Interchangeability and tolerability of two inactivated hepatitis A vaccines in Chinese children.

abstract：:The hemagglutinin/protease (HA/P) seems to be an attractive locus for the insertion of heterologous tags in live cholera vaccine strains. A deltaCTXphi spontaneous mutant derived from a pathogenic strain of O139 Vibrio cholerae was sequentially manipulated to obtain hapA Colon, two colons celA derivatives which were l...

journal_title：Vaccine

authors： Ledón T,Valle E,Valmaseda T,Cedré B,Campos J,Rodríguez BL,Marrero K,García H,García L,Fando R

更新日期：2003-03-07 00:00:00

abstract：:A synthetic T cell immunogen (TCI) has been designed as a candidate DNA-based vaccine against Human immunodeficiency virus (HIV)-1 using cytotoxic T lymphocytes (CD8(+) CTL) and T-helper lymphocytes (CD4(+) Th) epitopes retrieved from the Los Alamos HIV Molecular Immunology Database. The protein 392 amino acids in len...

journal_title：Vaccine

authors： Bazhan SI,Belavin PA,Seregin SV,Danilyuk NK,Babkina IN,Karpenko LI,Nekrasova NA,Lebedev LR,Ignatyev GM,Agafonov AP,Poryvaeva VA,Aborneva IV,Ilyichev AA

更新日期：2004-04-16 00:00:00

abstract：:Enterobactin (Ent)-mediated high affinity iron acquisition is critically important for Gram-negative bacterial pathogens to survive and infect the host. Recently, we reported an efficient method to prepare novel Ent conjugate vaccines for inducing high level of Ent-specific antibodies, which displayed similar bacterio...

journal_title：Vaccine

authors： Wang H,Zeng X,Lin J

更新日期：2020-11-17 00:00:00

abstract：BACKGROUND:British Columbia (BC) introduced a school-based HPV vaccine program in September 2008. As part of the HPV vaccine program evaluation, we determined the type-specific HPV prevalence in a population-based sample of women presenting for routine cervical cancer screening in the province. METHODS:From June 2010 ...

journal_title：Vaccine

authors： Ogilvie GS,Cook DA,Taylor DL,Rank C,Kan L,Yu A,Mei W,van Niekerk DJ,Coldman AJ,Krajden M

更新日期：2013-02-04 00:00:00

abstract：:The canarypox vaccine vector (ALVAC) technology has been used to develop and license several vaccines for companion animals and horses in the European Union and USA. ALVAC is a ubiquitous vector with high biosafety since it is non-replicative in mammalians, is genetically and physically stable, and able to induce both...

journal_title：Vaccine

authors： Poulet H,Minke J,Pardo MC,Juillard V,Nordgren B,Audonnet JC

更新日期：2007-07-26 00:00:00

abstract：:Establishing successful vaccine programs for pregnant women would be the quintessence of preventive medicine when you realize the preventive potential for reproductive problems of many of the new and old vaccines. The development of vaccines to prevent maternal, fetal and newborn disease is actually in its infancy. Th...

journal_title：Vaccine

authors： Brent RL

更新日期：2003-07-28 00:00:00

abstract：BACKGROUND:World Health Organization has recommended the introduction of pneumococcal conjugate vaccine (PCV) in the childhood immunisation programme of all the countries in the world. In lieu of its introduction in India, there is a need to generate evidence on cost-effectiveness of this vaccine. The current study loo...

journal_title：Vaccine

authors： Krishnamoorthy Y,Eliyas SK,Nair NP,Sakthivel M,Sarveswaran G,Chinnakali P

更新日期：2019-01-21 00:00:00

abstract：:It is generally recognized that DNA vaccines are often less effective in large animals than in mice. One possible reason for this reduced effectiveness may be transfection efficiency and the low level of expression elicited by plasmid vectors in large animals. A possible way to improve plasmid gene expression in vivo ...

journal_title：Vaccine

authors： Babiuk S,Baca-Estrada ME,Foldvari M,Storms M,Rabussay D,Widera G,Babiuk LA

更新日期：2002-09-10 00:00:00

abstract：:After introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in the infant national immunization program (NIP) in the Netherlands in 2006, Streptococcus pneumoniae strains of the non-vaccine serotype 19A emerged and became the dominant serotype in carriage in children and their parents. Similar patterns we...

journal_title：Vaccine

authors： Bosch AATM,van Houten MA,Bruin JP,Wijmenga-Monsuur AJ,Trzciński K,Bogaert D,Rots NY,Sanders EAM

更新日期：2016-01-20 00:00:00

abstract：:Carcinoembryonic antigen (CEA), which is expressed in several cancer types, is a potential target for specific immunotherapy. In this study, the feasibility of using dendrite cells (DCs) for tumor immunotherapy after transduction with a recombinant adenovirus containing CEA gene (AdVCEA) was investigated. The recombin...

journal_title：Vaccine

authors： Cho HI,Kim HJ,Oh ST,Kim TG

更新日期：2003-12-12 00:00:00

abstract：:Iscoms, with rCTB incorporated via the GM1 receptor, enhanced in mice the mucosal immunogenicity of rCTB as antigen after intranasal (i.n.) administration both by inducing IgA response in the remote intestinal tract mucosa and by a 100-fold increase of the specific IgA locally in the lungs. Iscom-matrix as a separate ...

journal_title：Vaccine

authors： Ekström J,Hu KF,Bengtsson KL,Morein B

更新日期：1999-06-04 00:00:00

abstract：:Prior to routine immunisation, Haemophilus influenzae serotype b (Hib) was a major cause of serious bacterial infections, particularly in young children. In the United Kingdom, introduction of the Hib conjugate vaccine into the national childhood immunisation schedule has led to a sustained decline in invasive Hib dis...

journal_title：Vaccine

authors： Townsend K,Ladhani SN,Findlow H,Borrow R

更新日期：2014-09-29 00:00:00

abstract：:Mycoplasma hyopneumoniae, the primary pathogen of enzootic pneumonia, occurs worldwide and causes major economic losses to the pig industry. M. hyopneumoniae infects pigs at mucosal surfaces of respiratory tract. The aim of the present study was to investigate if the protection rate against M. hyopneumoniae infection ...

journal_title：Vaccine

authors： Li Y,Li P,Wang X,Yu Q,Yang Q

更新日期：2012-03-09 00:00:00

abstract：:Humoral responses against extra-cellular HIV-1 Tat may be beneficial as Tat has been implicated in the viral pathogenesis associated with HIV-1 disease progression. We determined the levels of anti-Tat IgG in sera of HIV-1 seropositive individuals from the Rural Clinical Cohort in Uganda using nine different Tat prote...

journal_title：Vaccine

authors： Campbell GR,Senkaali D,Watkins J,Esquieu D,Opi S,Yirrell DL,Kaleebu P,Loret EP

更新日期：2007-12-05 00:00:00

abstract：BACKGROUND:The potential for development of autoimmune diseases after vaccination with new vaccines containing novel adjuvants is a theoretical concern. Randomised, placebo-controlled trials are the best method for assessing a potential causal relationship between an adverse event and vaccination, but usually have a sa...

journal_title：Vaccine

authors： Tavares Da Silva F,De Keyser F,Lambert PH,Robinson WH,Westhovens R,Sindic C

更新日期：2013-04-03 00:00:00

abstract：:A placebo-controlled, double-blind study on the efficacy of a hepatitis A vaccine (SmithKline Beecham Biologicals) was started in a region of Chile in September 1990, using hepatitis B vaccine as control. A total of 260 healthy children, 6-15 years of age, negative for antibody to hepatitis A virus (anti-HAV), antibod...

journal_title：Vaccine

authors： Riedemann S,Reinhardt G,Frösner GG,Ibarra H,Moraleda L,Hering V,Siegel F,Toledo C,Leon J,Gonzalez JL

更新日期：1992-01-01 00:00:00

abstract：:Genetic immunization holds promise as a vaccination method, but has so far proven ineffective in large primate and human trials. Herein, we examined the relative merits of genetic immunization and peptide immunization using bacteriophage λ. Bacteriophage λ has proven effective in immune challenge models using both imm...

journal_title：Vaccine

authors： Thomas BS,Nishikawa S,Ito K,Chopra P,Sharma N,Evans DH,Tyrrell DL,Bathe OF,Rancourt DE

更新日期：2012-02-01 00:00:00

abstract：:To evaluate the utility of plasmid DNA vaccination against disease caused by herpes simplex virus (HSV), we compared the strength of protection against lethal challenge following natural virus infection with that following vaccination with a plasmid encoding HSV glycoprotein gD (gD-DNA). We further determined the cell...

journal_title：Vaccine

authors： Nass PH,Elkins KL,Weir JP

更新日期：2001-01-08 00:00:00

abstract：:Prior work shows that an attenuated West Nile virus (WNV), the nonstructural (NS)4B-P38G mutant infection in mice induced strong immune responses and protected host from subsequent lethal wild-type WNV infection. Here, we investigated NS4B-P38G mutant infection in myeloid differentiation factor 88-deficient (MyD88(-/-...

journal_title：Vaccine

authors： Xie G,Welte T,Wang J,Whiteman MC,Wicker JA,Saxena V,Cong Y,Barrett AD,Wang T

更新日期：2013-08-28 00:00:00

abstract：:Vector-directed lymphokine expression represents a novel approach to the attenuation of live recombinant viruses which might be used as vaccines. Expression of interleukin-2 (IL-2) by recombinant vaccinia virus has been shown to significantly attenuate virus virulence in rodent species without diminishing immunogenici...

journal_title：Vaccine

authors： Flexner C,Moss B,London WT,Murphy BR

更新日期：1990-02-01 00:00:00

abstract：:The cost-effectiveness of different mass dog rabies vaccination strategies, defined as the costs per year of life lost (YLL) averted was evaluated for a period of 10 years by means of a dynamic simulation study for a typical village on Flores Island. In the base strategy (no dog vaccination and no post-exposure treatm...

journal_title：Vaccine

authors： Wera E,Mourits MCM,Hogeveen H

更新日期：2017-12-04 00:00:00

abstract：:Because recombinant empty viral capsids are potentially attractive vectors for gene therapy, here we examined the ability of human papillomavirus (HPV) virus-like particles (VLPs) to mediate delivery and expression of DNA plasmids in vitro and in vivo. VLP-mediated delivery and expression of a GFP reporter construct i...

journal_title：Vaccine

authors： Malboeuf CM,Simon DA,Lee YE,Lankes HA,Dewhurst S,Frelinger JG,Rose RC

更新日期：2007-04-30 00:00:00

abstract：:This work describes the optimization of a cost-effective process for the production of an inactivated bacterial vaccine against heartwater and the first attempt to produce the causative agent of this disease, the rickettsia Ehrlichia ruminantium (ER), using stirred tanks. In vitro, it is possible to produce ER using c...

journal_title：Vaccine

authors： Marcelino I,Sousa MF,Veríssimo C,Cunha AE,Carrondo MJ,Alves PM

更新日期：2006-03-06 00:00:00

abstract：:To determine the potential for biodegradable alginate microspheres to be used as a delivery vehicle for DNA based vaccines, we constructed a plasmid, pMNe-gal-SV40, containing the bacterial beta-galactosidase (LacZ) gene under the control of the murine cytomegalovirus (MCMV) immediate-early promoter and the simian vir...

journal_title：Vaccine

authors： Mittal SK,Aggarwal N,Sailaja G,van Olphen A,HogenEsch H,North A,Hays J,Moffatt S

更新日期：2000-09-15 00:00:00

abstract：:National Organized Cervical Cancer Screening (NOCCS) programs are lacking in most of the "Extended Middle East and North Africa" (EMENA) countries. Consequently, most cervical cancers are diagnosed late and are associated with high mortality. In fact, in most of these countries, national mortality data are unknown due...

journal_title：Vaccine

authors： Sancho-Garnier H,Khazraji YC,Cherif MH,Mahnane A,Hsairi M,El Shalakamy A,Osgul N,Tuncer M,Jumaan AO,Seoud M

更新日期：2013-12-30 00:00:00

abstract：:Immunization protocols based on priming with plasmid DNA and boosting with recombinants of vaccinia virus (rVV) encoding the same antigen offer great promise for the prevention and treatment of many parasitic and viral infections for which conventional vaccination has little or no effect. To overcome some of the poten...

journal_title：Vaccine

authors： López-Fuertes L,Pérez-Jiménez E,Vila-Coro AJ,Sack F,Moreno S,Konig SA,Junghans C,Wittig B,Timón M,Esteban M

更新日期：2002-12-13 00:00:00

abstract：:Development of effective new mucosal vaccine adjuvants has become a priority with the increase in emerging viral and bacterial pathogens. We previously reported that cationic liposomes complexed with non-coding plasmid DNA (CLDC) were effective parenteral vaccine adjuvants. However, little is known regarding the abili...

journal_title：Vaccine

authors： Henderson A,Propst K,Kedl R,Dow S

更新日期：2011-07-18 00:00:00

abstract：:Effort has been made to identify protective antigens in order to develop a recombinant vaccine against leptospirosis. Several attempts failed to conclusively demonstrate efficacy of vaccine candidates due to the lack of an appropriate model of lethal leptospirosis. The purposes of our study were: (i) to test the virul...

journal_title：Vaccine

authors： Silva EF,Santos CS,Athanazio DA,Seyffert N,Seixas FK,Cerqueira GM,Fagundes MQ,Brod CS,Reis MG,Dellagostin OA,Ko AI

更新日期：2008-07-23 00:00:00

abstract：BACKGROUND:Long-term immunosuppressive medications are being used more commonly for a variety of medical conditions, including immune-mediated diseases and organ transplantation. While these medications are often necessary, they are associated with an increased risk of serious infections. Vaccination may be a way to pr...

journal_title：Vaccine

authors： Agarwal N,Ollington K,Kaneshiro M,Frenck R,Melmed GY

更新日期：2012-02-14 00:00:00

abstract：INTRODUCTION:Institutionalized mentally retarded subjects are well-known to be at-risk for HBV infection. We studied the persistence of vaccine-induced anti-HBs antibodies and the robustness of the HBsAg-specific immune memory in this population, 18-20 years after the first vaccine dose. MATERIALS AND METHODS:Non-immu...

journal_title：Vaccine

authors： Braeckman T,Van Herck K,Jilg W,Bauer T,Van Damme P

更新日期：2012-07-06 00:00:00