Abstract：
OBJECTIVE:We related seroprevalence and outbreaks data in order to identify factors that could explain the occurrence of outbreaks despite high vaccination coverage in Medellín Colombia. METHODS:Samples from a population seroprevalence data obtained in 2009 in a random survey were analyzed. IgG levels were determined for mumps using 2 commercial tests of 2119 individuals aged 6-64 years. A comparative analysis was undertaken using age-specific mumps seroprevalence data and information of 98 epidemiological investigations of mumps outbreaks reported in 2009. RESULTS:Overall, seroprevalence was 91.6% (95% CI=89.3-93.5%). The age-specific seronegativity was 20.3% and 20.6% in age groups 11-15 years and 16-20 years respectively. Individuals aged 6-20 years were the most affected during outbreaks. In individuals born in 2003, a year after the change in the booster schedule from 10 to 5 years, the proportion of unvaccinated individuals (14%) and those who received only one dose of MMR (45%) increased substantially. On average, 23.5 days elapsed between the onset of symptoms in secondary cases and the outbreak investigation. CONCLUSION:Potential contributing factors for the occurrence of outbreaks of mumps were the relatively high prevalence of seronegativity among individuals aged 11-20 years, delays in investigation and control of outbreaks, and incomplete vaccination schedules.
journal_name
Vaccinejournal_title
Vaccineauthors
Santacruz-Sanmartín E,Hincapié-Palacio D,Ospina MC,Perez-Toro O,Bernal-Restrepo LM,Buitrago-Giraldo S,Lenis-Ballesteros V,Díaz FJdoi
10.1016/j.vaccine.2015.08.088subject
Has Abstractpub_date
2015-10-13 00:00:00pages
5606-5612issue
42eissn
0264-410Xissn
1873-2518pii
S0264-410X(15)01241-4journal_volume
33pub_type
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