A discrete computer model of the immune system reveals competitive interactions between the humoral and cellular branch and between cross-reacting memory and naïve responses.

Abstract:

:In an agent-based computer model, we simulate the formation and recall of anti-virus immunological memory. Specifically we try to predict what will happen, both to the response and to memory, when the second infecting virus is partly different from the first one, and when the cross-reactivity of the two branches of the immune system (IS), humoral and cellular, is asymmetrical, or "split". The simulations explore systematically epitope distances, and measure all changes in affinity, cellularity and efficiency in clearing the infection. Besides obvious cooperation, they reveal powerful competitions between the branches, and more intriguing, between cross-reacting and new responses when the latter suffer the competition by preformed cell-rich but inefficient clones, as memory, usually an asset, becomes a liability.

journal_name

Vaccine

journal_title

Vaccine

authors

Cheng Y,Ghersi D,Calcagno C,Selin LK,Puzone R,Celada F

doi

10.1016/j.vaccine.2008.11.109

subject

Has Abstract

pub_date

2009-02-05 00:00:00

pages

833-45

issue

6

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(08)01648-4

journal_volume

27

pub_type

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