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Chloroplast-derived vaccine antigens and other therapeutic proteins.

Abstract：

:The chloroplast genetic engineering offers a number of unique advantages including high level of transgene expression, multi-gene expression in single transformation event and transgene containment due to maternal inheritance. Hyper-expression of vaccine antigens or therapeutic proteins in transgenic chloroplasts (leaves) or chromoplasts (fruits/roots) facilitates efficient oral delivery. Ability of chloroplasts to correctly fold human blood proteins with proper disulfide bridges (human serum albumin or interferons) or presence of chaperones in chloroplasts to facilitate assembly of complex multi-subunit proteins or their prokaryotic nature to express native bacterial genes (up to 46.1% total leaf protein) are attractive features for therapeutic protein production. Purification of therapeutic proteins has been achieved using novel purification strategies that do not require expensive column chromatography.

journal_name

Vaccine

journal_title

Vaccine

authors

Daniell H,Chebolu S,Kumar S,Singleton M,Falconer R

doi

10.1016/j.vaccine.2004.11.004

subject

Has Abstract

pub_date

2005-03-07 00:00:00

pages

1779-83

issue

15

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(04)00821-7

journal_volume

23

pub_type

杂志文章,评审

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