Immunogenicity and tolerability of an HPV-16/18 AS04-adjuvanted prophylactic cervical cancer vaccine in women aged 15-55 years.

Abstract:

:The immunogenicity and safety of an HPV-16/18 AS04-adjuvanted vaccine were assessed in women aged 26-55 years and compared with women aged 15-25 years in a Phase III, non-randomised, open-label, age-stratified study. Overall the vaccine was well tolerated and 100% seropositivity was achieved 1 month after the third dose in all age groups. There was a high correlation between HPV-16 and HPV-18 antibody levels (IgG) in cervicovaginal secretions and sera, regardless of age. The HPV-16/18 AS04-adjuvanted vaccine induces a robust and persistent immune response in women >26 years of age and generates antibodies that transudate through the cervix epithelium.

journal_name

Vaccine

journal_title

Vaccine

authors

Schwarz TF,Spaczynski M,Schneider A,Wysocki J,Galaj A,Perona P,Poncelet S,Zahaf T,Hardt K,Descamps D,Dubin G,HPV Study Group for Adult Women.

doi

10.1016/j.vaccine.2008.10.088

subject

Has Abstract

pub_date

2009-01-22 00:00:00

pages

581-7

issue

4

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(08)01500-4

journal_volume

27

pub_type

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