,Biagini M,Berti F,Costantino P,Romano MR,Study Group.

    更新日期：2015-01-03 00:00:00

  • Enhancing immune responses to inactivated porcine parvovirus oil emulsion vaccine by co-inoculating porcine transfer factor in mice.

    abstract：:Inactivated porcine parvovirus (PPV) vaccines are available commercially and widely used in the breeding herds. However, inactivated PPV vaccines have deficiencies in induction of specific cellular immune response. Transfer factor (TF) is a material that obtained from the leukocytes, and is a novel immune-stimulatory ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.05.077

    authors： Wang RN,Wang YB,Geng JW,Guo DH,Liu F,Chen HY,Zhang HY,Cui BA,Wei ZY

    更新日期：2012-07-27 00:00:00

  • Development and phase 1 clinical testing of a conjugate vaccine against meningococcus A and C.

    abstract：:A conjugate vaccine against meningococcus A and C was prepared using the non-toxic mutant of diphtheria toxin CRM 197 as a carrier protein. Capsular polysaccharides of Neisseria meningitidis group A and C were hydrolysed and the resulting oligosaccharides were then coupled to CRM 197 in order to obtain conjugates with...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章

    doi：10.1016/0264-410x(92)90091-w

    authors： Costantino P,Viti S,Podda A,Velmonte MA,Nencioni L,Rappuoli R

    更新日期：1992-01-01 00:00:00

  • Management of acute and fulminant hepatitis A.

    abstract：:Symptomatic viral hepatitis A usually only requires supportive therapy and the majority of cases are managed in the community. The prodromal symptoms of nausea, anorexia and lethargy tend to improve with the onset of clinical jaundice. Fulminant hepatic failure is said to be an uncommon complication, occurring in only...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/0264-410x(92)90535-r

    authors： O'Grady J

    更新日期：1992-01-01 00:00:00

  • Response to hepatitis-B vaccination in healthy homosexual individuals: retrospective case control study.

    abstract：:The aim of the study was to compare the responses of homosexual men (HM) receiving a standard course of recombinant hepatitis B vaccine with those of healthcare workers vaccinated in the same hospital over the same period. Boosters for inadequate responders and repeat courses for non-responders were given. Forty of 61...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(03)00392-x

    authors： Das S,Brassington M,Drake SM,Boxall E

    更新日期：2003-09-08 00:00:00

  • HPV vaccine efficacy in preventing persistent cervical HPV infection: a systematic review and meta-analysis.

    abstract：INTRODUCTION:We performed a pooled analysis of randomised clinical trials (RCT) on HPV vaccine efficacy in preventing cervical persistent infection. METHODS:We carried out a bibliographic search on electronic databases and we selected RCT to perform the meta-analyses. RESULTS:We selected five studies. The first meta-...

    journal_title：Vaccine

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.vaccine.2007.09.027

    authors： La Torre G,de Waure C,Chiaradia G,Mannocci A,Ricciardi W

    更新日期：2007-12-05 00:00:00

  • Crossreactive neutralizing antibodies induced by immunization with caprine arthritis-encephalitis virus surface glycoprotein.

    abstract：:Four Saanen goats were immunized with affinity purified gp135 surface glycoprotein (SU) of caprine arthritis-encephalitis virus isolate 79-63 (CAEV-63) and evaluated for homologous and crossreactive serum neutralizing antibodies. CAEV-63 neutralizing antibodies were detected in all goats after seven immunizations with...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(99)00181-4

    authors： Kemp RK,Knowles DP,Perry LL,McGuire TC,Besser TE,Cheevers WP

    更新日期：2000-01-18 00:00:00

  • Pneumococcal conjugate serotype distribution and predominating role of serotype 3 in German adults with community-acquired pneumonia.

    abstract：INTRODUCTION:Implementation of the 7-valent pneumococcal conjugate vaccine (PCV7) in infant vaccination programs has substantially reduced the burden of PCV7 serotypes also in adult community-acquired pneumonia (CAP). Currently, it is unclear, if this extensive herd protection effect can be extrapolated to the addition...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.11.026

    authors： Forstner C,Kolditz M,Kesselmeier M,Ewig S,Rohde G,Barten-Neiner G,Rupp J,Witzenrath M,Welte T,Pletz MW,CAPNETZ study group.

    更新日期：2020-01-29 00:00:00

  • Adenovectors induce functional antibodies capable of potent inhibition of blood stage malaria parasite growth.

    abstract：:An effective malaria vaccine remains a global health priority. Recombinant adenoviruses are a promising vaccine platform, and Plasmodium falciparum apical membrane antigen 1 (AMA1) and merozoite surface protein 1-42 (MSP1(42)) are leading blood stage vaccine candidates. We evaluated the importance of surface antigen l...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2010.02.024

    authors： Bruder JT,Stefaniak ME,Patterson NB,Chen P,Konovalova S,Limbach K,Campo JJ,Ettyreddy D,Li S,Dubovsky F,Richie TL,King CR,Long CA,Doolan DL

    更新日期：2010-04-19 00:00:00

  • A method for evaluating and comparing immunisation schedules that cover multiple diseases: Illustrative application to the UK routine childhood vaccine schedule.

    abstract：BACKGROUND:In the UK, the childhood immunisation programme is given in the first 5 years of life and protects against 12 vaccine-preventable diseases. Recently, this programme has undergone changes with addition of vaccination against Meningitis B from September 2015 and the removal of the primary dose of protection ag...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.05.083

    authors： Panovska-Griffiths J,Crowe S,Pagel C,Shiri T,Grove P,Utley M

    更新日期：2018-08-23 00:00:00

  • Predictive value of seizure ICD-9 codes for vaccine safety research.

    abstract：:Post-licensure vaccine safety studies often monitor for seizures using automated screening of ICD-9 codes. This study assessed the positive predictive value (PPV) of ICD-9 codes used to identify seizure visits in children aged 6 weeks to 23 months who were enrolled in seven managed care organizations during January 20...

    journal_title：Vaccine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.vaccine.2009.06.092

    authors： Shui IM,Shi P,Dutta-Linn MM,Weintraub ES,Hambidge SJ,Nordin JD,Lieu TA,Vaccine Safety Datalink Research Team.

    更新日期：2009-08-27 00:00:00

  • Mucosal inoculation with an attenuated mouse pneumovirus strain protects against virulent challenge in wild type and interferon-gamma receptor deficient mice.

    abstract：:Protective mechanisms underlying the responses to mucosal vaccination are not yet clearly defined. Using the natural mouse pneumovirus pathogen, pneumonia virus of mice (PVM), we explore responses of wild type and interferon-gamma (IFNgamma) receptor gene-deleted mice to virulent challenge after mucosal vaccination wi...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.09.081

    authors： Ellis JA,Martin BV,Waldner C,Dyer KD,Domachowske JB,Rosenberg HF

    更新日期：2007-01-22 00:00:00