Antigen adsorbed surface modified poly-ɛ-caprolactone microspheres stimulates both adaptive and innate immune response in fish.

abstract：:The chloroplast genetic engineering offers a number of unique advantages including high level of transgene expression, multi-gene expression in single transformation event and transgene containment due to maternal inheritance. Hyper-expression of vaccine antigens or therapeutic proteins in transgenic chloroplasts (lea...

journal_title：Vaccine

authors： Daniell H,Chebolu S,Kumar S,Singleton M,Falconer R

更新日期：2005-03-07 00:00:00

abstract：:Vaccines are among the most cost-effective interventions against infectious diseases. Many candidate vaccines targeting neglected diseases in low- and middle-income countries are now progressing to large-scale clinical testing. However, controversy surrounds the appropriate design of vaccine trials and, in particular,...

journal_title：Vaccine

authors： Rid A,Saxena A,Baqui AH,Bhan A,Bines J,Bouesseau MC,Caplan A,Colgrove J,Dhai A,Gomez-Diaz R,Green SK,Kang G,Lagos R,Loh P,London AJ,Mulholland K,Neels P,Pitisuttithum P,Sarr SC,Selgelid M,Sheehan M,Smith PG

更新日期：2014-08-20 00:00:00

abstract：:While the immunological correlates of hepatitis C virus (HCV)-specific immunity are not well understood, it is now admitted that an effective vaccine against HCV will need to induce both cellular and humoral immune responses and address viral heterogeneity to prevent immune escape. We developed a vaccine platform spec...

journal_title：Vaccine

authors： Huret C,Desjardins D,Miyalou M,Levacher B,Amadoudji Zin M,Bonduelle O,Combadière B,Dalba C,Klatzmann D,Bellier B

更新日期：2013-03-01 00:00:00

abstract：:The increased risk of intussusception after vaccination with the rhesus-human reassortant rotavirus vaccine Rotashield led to its withdrawal in 2005. We assess the risk of intussusception following the pentavalent rotavirus vaccine (RV5) on the basis of worldwide reports to the manufacturer up to May 2014, using a sel...

journal_title：Vaccine

authors： Escolano S,Hill C,Tubert-Bitter P

更新日期：2015-02-18 00:00:00

abstract：:Mathematical models provide valuable insights into the public health and economic impact of cervical cancer vaccination programmes. An in-depth economic analysis should explore the effects of different vaccine-related factors and vaccination scenarios (independent of screening practices) on health benefits and costs. ...

journal_title：Vaccine

authors： Suárez E,Smith JS,Bosch FX,Nieminen P,Chen CJ,Torvinen S,Demarteau N,Standaert B

更新日期：2008-09-15 00:00:00

abstract：:There are currently no vaccines or therapeutics to prevent dengue disease which ranges in severity from asymptomatic infections to life-threatening illness. The National Institute of Allergy and Infectious Diseases (NIAID) Division of Intramural Research has developed live, attenuated vaccines to each of the four deng...

journal_title：Vaccine

authors： Lindow JC,Durbin AP,Whitehead SS,Pierce KK,Carmolli MP,Kirkpatrick BD

更新日期：2013-07-18 00:00:00

abstract：BACKGROUND:Development of influenza vaccines that do not use embryonated eggs as the substrate for vaccine production is a high priority. We conducted this study to determine the protective efficacy a recombinant, baculovirus-expressed seasonal trivalent influenza virus hemagglutinin (rHA0) vaccine (FluBlok(®)). METHO...

journal_title：Vaccine

authors： Treanor JJ,El Sahly H,King J,Graham I,Izikson R,Kohberger R,Patriarca P,Cox M

更新日期：2011-10-13 00:00:00

abstract：:Crystallization of inulin with alum forms a fine (1-2 micron) suspension of electron-dense ovoids; the alum is embedded in inulin particles, which are then converted to the immune stimulant polymorphic form, gamma inulin. This very stable hybrid preparation is termed Algammulin. Preferred conditions for its preparatio...

journal_title：Vaccine

authors： Cooper PD,Steele EJ

更新日期：1991-05-01 00:00:00

abstract：:Since 1992, hepatitis B vaccine has been an integrated part of Thailand's expanded programme on immunisation (EPI). Based on the data from five representative provinces, we have evaluated its impact on the countrywide prevalence of HBV infection and carrier rate. The population studied comprised 400-488 healthy and im...

journal_title：Vaccine

authors： Poovorawan Y,Theamboonlers A,Vimolket T,Sinlaparatsamee S,Chaiear K,Siraprapasiri T,Khwanjaipanich S,Owatanapanich S,Hirsch P,Chunsuttiwat S

更新日期：2000-11-22 00:00:00

abstract：:Serogroup X Neisseria meningitidis (MenX) has recently emerged as a cause of localized disease outbreaks in sub-Saharan Africa. In order to prepare for vaccine development, MenX polysaccharide (MenX PS) was purified by standard methods and analyzed for identity and structure by NMR spectroscopy. This study presents th...

journal_title：Vaccine

authors： Xie O,Bolgiano B,Gao F,Lockyer K,Swann C,Jones C,Delrieu I,Njanpop-Lafourcade BM,Tamekloe TA,Pollard AJ,Norheim G

更新日期：2012-08-31 00:00:00

abstract：BACKGROUND:Since special efforts are necessary to vaccinate people living far from fixed vaccination posts, decision makers are interested in knowing the economic value of such efforts. METHODS:Using our immunization geospatial information system platform and a measles compartment model, we quantified the health and e...

journal_title：Vaccine

authors： Lee BY,Brown ST,Haidari LA,Clark S,Abimbola T,Pallas SE,Wallace AS,Mitgang EA,Leonard J,Bartsch SM,Yemeke TT,Zenkov E,Ozawa S

更新日期：2019-04-17 00:00:00

abstract：:Infection of rubella virus at the early stages of pregnancy in women who are not immune to rubella often induces congenital anomalies in infants, namely congenital rubella syndrome (CRS). This paper is the first comprehensive report of CRS cases in Japan, compiled from a questionnaire to major hospitals, reports to jo...

journal_title：Vaccine

authors： Katow S

更新日期：2004-09-28 00:00:00

abstract：BACKGROUND:Currently, one lifetime booster of a 23-valent pneumococcal polysaccharide vaccine (PPV23) is recommended for those at highest risk of invasive pneumococcal disease (IPD) 3-5 years after initial vaccination. Due to a lack of evidence on multiple revaccinations, recommendations on repeat revaccination do not ...

journal_title：Vaccine

authors： Caya CA,Boikos C,Desai S,Quach C

更新日期：2015-03-10 00:00:00

abstract：:The purpose of this study was to assess clinical protection in pigs vaccinated with a commercially available attenuated porcine reproductive and respiratory syndrome virus (PRRSV) vaccine (Porcilis) PRRS) and then naturally exposed under field conditions to a heterologous (Italian cluster) strain of virulent PRRSV. A ...

journal_title：Vaccine

authors： Martelli P,Gozio S,Ferrari L,Rosina S,De Angelis E,Quintavalla C,Bottarelli E,Borghetti P

更新日期：2009-06-08 00:00:00

abstract：BACKGROUND:While many clinicians encounter parents or adolescents who refuse HPV vaccine, little is known about the prevalence of hesitancy for HPV vaccine nationally or its association with vaccination. METHODS:In April 2019, we surveyed families with adolescents 11-17 years using a national online panel (Knowledge P...

journal_title：Vaccine

authors： Szilagyi PG,Albertin CS,Gurfinkel D,Saville AW,Vangala S,Rice JD,Helmkamp L,Zimet GD,Valderrama R,Breck A,Rand CM,Humiston SG,Kempe A

更新日期：2020-08-27 00:00:00

abstract：:DNA immunization with HIV envelope plasmids induce only moderate levels of specific antibodies which may in part be due to limitations in expression influenced by a species-specific and biased HIV codon usage. We compared antibody levels, Th1/Th2 type and CTL responses induced by synthetic genes encoding membrane boun...

journal_title：Vaccine

authors： Vinner L,Nielsen HV,Bryder K,Corbet S,Nielsen C,Fomsgaard A

更新日期：1999-04-23 00:00:00

abstract：:Two double-blind randomised controlled studies (phase I and I/II) were performed to assess for the first time the safety and immunogenicity of a recombinant subunit gp350 Epstein-Barr virus (EBV) vaccine in 148 healthy adult volunteers. All candidate vaccine formulations had a good safety profile and were well tolerat...

journal_title：Vaccine

authors： Moutschen M,Léonard P,Sokal EM,Smets F,Haumont M,Mazzu P,Bollen A,Denamur F,Peeters P,Dubin G,Denis M

更新日期：2007-06-11 00:00:00

abstract：:Killed whole-cell preparations were used as bacterins against leptospirosis. As this type of protection is considered to be serogroup-specific, several serogroups were added to the usual vaccines, and the most pathogenic serovar was chosen for each group. Different leptospire extracts were evaluated for their protecti...

journal_title：Vaccine

authors： Sonrier C,Branger C,Michel V,Ruvoën-Clouet N,Ganière JP,André-Fontaine G

更新日期：2000-08-15 00:00:00

abstract：:Visceral leishmaniasis, caused by the intracellular parasite Leishmania donovani is a significant public health problem in many regions of the world. Anti-leishmanial immune defences are primarily dependent on the ability of the host to mount an interleukin-12 (IL-12) driven Th1 type of responses. Thus, IL-12 plays a ...

journal_title：Vaccine

authors： Tewary P,Saxena S,Madhubala R

更新日期：2006-03-20 00:00:00

abstract：:Enterobactin (Ent)-mediated high affinity iron acquisition is critically important for Gram-negative bacterial pathogens to survive and infect the host. Recently, we reported an efficient method to prepare novel Ent conjugate vaccines for inducing high level of Ent-specific antibodies, which displayed similar bacterio...

journal_title：Vaccine

authors： Wang H,Zeng X,Lin J

更新日期：2020-11-17 00:00:00

abstract：:The immunogenicity and safety of an HPV-16/18 AS04-adjuvanted vaccine were assessed in women aged 26-55 years and compared with women aged 15-25 years in a Phase III, non-randomised, open-label, age-stratified study. Overall the vaccine was well tolerated and 100% seropositivity was achieved 1 month after the third do...

journal_title：Vaccine

authors： Schwarz TF,Spaczynski M,Schneider A,Wysocki J,Galaj A,Perona P,Poncelet S,Zahaf T,Hardt K,Descamps D,Dubin G,HPV Study Group for Adult Women.

更新日期：2009-01-22 00:00:00

abstract：:Due to viral strains, influenza season, and consultations and admission rates varying from country to country, the continued economic evaluation of influenza vaccination for the elderly people aged 65 years and above is paramount, particularly in areas with dense population. Efficacy and cost-effective analysis of inf...

journal_title：Vaccine

authors： Wang ST,Lee LT,Chen LS,Chen TH

更新日期：2005-03-14 00:00:00

abstract：:A pilot study compared the immune response of regular (0, 3, 6, 32 weeks) and extended (0, 10, 13, 32 weeks) schedules of the UK anthrax vaccine (anthrax vaccine precipitated, AVP). Concentrations of antibodies to protective antigen (PA) were higher (p<0.05) among recipients of the extended (n=7) versus regular schedu...

journal_title：Vaccine

authors： Hepburn MJ,Hugh Dyson E,Simpson AJ,Brenneman KE,Bailey N,Wilkinson L,Hornby R,Mateczun AJ,Bell MG,Baillie LW

更新日期：2007-08-10 00:00:00

abstract：BACKGROUND:Efforts to develop a Clostridium difficile vaccine are underway; identification of patients at risk for C. difficile infection (CDI) is critical to inform vaccine trials. We identified groups at high risk of CDI ≥ 2 8 days after hospital discharge. METHODS:Hospital discharge data and pharmacy data from two ...

journal_title：Vaccine

authors： Baggs J,Yousey-Hindes K,Ashley ED,Meek J,Dumyati G,Cohen J,Wise ME,McDonald LC,Lessa FC

更新日期：2015-11-17 00:00:00

abstract：:During the 2000/2001 influenza season in Japan, children ranging in age from 6 months to 13 years with fever exceeding 37.5 degrees C were recruited. Vaccine efficacy was evaluated by comparing the rates of pre-seasonal vaccination between groups stratified by fever severity. Seven hundred and sixty one patients (33.1...

journal_title：Vaccine

authors： Kamada M,Nagai T,Kumagai T,Igarashi M,Ihara T,Okafuji T,Ochiai H,Sakiyama H,Shimomura K,Suzuki E,Torigoe S,Miyazaki C,Miyata A,Yuri K,Ito Y,Nakayama T,Kase T,Okuno Y

更新日期：2006-04-24 00:00:00

abstract：:This study investigated predictors of influenza vaccination uptake since the introduction of the policy to target over 65s. Four hundred and forty-four participants completed a cross-sectional structured interview. The predictors of vaccination uptake were: having a doctor or nurse who explained why the vaccination is...

journal_title：Vaccine

authors： Burns VE,Ring C,Carroll D

更新日期：2005-05-20 00:00:00

abstract：:Recombinant replication-defective human adenovirus type 5 (Ad5) vaccines containing capsid-coding regions from foot-and-mouth disease virus (FMDV) have been demonstrated to induce effective immune responses and provide homologous protective immunity against FMDV in cattle. However, basic mechanisms of Ad5-FMDV vaccine...

journal_title：Vaccine

authors： Montiel N,Smoliga G,Arzt J

更新日期：2012-02-21 00:00:00

abstract：BACKGROUND:Pneumococcal conjugate vaccines (PCV) were first licensed for use with 3 primary doses in infancy and a booster dose. The evidence for the effects of different schedules was examined in this systematic review and meta-analysis. METHODS:We searched 12 databases and trial registers up to March 2010. We select...

journal_title：Vaccine

authors： Scott P,Rutjes AW,Bermetz L,Robert N,Scott S,Lourenço T,Egger M,Low N

更新日期：2011-12-06 00:00:00

abstract：BACKGROUND:Measles-containing vaccine (MCV) was introduced in 1965 in Beijing and given to the children aged 8m-14y. In population-based surveillance system, real-time polymerase chain reaction (RT-PCR) and immunoglobulin M(IgM) serology tests have been conducted for each suspected case since 2013. We used the surveill...

journal_title：Vaccine

authors： Ma R,Lu L,Suo L,Zhangzhu J,Chen M,Pang X

更新日期：2019-06-27 00:00:00

abstract：:Plasmid DNA is a promising vaccine platform that has been shown to be safe and able to be administered repeatedly without vector interference. Enhancing the potency of DNA vaccination through co-delivery of molecular adjuvants is one strategy currently under investigation. Here we describe the use of the novel chemoki...

journal_title：Vaccine

authors： Kraynyak KA,Kutzler MA,Cisper NJ,Khan AS,Draghia-Akli R,Sardesal NY,Lewis MG,Yan J,Weiner DB

更新日期：2010-02-23 00:00:00