Co-administration of IL-12 DNA with rORFF antigen confers long-term protective immunity against experimental visceral leishmaniaisis.

Abstract:

:Visceral leishmaniasis, caused by the intracellular parasite Leishmania donovani is a significant public health problem in many regions of the world. Anti-leishmanial immune defences are primarily dependent on the ability of the host to mount an interleukin-12 (IL-12) driven Th1 type of responses. Thus, IL-12 plays a pivotal role in diversification of the immune responses towards Th1 type. In this report, we investigated the effect of IL-12 DNA as an adjuvant with leishmanial recombinant open reading frame F (rORFF) protein. We demonstrate that an expression plasmid encoding both p35 and p40 subunits of IL-12 when co-administered with rORFF induces a significant protection with around 82% protection in both liver and spleen. The protection correlated with increased proliferative response of splenocytes and subsequent release of Th1 cytokine IFN-gamma. The levels of IFN-gamma were sustained 4 and 8 weeks after challenge with L. donovani promastigotes. Interestingly, IL-12 DNA played a key role in modulating the antibody response towards IgG2a isotype suggesting its use as a potential vaccine adjuvant against intracellular infections like leishmaniasis.

journal_name

Vaccine

journal_title

Vaccine

authors

Tewary P,Saxena S,Madhubala R

doi

10.1016/j.vaccine.2005.11.058

subject

Has Abstract

pub_date

2006-03-20 00:00:00

pages

2409-16

issue

13

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(05)01208-9

journal_volume

24

pub_type

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